JP4328246B2 - Liquid oral composition - Google Patents

Description

  The present invention relates to a composition for a liquid oral cavity in which a fragrance component is stably dissolved and irritation and taste of a surfactant and the like are suppressed.

  Liquid oral compositions such as mouthwashes often contain medicinal ingredients such as fragrance ingredients and bactericides. However, since the fragrance component and some medicinal components are oil-soluble, a large amount of a surfactant and a solvent are blended in order to dissolve them stably.

However, since surfactants and solvents have irritation, taste and odor, blending a large amount of them significantly deteriorates the feeling of use. For this reason, various techniques for reducing the blending amount of the surfactant in the liquid oral composition and maintaining the stability have been studied.
As such a technique, a technique is known in which a nonionic surfactant (nonionic surfactant) is blended in a small amount of 1000: 1 to 1: 1 with respect to an oil-soluble component (Patent Document 1). However, in order to obtain a stable composition by blending the nonionic surfactant in the above ratio with respect to the oil-soluble component, it must be mixed under special conditions such as pressurization of about 10 to 100 MPa. It was difficult to obtain a composition.
JP 2001-302478 A

  An object of the present invention is to provide a liquid oral composition that is excellent in use feeling, stable as a composition, and easy to produce.

  As a result of various studies on liquid oral compositions containing 0.1% by mass or more of a fragrance component, the present inventors have found that a small amount of anionic surfactant and a large amount of sugar alcohol in addition to a specific amount of nonionic surfactant. It has been found that by combining and blending, stability and usability can be achieved, and manufacturing is easy.

That is, the present invention includes the following components (A), (B), (C) and (D):
(A) Fragrance component 0.1% by mass or more,
(B) Anionic surfactant 0.002-0.2 mass%,
(C) nonionic surfactant 0.01-0.9 mass%,
(D) Sugar alcohol 5-50 mass%
The liquid oral cavity composition containing this is provided.
The present invention also includes the following components (A), (B), (C) and (E):
(A) Fragrance component 0.1% by mass or more,
(B) Anionic surfactant 0.002-0.2 mass%,
(C) nonionic surfactant 0.01-0.9 mass%,
(E) 1 type (s) or 2 or more types selected from erythritol, xylitol, and paratinite 5-35 mass%
The liquid oral cavity composition containing this is provided.

  According to the present invention, since the fragrance component is stably contained in an amount of 0.1% by mass or more, there is a good refreshing feeling and flavor, and the feeling of use in which irritation and off-flavor by the surfactant is suppressed is very good, and easy to manufacture Liquid oral compositions are provided.

  In addition to synthetic fragrances such as menthol, carvone, anethole, eugenol, cineol, thymol, methyl salicylate, pregon, menthone, pinene, limonene, menthyl acetate, etc., component (A) used in the present invention includes peppermint oil, spearmint oil Mint oil such as peppermint oil, citrus oil such as lemon, orange, grapefruit, lime, eucalyptus, sage, rosemary, thyme, laurel, basil, perilla, bay, estragon, parsley, celery, coriander herb oil, cinnamon Natural essential oils such as pepper, nutmeg, mace, clove, ginger, cardamom, anise and other spice oils, apple, banana, melon, grape, peach, strawberry, blueberry, raspberry, blackcurrant, lychee, squirrel Over fruit, passion fruit, can be used plum, pineapple, and fruit flavors, such as Muscat. Among these fragrance components, menthol, carvone, peppermint oil, spearmint oil, peppermint oil, methyl salicylate, cineol, limonene, and pinene are particularly preferable in terms of imparting a refreshing feeling and refreshingness to the oral cavity. These perfume ingredients are used alone or in combination of two or more.

  The fragrance component is required to be blended in the liquid oral composition of the present invention in an amount of 0.1% by mass or more from the point of obtaining the original flavor imparting effect of the fragrance, but 0.1 to 1.0% by mass, It is preferable to add 0.2 to 0.6% by mass, particularly 0.3 to 0.5% by mass.

