IL155249A0 - Methods of isolating bipotent hepatic progenitor cells - Google Patents
Methods of isolating bipotent hepatic progenitor cellsInfo
- Publication number
- IL155249A0 IL155249A0 IL15524900A IL15524900A IL155249A0 IL 155249 A0 IL155249 A0 IL 155249A0 IL 15524900 A IL15524900 A IL 15524900A IL 15524900 A IL15524900 A IL 15524900A IL 155249 A0 IL155249 A0 IL 155249A0
- Authority
- IL
- Israel
- Prior art keywords
- progenitors
- cells
- hepatic
- antigen
- cell
- Prior art date
Links
- 230000002440 hepatic effect Effects 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 210000000130 stem cell Anatomy 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 102100036242 HLA class II histocompatibility antigen, DQ alpha 2 chain Human genes 0.000 abstract 2
- 101000930801 Homo sapiens HLA class II histocompatibility antigen, DQ alpha 2 chain Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000004738 parenchymal cell Anatomy 0.000 abstract 2
- 102100036774 Afamin Human genes 0.000 abstract 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 abstract 1
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 abstract 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 abstract 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 abstract 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 abstract 1
- 108010090535 alpha-albumin Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000007773 growth pattern Effects 0.000 abstract 1
- 210000004524 haematopoietic cell Anatomy 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000002110 toxicologic effect Effects 0.000 abstract 1
- 231100000027 toxicology Toxicity 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/027429 WO2002028997A2 (en) | 2000-10-03 | 2000-10-03 | Methods of isolating bipotent hepatic progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155249A0 true IL155249A0 (en) | 2003-11-23 |
Family
ID=21741847
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15524900A IL155249A0 (en) | 2000-10-03 | 2000-10-03 | Methods of isolating bipotent hepatic progenitor cells |
| IL155249A IL155249A (en) | 2000-10-03 | 2003-04-03 | Population of cells enriched in isolated bipotent hepatic progenitors and methods for obtaining the same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL155249A IL155249A (en) | 2000-10-03 | 2003-04-03 | Population of cells enriched in isolated bipotent hepatic progenitors and methods for obtaining the same |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1325112B1 (de) |
| JP (1) | JP2004510432A (de) |
| CN (1) | CN1258589C (de) |
| AT (1) | ATE510905T1 (de) |
| AU (2) | AU7858200A (de) |
| CA (1) | CA2424781C (de) |
| DK (1) | DK1325112T3 (de) |
| ES (1) | ES2367005T3 (de) |
| HK (1) | HK1054569B (de) |
| IL (2) | IL155249A0 (de) |
| WO (1) | WO2002028997A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020187133A1 (en) | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
| JP2004510434A (ja) * | 2000-10-03 | 2004-04-08 | ユニバーシティ オブ ノース カロライナ | 肝前駆細胞のクローン増殖方法 |
| DE60232322D1 (de) | 2001-03-27 | 2009-06-25 | Vertex Pharma | Verfahren |
| EP1956078A3 (de) | 2001-06-22 | 2008-10-29 | StemCells, Inc. | Zellen zur Einpflanzung in die Leber, Assays dafür und Verwendungen davon |
| US20060040386A1 (en) * | 2004-01-14 | 2006-02-23 | Suchitra Holgersson | Human hepatic progenitor cells and methods of use thereof |
| US8951792B2 (en) | 2007-07-20 | 2015-02-10 | Cellartis Ab | Methods for making definitive endoderm hepatocyte (DE-hep) progenitor cells |
| ES2659764T3 (es) * | 2011-08-23 | 2018-03-19 | Roche Glycart Ag | Moléculas biespecíficas de unión a antígeno activadoras de linfocitos T |
| KR20190003833A (ko) | 2014-08-28 | 2019-01-09 | 프로메테라 바이오사이언시즈 에스.에이./엔.브이. | 성체 간 전구 세포의 제조 방법 |
| SG10202009095VA (en) | 2014-11-26 | 2020-10-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| JP6704617B2 (ja) * | 2016-01-29 | 2020-06-03 | 北海道公立大学法人 札幌医科大学 | 小型肝細胞の継代培養方法 |
| CN109385394A (zh) * | 2018-11-02 | 2019-02-26 | 大连理工大学 | 一种提取、分离和培养同体异种肝原代细胞的方法 |
| WO2020120664A1 (en) * | 2018-12-14 | 2020-06-18 | Promethera Biosciences S.A./N.V. | Cell composition comprising liver progenitor cells expressing hla-e |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129911A (en) * | 1998-07-10 | 2000-10-10 | Rhode Island Hospital, A Lifespan Partner | Liver stem cell |
| WO2000043498A2 (en) * | 1999-01-19 | 2000-07-27 | University Of North Carolina At Chapel Hill | Human liver progenitors |
-
2000
- 2000-10-03 AT AT00968708T patent/ATE510905T1/de active
- 2000-10-03 AU AU7858200A patent/AU7858200A/xx active Pending
- 2000-10-03 DK DK00968708.8T patent/DK1325112T3/da active
- 2000-10-03 EP EP00968708A patent/EP1325112B1/de not_active Expired - Lifetime
- 2000-10-03 AU AU2000278582A patent/AU2000278582B2/en not_active Ceased
- 2000-10-03 WO PCT/US2000/027429 patent/WO2002028997A2/en not_active Ceased
- 2000-10-03 CN CNB008200483A patent/CN1258589C/zh not_active Expired - Fee Related
- 2000-10-03 JP JP2002532568A patent/JP2004510432A/ja active Pending
- 2000-10-03 HK HK03106717.6A patent/HK1054569B/en not_active IP Right Cessation
- 2000-10-03 CA CA2424781A patent/CA2424781C/en not_active Expired - Fee Related
- 2000-10-03 ES ES00968708T patent/ES2367005T3/es not_active Expired - Lifetime
- 2000-10-03 IL IL15524900A patent/IL155249A0/xx unknown
-
2003
- 2003-04-03 IL IL155249A patent/IL155249A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1258589C (zh) | 2006-06-07 |
| EP1325112A2 (de) | 2003-07-09 |
| EP1325112B1 (de) | 2011-05-25 |
| ATE510905T1 (de) | 2011-06-15 |
| WO2002028997A3 (en) | 2002-09-12 |
| AU2000278582B2 (en) | 2007-08-30 |
| AU7858200A (en) | 2002-04-15 |
| DK1325112T3 (da) | 2011-09-12 |
| ES2367005T3 (es) | 2011-10-27 |
| CA2424781A1 (en) | 2002-04-11 |
| HK1054569A1 (en) | 2003-12-05 |
| WO2002028997A2 (en) | 2002-04-11 |
| CA2424781C (en) | 2018-11-06 |
| HK1054569B (en) | 2012-03-02 |
| IL155249A (en) | 2011-12-29 |
| JP2004510432A (ja) | 2004-04-08 |
| CN1461340A (zh) | 2003-12-10 |
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