JP4490110B2 - 炎症性症状の治療のためのｃｃｒ３拮抗薬としての、ｎ−｛［（２ｓ）−４−（３，４−ジフルオロベンジル）モルホリン−２−イル］メチル｝−２−｛３−［（メチルスルホニル）アミノ］フェニル｝アセトアミド - Google Patents
炎症性症状の治療のためのｃｃｒ３拮抗薬としての、ｎ−｛［（２ｓ）−４−（３，４−ジフルオロベンジル）モルホリン−２−イル］メチル｝−２−｛３−［（メチルスルホニル）アミノ］フェニル｝アセトアミド Download PDFInfo
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- JP4490110B2 JP4490110B2 JP2003579828A JP2003579828A JP4490110B2 JP 4490110 B2 JP4490110 B2 JP 4490110B2 JP 2003579828 A JP2003579828 A JP 2003579828A JP 2003579828 A JP2003579828 A JP 2003579828A JP 4490110 B2 JP4490110 B2 JP 4490110B2
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- 210000001616 monocyte Anatomy 0.000 description 1
- OXYALYJRWGRVAM-UHFFFAOYSA-N morpholin-2-ylmethanamine Chemical compound NCC1CNCCO1 OXYALYJRWGRVAM-UHFFFAOYSA-N 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 229960002259 nedocromil sodium Drugs 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 208000015768 polyposis Diseases 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 201000009732 pulmonary eosinophilia Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 239000003087 receptor blocking agent Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 229960004017 salmeterol Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229940023144 sodium glycolate Drugs 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 229960004016 sucrose syrup Drugs 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000008181 tonicity modifier Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 239000002750 tryptase inhibitor Substances 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207449.0A GB0207449D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| PCT/EP2003/003339 WO2003082291A1 (en) | 2002-03-28 | 2003-03-27 | N-{´ (2s) -4- (3, 4-difluorobenzyl) morpholin-2yl!methyl} -2-{3-' (methylsulphonyl) amino! phenyl}acetamide as ccr3 antagonist for the treatment of inflammatory conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525390A JP2005525390A (ja) | 2005-08-25 |
| JP2005525390A5 JP2005525390A5 (enExample) | 2006-05-18 |
| JP4490110B2 true JP4490110B2 (ja) | 2010-06-23 |
Family
ID=9933998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579828A Expired - Lifetime JP4490110B2 (ja) | 2002-03-28 | 2003-03-27 | 炎症性症状の治療のためのｃｃｒ３拮抗薬としての、ｎ−｛［（２ｓ）−４−（３，４−ジフルオロベンジル）モルホリン−２−イル］メチル｝−２−｛３−［（メチルスルホニル）アミノ］フェニル｝アセトアミド |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20060058299A1 (enExample) |
| EP (1) | EP1487453B1 (enExample) |
| JP (1) | JP4490110B2 (enExample) |
| KR (1) | KR20040095347A (enExample) |
| CN (1) | CN1642553A (enExample) |
| AR (1) | AR039177A1 (enExample) |
| AT (1) | ATE454892T1 (enExample) |
| AU (1) | AU2003216905A1 (enExample) |
| BR (1) | BR0308719A (enExample) |
| CA (1) | CA2479910A1 (enExample) |
| DE (1) | DE60330952D1 (enExample) |
| ES (1) | ES2339436T3 (enExample) |
| GB (1) | GB0207449D0 (enExample) |
| IL (1) | IL163648A0 (enExample) |
| IS (1) | IS7415A (enExample) |
| MX (1) | MXPA04009458A (enExample) |
| NO (1) | NO20044098L (enExample) |
| PL (1) | PL372930A1 (enExample) |
| RU (1) | RU2004126145A (enExample) |
| TW (1) | TW200400823A (enExample) |
| WO (1) | WO2003082291A1 (enExample) |
| ZA (1) | ZA200406990B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004028530A1 (en) | 2002-09-26 | 2004-04-08 | Bristol-Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| JP2009501792A (ja) * | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体のモジュレーターとしてのｎ−ベンジル−モルホリン誘導体 |
| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| WO2007034252A1 (en) * | 2005-09-22 | 2007-03-29 | Sanofi-Aventis | Amino-alkyl-amide derivatives as ccr3 receptor liquids |
| HUP0800478A2 (en) * | 2008-07-31 | 2010-03-01 | Sanofi Aventis | Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands |
