JP4294092B2 - テロメア長を測定するための方法 - Google Patents

テロメア長を測定するための方法 Download PDF

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Publication number
JP4294092B2
JP4294092B2 JP50217097A JP50217097A JP4294092B2 JP 4294092 B2 JP4294092 B2 JP 4294092B2 JP 50217097 A JP50217097 A JP 50217097A JP 50217097 A JP50217097 A JP 50217097A JP 4294092 B2 JP4294092 B2 JP 4294092B2
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dna
telomere
cells
telomere length
probe
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Expired - Lifetime
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JP50217097A
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English (en)
Japanese (ja)
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JPH10507085A (ja
JPH10507085A5 (https=
Inventor
マイケル アール． コズロウスキー，
カレン アール． プロウズ，
シ−シ ウァン，
シャロン ウォン，
ナム ウォー キム，
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Geron Corp
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Geron Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
JP50217097A 1995-06-07 1996-06-06 テロメア長を測定するための方法 Expired - Lifetime JP4294092B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/479,916 1995-06-07
US08/479,916 US5741677A (en) 1995-06-07 1995-06-07 Methods for measuring telomere length
PCT/US1996/010035 WO1996041016A1 (en) 1995-06-07 1996-06-06 Methods for measuring telomere length

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007329366A Division JP2008119005A (ja) 1995-06-07 2007-12-20 テロメア長を測定するための方法

Publications (3)

Publication Number Publication Date
JPH10507085A JPH10507085A (ja) 1998-07-14
JPH10507085A5 JPH10507085A5 (https=) 2004-07-08
JP4294092B2 true JP4294092B2 (ja) 2009-07-08

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ID=23905964

Family Applications (2)

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JP50217097A Expired - Lifetime JP4294092B2 (ja) 1995-06-07 1996-06-06 テロメア長を測定するための方法
JP2007329366A Pending JP2008119005A (ja) 1995-06-07 2007-12-20 テロメア長を測定するための方法

Family Applications After (1)

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JP2007329366A Pending JP2008119005A (ja) 1995-06-07 2007-12-20 テロメア長を測定するための方法

Country Status (7)

Country Link
US (2) US5741677A (https=)
EP (1) EP0774014A4 (https=)
JP (2) JP4294092B2 (https=)
AU (1) AU697882B2 (https=)
CA (1) CA2196898C (https=)
MX (1) MX9700950A (https=)
WO (1) WO1996041016A1 (https=)

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US5871926A (en) * 1997-04-21 1999-02-16 The University Of New Mexico Sensitive method for measurement of telomeric DNA content in human tissues
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US7270958B2 (en) 1998-09-10 2007-09-18 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
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US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
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US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
AU5466500A (en) * 1999-06-04 2000-12-28 Jessie L.S. Au Methods and compositions for modulating drug activity through telomere damage
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EP1399591A2 (en) * 2001-06-23 2004-03-24 University of Wales College of Medicine Method for the determination of telomere length
US20030124549A1 (en) * 2001-10-11 2003-07-03 Xerox Corporation Devices and methods for detecting genetic sequences
DE10161829B4 (de) * 2001-12-15 2006-02-16 Peter Lahnert Neue Methode zur Bestimmung der Telomerlänge und ihre Verwendung zur Abschätzung des Lebensalters
CA2474468C (en) * 2002-01-31 2014-03-25 University Of Utah Amplifying repetitive nucleic acid sequences
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20040234961A1 (en) * 2002-04-22 2004-11-25 Fordyce Colleen A. Telomere length determination and applications
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WO2004035597A2 (en) * 2002-10-16 2004-04-29 Women And Infants Hospital Of Rhode Island, Inc. Methods of assessing the risk of reproductive failure by measuring telomere length
KR100479264B1 (ko) * 2002-11-01 2005-03-28 한국전자통신연구원 주기적 가열과 냉각을 통한 혼성화 방법 및 이를 사용하는폴리뉴클레오타이드 검출 장치
WO2004068110A2 (en) 2003-01-24 2004-08-12 University Of Utah Methods of predicting mortality risk by determining telomere length
WO2004106490A2 (en) * 2003-05-28 2004-12-09 The Johns Hopkins University NOVEL METHODS FOR FINDING MUTATIONS CAUSED BY THE INSERTION OF REPETEAD DNAs
US20080108057A1 (en) * 2004-06-22 2008-05-08 Griffith Jeffrey K Allelic imbalance in the diagnosis and prognosis of cancer
US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
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US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
US8084203B2 (en) 2008-05-12 2011-12-27 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
WO2009138117A1 (en) * 2008-05-12 2009-11-19 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Methods and reagents for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
US20090298709A1 (en) * 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
LT3029154T (lt) 2008-10-17 2017-12-27 Geron Corporation Paciento jautrumo telomerazės slopinimo terapijai nustatymo būdas
US9689028B2 (en) 2008-12-22 2017-06-27 University Of Utah Foundation Monochrome multiplex quantitative PCR
CN102791877A (zh) * 2009-11-06 2012-11-21 酶学有限公司 使用双链核酸复合物与耐热聚合酶用于合成脱氧核糖核苷酸链的组合物和方法
WO2012027547A2 (en) * 2010-08-25 2012-03-01 Columbia University Quantitative total definition of biologically active sequence elements
US20120196284A1 (en) * 2010-12-16 2012-08-02 University Of Medicine And Dentistry Of New Jersey Method of Measuring Telomere Length
RU2508407C9 (ru) * 2012-10-10 2014-05-20 Елена Андреевна Чирясова Способ количественной оценки терминальных нуклеотидов g-цепи теломерной днк человека с помощью полимеразной цепной реакции и дуплекс-специфического анализа, наборы синтетических олигонуклеотидных праймеров и зондов для осуществления этого способа
US9200327B2 (en) 2012-11-30 2015-12-01 Geron Corporation Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
CN105246490A (zh) * 2013-03-15 2016-01-13 伊利克斯根公司 使用zscan4复壮人细胞的方法
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CN105899232A (zh) 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂
US10287354B2 (en) 2013-12-20 2019-05-14 Novartis Ag Regulatable chimeric antigen receptor
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
KR102255304B1 (ko) 2014-09-26 2021-05-24 삼성전자주식회사 텔로미어 증폭 방법
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HK1245095A1 (zh) 2015-05-20 2018-08-24 Novartis Ag 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
CN110114070A (zh) 2016-11-23 2019-08-09 诺华公司 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法
CN106755429A (zh) * 2016-12-27 2017-05-31 上海三誉生物科技有限公司 一种精确测量人群端粒长度的方法
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Also Published As

Publication number Publication date
MX9700950A (es) 1998-01-31
JP2008119005A (ja) 2008-05-29
US5741677A (en) 1998-04-21
EP0774014A1 (en) 1997-05-21
AU697882B2 (en) 1998-10-22
WO1996041016A1 (en) 1996-12-19
JPH10507085A (ja) 1998-07-14
EP0774014A4 (en) 2002-01-02
CA2196898C (en) 2007-10-30
AU6272496A (en) 1996-12-30
CA2196898A1 (en) 1996-12-19
US5834193A (en) 1998-11-10

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