MX9700950A - Metodos para medir la longitud de un telomero. - Google Patents

Metodos para medir la longitud de un telomero.

Info

Publication number
MX9700950A
MX9700950A MX9700950A MX9700950A MX9700950A MX 9700950 A MX9700950 A MX 9700950A MX 9700950 A MX9700950 A MX 9700950A MX 9700950 A MX9700950 A MX 9700950A MX 9700950 A MX9700950 A MX 9700950A
Authority
MX
Mexico
Prior art keywords
methods
telomere length
probe
telomere
primer extension
Prior art date
Application number
MX9700950A
Other languages
English (en)
Spanish (es)
Other versions
MXPA97000950A (en
Inventor
Michael R Kozlowski
Karen R Prowse
Sy-Shi Wang
Sharon Wong
Nam Woo Kim
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of MXPA97000950A publication Critical patent/MXPA97000950A/xx
Publication of MX9700950A publication Critical patent/MX9700950A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
MX9700950A 1995-06-07 1996-06-06 Metodos para medir la longitud de un telomero. MX9700950A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08479916 1995-06-07
US08/479,916 US5741677A (en) 1995-06-07 1995-06-07 Methods for measuring telomere length
PCT/US1996/010035 WO1996041016A1 (en) 1995-06-07 1996-06-06 Methods for measuring telomere length

Publications (2)

Publication Number Publication Date
MXPA97000950A MXPA97000950A (en) 1998-01-01
MX9700950A true MX9700950A (es) 1998-01-31

Family

ID=23905964

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700950A MX9700950A (es) 1995-06-07 1996-06-06 Metodos para medir la longitud de un telomero.

Country Status (7)

Country Link
US (2) US5741677A (https=)
EP (1) EP0774014A4 (https=)
JP (2) JP4294092B2 (https=)
AU (1) AU697882B2 (https=)
CA (1) CA2196898C (https=)
MX (1) MX9700950A (https=)
WO (1) WO1996041016A1 (https=)