  Examples of the (B) anionic surfactant used in the present invention include alkyl sulfate salts such as sodium lauryl sulfate and sodium myristyl sulfate; N-acyl amino acid salts such as sodium lauroyl sarcosine; acyl taurine salts such as sodium lauroylmethyl taurine; Examples include fatty acid ester sulfonates such as coconut oil fatty acid ethyl ester sulfonate sodium salt. Of these, alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate are preferred from the viewpoint of irritation and aftertaste. These anionic surfactants are used alone or in combination of two or more.

  These anionic surfactants need to be blended in the liquid oral composition of the present invention in an amount of 0.002 to 0.2% by mass from the viewpoint of stability and irritation, but 0.005 to 0.15. It is preferable to blend by mass%, further 0.01-0.1 mass%, especially 0.03-0.08 mass%. When the content of the anionic surfactant exceeds 0.2% by mass, the raw material odor (alcohol odor) and irritation occur, the aftertaste is deteriorated, and the usability is lowered. On the other hand, if it is less than 0.002 mass%, the effect | action which dissolves a fragrance | flavor component stably is not enough.

  Examples of the (C) nonionic surfactant used in the present invention include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, Polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene phytosterol and phytostanol, polyoxyethylene lanolin and lanolin alcohol, poly Oxyethylene alkylamines and fatty acid amides, polyoxyethylene alkylphenyl formaldehyde condensates, poly Alkoxy polyoxypropylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene alkyl phenyl ether and fatty ethanol amides. Among these, fatty acid esters having about 8 to 20 carbon atoms in the fatty acid are preferable from the viewpoint of stability and aftertaste. These nonionic surfactants are used alone or in combination of two or more.

  These nonionic surfactants need to be blended in the liquid oral composition of the present invention in an amount of 0.01 to 0.9% by mass from the viewpoint of stability and aftertaste, but 0.05 to 0.8% by mass. %, More preferably 0.1 to 0.7% by mass, and particularly preferably 0.2 to 0.6% by mass. When the content of the nonionic surfactant exceeds 0.9% by mass, a raw material odor (alcohol odor) and oiliness are produced, the aftertaste is deteriorated, and the usability is lowered. On the other hand, if it is less than 0.01% by mass, the effect of stably dissolving the fragrance component is not sufficient.

  In the present invention, a small amount of both component (B) and component (C) must be combined. That is, in any one of a component (B) and a component (C), the fragrance | flavor component of the quantity which can fully exhibit a flavor is melt | dissolved stably, and a usability | use_condition cannot be hold | maintained. Here, the content weight ratio of the component (B) and the component (C) is 1: 400 to 1: 1, more preferably 1: 200 to 1: 5, particularly 1: 100 to 1:10, from the viewpoint of obtaining these effects. Is preferred.

  Examples of the sugar alcohol (D) used in the present invention include erythritol, xylitol, ribitol, arabitol, galactitol, sorbitol, mannitol, maltitol, palatinit, lactitol, maltotriitol, isomaltoteitol, maltotetriitol, Examples thereof include malttetriitol and reduced water candy. Among these, erythritol, xylitol, and paratinite are preferable. In particular, erythritol is preferable in terms of aftertaste. The total content (mass ratio) of erythritol, xylitol, and palatinit in the sugar alcohol is preferably 1/2 or more, and more preferably 2/3 or more.

  These sugar alcohols need to be blended in the liquid oral composition of the present invention in an amount of 5 to 50% by mass from the viewpoint of obtaining a good refreshing feeling and a taste and odor prevention effect. When the content of the sugar alcohol is less than 5% by mass, good refreshing feeling and taste / odour prevention effect cannot be obtained. When the content exceeds 50% by mass, it becomes difficult to stably dissolve the oil-soluble component when the content of the component (B) or component (C) is small as described above, and the sugar alcohol itself is not sticky or sweet. The refreshing feeling and the feeling of use are impaired. One or two or more sugar alcohols selected from erythritol, xylitol, and paratinite are preferably blended in an amount of 5 to 35% by mass, particularly 6 to 20% by mass.

