JP4377376B2 - ミクロ流体素子装置における変形可能バルブのためのアクチュエータ、および方法 - Google Patents

ミクロ流体素子装置における変形可能バルブのためのアクチュエータ、および方法 Download PDF

Info

Publication number
JP4377376B2
JP4377376B2 JP2005505603A JP2005505603A JP4377376B2 JP 4377376 B2 JP4377376 B2 JP 4377376B2 JP 2005505603 A JP2005505603 A JP 2005505603A JP 2005505603 A JP2005505603 A JP 2005505603A JP 4377376 B2 JP4377376 B2 JP 4377376B2
Authority
JP
Japan
Prior art keywords
microfluidic device
roller
deformable
blade tip
blade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2005505603A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006508817A (ja
Inventor
デービッド エム． コックス，
ビンニュー ティー． ブリニング，
Original Assignee
アプライド バイオシステムズ， エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/336,274 external-priority patent/US7198759B2/en
Priority claimed from US10/336,706 external-priority patent/US7214348B2/en
Application filed by アプライド バイオシステムズ， エルエルシー filed Critical アプライド バイオシステムズ， エルエルシー
Publication of JP2006508817A publication Critical patent/JP2006508817A/ja
Application granted granted Critical
Publication of JP4377376B2 publication Critical patent/JP4377376B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/082—Machines, pumps, or pumping installations having flexible working members having tubular flexible members the tubular flexible member being pressed against a wall by a number of elements, each having an alternating movement in a direction perpendicular to the axes of the tubular member and each having its own driving mechanism
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1223—Machines, pumps, or pumping installations having flexible working members having peristaltic action the actuating elements, e.g. rollers, moving in a straight line during squeezing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
JP2005505603A 2002-07-26 2003-07-16 ミクロ流体素子装置における変形可能バルブのためのアクチュエータ、および方法 Expired - Lifetime JP4377376B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US39894602P 2002-07-26 2002-07-26
US39877702P 2002-07-26 2002-07-26
US39885102P 2002-07-26 2002-07-26
US10/336,274 US7198759B2 (en) 2002-07-26 2003-01-03 Microfluidic devices, methods, and systems
US10/336,706 US7214348B2 (en) 2002-07-26 2003-01-03 Microfluidic size-exclusion devices, systems, and methods
US10/403,640 US7201881B2 (en) 2002-07-26 2003-03-31 Actuator for deformable valves in a microfluidic device, and method
PCT/US2003/022459 WO2004011148A2 (fr) 2002-07-26 2003-07-16 Element de commande pour vannes deformables dans un dispositif microfluidique et procede correspondant

Publications (2)

Publication Number Publication Date
JP2006508817A JP2006508817A (ja) 2006-03-16
JP4377376B2 true JP4377376B2 (ja) 2009-12-02

Family

ID=31192532

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005505603A Expired - Lifetime JP4377376B2 (ja) 2002-07-26 2003-07-16 ミクロ流体素子装置における変形可能バルブのためのアクチュエータ、および方法

Country Status (6)