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EP0932686A2 (en) 1996-10-01 1999-08-04 Geron Corporation Telomerase reverse transcriptase
US6117634A (en) 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US6197557B1 (en) 1997-03-05 2001-03-06 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US5871926A (en) * 1997-04-21 1999-02-16 The University Of New Mexico Sensitive method for measurement of telomeric DNA content in human tissues
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
US7270958B2 (en) 1998-09-10 2007-09-18 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (en) * 1999-04-08 2007-10-10 Antisoma Research Limited Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
AU5466500A (en) * 1999-06-04 2000-12-28 Jessie L.S. Au Methods and compositions for modulating drug activity through telomere damage
GB0005281D0 (en) 2000-03-07 2000-04-26 Secr Defence Analytical method
GB0009784D0 (en) * 2000-04-20 2000-06-07 Simeg Limited Methods for clinical diagnosis
EP1399591A2 (en) * 2001-06-23 2004-03-24 University of Wales College of Medicine Method for the determination of telomere length
US20030124549A1 (en) * 2001-10-11 2003-07-03 Xerox Corporation Devices and methods for detecting genetic sequences
DE10161829B4 (de) * 2001-12-15 2006-02-16 Peter Lahnert Neue Methode zur Bestimmung der Telomerlänge und ihre Verwendung zur Abschätzung des Lebensalters
CA2474468C (en) * 2002-01-31 2014-03-25 University Of Utah Amplifying repetitive nucleic acid sequences
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20040234961A1 (en) * 2002-04-22 2004-11-25 Fordyce Colleen A. Telomere length determination and applications
GB0214842D0 (en) * 2002-06-27 2002-08-07 Simeg Ltd Diagnostic method
WO2004035597A2 (en) * 2002-10-16 2004-04-29 Women And Infants Hospital Of Rhode Island, Inc. Methods of assessing the risk of reproductive failure by measuring telomere length
KR100479264B1 (ko) * 2002-11-01 2005-03-28 한국전자통신연구원 주기적 가열과 냉각을 통한 혼성화 방법 및 이를 사용하는폴리뉴클레오타이드 검출 장치
WO2004068110A2 (en) 2003-01-24 2004-08-12 University Of Utah Methods of predicting mortality risk by determining telomere length
WO2004106490A2 (en) * 2003-05-28 2004-12-09 The Johns Hopkins University NOVEL METHODS FOR FINDING MUTATIONS CAUSED BY THE INSERTION OF REPETEAD DNAs
US20080108057A1 (en) * 2004-06-22 2008-05-08 Griffith Jeffrey K Allelic imbalance in the diagnosis and prognosis of cancer
US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
US20100291560A1 (en) * 2007-03-27 2010-11-18 The Johns Hopkins University Methods and compositions for diagnosis and treatment of dyskeratosis congenita and related disorders
CA2695414A1 (en) * 2007-08-10 2009-02-19 Tina Holding Aps Method for estimating telomere length
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
US8084203B2 (en) 2008-05-12 2011-12-27 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
WO2009138117A1 (en) * 2008-05-12 2009-11-19 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Methods and reagents for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
US20090298709A1 (en) * 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
LT3029154T (lt) 2008-10-17 2017-12-27 Geron Corporation Paciento jautrumo telomerazės slopinimo terapijai nustatymo būdas
US9689028B2 (en) 2008-12-22 2017-06-27 University Of Utah Foundation Monochrome multiplex quantitative PCR
CN102791877A (zh) * 2009-11-06 2012-11-21 酶学有限公司 使用双链核酸复合物与耐热聚合酶用于合成脱氧核糖核苷酸链的组合物和方法
WO2012027547A2 (en) * 2010-08-25 2012-03-01 Columbia University Quantitative total definition of biologically active sequence elements
US20120196284A1 (en) * 2010-12-16 2012-08-02 University Of Medicine And Dentistry Of New Jersey Method of Measuring Telomere Length
RU2508407C9 (ru) * 2012-10-10 2014-05-20 Елена Андреевна Чирясова Способ количественной оценки терминальных нуклеотидов g-цепи теломерной днк человека с помощью полимеразной цепной реакции и дуплекс-специфического анализа, наборы синтетических олигонуклеотидных праймеров и зондов для осуществления этого способа
US9200327B2 (en) 2012-11-30 2015-12-01 Geron Corporation Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
CN105246490A (zh) * 2013-03-15 2016-01-13 伊利克斯根公司 使用zscan4复壮人细胞的方法
EP2999800B1 (en) 2013-05-22 2019-09-25 Telomere Diagnostics Inc. Measures of short telomere abundance
CN105899232A (zh) 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂
US10287354B2 (en) 2013-12-20 2019-05-14 Novartis Ag Regulatable chimeric antigen receptor
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
KR102255304B1 (ko) 2014-09-26 2021-05-24 삼성전자주식회사 텔로미어 증폭 방법
GB201418144D0 (en) 2014-10-14 2014-11-26 Univ Cardiff High throughput sequencing
US9944978B2 (en) 2014-12-30 2018-04-17 Telomere Diagnostics, Inc. Multiplex quantitative PCR
WO2016149612A2 (en) * 2015-03-19 2016-09-22 The Johns Hopkins University Assay for telomere length regulators
HK1245095A1 (zh) 2015-05-20 2018-08-24 Novartis Ag 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
CN110114070A (zh) 2016-11-23 2019-08-09 诺华公司 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法
CN106755429A (zh) * 2016-12-27 2017-05-31 上海三誉生物科技有限公司 一种精确测量人群端粒长度的方法
CA3061907A1 (en) 2017-05-02 2018-11-08 Revolution Medicines, Inc. Rapamycin analogs as mtor inhibitors
WO2019040993A1 (en) * 2017-09-01 2019-03-07 Children's Medical Research Institute TELOMER EVALUATION METHOD
US10098922B1 (en) 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
IL300091A (en) 2018-05-01 2023-03-01 Revolution Medicines Inc C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors
CN112368289B (zh) 2018-05-01 2024-02-20 锐新医药公司 作为mtor抑制剂的c26-连接的雷帕霉素类似物
EP3674418A1 (en) * 2018-12-26 2020-07-01 Life Length S.L. Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases
WO2021025935A1 (en) * 2019-08-02 2021-02-11 Georgetown University Dna-fish method for measurement of telomere length
AU2023275778A1 (en) 2022-05-25 2024-12-12 Revolution Medicines, Inc. Methods of treating cancer with an mtor inhibitor
CN117248003B (zh) * 2023-11-13 2024-04-12 元码基因科技（北京）股份有限公司 用于完整端粒扩增子测序的组合物、预文库及其构建方法
CN117230169B (zh) * 2023-11-13 2024-02-13 元码基因科技（北京）股份有限公司 用于长片段端粒序列测序的接头、预文库及其构建方法

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US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5629154A (en) * 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
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EP0787203A1 (en) * 1994-10-21 1997-08-06 Zeneca Limited Method for characterising variability in telomere dna by pcr

Also Published As

Publication number Publication date
JP2008119005A (ja) 2008-05-29
US5741677A (en) 1998-04-21
EP0774014A1 (en) 1997-05-21
AU697882B2 (en) 1998-10-22
WO1996041016A1 (en) 1996-12-19
JP4294092B2 (ja) 2009-07-08
JPH10507085A (ja) 1998-07-14
EP0774014A4 (en) 2002-01-02
CA2196898C (en) 2007-10-30
AU6272496A (en) 1996-12-30
CA2196898A1 (en) 1996-12-19
US5834193A (en) 1998-11-10

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