JP4366186B2 - アデノシンＡ２ａ受容体のリガンドとして有用なトリアゾリル−イミダゾピリジンおよびトリアゾリルプリンの誘導体およびその薬物としての使用 - Google Patents

アデノシンＡ２ａ受容体のリガンドとして有用なトリアゾリル−イミダゾピリジンおよびトリアゾリルプリンの誘導体およびその薬物としての使用 Download PDF

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JP4366186B2
JP4366186B2 JP2003517056A JP2003517056A JP4366186B2 JP 4366186 B2 JP4366186 B2 JP 4366186B2 JP 2003517056 A JP2003517056 A JP 2003517056A JP 2003517056 A JP2003517056 A JP 2003517056A JP 4366186 B2 JP4366186 B2 JP 4366186B2
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ジョルジョ・タルツィア
ジョヴァンニ・ピエルサンティ
パトリツィア・ミネッティ
マリア・アッスンタ・ディ・チェサレ
グラツィア・ガッロ
ファブリツィオ・ジョルジ
ルカ・ジョルジ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003517056A 2001-07-31 2002-07-25 アデノシンＡ２ａ受容体のリガンドとして有用なトリアゾリル−イミダゾピリジンおよびトリアゾリルプリンの誘導体およびその薬物としての使用 Expired - Fee Related JP4366186B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001RM000465A ITRM20010465A1 (it) 2001-07-31 2001-07-31 Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
PCT/IT2002/000489 WO2003011864A1 (en) 2001-07-31 2002-07-25 DERIVATIVES OF TRIAZOLYL-IMIDAZOPYRIDINE AND OF THE TRIAZOLYLPURINES USEFUL AS LIGANDS OF THE ADENOSINE A2a RECEPTOR AND THEIR USE AS MEDICAMENTS

Publications (3)

Publication Number Publication Date
JP2005500355A JP2005500355A (ja) 2005-01-06
JP2005500355A5 JP2005500355A5 (cg-RX-API-DMAC7.html) 2006-01-05
JP4366186B2 true JP4366186B2 (ja) 2009-11-18

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JP2003517056A Expired - Fee Related JP4366186B2 (ja) 2001-07-31 2002-07-25 アデノシンＡ２ａ受容体のリガンドとして有用なトリアゾリル−イミダゾピリジンおよびトリアゾリルプリンの誘導体およびその薬物としての使用

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US (2) US7230102B2 (cg-RX-API-DMAC7.html)
EP (1) EP1412354B1 (cg-RX-API-DMAC7.html)
JP (1) JP4366186B2 (cg-RX-API-DMAC7.html)
KR (1) KR100884818B1 (cg-RX-API-DMAC7.html)
CN (1) CN1271070C (cg-RX-API-DMAC7.html)
AT (1) ATE325796T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002326146B2 (cg-RX-API-DMAC7.html)
BR (1) BR0211550A (cg-RX-API-DMAC7.html)
CA (1) CA2451279C (cg-RX-API-DMAC7.html)
DE (1) DE60211343T2 (cg-RX-API-DMAC7.html)
DK (1) DK1412354T3 (cg-RX-API-DMAC7.html)
ES (1) ES2263810T3 (cg-RX-API-DMAC7.html)
HU (1) HU228985B1 (cg-RX-API-DMAC7.html)
IT (1) ITRM20010465A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA04000886A (cg-RX-API-DMAC7.html)
PL (1) PL217269B1 (cg-RX-API-DMAC7.html)
PT (1) PT1412354E (cg-RX-API-DMAC7.html)
WO (1) WO2003011864A1 (cg-RX-API-DMAC7.html)