  The liquid oral composition of the present invention may contain a bactericidal agent, a binder, a polyhydric alcohol, a buffering agent, other medicinal agents, a sweetener, a lower alcohol such as ethanol, water or the like other than the above components. it can.

  Here, the disinfectant includes benzoic acid and its salt, salicylic acid and its salt, parabens, potassium sorbate, cetylpyridinium chloride, decalinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, isopropylmethylphenol , Triclosan, hinokitiol, phenol or the like is used. The amount is usually preferably 0.001 to 0.5% by mass.

  As a binder, cellulose derivatives such as sodium carboxymethylcellulose and hydroxyethylcellulose, alginic acid derivatives such as sodium alginate and propylene glycol alginate, gums such as carrageenan, xanthan gum, duran gum, tragacanth gum and karaya gum, polyvinyl alcohol, sodium polyacrylate, Examples thereof include synthetic binders such as carboxyvinyl polymer, inorganic binders such as silica gel, bee gum and laponite, and starch degradation products such as dextrin and reduced dextrin. One or more of these can be mixed and used.

  Examples of the polyhydric alcohol include propylene glycol, glycerin, and polyethylene glycol. Examples of the buffer include citric acid and its salt, malic acid and its salt, phosphoric acid and its salt, and the like. Examples of the sweetening agent include saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, somatin, asparatylphenylalanyl methyl ester and the like. Other medicinal agents include anti-plasmin agents such as tranexamic acid and epsilon aminocaproic acid, vitamins such as ascorbic acid and tocopherol esters, glycyrrhizin salts, allantoins, plant extracts such as buckwheat, ogon, chamomile, latania, myrrh, Enzymes such as stranase, mutanase, lysozyme chloride, alkali metal monofluorophosphates such as sodium monofluorophosphate, fluorides such as sodium fluoride, stannous fluoride, sodium chloride, potassium nitrate, carbonate, bicarbonate , Salts such as sesquicarbonate, copper chlorophyllin sodium, copper gluconate, zinc chloride, zeolite, water-soluble inorganic phosphate compound, aluminum lactate, etc.

  The liquid oral composition of the present invention can be applied as liquid dentifrice, water dentifrice, mouthwash, mouth spray, mouthwash, and the like.

A mouthwash having the composition shown in Table 1 was prepared, and the properties of the solution were confirmed according to the property evaluation criteria shown below. Further, three panelists were allowed to contain 10 mL of each mouthwash for 30 seconds and evaluated according to the sensory evaluation criteria shown below. The results are shown in Tables 2-4. % In the table indicates mass%.
(Property evaluation criteria)
For the property evaluation, the following indications were given only for those in which turbidity occurred.
±: Stable with turbidity-: Unstable due to separation or turbidity (sensory evaluation criteria)
◎: No off-flavor and off-flavor, good aftertaste and strong refreshing feeling ○: No off-taste and off-flavor, but low refreshing feeling △: Off-flavor and oiliness (derived from nonionic) remain, poor aftertaste and weak cooling feeling ×: Offensive odor・ Stimulation (derived from anions) remains and the aftertaste is poor.

  From the results of Tables 2 to 4, the liquid oral composition containing 0.3% by mass of a fragrance improves the irritation and taste of anionic and nonionic surfactants by adding 5 to 50% by mass of sugar alcohol. In addition, it was confirmed that a good refreshing feeling was obtained.

Examples 3) to 7)
When the liquid oral cavity composition of the composition shown below was manufactured and the same evaluation was performed, it was confirmed that it was a very good mouthwash having both stability and usability.