Country Link
US (1) US7201881B2 (fr)
EP (1) EP1531936A4 (fr)
JP (1) JP4377376B2 (fr)
AU (1) AU2003252021A1 (fr)
CA (1) CA2493687A1 (fr)
WO (1) WO2004011148A2 (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US8097471B2 (en) * 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
EP1532275A4 (fr) * 2002-07-26 2005-09-14 Applera Corp Reactions biochimiques a demarrage a chaud induit par mg
US7507376B2 (en) * 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
US7854897B2 (en) * 2003-05-12 2010-12-21 Yokogawa Electric Corporation Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
US7932090B2 (en) * 2004-08-05 2011-04-26 3M Innovative Properties Company Sample processing device positioning apparatus and methods
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US20070026439A1 (en) * 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
JP2007021351A (ja) * 2005-07-15 2007-02-01 Yokogawa Electric Corp 化学反応用カートリッジおよび化学反応処理システム
US20070048189A1 (en) * 2005-08-26 2007-03-01 Applera Corporation Fluid processing device, system, kit, and method
US20090305238A1 (en) * 2006-01-23 2009-12-10 Applera Corporation Microarray Microcard
US20070224088A1 (en) * 2006-03-24 2007-09-27 Applera Corporation Fluid processing device including output interface with analyzer
JP2008051544A (ja) * 2006-08-22 2008-03-06 Yokogawa Electric Corp 化学反応用装置
MX2009007473A (es) * 2007-01-12 2010-02-17 Environmental Biotechnology Cr Dispositivo de manejo de muestras.
WO2008118098A1 (fr) * 2007-03-26 2008-10-02 Agency For Science, Technology And Research Cartouche de fluide, pompe et agencement de vanne de fluide
EP2425894B1 (fr) 2007-06-21 2016-12-28 Gen-Probe Incorporated Instruments et procédé pour exposer un récipient à plusieurs zones thermiques
KR101321912B1 (ko) * 2007-08-28 2013-10-30 삼성전자주식회사 탄성 밸브 및 이를 구비한 미세유동 장치
EP2143491A1 (fr) * 2008-07-10 2010-01-13 Carpegen GmbH Dispositif pour l'analyse d'un échantillon chimique ou biologique
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
JP2010207865A (ja) * 2009-03-10 2010-09-24 Toshiba Mach Co Ltd 塑性加工方法及びその装置と、金型の製造方法
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
JP2012194062A (ja) * 2011-03-16 2012-10-11 Tokyo Denki Univ マイクロ流体チップ及びそれを用いたマイクロ流体システム
AU2012255151B2 (en) 2011-05-18 2015-09-03 Diasorin Italia S.P.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
WO2012158988A1 (fr) 2011-05-18 2012-11-22 3M Innovative Properties Company Systèmes et procédés de distribution sur un dispositif de traitement d'échantillons
US8931331B2 (en) 2011-05-18 2015-01-13 3M Innovative Properties Company Systems and methods for volumetric metering on a sample processing device
AU2013203281A1 (en) 2012-02-03 2013-08-22 Axxin Pty Ltd Nucleic acid amplification and detection apparatus and method
WO2014004573A1 (fr) * 2012-06-25 2014-01-03 T2 Biosystems, Inc. Dispositif portatif pour analyse par rmn de modifications rhéologiques dans des échantillons liquides
US10272427B2 (en) 2012-09-06 2019-04-30 The Board Of Trustees Of The Leland Stanford Junior University Punch card programmable microfluidics
EP4170031A1 (fr) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamères et leurs utilisations
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP2912432B1 (fr) 2012-10-24 2018-07-04 Genmark Diagnostics Inc. Analyse cible à multiplexe intégré
WO2014100434A1 (fr) 2012-12-19 2014-06-26 Caris Science, Inc. Compositions et procédés pour le criblage d'aptamères
US9453613B2 (en) * 2013-03-15 2016-09-27 Genmark Diagnostics, Inc. Apparatus, devices, and methods for manipulating deformable fluid vessels
JP2016533752A (ja) 2013-08-28 2016-11-04 カリス ライフ サイエンシズ スウィッツァーランド ホー オリゴヌクレオチドプローブおよびその使用
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
WO2016145128A1 (fr) 2015-03-09 2016-09-15 Caris Science, Inc. Sondes oligonucléotidiques et utilisations de celles-ci
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
AU2016295422B2 (en) * 2015-07-17 2022-01-06 Axxin Pty Ltd Diagnostic test assembly, apparatus, method
CA2993652A1 (fr) 2015-07-28 2017-02-02 Caris Science, Inc. Oligonucleotides cibles
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
CA3025486A1 (fr) 2016-05-25 2017-11-30 Caris Science, Inc. Sondes oligonucleotidiques et utilisations de celles-ci
CA3076836A1 (fr) 2017-09-27 2019-04-04 Axxin Pty Ltd Systeme et procede de test diagnostique
WO2020113237A1 (fr) 2018-11-30 2020-06-04 Caris Mpi, Inc. Profilage moléculaire de nouvelle génération
WO2021112918A1 (fr) 2019-12-02 2021-06-10 Caris Mpi, Inc. Prédicteur de réponse au platine dans une approche pan-cancer

