JP4259762B2 - 光を検出するための光学的構成 - Google Patents
光を検出するための光学的構成 Download PDFInfo
- Publication number
- JP4259762B2 JP4259762B2 JP2000535927A JP2000535927A JP4259762B2 JP 4259762 B2 JP4259762 B2 JP 4259762B2 JP 2000535927 A JP2000535927 A JP 2000535927A JP 2000535927 A JP2000535927 A JP 2000535927A JP 4259762 B2 JP4259762 B2 JP 4259762B2
- Authority
- JP
- Japan
- Prior art keywords
- face
- sample
- light
- optical waveguide
- optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6478—Special lenses
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/42—Coupling light guides with opto-electronic elements
- G02B6/4201—Packages, e.g. shape, construction, internal or external details
- G02B6/4204—Packages, e.g. shape, construction, internal or external details the coupling comprising intermediate optical elements, e.g. lenses, holograms
- G02B6/4206—Optical features
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/42—Coupling light guides with opto-electronic elements
- G02B6/4298—Coupling light guides with opto-electronic elements coupling with non-coherent light sources and/or radiation detectors, e.g. lamps, incandescent bulbs, scintillation chambers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19810615.7 | 1998-03-12 | ||
DE19810615A DE19810615A1 (de) | 1998-03-12 | 1998-03-12 | Optische Anordnung zum Erfassen von Licht |
PCT/EP1999/001548 WO1999046596A1 (de) | 1998-03-12 | 1999-03-10 | Optische anordnung zum erfassen von licht |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002506972A JP2002506972A (ja) | 2002-03-05 |
JP2002506972A5 JP2002506972A5 (US06811534-20041102-M00003.png) | 2008-07-31 |
JP4259762B2 true JP4259762B2 (ja) | 2009-04-30 |
Family
ID=7860552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000535927A Expired - Fee Related JP4259762B2 (ja) | 1998-03-12 | 1999-03-10 | 光を検出するための光学的構成 |
Country Status (6)
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10024132B4 (de) * | 2000-01-28 | 2007-03-22 | Leica Microsystems Cms Gmbh | Anordnung zur Detektion von Fluoreszenzlicht mehrerer Probenpunkte |
AUPR055000A0 (en) * | 2000-10-03 | 2000-10-26 | Varian Australia Pty Ltd | Fluorescence probe |
EP1360473B1 (en) * | 2001-01-23 | 2009-04-15 | Dublin City University | A luminescence based sensor |
CA2354321A1 (en) | 2001-07-26 | 2003-01-26 | Viamode Photonics Inc. | Apparatus for writing features in or on photosensitive medium |
WO2003023377A1 (en) * | 2001-09-11 | 2003-03-20 | Dublin City University | A luminescence-based sensor assembly |
DE10161529A1 (de) * | 2001-12-14 | 2003-07-03 | Infineon Technologies Ag | Biosensor zum Erfassen von makromolekularen Biopolymeren, Sensoranordnung mit einem Biosensor, Verfahren zur Herstellung des Biosensors und Verfahren zum Erfassen von Nukleinsäuremolekülen mittels mindestens einer Einheit zum Immobilisieren von Nukleinsäuren |
DE102004016361B4 (de) * | 2004-04-01 | 2006-07-06 | Cybio Ag | Optisches Analysenmessgerät für Fluoreszenzmessungen an Multiprobenträgern |
DE102004063098B4 (de) | 2004-12-22 | 2008-09-04 | Airbus Deutschland Gmbh | Klebeverbindung zum Verbinden von Bauteilen von Verkehrsmitteln sowie Verfahren zur Ermittlung eines in einer Klebeverbindung herrschenden mechanischen Belastungszustandes |
JP5065913B2 (ja) * | 2005-02-16 | 2012-11-07 | 株式会社日立ハイテクノロジーズ | キャピラリ照明における屈折率整合 |
SE529711C2 (sv) | 2006-03-22 | 2007-11-06 | Aamic Ab | Fluorescensläsare |
JP2009536339A (ja) | 2006-05-05 | 2009-10-08 | ダブリン シティ ユニバーシティ | 光学プローブ |
US7750316B2 (en) * | 2006-05-10 | 2010-07-06 | Dublin City University | Polymer biochip for detecting fluorescence |
DE102007020610A1 (de) * | 2007-04-30 | 2008-11-20 | Thomas Dr. Ruckstuhl | Behälter und Verfahren zum Nachweis von Fluoreszenz |
EP2017354A1 (en) * | 2007-07-20 | 2009-01-21 | Eppendorf Ag | Detection and/or quantification of target molecules on a solid support |
DE202008009859U1 (de) * | 2007-12-21 | 2009-03-05 | Berthold Technologies Gmbh & Co. Kg | Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung |
EP2269737B1 (en) | 2009-07-02 | 2017-09-13 | Amic AB | Assay device comprising serial reaction zones |
FI128503B (en) * | 2013-02-27 | 2020-06-30 | Teknologian Tutkimuskeskus Vtt Oy | Sample plate and assay procedure |