Example 3) Mouthwash ethanol 20%
Polyoxyethylene (60) hydrogenated castor oil 0.8%
Sodium myristyl sulfate 0.1%
Erythritol 12%
Saccharin sodium 0.1%
Benzethonium chloride 0.01%
Citric acid 0.01%
Trisodium citrate 0.3%
Peppermint oil 0.5%
Fragrance 0.5%
Water balance
100%

Example 4) Mouthwash glycerin 15%
Sucrose myristic acid ester 0.5%
Decaglycerin oleate 0.2%
Sodium lauryl sulfate 0.002%
Xylitol 5%
Aspartame 0.01%
Ethanol 3.0%
Cetylpyridinium chloride 0.1%
Sodium monofluorophosphate 0.1%
Triclosan 0.02%
Fragrance 0.1%
Spearmint oil 0.1%
Carvone 0.2%
Dextranase 0.2%
Water balance
100%

Example 5) Liquid toothpaste decaglycerin laurate 0.4%
Hexaglycerin stearate 0.1%
Lauroylmethyl taurine sodium 0.02%
Glycerin 10%
Propylene glycol 2%
Dextrin 0.5%
Maltitol 10%
Erythritol 20%
Saccharin sodium 0.2%
Glycyrrhetinic acid 0.05%
Vitamin E 0.1%
Sodium benzoate 0.2%
Limonene 0.01%
Cineol 0.09%
Fragrance 0.5%
Purified water balance
100%

Example 6) Liquid toothpaste sucrose myristic acid ester 0.8%
Sodium lauryl sulfate 0.01%
Glycerin 10%
Sorbitol 5%
Propylene glycol 2%
Sodium alginate 0.1%
Lactitol 5%
Paratinit 5%
Saccharin sodium 0.1%
Triclosan 0.02%
Vitamin E 0.1%
Sodium benzoate 0.2%
Cineol 0.01%
Peppermint oil 0.1%
Fragrance 0.8%
Purified water balance
100%

Example 7) Mouse spray ethanol 35%
Polyoxyethylene sorbitan monostearate 0.9%
Sodium myristyl sulfate 0.2%
Glycerin 15%
Paratinit 3%
Elistor 5%
Stevioside 0.01%
Chlorhexidine hydrochloride 0.01%
Menthol 2.0%
Fragrance 0.8%
Purified water balance
100%

Claims (6)

The following components (A), (B), (C) and (D):
(A) Fragrance component 0.1% by mass or more,
(B) anionic surfactant 0.005 to 0.2% by mass,
(C) 0.1 to 0.8 % by mass of a nonionic surfactant,
(D) Erythritol 5-50 mass%
The weight ratio of component (B) to component (C) is 0.005: 0.8 to 1: 1, and the weight ratio of component (B) to component (D) is 0.005. : The composition for liquid oral cavity which is 30-0.08: 10 .   The composition for liquid oral cavity according to claim 1, wherein the component (B) is 0.03 to 0.08% by mass. The liquid oral composition according to claim 1 or 2 , wherein the content weight ratio of the component (C) and the component (D) is 0.8: 10 to 0.2: 30. The composition for liquid oral cavity according to any one of claims 1 to 3 , wherein the perfume component (A) contains one or more selected from the group consisting of menthol, carvone, methyl salicylate, cineol, limonene and pinene. object. The composition for liquid oral cavity according to any one of claims 1 to 3 , wherein the perfume component (A) contains one or more selected from the group consisting of peppermint oil, spearmint oil and peppermint oil. The following components (A), (B), (C) and (D):
(A) Fragrance component 0.1% by mass or more,
(B) anionic surfactant 0.005 to 0.2% by mass,
(C) 0.1 to 0.8 % by mass of a nonionic surfactant,
(D) erythritol 10-35 wt%
The weight ratio of component (B) to component (C) is 0.005: 0.8 to 1: 1, and the weight ratio of component (B) to component (D) is 0.005. : The composition for liquid oral cavity which is 30-0.08: 10 .