JP4456367B2 - 一部が蛋白質に結合した物質を取除く方法および装置 - Google Patents
一部が蛋白質に結合した物質を取除く方法および装置 Download PDFInfo
- Publication number
- JP4456367B2 JP4456367B2 JP2003577978A JP2003577978A JP4456367B2 JP 4456367 B2 JP4456367 B2 JP 4456367B2 JP 2003577978 A JP2003577978 A JP 2003577978A JP 2003577978 A JP2003577978 A JP 2003577978A JP 4456367 B2 JP4456367 B2 JP 4456367B2
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- Prior art keywords
- blood
- dialysis fluid
- fluid
- dialyzer
- dialysis
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3465—Substitution fluids using dialysate as substitution fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
- B01D61/244—Dialysis comprising multiple dialysis steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3324—PH measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Water Supply & Treatment (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
ここで、eは指数関数を示し、指数fは数2で計算される。
本発明は、血液回路と、流体回路と、流体室を血液室から隔離する半透膜を有する濾過器とを含み、血液および浄化流体を混合し、前記混合液を血液室に通して導くための手段と、流体室への限外濾過が生じるように膜を隔てて圧力勾配を与える手段とを備え、流体室は浄化流体流量と患者の望ましい重量減との合計に寸法が等しく構成され、血液から一部が担体に結合した物質を除去するようになっていて、濾過器の水透過係数L p Aが少なくとも10ml/分/mmHgであり、浄化流体流量が少なくとも1000ml/分であり、浄化流体流量と血液流量との間の比率が少なくとも5である装置を提供する。
11 動脈血ライン
12 合流点
15 血液ライン
17 静脈血ライン
18 血液ヒーター
20 大形透析器
21 血液室
22,32 半透膜
23,33 透析液体室
30 小型透析器
31 血液室
40 限外濾過器
41,43 室
50 水入口または入口
51 主流体ライン
60 濃縮液ポンプ
61,71 容器
62,63 濃縮液ライン
65,75 合流点
66,76 伝導セル
70 濃縮液ポンプ
72,73 濃縮液ライン
80 制限器
85 ヒーター
90 ポンプ
100,101 流量セル
110,111,113,114,115 ライン
120 ヒーター
122,123 ライン
130 制限器
135 ポンプ
140 三路バルブ
141,151 バイパス・ライン
145 流量計
150 バルブ
160 血液漏洩検出器
170 ポンプ
180 制限器
190 気泡分離器
200 透析器
210,220 吸着塔
Claims (4)
- 血液回路と、流体回路と、流体室を血液室から隔離する半透膜を有する濾過器とを含み、血液および浄化流体を混合し、前記混合液を血液室に通して導くための手段と、流体室への限外濾過が生じるように膜を隔てて圧力勾配を与える手段とを備え、流体室は浄化流体流量と患者の望ましい重量減との合計に寸法が等しく構成され、血液から一部が担体に結合した物質を除去するための装置であって、
濾過器の水透過係数L p Aが少なくとも10ml/分/mmHgであり、
浄化流体流量が少なくとも1000ml/分であり、
浄化流体流量と血液流量との間の比率が少なくとも5であることを特徴とする装置。 - 濾過器が直列または並列、またはその組合せで配置された幾つかの濾過器によって置き換えられた請求項1に記載された装置。
- 血液が患者に戻される前に血液を加熱するためにヒーターが配置された請求項1または2に記載された装置。
- 血液が患者に戻される前の血液の通路に沿う最終の透析器がヒーターである請求項3に記載された装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0200956A SE0200956D0 (sv) | 2002-03-27 | 2002-03-27 | Method and device for the removal of protein bound substances |
SE0201317A SE522692C2 (sv) | 2002-03-27 | 2002-05-02 | Förfarande och anordning för avlägsnande av delvis proteinbundna substanser |
PCT/SE2003/000497 WO2003080154A1 (en) | 2002-03-27 | 2003-03-25 | Method and device for the removal of partially protein bound substances |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009231605A Division JP5438456B2 (ja) | 2002-03-27 | 2009-10-05 | 一部が蛋白質に結合した物質を取除く装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005520643A JP2005520643A (ja) | 2005-07-14 |
JP4456367B2 true JP4456367B2 (ja) | 2010-04-28 |
Family
ID=26655692
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003577978A Expired - Lifetime JP4456367B2 (ja) | 2002-03-27 | 2003-03-25 | 一部が蛋白質に結合した物質を取除く方法および装置 |
JP2009231605A Expired - Lifetime JP5438456B2 (ja) | 2002-03-27 | 2009-10-05 | 一部が蛋白質に結合した物質を取除く装置 |