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399103A (en) * 1981-01-28 1983-08-16 Ferrara Louis T Blood dispenser device
FR2634894B1 (fr) * 1988-07-28 1990-09-14 Guigan Jean
FR2634892B1 (fr) * 1988-07-28 1990-09-14 Guigan Jean Dispositif pour la realisation d'analyses biologiques par detection immuno-enzymatique d'anticorps ou d'antigenes dans un serum
US6645758B1 (en) 1989-02-03 2003-11-11 Johnson & Johnson Clinical Diagnostics, Inc. Containment cuvette for PCR and method of use
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
CA1329698C (fr) * 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Regulateur de temperature
US5154888A (en) * 1990-10-25 1992-10-13 Eastman Kodak Company Automatic sealing closure means for closing off a passage in a flexible cuvette
US5256376A (en) 1991-09-12 1993-10-26 Medical Laboratory Automation, Inc. Agglutination detection apparatus
US5254479A (en) 1991-12-19 1993-10-19 Eastman Kodak Company Methods for preventing air injection into a detection chamber supplied with injected liquid
US5290518A (en) 1992-08-17 1994-03-01 Eastman Kodak Company Flexible extraction device with burstable sidewall
US5288463A (en) 1992-10-23 1994-02-22 Eastman Kodak Company Positive flow control in an unvented container
US5422271A (en) * 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
JPH0727686A (ja) 1993-07-14 1995-01-31 Shimahisa Yakuhin Kk 破砕分散用器具
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
JP2002503331A (ja) 1995-12-05 2002-01-29 ガメラ バイオサイエンス コーポレイション 機内に搭載された情報科学を備えた超微量液体素子工学システムにおいて液体移動を推進するために求心性加速を使用するための装置及び方法
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5804141A (en) 1996-10-15 1998-09-08 Chianese; David Reagent strip slide treating apparatus
DE19749011A1 (de) 1996-11-19 1998-05-20 Lang Volker Mikroventil
CA2276251A1 (fr) 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Dispositifs microfabriques et procedes d'amplification isotherme d'acides nucleiques
US5811296A (en) 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
WO1998053311A2 (fr) 1997-05-23 1998-11-26 Gamera Bioscience Corporation Dispositifs et procedes permettant d'utiliser l'acceleration centripete pour commander le deplacement de fluides sur un systeme microfluidique
US6426230B1 (en) 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6375871B1 (en) * 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
WO1999009321A1 (fr) 1997-08-20 1999-02-25 Westonbridge International Limited Micropompe comprenant un organe de controle d'entree permettant son auto-amorcage
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
ATE215673T1 (de) 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
US6431212B1 (en) 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US6494433B2 (en) 2000-06-06 2002-12-17 The Regents Of The University Of Michigan Thermally activated polymer device
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
AU2002213400A1 (en) 2000-10-18 2002-04-29 Research Foundation Of State University Of New York Microvalve
US6951632B2 (en) 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
WO2002053290A2 (fr) 2001-01-08 2002-07-11 President And Fellows Of Harvard College Vannes et pompes destinees a des systemes microfluidiques et procede de realisation de systemes microfluidiques
US20020100714A1 (en) 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
WO2003015923A1 (fr) 2001-08-20 2003-02-27 Biomicro Systems, Inc. Melange de fluides dans des chambres a faible rapport de forme
US20020172622A1 (en) 2001-04-03 2002-11-21 Weigl Bernhard H. Microfluidic device for concentrating particles in a concentrating solution
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6729599B2 (en) 2001-06-26 2004-05-04 Tini Alloy Company Liquid microvalve
KR100421359B1 (ko) * 2001-07-24 2004-03-06 엘지전자 주식회사 탄성 재질의 기판 내에서 유체를 이송하는 방법 및 이를위한 장치
US7056475B2 (en) 2002-01-30 2006-06-06 Agilent Technologies, Inc. Fluidically isolated pumping and metered fluid delivery system and methods
US6886610B2 (en) 2002-06-05 2005-05-03 Techelan Liquid dispenser
US7056473B2 (en) * 2004-04-29 2006-06-06 Response Biomedical Corp. Method and apparatus of quantitative assays

Also Published As

Publication number Publication date
WO2004011148A2 (fr) 2004-02-05
AU2003252021A1 (en) 2004-02-16
WO2004011148A3 (fr) 2004-03-18
US20040131502A1 (en) 2004-07-08
EP1531936A2 (fr) 2005-05-25
JP2006508817A (ja) 2006-03-16
CA2493687A1 (fr) 2004-02-05
EP1531936A4 (fr) 2005-09-07
US7201881B2 (en) 2007-04-10

Similar Documents

Publication Publication Date Title
JP4377376B2 (ja) ミクロ流体素子装置における変形可能バルブのためのアクチュエータ、および方法
US8012431B2 (en) Closing blade for deformable valve in a microfluidic device and method
CN101060932B (zh) 弯曲的微结构
JP4125240B2 (ja) サーマルサイクリングのためのデバイスおよび方法
EP0077400A1 (fr) Dispositif d'enroulage d'une feuille d'enregistrement
JP4414430B2 (ja) 反応容器自動開閉用装置
JPH06243762A (ja) 安全スイッチ
AU2006262861A1 (en) Slidable switching mechanism for convertible retaining ring pliers
WO2007050418A1 (fr) Vanne reconfigurable utilisant une substance opto-active
US11631957B2 (en) Crimping pliers die and crimping pliers
JP5662844B2 (ja) ローラ寄せ板バネ装着装置およびローラ寄せ板バネ装着方法
JP4290696B2 (ja) 微小流体デバイスのための弁アセンブリ、およびその開閉のための方法
US6935617B2 (en) Valve assembly for microfluidic devices, and method for opening and closing the same
US20110011230A1 (en) Device for producing a hole in a sheet-shaped material
US20050223866A1 (en) Hole punch
US20080267827A1 (en) Contents transfer apparatus and chemical reaction system
US20210336400A1 (en) Crimping Pliers Die and Crimping Pliers
JPH10296694A (ja) シート材穿孔用パンチユニット
JP4609969B2 (ja) 用紙穿孔装置
AU2003265285A1 (en) Closing blade for deformable valve in a microfluidic device, and method
JP2005250198A (ja) オルゴール
JP2005521042A (ja) サンプリング・「プレート」のサンプルに近接できるようにしたデバイスとその蓋
KR101832298B1 (ko) 기록지 커팅 장치 및 인쇄 장치
JP4794027B2 (ja) 穿孔処理装置
JPH0729262Y2 (ja) ローラポンプ

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080627

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080926

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081003

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081024

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081031

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081119

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20090618

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090814

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090910

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120918

Year of fee payment: 3