JP4323317B2 - 可変領域配列のクローニング方法 - Google Patents
可変領域配列のクローニング方法 Download PDFInfo
- Publication number
- JP4323317B2 JP4323317B2 JP2003554732A JP2003554732A JP4323317B2 JP 4323317 B2 JP4323317 B2 JP 4323317B2 JP 2003554732 A JP2003554732 A JP 2003554732A JP 2003554732 A JP2003554732 A JP 2003554732A JP 4323317 B2 JP4323317 B2 JP 4323317B2
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- Prior art keywords
- primer
- igvd
- sequence
- specific
- species
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01205100 | 2001-12-21 | ||
| PCT/EP2002/014662 WO2003054016A2 (en) | 2001-12-21 | 2002-12-20 | Method for cloning of variable domain sequences |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009060673A Division JP2009171975A (ja) | 2001-12-21 | 2009-03-13 | 可変領域配列のクローニング方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524391A JP2005524391A (ja) | 2005-08-18 |
| JP2005524391A5 JP2005524391A5 (https=) | 2006-01-12 |
| JP4323317B2 true JP4323317B2 (ja) | 2009-09-02 |
Family
ID=8181517
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554732A Expired - Fee Related JP4323317B2 (ja) | 2001-12-21 | 2002-12-20 | 可変領域配列のクローニング方法 |
| JP2009060673A Pending JP2009171975A (ja) | 2001-12-21 | 2009-03-13 | 可変領域配列のクローニング方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009060673A Pending JP2009171975A (ja) | 2001-12-21 | 2009-03-13 | 可変領域配列のクローニング方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20050037358A1 (https=) |
| EP (1) | EP1456237A2 (https=) |
| JP (2) | JP4323317B2 (https=) |
| AU (1) | AU2002360068B2 (https=) |
| CA (1) | CA2471116A1 (https=) |
| NO (1) | NO20043066L (https=) |
| WO (1) | WO2003054016A2 (https=) |
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| EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
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| WO2008105886A2 (en) * | 2006-05-26 | 2008-09-04 | Macrogenics, Inc. | HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
| CN101563365B (zh) * | 2006-08-03 | 2012-10-31 | 瓦西尼斯公司 | 抗-il-6单克隆抗体及其用途 |
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| FR2924440B1 (fr) | 2007-12-04 | 2015-01-09 | Pf Medicament | Nouveau procede de generation et de criblage d'une banque d'anticorps |
| EP2088432A1 (en) * | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| GB2470328A (en) | 2008-03-05 | 2010-11-17 | Ablynx Nv | Novel antigen binding dimer complexes, methods of making and uses thereof |
| JP2011516520A (ja) | 2008-04-07 | 2011-05-26 | アブリンクス エン.ヴェー. | Notch経路に指向性を有するアミノ酸配列及びその使用 |
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| LT2285408T (lt) | 2008-06-05 | 2019-01-25 | Ablynx N.V. | Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui |
| WO2010010119A1 (en) | 2008-07-22 | 2010-01-28 | Ablynx Nv | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368684B2 (en) * | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| US6291161B1 (en) * | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JP2843675B2 (ja) * | 1992-03-11 | 1999-01-06 | ダナ−ファーバー・キャンサー・インスチチュート・インコーポレーテッド | メッセンジャーrnaの同定、単離およびクローニング |
| DK1621554T4 (da) * | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| US5580726A (en) * | 1994-04-29 | 1996-12-03 | Geron Corporation | Method and Kit for enhanced differential display |
| AU6808194A (en) * | 1993-05-31 | 1994-12-20 | Chugai Seiyaku Kabushiki Kaisha | Reconstructed human antibody against human interleukin-6 |
| WO1997002479A2 (en) * | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US6114119A (en) * | 1997-08-29 | 2000-09-05 | Wisconsin Alumni Research Foundation | Transglutaminase and gene encoding same |
| DK1027439T3 (da) * | 1997-10-27 | 2010-05-10 | Bac Ip Bv | Multivalente antigenbindende proteiner |
| JP4213586B2 (ja) * | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| EP1456410A2 (en) * | 2001-12-11 | 2004-09-15 | AlgoNomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
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2002
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- 2002-12-20 US US10/499,500 patent/US20050037358A1/en not_active Abandoned
- 2002-12-20 CA CA002471116A patent/CA2471116A1/en not_active Abandoned
- 2002-12-20 JP JP2003554732A patent/JP4323317B2/ja not_active Expired - Fee Related
- 2002-12-20 AU AU2002360068A patent/AU2002360068B2/en not_active Expired - Fee Related
- 2002-12-20 WO PCT/EP2002/014662 patent/WO2003054016A2/en not_active Ceased
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| US20050037358A1 (en) | 2005-02-17 |
| AU2002360068A1 (en) | 2003-07-09 |
| JP2009171975A (ja) | 2009-08-06 |
| EP1456237A2 (en) | 2004-09-15 |
| WO2003054016A3 (en) | 2004-02-19 |
| US20070009527A1 (en) | 2007-01-11 |
| AU2002360068B2 (en) | 2009-09-03 |
| WO2003054016A2 (en) | 2003-07-03 |
| NO20043066L (no) | 2004-09-21 |
| CA2471116A1 (en) | 2003-07-03 |
| JP2005524391A (ja) | 2005-08-18 |
| WO2003054016A8 (en) | 2004-09-30 |
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