JP2010042272A - 一部が蛋白質に結合した物質を取除く装置 - Google Patents
一部が蛋白質に結合した物質を取除く装置 Download PDFInfo
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- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1692—Detection of blood traces in dialysate
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- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
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- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
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- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
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- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
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- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
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- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
Abstract
【解決手段】浄化流体流量と濾過器の物質移動係数koAとを、従来の透析器に比較して大幅に増大させ、浄化流体流量が少なくとも2000ml/分であり、物質移動係数koAが少なくとも2000ml/分である。また、濾過器の物質移動係数koAと血液流量との間の比率は少なくとも5であり、浄化流体流量と血液流量との間の比率が少なくとも5である構成とする。
【選択図】図1
Description
ここで、eは指数関数を示し、指数fは数2で計算される。
物質の大部分が担体に結合し、濃度勾配が小さな場合には、移送を向上させるように膜自体を改善すれば良好な結果が達成される。これは米国特許第5744042号に示唆されており、それによれば膜はその内外両面をアルブミンで被覆するようにアルブミンを下塗りされており、アルブミンは表面に付着されている。したがって、膜を横断して移送させるための仲介部分として作用することのできる場所が膜内部に形成される。
本発明のさらに他の実施例では、約4000ml/分の大流量の透析流体が約4000ml/分のkoAを有する大きな膜と、約5g/lのアルブミン血清のような担体の濃度と組合わされる。この実施例は高価なアルブミンの濃度が制限され、透析処置の効果が許容レベルに保たれるので有利である。
1. 血液回路と、流体回路と、流体室を血液室から隔離する半透膜を有する濾過器とを含み、血液および浄化流体を混合し、前記混合液を血液室に通して導くための手段と、流体室への限外濾過が生じるように膜を隔てて圧力勾配を与える手段とを備え、流体室は浄化流体流量と患者の望ましい重量減との合計に寸法が等しく構成され、血液から一部が担体に結合した物質を除去するための装置であって、
濾過器の水透過係数LpAが少なくとも10ml/分/mmHgであり、
浄化流体流量が少なくとも1000ml/分であり、
浄化流体流量と血液流量との間の比率が少なくとも5であることを特徴とする装置。
2. 濾過器が直列または並列、またはその組合せで配置された幾つかの濾過器によって置き換えられた前記1項又は特許請求の範囲の請求項1から11までのいずれか一項に記載された装置。
3. 血液が患者に戻される前に血液を加熱するためにヒーターが配置された前記1項又は2項、又は特許請求の範囲の請求項1から11までのいずれか一項に記載された装置。
4. 血液が患者に戻される前の血液の通路に沿う最終の透析器がヒーターである前記3項に記載された装置。
Claims (11)
- 血液回路と、流体回路と、流体室を血液室から隔離する半透膜を有する濾過器とを含み、血液は血液室を通して導かれ、浄化流体は流体室を通して導かれるように構成され、血液から一部が担体に結合した物質を除去するための装置であって、
前記血液から前記各担体に結合した物質を除去するための濾過器の物質移動係数koAが少なくとも2000ml/分であり、
濾過器の物質移動係数koAと血液流量との間の比率が少なくとも5であり、
浄化流体流量が少なくとも2000ml/分であり、
浄化流体流量と血液流量との間の比率が少なくとも5であることを特徴とする装置。 - 濾過器の物質移動係数koAと血液流量との間の比率が少なくとも10であり、
浄化流体流量と血液流量との間の比率が少なくとも10である請求項1に記載された装置。 - 濾過器の物質移動係数koAが少なくとも5000ml/分であり、
浄化流体流量が少なくとも5000ml/分である請求項1または請求項2に記載された装置。 - 血液の流量Qbと、血漿中に溶解した分屑に関する除去すべき物質の全量を表す係数αとの積に関してパラメータが選ばれ、
濾過器の物質移動係数koAがこの積の値の少なくとも10%であり、
浄化流体流量がこの積の値の少なくとも10%である請求項1、請求項2または請求項3に記載された装置。 - 濾過器の物質移動係数koAがこの積の値の少なくとも100%であり、および(または)
浄化流体流量がこの積の値の少なくとも100%である請求項4に記載された装置。 - 血液回路と、流体回路と、流体室を血液室から隔離する半透膜を有する濾過器とを含み、血液が血液室を通して導かれ、浄化流体が流体室を通して導かれるように構成され、血液から一部が担体に結合した物質を除去するための装置であって、
前記血液から前記各担体に結合した物質を除去するための濾過器の物質移動係数koAが少なくとも2000ml/分であり、