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KR100883292B1 (ko) * 2001-06-29 2009-02-11 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ２ｂ 아데노신 수용체 길항제로서의 퓨린 유도체
ITRM20010465A1 (it) * 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam
US7189730B2 (en) * 2001-12-18 2007-03-13 Cv Therapeutics, Inc. A2A adenosine receptor antagonists
CA2559036C (en) 2004-03-26 2013-08-20 Dainippon Sumitomo Pharma Co., Ltd. 9-substituted 8-oxoadenine compound
US8063063B2 (en) * 2006-03-23 2011-11-22 Novartis Ag Immunopotentiating compounds
US8138172B2 (en) 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
ES2373616T3 (es) 2007-03-19 2012-02-07 Astrazeneca Ab Compuestos de 8-oxo-adenina 9 sustituidos como moduladores del receptor de tipo toll (tlr7).
JP5480637B2 (ja) 2007-03-19 2014-04-23 アストラゼネカ・アクチエボラーグ Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
TW200902018A (en) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co Novel adenine compound
HRP20130910T1 (hr) * 2007-03-20 2013-10-25 Curis, Inc. Kondenzirani aminopiridin kao inhibitori hsp90
WO2008114819A1 (ja) 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
JP5400763B2 (ja) * 2007-05-08 2014-01-29 アストラゼネカ・アクチエボラーグ 免疫調節特性を有するイミダゾキノリン類
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
JPWO2009091031A1 (ja) * 2008-01-17 2011-05-26 大日本住友製薬株式会社 アデニン化合物の製造方法
CA2711769A1 (en) 2008-01-17 2009-07-23 Dainippon Sumitomo Pharma Co. Ltd. Method for preparing adenine compound
TWI473614B (zh) * 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
US8846947B2 (en) 2008-07-03 2014-09-30 Glaxosmithkline Llc Benzimidazoles and related analogs as sirtuin modulators
AU2009274876C1 (en) 2008-07-23 2016-08-18 Kyowa Kirin Co., Ltd. Therapeutic agent for migraine
PT2408775E (pt) 2009-03-20 2015-08-05 Sigma Tau Ind Farmaceuti Derivados oxidados de triazolil purinas úteis como ligandos do recetor a2a de adenosina e a sua utilização como medicamentos
TWI398255B (zh) 2009-11-13 2013-06-11 Academia Sinica 結合至腺苷酸ａａ受體和腺苷酸轉運子以預防及治療神經退化疾病的雙功能化合物
WO2011068233A1 (en) * 2009-12-03 2011-06-09 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
WO2012070601A1 (ja) * 2010-11-24 2012-05-31 ヤマサ醤油株式会社 新規な２－アルキニル－ｎ９－プロパギルアデニンおよびその医薬用途
WO2012080728A1 (en) 2010-12-16 2012-06-21 Astrazeneca Ab Imidazo [4, 5 -c] quinolin- 1 -yl derivative useful in therapy
DK2651943T3 (en) 2010-12-17 2017-06-06 Sumitomo Dainippon Pharma Co Ltd purine derivatives
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ITRM20010465A1 (it) 2001-07-31 2003-01-31 Sigma Tau Ind Farmaceuti Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam

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CA2451279C (en) 2011-05-10
EP1412354A1 (en) 2004-04-28
CN1271070C (zh) 2006-08-23
CN1525974A (zh) 2004-09-01
ES2263810T3 (es) 2006-12-16
HUP0401987A3 (en) 2012-12-28
US20040204428A1 (en) 2004-10-14
ATE325796T1 (de) 2006-06-15
DE60211343D1 (de) 2006-06-14
PL368409A1 (en) 2005-03-21
ITRM20010465A0 (it) 2001-07-31
US7230102B2 (en) 2007-06-12
KR20040023641A (ko) 2004-03-18
WO2003011864A1 (en) 2003-02-13
PL217269B1 (pl) 2014-06-30
CA2451279A1 (en) 2003-02-13
MXPA04000886A (es) 2004-06-03
DE60211343T2 (de) 2007-05-10
DK1412354T3 (da) 2006-09-18
US20070249638A1 (en) 2007-10-25
AU2002326146B2 (en) 2008-05-01
HU228985B1 (en) 2013-07-29
KR100884818B1 (ko) 2009-02-20
EP1412354B1 (en) 2006-05-10
ITRM20010465A1 (it) 2003-01-31
BR0211550A (pt) 2004-07-13
HK1068334A1 (en) 2005-04-29
HUP0401987A2 (hu) 2005-01-28
PT1412354E (pt) 2006-09-29
US7528252B2 (en) 2009-05-05
JP2005500355A (ja) 2005-01-06

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