AU2003217349B2 - Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts - Google Patents
Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts Download PDFInfo
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- High Energy & Nuclear Physics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/US2003/003740 WO2003065882A2 (en) | 2002-02-06 | 2003-02-06 | Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts |
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| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| TWI266634B (en) * | 2002-02-06 | 2006-11-21 | Univ Johns Hopkins | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| ES2541769T3 (es) * | 2003-08-22 | 2015-07-24 | Antipodean Pharmaceuticals, Inc. | Derivados de mitoquinona usados como antioxidantes dirigidos a las mitocondrias |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| EP2388017B1 (en) * | 2004-02-24 | 2014-12-24 | The General Hospital Corporation | Catalytic radiofluorination |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) * | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| AU2011203177B2 (en) * | 2004-02-24 | 2012-04-26 | The General Hospital Corporation | Catalytic radiofluorination |
| US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| US7738096B2 (en) | 2004-10-21 | 2010-06-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof |
| JP2006315958A (ja) * | 2005-05-10 | 2006-11-24 | Nihon Medi Physics Co Ltd | 放射性ハロゲン標識有機化合物の製造方法 |
| US7824659B2 (en) | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
| US8163039B2 (en) * | 2006-08-03 | 2012-04-24 | Hammersmith Imanet Limited | Fluoride drying method |
| US20100111867A1 (en) * | 2007-02-16 | 2010-05-06 | The University Of Sydney | Carborane-phosphonium compounds and their use in boron neutron capture therapy and imaging |
| EP1990310A1 (en) * | 2007-04-23 | 2008-11-12 | Trasis S.A. | Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step |
| WO2008151003A2 (en) * | 2007-05-30 | 2008-12-11 | Children's Medical Center Corporation | Novel fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography |
| US9717896B2 (en) | 2007-12-18 | 2017-08-01 | Gearbox, Llc | Treatment indications informed by a priori implant information |
| US8636670B2 (en) | 2008-05-13 | 2014-01-28 | The Invention Science Fund I, Llc | Circulatory monitoring systems and methods |
| US20090287120A1 (en) | 2007-12-18 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
| US8388936B2 (en) * | 2008-02-22 | 2013-03-05 | Mcw Research Foundation, Inc. | In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging |
| US8388931B2 (en) * | 2008-02-29 | 2013-03-05 | Marcos Lopez | 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors |
| KR101616139B1 (ko) | 2008-02-29 | 2016-04-27 | 랜티우스 메디컬 이메징, 인크. | 관류 영상화를 포함하는 용도를 위한 조영제 |
| EP3231804B1 (en) | 2008-03-21 | 2021-03-03 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders |
| JP5539962B2 (ja) | 2008-04-25 | 2014-07-02 | ノースウェスタン、ユニバーシティ | コレステロールを隔離するのに適したナノ構造体 |
| JP5322527B2 (ja) * | 2008-07-17 | 2013-10-23 | 浜松ホトニクス株式会社 | アポトーシスの検出に適した化合物 |
| DK2419096T3 (da) | 2009-04-15 | 2020-02-03 | Lantheus Medical Imaging Inc | Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre |
| WO2011003591A1 (en) | 2009-07-10 | 2011-01-13 | Bayer Schering Pharma Aktiengesellschaft | Usage of low to medium-pressure liquid chromatography for the purification of radiotracers |
| MX348958B (es) | 2010-02-08 | 2017-07-04 | Lantheus Medical Imaging Inc | Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos. |
| GB201005624D0 (en) * | 2010-04-01 | 2010-05-19 | Medical Res Council | Probe |
| KR101172157B1 (ko) | 2010-05-27 | 2012-08-07 | 전남대학교산학협력단 | 미토콘드리아 영상을 위한 방사성 약물의 제조 방법 |
| US9205156B2 (en) | 2010-05-27 | 2015-12-08 | Hadasit Medical Research Services & Development Limited | Molecular imaging agents |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN102898470B (zh) * | 2012-11-02 | 2014-12-10 | 北京师范大学 | 一类新型有机膦化合物及其制备方法和应用 |
| EP3076918A4 (en) | 2013-12-03 | 2017-06-07 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| CN107002081A (zh) | 2014-10-06 | 2017-08-01 | 埃克西奎雷股份有限公司 | 抗tnf化合物 |
| US20180030074A1 (en) * | 2014-11-05 | 2018-02-01 | Shozo Furumoto | Phosphonium compound and production method therefor |
| TWI611795B (zh) * | 2016-07-18 | 2018-01-21 | 許百靈 | 多針孔單光子ｓｐｅｃｔ心肌血流絕對定量方法與用途 |
| CN107233585B (zh) * | 2017-06-09 | 2021-01-22 | 四川大学华西医院 | 黄连素或其衍生物在制备心肌灌注显像剂中的用途 |
| KR20200028997A (ko) | 2017-07-13 | 2020-03-17 | 노오쓰웨스턴 유니버시티 | 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법 |
| PL239871B1 (pl) * | 2018-09-05 | 2022-01-24 | Synektik Spolka Akcyjna | Znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej, zastosowanie znakowanego radioizotopem związku w metodzie diagnostycznej pozytonowej tomografii emisyjnej, a także kompozycja farmaceutyczna zawierająca znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej |
| CN110577478A (zh) * | 2018-10-25 | 2019-12-17 | 南方医科大学南方医院 | 一种正电子探针及其制备方法与应用 |
| WO2021055814A1 (en) * | 2019-09-18 | 2021-03-25 | The Regents Of The University Of California | Positron emission tomography guided delivery of mitochondral complex i inhibitors |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
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| US4446123A (en) * | 1982-10-13 | 1984-05-01 | Hahnemann University | Process of radioimaging the myocardium of mammals utilizing radiolabeled lipophilic cations |
| JP3992923B2 (ja) | 1997-09-03 | 2007-10-17 | イムノメディクス， インコーポレイテッド | Ｆ−１８陽電子放出トモグラフィー用のタン白及びペプチドのフッ素化方法 |
| JPH11295494A (ja) | 1998-04-08 | 1999-10-29 | Nippon Meji Physics Kk | ［ｆ−１８］−フッ化物イオンの製造方法 |
| WO2001082864A2 (en) * | 2000-04-28 | 2001-11-08 | Duke University | 18f-labeled choline analogs |
| EP1174771B1 (en) * | 2000-06-21 | 2008-06-11 | Canon Kabushiki Kaisha | Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus |
| TWI266634B (en) * | 2002-02-06 | 2006-11-21 | Univ Johns Hopkins | Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts |
| US7515953B2 (en) | 2002-08-01 | 2009-04-07 | The Johns Hopkins University | Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence |
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| US8524193B2 (en) | 2013-09-03 |
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| HK1077500A1 (zh) | 2006-02-17 |
| JP2005532262A (ja) | 2005-10-27 |
| CN100577213C (zh) | 2010-01-06 |
| TWI266634B (en) | 2006-11-21 |
| AU2003217349A1 (en) | 2003-09-02 |
| WO2003065882A2 (en) | 2003-08-14 |
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| WO2003065882A3 (en) | 2004-02-19 |
| EP1474177A2 (en) | 2004-11-10 |
| US20040033197A1 (en) | 2004-02-19 |
| CA2474142C (en) | 2013-02-05 |
| CN101838289A (zh) | 2010-09-22 |
| TW200307524A (en) | 2003-12-16 |
| JP4530665B2 (ja) | 2010-08-25 |
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