| WO2013079696A1 (en) * | 2011-12-01 | 2013-06-06 | Glaxo Group Limited | Methods of treatment and prevention of eye diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562929A (en) * | 1979-06-21 | 1981-01-13 | Sumitomo Chem Co Ltd | Preparation of optically active cyclopentenolone |
| US4870074A (en) * | 1986-04-30 | 1989-09-26 | Dainippon Pharmaceutical Co., Ltd. | Substituted benzamide derivatives, for enhancing gastrointestinal motility |
| JPH01117882A (ja) * | 1987-10-30 | 1989-05-10 | Dainippon Pharmaceut Co Ltd | 複素環式カルボン酸アミド誘導体 |
| JPH03291274A (ja) * | 1990-04-09 | 1991-12-20 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| TW223629B (enExample) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US6031097A (en) * | 1997-10-27 | 2000-02-29 | Neurogen Corporation | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands |
| AU2056800A (en) * | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
| ATE254620T1 (de) * | 1999-09-14 | 2003-12-15 | Aventis Pharma Inc | Unsubstituierte ethyl- und propylderivate von phenoxythienoisoxazolen als d4 antagonisten |
| CZ20031195A3 (cs) * | 2000-09-29 | 2003-09-17 | Glaxo Group Limited | Morfolinacetamidové deriváty |
| ES2275729T3 (es) * | 2000-09-29 | 2007-06-16 | Glaxo Group Limited | Compuestos utiles en el tratamiento de enfermedades inflamatorias. |
-
2002
- 2002-03-28 GB GBGB0207449.0A patent/GB0207449D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106782A patent/TW200400823A/zh unknown
- 2003-03-27 WO PCT/EP2003/003339 patent/WO2003082291A1/en not_active Ceased
- 2003-03-27 US US10/509,417 patent/US20060058299A1/en not_active Abandoned
- 2003-03-27 CA CA002479910A patent/CA2479910A1/en not_active Abandoned
- 2003-03-27 IL IL16364803A patent/IL163648A0/xx unknown
- 2003-03-27 AT AT03712117T patent/ATE454892T1/de not_active IP Right Cessation
- 2003-03-27 DE DE60330952T patent/DE60330952D1/de not_active Expired - Lifetime
- 2003-03-27 MX MXPA04009458A patent/MXPA04009458A/es unknown
- 2003-03-27 KR KR10-2004-7015447A patent/KR20040095347A/ko not_active Withdrawn
- 2003-03-27 AU AU2003216905A patent/AU2003216905A1/en not_active Abandoned
- 2003-03-27 AR ARP030101090A patent/AR039177A1/es unknown
- 2003-03-27 BR BR0308719-0A patent/BR0308719A/pt not_active Application Discontinuation
- 2003-03-27 ES ES03712117T patent/ES2339436T3/es not_active Expired - Lifetime
- 2003-03-27 CN CNA038068656A patent/CN1642553A/zh active Pending
- 2003-03-27 EP EP03712117A patent/EP1487453B1/en not_active Expired - Lifetime
- 2003-03-27 RU RU2004126145/04A patent/RU2004126145A/ru not_active Application Discontinuation
- 2003-03-27 PL PL03372930A patent/PL372930A1/xx not_active Application Discontinuation
- 2003-03-27 JP JP2003579828A patent/JP4490110B2/ja not_active Expired - Lifetime
-
2004
- 2004-08-19 IS IS7415A patent/IS7415A/is unknown
- 2004-09-01 ZA ZA200406990A patent/ZA200406990B/en unknown
- 2004-09-27 NO NO20044098A patent/NO20044098L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1642553A (zh) | 2005-07-20 |
| RU2004126145A (ru) | 2005-06-27 |
| CA2479910A1 (en) | 2003-10-09 |
| KR20040095347A (ko) | 2004-11-12 |
| ATE454892T1 (de) | 2010-01-15 |
| NO20044098L (no) | 2004-10-04 |
| IS7415A (is) | 2004-08-19 |
| IL163648A0 (en) | 2005-12-18 |
| GB0207449D0 (en) | 2002-05-08 |
| PL372930A1 (en) | 2005-08-08 |
| DE60330952D1 (de) | 2010-03-04 |
| ZA200406990B (en) | 2005-11-08 |
| BR0308719A (pt) | 2005-01-04 |
| ES2339436T3 (es) | 2010-05-20 |
| AU2003216905A1 (en) | 2003-10-13 |
| JP2005525390A (ja) | 2005-08-25 |
| EP1487453A1 (en) | 2004-12-22 |
| EP1487453B1 (en) | 2010-01-13 |
| AR039177A1 (es) | 2005-02-09 |
| US20060058299A1 (en) | 2006-03-16 |
| WO2003082291A1 (en) | 2003-10-09 |
| TW200400823A (en) | 2004-01-16 |
| MXPA04009458A (es) | 2005-07-27 |
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| JPWO2001034569A1 (ja) | 膵炎治療剤 |
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