IS7415A - N-{'(2S)-4-(3,4-díflúrbensýl)morfólín-2ýl!metýl}-2-{3-'(metýlsúlfónýl)amínó!fenýl} asetamíð sem CCR3 mótlyf fyrir meðhöndlun bólgusjúkdóma - Google Patents
N-{'(2S)-4-(3,4-díflúrbensýl)morfólín-2ýl!metýl}-2-{3-'(metýlsúlfónýl)amínó!fenýl} asetamíð sem CCR3 mótlyf fyrir meðhöndlun bólgusjúkdómaInfo
- Publication number
- IS7415A IS7415A IS7415A IS7415A IS7415A IS 7415 A IS7415 A IS 7415A IS 7415 A IS7415 A IS 7415A IS 7415 A IS7415 A IS 7415A IS 7415 A IS7415 A IS 7415A
- Authority
- IS
- Iceland
- Prior art keywords
- difluorobenzyl
- methylsulfonyl
- ylmethyl
- acetamide
- morpholine
- Prior art date
Links
- NDZYPHLNJZSQJY-QNWVGRARSA-N 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(1r,2s)-2-[[(3s)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea Chemical compound CC1=C(C(=O)C)SC(NC(=O)N[C@H]2[C@@H](CCCC2)CN2C[C@H](CC=3C=CC(F)=CC=3)CCC2)=N1 NDZYPHLNJZSQJY-QNWVGRARSA-N 0.000 title 1
- 125000006509 3,4-difluorobenzyl group Chemical group [H]C1=C(F)C(F)=C([H])C(=C1[H])C([H])([H])* 0.000 title 1
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207449.0A GB0207449D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| PCT/EP2003/003339 WO2003082291A1 (en) | 2002-03-28 | 2003-03-27 | N-{´ (2s) -4- (3, 4-difluorobenzyl) morpholin-2yl!methyl} -2-{3-' (methylsulphonyl) amino! phenyl}acetamide as ccr3 antagonist for the treatment of inflammatory conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS7415A true IS7415A (is) | 2004-08-19 |
Family
ID=9933998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7415A IS7415A (is) | 2002-03-28 | 2004-08-19 | N-{'(2S)-4-(3,4-díflúrbensýl)morfólín-2ýl!metýl}-2-{3-'(metýlsúlfónýl)amínó!fenýl} asetamíð sem CCR3 mótlyf fyrir meðhöndlun bólgusjúkdóma |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20060058299A1 (enExample) |
| EP (1) | EP1487453B1 (enExample) |
| JP (1) | JP4490110B2 (enExample) |
| KR (1) | KR20040095347A (enExample) |
| CN (1) | CN1642553A (enExample) |
| AR (1) | AR039177A1 (enExample) |
| AT (1) | ATE454892T1 (enExample) |
| AU (1) | AU2003216905A1 (enExample) |
| BR (1) | BR0308719A (enExample) |
| CA (1) | CA2479910A1 (enExample) |
| DE (1) | DE60330952D1 (enExample) |
| ES (1) | ES2339436T3 (enExample) |
| GB (1) | GB0207449D0 (enExample) |
| IL (1) | IL163648A0 (enExample) |
| IS (1) | IS7415A (enExample) |
| MX (1) | MXPA04009458A (enExample) |
| NO (1) | NO20044098L (enExample) |
| PL (1) | PL372930A1 (enExample) |
| RU (1) | RU2004126145A (enExample) |
| TW (1) | TW200400823A (enExample) |
| WO (1) | WO2003082291A1 (enExample) |
| ZA (1) | ZA200406990B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003275257A1 (en) | 2002-09-26 | 2004-04-19 | Bristol-Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| JP2009501792A (ja) * | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体のモジュレーターとしてのｎ−ベンジル−モルホリン誘導体 |
| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| CA2623317A1 (en) * | 2005-09-22 | 2007-03-29 | Sanofi-Aventis | Amino-alkyl-amide derivatives as ccr3 receptor liquids |
| HUP0800478A2 (en) * | 2008-07-31 | 2010-03-01 | Sanofi Aventis | Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands |
| CN104203231A (zh) * | 2011-12-01 | 2014-12-10 | 葛兰素集团有限公司 | 治疗和预防眼疾病的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562929A (en) * | 1979-06-21 | 1981-01-13 | Sumitomo Chem Co Ltd | Preparation of optically active cyclopentenolone |
| US4870074A (en) * | 1986-04-30 | 1989-09-26 | Dainippon Pharmaceutical Co., Ltd. | Substituted benzamide derivatives, for enhancing gastrointestinal motility |
