JP4308230B2 - カテキン類の着色抑制方法 - Google Patents
カテキン類の着色抑制方法 Download PDFInfo
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- JP4308230B2 JP4308230B2 JP2006199515A JP2006199515A JP4308230B2 JP 4308230 B2 JP4308230 B2 JP 4308230B2 JP 2006199515 A JP2006199515 A JP 2006199515A JP 2006199515 A JP2006199515 A JP 2006199515A JP 4308230 B2 JP4308230 B2 JP 4308230B2
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- Prior art keywords
- catechin
- water
- catechins
- polymer
- pvp
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Description
イオン交換水330gにポリビニルピロリドン(ISP製、K−15、重量平均分子量8000)を20g溶解させて調製した水溶液(85℃)と、イオン交換水140gにカテキン粉末(太陽化学(株)製、サンフェノン100S)10gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合し(8000r/min、1分)、表1に示す組成のカテキン/PVP複合体水分散液を得た。
イオン交換水321.5gに寒天(伊那食品工業(株)製、UP−37)を12.5g、PVP(ISP製、K−30、重量平均分子量60000)を4g、PVP(ISP製、K−90、重量平均分子量1300000)を12g溶解させて調製した水溶液(85℃)と、イオン交換水140gにカテキン粉末(サンフェノン100S)10gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合(8000r/min、1分)した後、気相中に噴霧することによって表2に示す組成のカテキン/PVP複合体内包ハイドロゲル粒子を得た。ハイドロゲル粒子の平均粒径は195μmであった。
イオン交換水490gにカテキン粉末(サンフェノン100S)を10g溶解し、2重量%のカテキン水溶液を調製した。
実施例1で得られたカテキン/PVP複合体水分散液、実施例2で得られたカテキン/PVP複合体内包ハイドロゲル粒子、比較例1で得られたカテキン水溶液を用い、表3に示す組成の製剤を調製した。得られた製剤を50℃にて1ヶ月間保存し、保存前後の明度差を下記方法により測定し、この明度差によって変色度合いを評価した。結果を表3に示す。
保存後の製剤を透明で内容量が3cm×3cm×1cmのケース(AS ONE社、PS CASE No.1)にいっぱいになるように詰める。そのケースと共に、色濃度標準としてKODAK GRAY SCALEのA、2、4,6,8,10、12、14、Bの9点(色濃度1〜9とする)と、CASMATCH(大日本印刷製)が同視野に入るようにし、白紙の上で撮影を行った。撮影条件はリングライト一様照明の下、一定のシャッター速度、しぼり、焦点距離で行った。撮影した画像をADOBE PHOTOSHOP上にてCASMATCHを基準に用いて色補正後、WINROOF(三谷商事株式会社)にて被測定部位の明度(HSBカラーモデルのBrightness)を定量化し、50℃、1ヶ月保存品の明度と初期の明度の差異を下記式で求め、変色度とした。
実施例1で得られたカテキン/PVP複合体水分散液、実施例2で得られたカテキン/PVP複合体内包ハイドロゲル粒子、比較例1で得られたカテキン水溶液を用い、表4に示す組成のラウリル硫酸ナトリウム水溶液を調製した。室温で1ケ月保存後のラウリル硫酸ナトリウム水溶液中に溶出したカテキン量を下記方法で定量し、溶出率を求めた。結果を表4に示す。
試料(ラウリル硫酸ナトリウム水溶液)を1.0g採取し、リン酸緩衝液19.0g、及び酒石酸鉄試薬5.0gを混合する。調製した混合液の540nmにおける吸光度を測定する。次いで、カテキン粉末(サンフェノン100S)を用い濃度既知のカテキン水溶液を調製して作成した検量線から試料中のカテキン濃度を計算し、溶出率を求める。なお、酒石酸鉄試薬は、硫酸第一鉄(7水塩)100mgと酒石酸ナトリウムカリウム500mgを水に溶かして100mlとして調製し、リン酸緩衝液はM/15リン酸水素二ナトリウム溶液とM/15リン酸水素二カリウム溶液を84:16の割合に混合して調製する。
イオン交換水327.5gに寒天(UP−37)を12.5g、PVP(K−30、重量平均分子量60000)を10.0g溶解させて調製した水溶液(85℃)と、イオン交換水145gにカテキン粉末(サンフェノン100S)5gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合(8000r/min、1分)した後、気相中に噴霧することによって、表5に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を得た。
PVPとして、PVP(ISP製、K−60、重量平均分子量400000)を10.0g用いる以外は、実施例3と同様にして表5に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を得た。
PVPとして、PVP(K−90、重量平均分子量1300000)を10.0g用いる以外は、実施例3と同様にして表5に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を得た。