濾過器の物質移動係数koAと血液流量との間の比率が少なくとも5であり、
一部が担体に結合している血液中の物質に結合することのできる担体を浄化流体が含んでいることを特徴とする装置。 - 血液回路と、流体回路と、流体室を血液室から隔離する半透膜を有する濾過器とを含み、血液が血液室を通して導かれ、浄化流体が流体室を通して導かれるように構成され、血液から一部が担体に結合した物質を除去するための装置であって、
一部が担体に結合している血液中の物質に結合することのできる担体を含む流体によって膜が事前処理されており、
浄化流体流量が少なくとも2000ml/分であり、
浄化流体流量と血液流量との間の比率が少なくとも10であることを特徴とする装置。 - 一部が担体に結合している血液中の物質に結合することのできる担体を含む流体で膜が事前処理されている請求項6に記載された装置。
- 一部が担体に結合している血液中の物質に結合することのできる担体を浄化流体が含んでいる請求項7に記載された装置。
- 担体がアルブミン血清である請求項6、請求項7、請求項8または請求項9に記載された装置。
- アルブミン血清の濃度が10g/lを超える請求項10に記載された装置。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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SE0200956A SE0200956D0 (sv) | 2002-03-27 | 2002-03-27 | Method and device for the removal of protein bound substances |
SE0200956-1 | 2002-03-27 | ||
SE0201317A SE522692C2 (sv) | 2002-03-27 | 2002-05-02 | Förfarande och anordning för avlägsnande av delvis proteinbundna substanser |
SE0201317-5 | 2002-05-02 |
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JP2003577978A Division JP4456367B2 (ja) | 2002-03-27 | 2003-03-25 | 一部が蛋白質に結合した物質を取除く方法および装置 |
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JP2010042272A true JP2010042272A (ja) | 2010-02-25 |
JP5438456B2 JP5438456B2 (ja) | 2014-03-12 |
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JP2009231605A Expired - Lifetime JP5438456B2 (ja) | 2002-03-27 | 2009-10-05 | 一部が蛋白質に結合した物質を取除く装置 |
JP2013196882A Expired - Lifetime JP5711330B2 (ja) | 2002-03-27 | 2013-09-24 | 一部が蛋白質に結合した物質を取除く装置 |
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US (3) | US7615158B2 (ja) |
EP (1) | EP1490129B1 (ja) |
JP (3) | JP4456367B2 (ja) |
KR (1) | KR101044980B1 (ja) |
CN (1) | CN100502959C (ja) |
AT (1) | ATE441444T1 (ja) |
AU (1) | AU2003214752A1 (ja) |
DE (1) | DE60329088D1 (ja) |
ES (1) | ES2333002T3 (ja) |
SE (1) | SE522692C2 (ja) |
WO (1) | WO2003080154A1 (ja) |
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AU2003214752A1 (en) | 2003-10-08 |
JP2005520643A (ja) | 2005-07-14 |
SE0201317D0 (sv) | 2002-05-02 |
ATE441444T1 (de) | 2009-09-15 |
US20050115898A1 (en) | 2005-06-02 |
CN100502959C (zh) | 2009-06-24 |
JP5438456B2 (ja) | 2014-03-12 |
JP2014028290A (ja) | 2014-02-13 |
KR20040093102A (ko) | 2004-11-04 |
EP1490129B1 (en) | 2009-09-02 |
US20110089112A1 (en) | 2011-04-21 |
SE0201317L (sv) | 2003-09-28 |
US7615158B2 (en) | 2009-11-10 |
SE522692C2 (sv) | 2004-03-02 |
JP5711330B2 (ja) | 2015-04-30 |
CN1630540A (zh) | 2005-06-22 |
EP1490129A1 (en) | 2004-12-29 |
WO2003080154A1 (en) | 2003-10-02 |
US8048310B2 (en) | 2011-11-01 |
JP4456367B2 (ja) | 2010-04-28 |
US7879242B2 (en) | 2011-02-01 |
ES2333002T3 (es) | 2010-02-16 |
DE60329088D1 (de) | 2009-10-15 |
KR101044980B1 (ko) | 2011-06-29 |
US20100044313A1 (en) | 2010-02-25 |
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