JP4455876B2 - 肝移植細胞、アッセイ法、およびその使用法 - Google Patents

肝移植細胞、アッセイ法、およびその使用法 Download PDF

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JP4455876B2
JP4455876B2 JP2003507235A JP2003507235A JP4455876B2 JP 4455876 B2 JP4455876 B2 JP 4455876B2 JP 2003507235 A JP2003507235 A JP 2003507235A JP 2003507235 A JP2003507235 A JP 2003507235A JP 4455876 B2 JP4455876 B2 JP 4455876B2
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cells
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liver
hepatocytes
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JP2004531270A5 (cg-RX-API-DMAC7.html
JP2004531270A (ja
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エリック ラガッセ
ティモシー オースティン
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ステムセルズ インコーポレーティッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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JP2003507235A 2001-06-22 2002-06-21 肝移植細胞、アッセイ法、およびその使用法 Expired - Fee Related JP4455876B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30053501P 2001-06-22 2001-06-22
PCT/US2002/019646 WO2003000848A2 (en) 2001-06-22 2002-06-21 Liver engrafting cells, assays, and uses thereof

Related Child Applications (1)

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JP2009090608A Division JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

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JP2004531270A JP2004531270A (ja) 2004-10-14
JP2004531270A5 JP2004531270A5 (cg-RX-API-DMAC7.html) 2006-01-05
JP4455876B2 true JP4455876B2 (ja) 2010-04-21

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JP2003507235A Expired - Fee Related JP4455876B2 (ja) 2001-06-22 2002-06-21 肝移植細胞、アッセイ法、およびその使用法
JP2009090608A Withdrawn JP2009183299A (ja) 2001-06-22 2009-04-03 肝移植細胞、アッセイ法、およびその使用法

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US (3) US7211404B2 (cg-RX-API-DMAC7.html)
EP (3) EP1956078A3 (cg-RX-API-DMAC7.html)
JP (2) JP4455876B2 (cg-RX-API-DMAC7.html)
CN (2) CN1665920A (cg-RX-API-DMAC7.html)
AT (1) ATE371018T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002315392B2 (cg-RX-API-DMAC7.html)
CA (1) CA2451637C (cg-RX-API-DMAC7.html)
DE (1) DE60221987T2 (cg-RX-API-DMAC7.html)
DK (1) DK1406998T3 (cg-RX-API-DMAC7.html)
ES (1) ES2292772T3 (cg-RX-API-DMAC7.html)
WO (1) WO2003000848A2 (cg-RX-API-DMAC7.html)

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US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
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JP6813514B2 (ja) 2015-06-23 2021-01-13 ザ ジャクソン ラボラトリーＴｈｅ Ｊａｃｋｓｏｎ Ｌａｂｏｒａｔｏｒｙ 患者由来異種移植片を用いた非ｈｌａマッチヒト化ｎｓｇマウスモデル
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