JP4445042B2 - １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 - Google Patents

１，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 Download PDF

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JP4445042B2
JP4445042B2 JP50155499A JP50155499A JP4445042B2 JP 4445042 B2 JP4445042 B2 JP 4445042B2 JP 50155499 A JP50155499 A JP 50155499A JP 50155499 A JP50155499 A JP 50155499A JP 4445042 B2 JP4445042 B2 JP 4445042B2
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compound
acid
salt
solution
mol
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JP2002503238A5 (US06559137-20030506-C00182.png
JP2002503238A (ja
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リパ，ジョルジオ
スカーラ，アレッサンドロ
ムッル，マルセラ
パネッタ，エマニュエラ
ヴィスカルディ，カルロ・フェリース
オーソニオ，マリナ
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ブラッコ インターナショナル ベースローテン フェンノートシャップ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
JP50155499A 1997-06-11 1998-06-08 １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法 Expired - Lifetime JP4445042B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT97MI001373A IT1292130B1 (it) 1997-06-11 1997-06-11 Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT97A001373 1997-06-11
PCT/EP1998/003408 WO1998056776A1 (en) 1997-06-11 1998-06-08 A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof

Related Child Applications (1)

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JP2009133854A Division JP5204724B2 (ja) 1997-06-11 2009-06-03 １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法

Publications (3)

Publication Number Publication Date
JP2002503238A JP2002503238A (ja) 2002-01-29
JP2002503238A5 JP2002503238A5 (US06559137-20030506-C00182.png) 2005-12-08
JP4445042B2 true JP4445042B2 (ja) 2010-04-07

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JP50155499A Expired - Lifetime JP4445042B2 (ja) 1997-06-11 1998-06-08 １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法
JP2009133854A Expired - Lifetime JP5204724B2 (ja) 1997-06-11 2009-06-03 １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法

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JP2009133854A Expired - Lifetime JP5204724B2 (ja) 1997-06-11 2009-06-03 １，４，７，１０−テトラアザシクロドデカン−１，４，７−三酢酸及びその誘導体の調製のための方法

Country Status (14)

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US (2) US5962679A (US06559137-20030506-C00182.png)
EP (1) EP0989974B1 (US06559137-20030506-C00182.png)
JP (2) JP4445042B2 (US06559137-20030506-C00182.png)
CN (2) CN1117088C (US06559137-20030506-C00182.png)
AT (1) ATE224379T1 (US06559137-20030506-C00182.png)
AU (1) AU738506B2 (US06559137-20030506-C00182.png)
DE (1) DE69808086T2 (US06559137-20030506-C00182.png)
ES (1) ES2184302T3 (US06559137-20030506-C00182.png)
IL (1) IL131255A (US06559137-20030506-C00182.png)
IN (1) IN186470B (US06559137-20030506-C00182.png)
IT (1) IT1292130B1 (US06559137-20030506-C00182.png)
NO (1) NO312548B1 (US06559137-20030506-C00182.png)
WO (1) WO1998056776A1 (US06559137-20030506-C00182.png)
ZA (1) ZA985023B (US06559137-20030506-C00182.png)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
US6838557B1 (en) * 2002-10-01 2005-01-04 Board Of Regents The University Of Texas System Process for making a chelating agent for labeling biomolecules using preformed active esters
US6852854B1 (en) 2002-10-01 2005-02-08 Psiloquest Inc. Preformed carboxylated active ester for labeling biomolecules
EP1641770A4 (en) * 2003-07-08 2008-12-31 Univ Hong Kong SYNTHESIS OF TRIS-N-ALKYLATED 1,4,7,10-TETRAAZACYCLODODECANES
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
CN103232403B (zh) * 2013-05-09 2016-04-27 浙江凯普化工有限公司 一种氮杂环的制备方法
WO2014191467A1 (en) * 2013-05-30 2014-12-04 Bracco Imaging Spa Fluorescent solid lipid nanoparticles composition and preparation thereof
CN108084105B (zh) * 2016-11-23 2020-07-24 四川科伦药物研究院有限公司 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP3870569A4 (en) * 2018-10-24 2022-08-24 Biophore India Pharmaceuticals Pvt. Ltd. NEW PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELATING TRIACETIC ACID 2,2',2''-(10-(2-HYDROXYPROPYL)-1,4,7,10-TETRA AZACYCLODODECANE-1,4,7-TRIYL) AND ITS COMPLEXES WITH PARAMAGNETIC METALLIC IONS
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN113549025B (zh) * 2021-07-14 2023-07-25 江苏美迪克化学品有限公司 一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸及其钠盐的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
IT1243801B (it) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
WO1995027705A1 (en) * 1994-04-08 1995-10-19 Bracco International B.V. Aromatic amide compounds and metal chelates thereof
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati

Also Published As

Publication number Publication date
JP5204724B2 (ja) 2013-06-05
NO995924L (no) 2000-01-26
CN1117088C (zh) 2003-08-06
ATE224379T1 (de) 2002-10-15
IT1292130B1 (it) 1999-01-25
DE69808086T2 (de) 2003-06-05
JP2002503238A (ja) 2002-01-29
AU8436998A (en) 1998-12-30
WO1998056776A1 (en) 1998-12-17
NO312548B1 (no) 2002-05-27
EP0989974B1 (en) 2002-09-18
AU738506B2 (en) 2001-09-20
US6054581A (en) 2000-04-25
EP0989974A1 (en) 2000-04-05
IL131255A (en) 2004-01-04
ITMI971373A1 (it) 1998-12-11
US5962679A (en) 1999-10-05
IL131255A0 (en) 2001-01-28
DE69808086D1 (de) 2002-10-24
JP2009242405A (ja) 2009-10-22
CN1215063C (zh) 2005-08-17
ES2184302T3 (es) 2003-04-01
NO995924D0 (no) 1999-12-03
ITMI971373A0 (US06559137-20030506-C00182.png) 1997-06-11
IN186470B (US06559137-20030506-C00182.png) 2001-09-08
CN1251094A (zh) 2000-04-19
ZA985023B (en) 1999-01-20
CN1473819A (zh) 2004-02-11

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