JP2005532262A5 - - Google Patents

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Publication number
JP2005532262A5
JP2005532262A5 JP2003565315A JP2003565315A JP2005532262A5 JP 2005532262 A5 JP2005532262 A5 JP 2005532262A5 JP 2003565315 A JP2003565315 A JP 2003565315A JP 2003565315 A JP2003565315 A JP 2003565315A JP 2005532262 A5 JP2005532262 A5 JP 2005532262A5
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JP
Japan
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optionally substituted
ion
tri
salt
fluorobenzyl
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JP2003565315A
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English (en)
Japanese (ja)
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JP4530665B2 (ja
JP2005532262A (ja
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Priority claimed from PCT/US2003/003740 external-priority patent/WO2003065882A2/en
Publication of JP2005532262A publication Critical patent/JP2005532262A/ja
Publication of JP2005532262A5 publication Critical patent/JP2005532262A5/ja
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Publication of JP4530665B2 publication Critical patent/JP4530665B2/ja
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JP2003565315A 2002-02-06 2003-02-06 放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術 Expired - Fee Related JP4530665B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35456302P 2002-02-06 2002-02-06
PCT/US2003/003740 WO2003065882A2 (en) 2002-02-06 2003-02-06 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts

Publications (3)

Publication Number Publication Date
JP2005532262A JP2005532262A (ja) 2005-10-27
JP2005532262A5 true JP2005532262A5 (enExample) 2006-01-05
JP4530665B2 JP4530665B2 (ja) 2010-08-25

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ID=27734391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003565315A Expired - Fee Related JP4530665B2 (ja) 2002-02-06 2003-02-06 放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術

Country Status (9)

Country Link
US (2) US7112318B2 (enExample)
EP (1) EP1474177A4 (enExample)
JP (1) JP4530665B2 (enExample)
CN (2) CN100577213C (enExample)
AU (1) AU2003217349B2 (enExample)
CA (1) CA2474142C (enExample)
NZ (1) NZ534496A (enExample)
TW (1) TWI266634B (enExample)
WO (1) WO2003065882A2 (enExample)

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US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
JP4648319B2 (ja) * 2003-08-22 2011-03-09 アンティポディーン ファーマシューティカルズ インコーポレイティド ミトコンドリアを標的とする抗酸化剤として使用されるミトキノン誘導体
AU2011203177B2 (en) * 2004-02-24 2012-04-26 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
EP2610234A1 (en) 2004-02-24 2013-07-03 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7738096B2 (en) 2004-10-21 2010-06-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
JP2006315958A (ja) * 2005-05-10 2006-11-24 Nihon Medi Physics Co Ltd 放射性ハロゲン標識有機化合物の製造方法
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
WO2008015392A1 (en) * 2006-08-03 2008-02-07 Hammersmith Imanet Limited Fluoride drying method
EP2121711A4 (en) * 2007-02-16 2011-07-27 Univ Sydney CARBON PHOSPHONIUM COMPOUNDS AND THEIR USE IN BORON NEUTRON CAPTURE THERAPY (BORON NEUTRON CAPTURE THERAPY) AND IMAGE DISPLAY
EP1990310A1 (en) * 2007-04-23 2008-11-12 Trasis S.A. Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step
WO2008151003A2 (en) * 2007-05-30 2008-12-11 Children's Medical Center Corporation Novel fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
ES2767973T3 (es) * 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
EP3231804B1 (en) 2008-03-21 2021-03-03 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
DK2288336T3 (en) 2008-04-25 2017-03-13 Univ Northwestern NANOSTRUCTURES SUITABLE FOR COMPLEXATION OF CHOLESTEROL
JP5322527B2 (ja) * 2008-07-17 2013-10-23 浜松ホトニクス株式会社 アポトーシスの検出に適した化合物
LT2419096T (lt) 2009-04-15 2020-04-10 Lantheus Medical Imaging, Inc. Radiofarmacinės kompozicijos stabilizavimas naudojant askorbo rūgštį
US8968701B2 (en) 2009-07-10 2015-03-03 Piramal Imaging Sa Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
KR101709372B1 (ko) 2010-02-08 2017-02-22 랜티우스 메디컬 이메징, 인크. 조영제 및 이의 중간체를 합성하는 방법 및 장치
GB201005624D0 (en) * 2010-04-01 2010-05-19 Medical Res Council Probe
KR101172157B1 (ko) 2010-05-27 2012-08-07 전남대학교산학협력단 미토콘드리아 영상을 위한 방사성 약물의 제조 방법
US9205156B2 (en) 2010-05-27 2015-12-08 Hadasit Medical Research Services & Development Limited Molecular imaging agents
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN102898470B (zh) * 2012-11-02 2014-12-10 北京师范大学 一类新型有机膦化合物及其制备方法和应用
JP6527516B2 (ja) 2013-12-03 2019-06-05 ノースウェスタン ユニバーシティ リポソーム粒子、前述のものを作製する方法及びその使用
AU2015328242A1 (en) 2014-10-06 2017-04-27 Exicure, Inc. Anti-TNF compounds
JP6555719B2 (ja) * 2014-11-05 2019-08-07 国立大学法人東北大学 ホスホニウム化合物およびその製造方法
TWI611795B (zh) * 2016-07-18 2018-01-21 許百靈 多針孔單光子ｓｐｅｃｔ心肌血流絕對定量方法與用途
CN107233585B (zh) * 2017-06-09 2021-01-22 四川大学华西医院 黄连素或其衍生物在制备心肌灌注显像剂中的用途
KR20200028997A (ko) 2017-07-13 2020-03-17 노오쓰웨스턴 유니버시티 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법
PL239871B1 (pl) * 2018-09-05 2022-01-24 Synektik Spolka Akcyjna Znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej, zastosowanie znakowanego radioizotopem związku w metodzie diagnostycznej pozytonowej tomografii emisyjnej, a także kompozycja farmaceutyczna zawierająca znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej
CN110577478A (zh) * 2018-10-25 2019-12-17 南方医科大学南方医院 一种正电子探针及其制备方法与应用
US20220347323A1 (en) * 2019-09-18 2022-11-03 The Regents Of The University Of California Positron Emission Tomography Guided Delivery of Mitochondral Complex I Inhibitors
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids

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US4446123A (en) * 1982-10-13 1984-05-01 Hahnemann University Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
ATE353864T1 (de) * 1997-09-03 2007-03-15 Immunomedics Inc Fluorierung von proteinen und peptiden für positronemissionstomographie
JPH11295494A (ja) 1998-04-08 1999-10-29 Nippon Meji Physics Kk ［ｆ−１８］−フッ化物イオンの製造方法
WO2001082864A2 (en) * 2000-04-28 2001-11-08 Duke University 18f-labeled choline analogs
DE60134366D1 (de) * 2000-06-21 2008-07-24 Canon Kk Elektrophotographisches photoempfindliches Element, Prozesskartusche und elektrophotographischer Apparat
WO2003065882A2 (en) * 2002-02-06 2003-08-14 The Johns Hopkins University Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
JP2006512109A (ja) 2002-08-01 2006-04-13 ザ ジョンズ ホプキンズ ユニバーシティ 蛍光発光を用いた、分子構造の特定技術、および身体内腔の内側に並ぶ細胞種の治療技術

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