JP2013196882A Expired - Lifetime JP5711330B2 (ja) | 2002-03-27 | 2013-09-24 | 一部が蛋白質に結合した物質を取除く装置 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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JP2009231605A Expired - Lifetime JP5438456B2 (ja) | 2002-03-27 | 2009-10-05 | 一部が蛋白質に結合した物質を取除く装置 |
JP2013196882A Expired - Lifetime JP5711330B2 (ja) | 2002-03-27 | 2013-09-24 | 一部が蛋白質に結合した物質を取除く装置 |
Country Status (11)
Country | Link |
---|---|
US (3) | US7615158B2 (ja) |
EP (1) | EP1490129B1 (ja) |
JP (3) | JP4456367B2 (ja) |
KR (1) | KR101044980B1 (ja) |
CN (1) | CN100502959C (ja) |
AT (1) | ATE441444T1 (ja) |
AU (1) | AU2003214752A1 (ja) |
DE (1) | DE60329088D1 (ja) |
ES (1) | ES2333002T3 (ja) |
SE (1) | SE522692C2 (ja) |
WO (1) | WO2003080154A1 (ja) |
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-
2002
- 2002-05-02 SE SE0201317A patent/SE522692C2/sv not_active IP Right Cessation
-
2003
- 2003-03-25 AU AU2003214752A patent/AU2003214752A1/en not_active Abandoned
- 2003-03-25 ES ES03710580T patent/ES2333002T3/es not_active Expired - Lifetime
- 2003-03-25 EP EP03710580A patent/EP1490129B1/en not_active Expired - Lifetime
- 2003-03-25 US US10/500,478 patent/US7615158B2/en not_active Expired - Lifetime
- 2003-03-25 CN CNB038037572A patent/CN100502959C/zh not_active Expired - Lifetime
- 2003-03-25 AT AT03710580T patent/ATE441444T1/de not_active IP Right Cessation
- 2003-03-25 WO PCT/SE2003/000497 patent/WO2003080154A1/en active Application Filing
- 2003-03-25 JP JP2003577978A patent/JP4456367B2/ja not_active Expired - Lifetime
- 2003-03-25 DE DE60329088T patent/DE60329088D1/de not_active Expired - Lifetime
- 2003-03-25 KR KR1020047013920A patent/KR101044980B1/ko active IP Right Grant
-
2009
- 2009-09-28 US US12/567,994 patent/US7879242B2/en not_active Expired - Lifetime
- 2009-10-05 JP JP2009231605A patent/JP5438456B2/ja not_active Expired - Lifetime
-
2010
- 2010-12-22 US US12/976,653 patent/US8048310B2/en not_active Expired - Fee Related
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2013
- 2013-09-24 JP JP2013196882A patent/JP5711330B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7615158B2 (en) | 2009-11-10 |
JP5711330B2 (ja) | 2015-04-30 |
KR20040093102A (ko) | 2004-11-04 |
ATE441444T1 (de) | 2009-09-15 |
WO2003080154A1 (en) | 2003-10-02 |
CN1630540A (zh) | 2005-06-22 |
SE522692C2 (sv) | 2004-03-02 |
JP5438456B2 (ja) | 2014-03-12 |
US8048310B2 (en) | 2011-11-01 |
SE0201317L (sv) | 2003-09-28 |
KR101044980B1 (ko) | 2011-06-29 |
ES2333002T3 (es) | 2010-02-16 |
DE60329088D1 (de) | 2009-10-15 |
JP2005520643A (ja) | 2005-07-14 |
EP1490129A1 (en) | 2004-12-29 |
US7879242B2 (en) | 2011-02-01 |
EP1490129B1 (en) | 2009-09-02 |
CN100502959C (zh) | 2009-06-24 |
US20050115898A1 (en) | 2005-06-02 |
US20110089112A1 (en) | 2011-04-21 |
AU2003214752A1 (en) | 2003-10-08 |
US20100044313A1 (en) | 2010-02-25 |
JP2010042272A (ja) | 2010-02-25 |
SE0201317D0 (sv) | 2002-05-02 |
JP2014028290A (ja) | 2014-02-13 |
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