| JPH01117882A (ja) * | 1987-10-30 | 1989-05-10 | Dainippon Pharmaceut Co Ltd | 複素環式カルボン酸アミド誘導体 |
| JPH03291274A (ja) * | 1990-04-09 | 1991-12-20 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| TW223629B (enExample) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US6031097A (en) * | 1997-10-27 | 2000-02-29 | Neurogen Corporation | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands |
| EP1140834A1 (en) * | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
| CA2383327C (en) * | 1999-09-14 | 2009-11-03 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| BR0114323A (pt) * | 2000-09-29 | 2003-07-01 | Glaxo Group Ltd | Composto ou um seu sal ou solvato farmaceuticamente aceitável, composição farmacêutica, uso do composto ou de um seu sal ou solvato farmaceuticamente aceitável, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar o composto |
| BR0114321A (pt) * | 2000-09-29 | 2003-07-01 | Glaxo Group Ltd | Composto, composição farmacêutica, uso de um composto, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar um composto |
-
2002
- 2002-03-28 GB GBGB0207449.0A patent/GB0207449D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106782A patent/TW200400823A/zh unknown
- 2003-03-27 JP JP2003579828A patent/JP4490110B2/ja not_active Expired - Lifetime
- 2003-03-27 CN CNA038068656A patent/CN1642553A/zh active Pending
- 2003-03-27 CA CA002479910A patent/CA2479910A1/en not_active Abandoned
- 2003-03-27 AU AU2003216905A patent/AU2003216905A1/en not_active Abandoned
- 2003-03-27 PL PL03372930A patent/PL372930A1/xx not_active Application Discontinuation
- 2003-03-27 ES ES03712117T patent/ES2339436T3/es not_active Expired - Lifetime
- 2003-03-27 AT AT03712117T patent/ATE454892T1/de not_active IP Right Cessation
- 2003-03-27 WO PCT/EP2003/003339 patent/WO2003082291A1/en not_active Ceased
- 2003-03-27 MX MXPA04009458A patent/MXPA04009458A/es unknown
- 2003-03-27 US US10/509,417 patent/US20060058299A1/en not_active Abandoned
- 2003-03-27 IL IL16364803A patent/IL163648A0/xx unknown
- 2003-03-27 AR ARP030101090A patent/AR039177A1/es unknown
- 2003-03-27 KR KR10-2004-7015447A patent/KR20040095347A/ko not_active Withdrawn
- 2003-03-27 RU RU2004126145/04A patent/RU2004126145A/ru not_active Application Discontinuation
- 2003-03-27 DE DE60330952T patent/DE60330952D1/de not_active Expired - Lifetime
- 2003-03-27 BR BR0308719-0A patent/BR0308719A/pt not_active Application Discontinuation
- 2003-03-27 EP EP03712117A patent/EP1487453B1/en not_active Expired - Lifetime
-
2004
- 2004-08-19 IS IS7415A patent/IS7415A/is unknown
- 2004-09-01 ZA ZA200406990A patent/ZA200406990B/en unknown
- 2004-09-27 NO NO20044098A patent/NO20044098L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2479910A1 (en) | 2003-10-09 |
| JP2005525390A (ja) | 2005-08-25 |
| ATE454892T1 (de) | 2010-01-15 |
| ES2339436T3 (es) | 2010-05-20 |
| AU2003216905A1 (en) | 2003-10-13 |
| CN1642553A (zh) | 2005-07-20 |
| EP1487453A1 (en) | 2004-12-22 |
| MXPA04009458A (es) | 2005-07-27 |
| KR20040095347A (ko) | 2004-11-12 |
| IL163648A0 (en) | 2005-12-18 |
| BR0308719A (pt) | 2005-01-04 |
| TW200400823A (en) | 2004-01-16 |
| DE60330952D1 (de) | 2010-03-04 |
| GB0207449D0 (en) | 2002-05-08 |
| NO20044098L (no) | 2004-10-04 |
| EP1487453B1 (en) | 2010-01-13 |
| WO2003082291A1 (en) | 2003-10-09 |
| PL372930A1 (en) | 2005-08-08 |
| AR039177A1 (es) | 2005-02-09 |
| US20060058299A1 (en) | 2006-03-16 |
| RU2004126145A (ru) | 2005-06-27 |
| JP4490110B2 (ja) | 2010-06-23 |
| ZA200406990B (en) | 2005-11-08 |
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