CN100577213C - 使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术 - Google Patents

使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术 Download PDF

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CN100577213C
CN100577213C CN03803440A CN03803440A CN100577213C CN 100577213 C CN100577213 C CN 100577213C CN 03803440 A CN03803440 A CN 03803440A CN 03803440 A CN03803440 A CN 03803440A CN 100577213 C CN100577213 C CN 100577213C
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salt
phosphonium ion
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CN1627962A (zh
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I·马达尔
H·T·拉韦特
R·达纳尔斯
U·A·舍费尔
J·J·弗罗斯特
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN03803440A 2002-02-06 2003-02-06 使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术 Expired - Fee Related CN100577213C (zh)

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CN200910221879A Pending CN101838289A (zh) 2002-02-06 2003-02-06 使用放射性同位素标示亲油性盐的用于线粒体机能障碍的非侵入性诊断显像技术

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CN102898470A (zh) * 2012-11-02 2013-01-30 北京师范大学 一类新型有机膦化合物及其制备方法和应用
CN110577478A (zh) * 2018-10-25 2019-12-17 南方医科大学南方医院 一种正电子探针及其制备方法与应用

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CN1839142B (zh) 2003-08-22 2010-06-16 澳新制药公司 用作靶向线粒体的抗氧化剂的线粒体醌衍生物
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
EP2388017B1 (en) * 2004-02-24 2014-12-24 The General Hospital Corporation Catalytic radiofluorination
AU2011203177B2 (en) * 2004-02-24 2012-04-26 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) * 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US7738096B2 (en) 2004-10-21 2010-06-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
JP2006315958A (ja) * 2005-05-10 2006-11-24 Nihon Medi Physics Co Ltd 放射性ハロゲン標識有機化合物の製造方法
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US8163039B2 (en) 2006-08-03 2012-04-24 Hammersmith Imanet Limited Fluoride drying method
US20100111867A1 (en) * 2007-02-16 2010-05-06 The University Of Sydney Carborane-phosphonium compounds and their use in boron neutron capture therapy and imaging
EP1990310A1 (en) * 2007-04-23 2008-11-12 Trasis S.A. Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step
EP2164524B1 (en) * 2007-05-30 2013-08-07 Children's Medical Center Corporation Fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
ES2767973T3 (es) * 2008-02-29 2020-06-19 Lantheus Medical Imaging Inc Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
CA2718035C (en) 2008-03-21 2017-10-24 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer' s disease and related disorders
CN102036652B (zh) 2008-04-25 2016-04-13 西北大学 适于螯合胆甾醇的纳米结构
JP5322527B2 (ja) * 2008-07-17 2013-10-23 浜松ホトニクス株式会社 アポトーシスの検出に適した化合物
DK2419096T3 (da) 2009-04-15 2020-02-03 Lantheus Medical Imaging Inc Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre
EP2451760A1 (en) 2009-07-10 2012-05-16 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
AU2011213568B2 (en) 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
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US9205156B2 (en) 2010-05-27 2015-12-08 Hadasit Medical Research Services & Development Limited Molecular imaging agents
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AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN105939699B (zh) 2013-12-03 2020-10-02 西北大学 脂质体颗粒、制备所述脂质体颗粒的方法以及其用途
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JP6555719B2 (ja) * 2014-11-05 2019-08-07 国立大学法人東北大学 ホスホニウム化合物およびその製造方法
TWI611795B (zh) * 2016-07-18 2018-01-21 許百靈 多針孔單光子ｓｐｅｃｔ心肌血流絕對定量方法與用途
CN107233585B (zh) * 2017-06-09 2021-01-22 四川大学华西医院 黄连素或其衍生物在制备心肌灌注显像剂中的用途
KR20200028997A (ko) 2017-07-13 2020-03-17 노오쓰웨스턴 유니버시티 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법
PL239871B1 (pl) * 2018-09-05 2022-01-24 Synektik Spolka Akcyjna Znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej, zastosowanie znakowanego radioizotopem związku w metodzie diagnostycznej pozytonowej tomografii emisyjnej, a także kompozycja farmaceutyczna zawierająca znakowany radioizotopem związek czwartorzędowej soli amoniowej wielopierścieniowej aminy aromatycznej
US20220347323A1 (en) * 2019-09-18 2022-11-03 The Regents Of The University Of California Positron Emission Tomography Guided Delivery of Mitochondral Complex I Inhibitors
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN102898470A (zh) * 2012-11-02 2013-01-30 北京师范大学 一类新型有机膦化合物及其制备方法和应用
CN102898470B (zh) * 2012-11-02 2014-12-10 北京师范大学 一类新型有机膦化合物及其制备方法和应用
CN110577478A (zh) * 2018-10-25 2019-12-17 南方医科大学南方医院 一种正电子探针及其制备方法与应用

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WO2003065882A3 (en) 2004-02-19
CA2474142C (en) 2013-02-05
TW200307524A (en) 2003-12-16
AU2003217349B2 (en) 2008-05-22
US7112318B2 (en) 2006-09-26
JP4530665B2 (ja) 2010-08-25
US20040033197A1 (en) 2004-02-19
WO2003065882A2 (en) 2003-08-14
CA2474142A1 (en) 2003-08-14
US8524193B2 (en) 2013-09-03
CN1627962A (zh) 2005-06-15
EP1474177A2 (en) 2004-11-10
NZ534496A (en) 2006-08-31
EP1474177A4 (en) 2010-07-21
CN101838289A (zh) 2010-09-22
AU2003217349A1 (en) 2003-09-02
TWI266634B (en) 2006-11-21
JP2005532262A (ja) 2005-10-27
US20050182027A1 (en) 2005-08-18
HK1077500A1 (zh) 2006-02-17

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