TWI266634B - Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts - Google Patents

Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts

Info

Publication number
TWI266634B
TWI266634B TW092102375A TW92102375A TWI266634B TW I266634 B TWI266634 B TW I266634B TW 092102375 A TW092102375 A TW 092102375A TW 92102375 A TW92102375 A TW 92102375A TW I266634 B TWI266634 B TW I266634B
Authority
TW
Taiwan
Prior art keywords
diagnostic imaging
imaging technology
invasive diagnostic
mitochondria dysfunction
lipophilic salts
Prior art date
Application number
TW092102375A
Other languages
English (en)
Chinese (zh)
Other versions
TW200307524A (en
Inventor
Igal Madar
Hayden T Ravert
Robert Dannals
Ursulla A Scheffel
James J Frost
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of TW200307524A publication Critical patent/TW200307524A/zh
Application granted granted Critical
Publication of TWI266634B publication Critical patent/TWI266634B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW092102375A 2002-02-06 2003-02-06 Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts TWI266634B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35456302P 2002-02-06 2002-02-06

Publications (2)

Publication Number Publication Date
TW200307524A TW200307524A (en) 2003-12-16
TWI266634B true TWI266634B (en) 2006-11-21

Family

ID=27734391

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092102375A TWI266634B (en) 2002-02-06 2003-02-06 Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts

Country Status (9)

Country Link
US (2) US7112318B2 (enExample)
EP (1) EP1474177A4 (enExample)
JP (1) JP4530665B2 (enExample)
CN (2) CN100577213C (enExample)
AU (1) AU2003217349B2 (enExample)
CA (1) CA2474142C (enExample)
NZ (1) NZ534496A (enExample)
TW (1) TWI266634B (enExample)
WO (1) WO2003065882A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
TWI266634B (en) * 2002-02-06 2006-11-21 Univ Johns Hopkins Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
CN1839142B (zh) 2003-08-22 2010-06-16 澳新制药公司 用作靶向线粒体的抗氧化剂的线粒体醌衍生物
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
EP2388017B1 (en) * 2004-02-24 2014-12-24 The General Hospital Corporation Catalytic radiofluorination
AU2011203177B2 (en) * 2004-02-24 2012-04-26 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) * 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7738096B2 (en) 2004-10-21 2010-06-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
JP2006315958A (ja) * 2005-05-10 2006-11-24 Nihon Medi Physics Co Ltd 放射性ハロゲン標識有機化合物の製造方法
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US8163039B2 (en) 2006-08-03 2012-04-24 Hammersmith Imanet Limited Fluoride drying method
US20100111867A1 (en) * 2007-02-16 2010-05-06 The University Of Sydney Carborane-phosphonium compounds and their use in boron neutron capture therapy and imaging
EP1990310A1 (en) * 2007-04-23 2008-11-12 Trasis S.A. Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step
EP2164524B1 (en) * 2007-05-30 2013-08-07 Children's Medical Center Corporation Fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
ES2767973T3 (es) * 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
CA2718035C (en) 2008-03-21 2017-10-24 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders
CN102036652B (zh) 2008-04-25 2016-04-13 西北大学 适于螯合胆甾醇的纳米结构
JP5322527B2 (ja) * 2008-07-17 2013-10-23 浜松ホトニクス株式会社 アポトーシスの検出に適した化合物
DK2419096T3 (da) 2009-04-15 2020-02-03 Lantheus Medical Imaging Inc Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre
EP2451760A1 (en) 2009-07-10 2012-05-16 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
AU2011213568B2 (en) 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
GB201005624D0 (en) * 2010-04-01 2010-05-19 Medical Res Council Probe
US9205156B2 (en) 2010-05-27 2015-12-08 Hadasit Medical Research Services & Development Limited Molecular imaging agents
KR101172157B1 (ko) 2010-05-27 2012-08-07 전남대학교산학협력단 미토콘드리아 영상을 위한 방사성 약물의 제조 방법
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN102898470B (zh) * 2012-11-02 2014-12-10 北京师范大学 一类新型有机膦化合物及其制备方法和应用
CN105939699B (zh) 2013-12-03 2020-10-02 西北大学 脂质体颗粒、制备所述脂质体颗粒的方法以及其用途
WO2016057549A1 (en) 2014-10-06 2016-04-14 Aurasense Therapeutics, Llc Anti-tnf compounds
JP6555719B2 (ja) * 2014-11-05 2019-08-07 国立大学法人東北大学 ホスホニウム化合物およびその製造方法
TWI611795B (zh) * 2016-07-18 2018-01-21 許百靈 多針孔單光子ｓｐｅｃｔ心肌血流絕對定量方法與用途
CN107233585B (zh) * 2017-06-09 2021-01-22 四川大学华西医院 黄连素或其衍生物在制备心肌灌注显像剂中的用途
KR20200028997A (ko) 2017-07-13 2020-03-17 노오쓰웨스턴 유니버시티 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법
PL239871B1 (pl) * 2018-09-05 2022-01-24 Synektik Spolka Akcyjna Znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej, zastosowanie znakowanego radioizotopem związku w metodzie diagnostycznej pozytonowej tomografii emisyjnej, a także kompozycja farmaceutyczna zawierająca znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej
CN110577478A (zh) * 2018-10-25 2019-12-17 南方医科大学南方医院 一种正电子探针及其制备方法与应用
US20220347323A1 (en) * 2019-09-18 2022-11-03 The Regents Of The University Of California Positron Emission Tomography Guided Delivery of Mitochondral Complex I Inhibitors
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446123A (en) * 1982-10-13 1984-05-01 Hahnemann University Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations
CA2302360C (en) 1997-09-03 2005-11-15 Immunomedics, Inc. Fluorination of proteins and peptides for f-18 positron emission tomography
JPH11295494A (ja) 1998-04-08 1999-10-29 Nippon Meji Physics Kk ［ｆ−１８］−フッ化物イオンの製造方法
US6630125B2 (en) * 2000-04-28 2003-10-07 Duke University 18F-labeled choline analogs
EP1174771B1 (en) * 2000-06-21 2008-06-11 Canon Kabushiki Kaisha Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus
TWI266634B (en) * 2002-02-06 2006-11-21 Univ Johns Hopkins Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
WO2004032621A2 (en) 2002-08-01 2004-04-22 The Johns Hopkins University Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence

Also Published As

Publication number Publication date
WO2003065882A3 (en) 2004-02-19
CA2474142C (en) 2013-02-05
TW200307524A (en) 2003-12-16
AU2003217349B2 (en) 2008-05-22
US7112318B2 (en) 2006-09-26
JP4530665B2 (ja) 2010-08-25
US20040033197A1 (en) 2004-02-19
WO2003065882A2 (en) 2003-08-14
CA2474142A1 (en) 2003-08-14
US8524193B2 (en) 2013-09-03
CN1627962A (zh) 2005-06-15
EP1474177A2 (en) 2004-11-10
NZ534496A (en) 2006-08-31
EP1474177A4 (en) 2010-07-21
CN101838289A (zh) 2010-09-22
AU2003217349A1 (en) 2003-09-02
JP2005532262A (ja) 2005-10-27
CN100577213C (zh) 2010-01-06
US20050182027A1 (en) 2005-08-18
HK1077500A1 (zh) 2006-02-17

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