実施例3〜5で作製したカテキン/PVP複合体内包ハイドロゲル粒子を用い、表6に示す組成のラウリル硫酸ナトリウム水溶液を調製した。室温で10日保存後のラウリル硫酸ナトリウム水溶液中に溶出したカテキン量を、試験例2と同様に定量し、溶出率を求めた。結果を表6に示す。
イオン交換水325.5gに寒天(UP−37)を12.5g、PVP(K−30)を3.0g、PVP(K−90)を9.0g溶解させて調製した水溶液(85℃)と、イオン交換水140gにカテキン粉末(サンフェノン100S)10gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合(8000r/min、1分)した後、気相中に噴霧することによって、表7に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を得た。
イオン交換水323.5gに寒天(UP−37)を12.5g、PVP(K−30)を3.5g、PVP(K−90)を10.5g溶解させて調製した水溶液(85℃)と、イオン交換水140gにカテキン粉末(サンフェノン100S)10gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合(8000r/min、1分)した後、気相中に噴霧することによって、表7に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を得た。
イオン交換水323.5gに寒天(UP−37)を12.5g、PVP(K−30)を5.0g、PVP(K−90)を15.0g溶解させて調製した水溶液(85℃)と、イオン交換水140gにカテキン粉末(サンフェノン100S)10gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合(8000r/min、1分)した後、気相中に噴霧することによって、表7に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を得た。
イオン交換水323.5gに寒天(UP−37)を12.5g、PVP(K−30)を5.5g、PVP(K−90)を16.5g溶解させて調製した水溶液(85℃)と、イオン交換水140gにカテキン粉末(サンフェノン100S)10gを溶解させて調製した水溶液(20℃)を、ホモミキサーによって混合(8000r/min、1分)した後、気相中に噴霧することによって、表7に示す組成及び平均粒径のカテキン/PVP複合体内包ハイドロゲル粒子を調製した。
実施例2、実施例6〜9で得られたカテキン/PVP複合体内包ハイドロゲル粒子を用い、表8に示す組成のラウリル硫酸ナトリウム水溶液を調製した。室温で20日保存後のラウリル硫酸ナトリウム水溶液中に溶出したカテキン量を、試験例2と同様に定量し、溶出率を求めた。結果を表8に示す。
Claims (6)
- 茶葉抽出物由来のカテキン類に、カテキン類と水不溶性の複合体を形成する、ポリビニルピロリドン、ポリビニルアルコール、ヒドロキシエチルセルロースから選択される水溶性ポリマー(以下ポリマーAという)を添加する、カテキン類の着色抑制方法。
- ポリマーAがポリビニルピロリドンである請求項1記載の抑制方法。
- ポリマーAの重量平均分子量が、6000〜3000000である請求項1又は2記載の抑制方法
- ポリマーAを、カテキン類に対して1〜4重量倍添加する請求項1〜3いずれかに記載の抑制方法
- カテキン類、カテキン類と水不溶性の複合体を形成する、ポリビニルピロリドン、ポリビニルアルコール、ヒドロキシエチルセルロースから選択される水溶性ポリマー(以下ポリマーAという)及びゲル形成剤を含有するハイドロゲル粒子。
- ポリマーAがポリビニルピロリドンである請求項5記載のハイドロゲル粒子。
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JP2006199515A JP4308230B2 (ja) | 2006-07-21 | 2006-07-21 | カテキン類の着色抑制方法 |
CN2007800277489A CN101495467B (zh) | 2006-07-21 | 2007-06-26 | 儿茶素类的着色抑制方法及洁牙剂组合物 |
PCT/JP2007/063202 WO2008010403A1 (fr) | 2006-07-21 | 2007-06-26 | Procédé de prévention de la coloration de catéchines et composition de dentifrice |
EP07767980.1A EP2045248B1 (en) | 2006-07-21 | 2007-06-26 | Method for preventing coloration of catechins and dentifrice composition |
US12/374,099 US20100008869A1 (en) | 2006-07-21 | 2007-06-26 | Method for preventing coloration of catechins and dentifrice composition |
TW096126176A TWI395745B (zh) | 2006-07-21 | 2007-07-18 | Catechu acid coloring inhibition method and toothpaste composition |
US14/680,145 US10213376B2 (en) | 2006-07-21 | 2015-04-07 | Method of suppressing coloration of catechins and a dentifrice composition |
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