ATE510905T1 - Verfahren zur isolierung von bipotenten lebervorläuferzellen - Google Patents

Verfahren zur isolierung von bipotenten lebervorläuferzellen

Info

Publication number
ATE510905T1
ATE510905T1 AT00968708T AT00968708T ATE510905T1 AT E510905 T1 ATE510905 T1 AT E510905T1 AT 00968708 T AT00968708 T AT 00968708T AT 00968708 T AT00968708 T AT 00968708T AT E510905 T1 ATE510905 T1 AT E510905T1
Authority
AT
Austria
Prior art keywords
progenitors
cells
hepatic
antigen
cell
Prior art date
Application number
AT00968708T
Other languages
English (en)
Inventor
Hiroshi Kubota
Lola Reid
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE510905T1 publication Critical patent/ATE510905T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00968708T 2000-10-03 2000-10-03 Verfahren zur isolierung von bipotenten lebervorläuferzellen ATE510905T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/027429 WO2002028997A2 (en) 2000-10-03 2000-10-03 Methods of isolating bipotent hepatic progenitor cells

Publications (1)

Publication Number Publication Date
ATE510905T1 true ATE510905T1 (de) 2011-06-15

Family

ID=21741847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00968708T ATE510905T1 (de) 2000-10-03 2000-10-03 Verfahren zur isolierung von bipotenten lebervorläuferzellen

Country Status (11)

Country Link
EP (1) EP1325112B1 (de)
JP (1) JP2004510432A (de)
CN (1) CN1258589C (de)
AT (1) ATE510905T1 (de)
AU (2) AU7858200A (de)
CA (1) CA2424781C (de)
DK (1) DK1325112T3 (de)
ES (1) ES2367005T3 (de)
HK (1) HK1054569B (de)
IL (2) IL155249A0 (de)
WO (1) WO2002028997A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020187133A1 (en) 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
CA2424779C (en) * 2000-10-03 2016-08-23 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
WO2002077206A1 (en) 2001-03-27 2002-10-03 Vertex Pharmaceuticals Incorporated Compositiona and methods useful for hcv infection
ATE371018T1 (de) 2001-06-22 2007-09-15 Stemcells Inc Le-zellen (liver engrafting cells), assays und verwendungen davon
ATE548447T1 (de) * 2004-01-14 2012-03-15 Novahep Ab Menschlicher hepatische vorläuferzellen und verfahren zur verwendung davon
AU2008280143B2 (en) * 2007-07-20 2014-04-17 Cellartis Ab A novel population of hepatocytes derived via definitive endoderm (DE-hep) from human blastocysts stem cells
NO2748201T3 (de) * 2011-08-23 2018-05-12
CN107208054B (zh) * 2014-11-26 2021-09-17 艾克塞利瑞提德生物技术公司 诱导的肝细胞及其用途
PT3140393T (pt) 2015-03-04 2023-09-04 Cellaion Sa Método para produzir células progenitoras hepáticas adultas
JP6704617B2 (ja) * 2016-01-29 2020-06-03 北海道公立大学法人 札幌医科大学 小型肝細胞の継代培養方法
CN109385394A (zh) * 2018-11-02 2019-02-26 大连理工大学 一种提取、分离和培养同体异种肝原代细胞的方法
EA202191673A1 (ru) * 2018-12-14 2021-09-28 Прометера Терапьютикс Са Композиция на основе клеток, содержащая клетки-предшественники печени, экспрессирующие hla-e

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
JP5068901B2 (ja) * 1999-01-19 2012-11-07 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル ヒト肝前駆細胞

Also Published As

Publication number Publication date
CA2424781C (en) 2018-11-06
AU7858200A (en) 2002-04-15
HK1054569B (zh) 2012-03-02
DK1325112T3 (da) 2011-09-12
EP1325112B1 (de) 2011-05-25
CN1461340A (zh) 2003-12-10
ES2367005T3 (es) 2011-10-27
EP1325112A2 (de) 2003-07-09
IL155249A0 (en) 2003-11-23
WO2002028997A3 (en) 2002-09-12
JP2004510432A (ja) 2004-04-08
IL155249A (en) 2011-12-29
AU2000278582B2 (en) 2007-08-30
WO2002028997A2 (en) 2002-04-11
HK1054569A1 (en) 2003-12-05
CA2424781A1 (en) 2002-04-11
CN1258589C (zh) 2006-06-07

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