JP4352613B2 - 血管新生促進剤及び血管新生作用増強剤 - Google Patents

血管新生促進剤及び血管新生作用増強剤 Download PDF

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Publication number
JP4352613B2
JP4352613B2 JP2000508370A JP2000508370A JP4352613B2 JP 4352613 B2 JP4352613 B2 JP 4352613B2 JP 2000508370 A JP2000508370 A JP 2000508370A JP 2000508370 A JP2000508370 A JP 2000508370A JP 4352613 B2 JP4352613 B2 JP 4352613B2
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Japan
Prior art keywords
hydrogen atom
pyridazinone
halogen atom
pharmaceutical composition
carbon atoms
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Expired - Fee Related
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JP2000508370A
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English (en)
Japanese (ja)
Inventor
康陽 江木
秀明 木戸
一孝 林
佳史 久保
憲史 中村
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Nissan Chemical Corp
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Nissan Chemical Corp
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Publication of JP4352613B2 publication Critical patent/JP4352613B2/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
JP2000508370A 1997-08-28 1998-08-26 血管新生促進剤及び血管新生作用増強剤 Expired - Fee Related JP4352613B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23264497 1997-08-28
PCT/JP1998/003820 WO1999011268A1 (fr) 1997-08-28 1998-08-26 Agents promoteurs et agents potentialisateurs de la neovascularisation

Publications (1)

Publication Number Publication Date
JP4352613B2 true JP4352613B2 (ja) 2009-10-28

Family

ID=16942531

Family Applications (1)

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JP2000508370A Expired - Fee Related JP4352613B2 (ja) 1997-08-28 1998-08-26 血管新生促進剤及び血管新生作用増強剤

Country Status (13)

Country Link
US (1) US6284758B1 (US06284758-20010904-C00004.png)
EP (1) EP1025847B1 (US06284758-20010904-C00004.png)
JP (1) JP4352613B2 (US06284758-20010904-C00004.png)
KR (1) KR100559192B1 (US06284758-20010904-C00004.png)
CN (1) CN1142779C (US06284758-20010904-C00004.png)
AT (1) ATE307584T1 (US06284758-20010904-C00004.png)
AU (1) AU8886298A (US06284758-20010904-C00004.png)
CA (1) CA2301852C (US06284758-20010904-C00004.png)
DE (1) DE69832089T2 (US06284758-20010904-C00004.png)
DK (1) DK1025847T3 (US06284758-20010904-C00004.png)
ES (1) ES2247716T3 (US06284758-20010904-C00004.png)
TW (1) TW490303B (US06284758-20010904-C00004.png)
WO (1) WO1999011268A1 (US06284758-20010904-C00004.png)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU768825B2 (en) * 1998-12-07 2004-01-08 Nissan Chemical Industries Ltd. Remedial agent for erectile dysfunction
KR20060125816A (ko) * 2003-12-26 2006-12-06 닛산 가가쿠 고교 가부시키 가이샤 호중구증다 억제제
BRPI0507518A8 (pt) * 2004-02-09 2015-12-01 Nissan Chemical Ind Ltd Inibidor de hiperplasia vascular da íntima
WO2007011707A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
ES2540059T3 (es) 2006-04-26 2015-07-08 Micell Technologies, Inc. Recubrimientos que contienen múltiples fármacos
CA2667228C (en) 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
EP2111184B1 (en) 2007-01-08 2018-07-25 Micell Technologies, Inc. Stents having biodegradable layers
WO2008105260A1 (ja) * 2007-02-28 2008-09-04 Ltt Bio-Pharma Co., Ltd. 下肢切断手術の予後を改善する治療剤
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
AU2008256684B2 (en) 2007-05-25 2012-06-14 Micell Technologies, Inc. Polymer films for medical device coating
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
AU2009251504B2 (en) 2008-04-17 2013-09-05 Micell Technologies, Inc. Stents having bioabsorbable layers
AU2009270849B2 (en) 2008-07-17 2013-11-21 Micell Technologies, Inc. Drug delivery medical device
WO2011009096A1 (en) 2009-07-16 2011-01-20 Micell Technologies, Inc. Drug delivery medical device
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
CA2756386C (en) 2009-03-23 2019-01-15 Micell Technologies, Inc. Drug delivery medical device
JP2012522589A (ja) 2009-04-01 2012-09-27 ミシェル テクノロジーズ,インコーポレイテッド 被覆ステント
US11369498B2 (en) 2010-02-02 2022-06-28 MT Acquisition Holdings LLC Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US9554888B2 (en) 2010-04-20 2017-01-31 University Of Utah Research Foundation Phase separation sprayed scaffold
US10232092B2 (en) 2010-04-22 2019-03-19 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
EP2593039B1 (en) 2010-07-16 2022-11-30 Micell Technologies, Inc. Drug delivery medical device
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
EP2953581B1 (en) 2013-02-05 2020-09-16 University of Utah Research Foundation Implantable devices for bone or joint defects
AU2014248508B2 (en) 2013-03-12 2018-11-08 Micell Technologies, Inc. Bioabsorbable biomedical implants
AU2014265460B2 (en) 2013-05-15 2018-10-18 Micell Technologies, Inc. Bioabsorbable biomedical implants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0482208B1 (en) * 1990-04-25 2000-07-19 Nissan Chemical Industries Ltd. Pyridazinone derivative
CA2063055A1 (en) * 1991-05-22 1992-11-23 Jacob Eyal Peptides having thrombospondin-like activity and their therapeutic use
JP3666042B2 (ja) 1994-01-25 2005-06-29 日産化学工業株式会社 ピリダジノン誘導体
IL112695A (en) 1994-02-22 1999-04-11 Green Cross Corp Pharmaceutical compositions containing pyridazinone derivatives

Also Published As

Publication number Publication date
CA2301852A1 (en) 1999-03-11
DE69832089D1 (de) 2005-12-01
CN1142779C (zh) 2004-03-24
CN1277553A (zh) 2000-12-20
US6284758B1 (en) 2001-09-04
CA2301852C (en) 2007-07-10
KR20010023331A (ko) 2001-03-26
KR100559192B1 (ko) 2006-03-13
TW490303B (en) 2002-06-11
DE69832089T2 (de) 2006-07-20
EP1025847A1 (en) 2000-08-09
WO1999011268A1 (fr) 1999-03-11
ES2247716T3 (es) 2006-03-01
DK1025847T3 (da) 2006-02-13
ATE307584T1 (de) 2005-11-15
EP1025847B1 (en) 2005-10-26
EP1025847A4 (en) 2003-01-08
AU8886298A (en) 1999-03-22

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