CN107561298B (zh) | 2016-06-30 | 2020-05-05 | 希森美康株式会社 | 测定装置以及测定方法 |
DE102017115661A1 (de) | 2017-07-12 | 2019-01-17 | Endress+Hauser Conducta Gmbh+Co. Kg | Optischer Sensor |
EP3460456B1 (en) * | 2017-09-20 | 2020-08-26 | IMEC vzw | A biosensor system for detecting supercritical angle fluorescent light |
EP3705875B1 (en) | 2019-03-05 | 2022-11-30 | IMEC vzw | An apparatus and method for detecting photoluminescent light emitted from a sample |
US11536650B2 (en) | 2019-10-18 | 2022-12-27 | Viavi Solutions Inc. | Image sensor system |
EP3869183A1 (de) * | 2020-02-24 | 2021-08-25 | Berthold Technologies GmbH & Co. KG | Vorrichtung zur ermittlung optischer eigenschaften von proben |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3015054A1 (de) * | 1980-04-18 | 1981-10-22 | Siemens AG, 1000 Berlin und 8000 München | Vorrichtung zum konzentrieren von optischer strahlung |
ATE41526T1 (de) * | 1984-06-13 | 1989-04-15 | Ares Serono Inc | Photometrische instrumente, ihre verwendung in optischen analysemethoden und dazu dienendes zubehoer. |
EP0184600B1 (en) * | 1984-12-10 | 1990-03-14 | Prutec Limited | Method for optically ascertaining parameters of species in a liquid analyte |
DE3626724C2 (de) | 1986-08-07 | 1994-06-16 | Siemens Ag | Anordnung zur Oberflächenprüfung |
EP0470982B1 (de) * | 1989-05-01 | 1993-07-14 | BOHNENKAMP, Wolfram | Reflexionsfluorimeter |
US5320814A (en) * | 1991-01-25 | 1994-06-14 | Trustees Of Tufts College | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
DE4226884C1 (de) * | 1992-08-13 | 1994-03-10 | Meinrad Maechler | Spektroskopisches System zur Durchführung der Mikroanalytik |
JPH0694613A (ja) * | 1992-09-11 | 1994-04-08 | Satoshi Kawada | 赤外顕微測定装置 |
JPH06214102A (ja) * | 1992-10-07 | 1994-08-05 | Sumitomo Electric Ind Ltd | 赤外光学部品及び測定装置 |
US5526112A (en) * | 1993-03-05 | 1996-06-11 | Sahagen; Armen N. | Probe for monitoring a fluid medium |
WO1995025972A1 (en) * | 1994-03-24 | 1995-09-28 | Kanagawa Academy Of Science And Technology | Optical fiber and its manufacture |
US5606170A (en) * | 1995-02-03 | 1997-02-25 | Research International, Inc. | Multifunctional sensor system |
US5581082A (en) * | 1995-03-28 | 1996-12-03 | The Regents Of The University Of California | Combined scanning probe and scanning energy microscope |
US5633724A (en) * | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
US5592578A (en) * | 1995-11-01 | 1997-01-07 | Hewlett-Packard Company | Peripheral optical element for redirecting light from an LED |
JP3093145B2 (ja) * | 1995-12-13 | 2000-10-03 | 科学技術振興事業団 | 光照射切り替え方法 |
US6287871B1 (en) * | 1996-03-19 | 2001-09-11 | University Of Utah Research Foundation | System for determining analyte concentration |
US5721435A (en) * | 1996-04-09 | 1998-02-24 | Hewlett Packard Company | Methods and apparatus for measuring optical properties of biological and chemical substances |
US5715059A (en) * | 1996-06-28 | 1998-02-03 | Polaroid Corporation | Dark field, photon tunneling imaging systems and methods |
DE19628002C1 (de) * | 1996-07-11 | 1997-12-18 | Inst Chemo Biosensorik | Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests |
DE19651935A1 (de) * | 1996-12-14 | 1998-06-18 | Ruckstuhl Thomas | Detektionssystem für den optischen Nachweis von Molekülen |
US5776785A (en) * | 1996-12-30 | 1998-07-07 | Diagnostic Products Corporation | Method and apparatus for immunoassay using fluorescent induced surface plasma emission |
-
1998
- 1998-03-12 DE DE19810615A patent/DE19810615A1/de not_active Withdrawn
-
1999
- 1999-03-10 US US09/646,031 patent/US6714297B1/en not_active Expired - Fee Related
- 1999-03-10 WO PCT/EP1999/001548 patent/WO1999046596A1/de active IP Right Grant
- 1999-03-10 EP EP99907618A patent/EP1076823B1/de not_active Expired - Lifetime
- 1999-03-10 JP JP2000535927A patent/JP4259762B2/ja not_active Expired - Fee Related
- 1999-03-10 AU AU27288/99A patent/AU2728899A/en not_active Abandoned
- 1999-03-10 DE DE59903655T patent/DE59903655D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6714297B1 (en) | 2004-03-30 |
EP1076823B1 (de) | 2002-12-04 |
DE19810615A1 (de) | 1999-09-16 |
WO1999046596A1 (de) | 1999-09-16 |
DE59903655D1 (de) | 2003-01-16 |
EP1076823A1 (de) | 2001-02-21 |
JP2002506972A (ja) | 2002-03-05 |
AU2728899A (en) | 1999-09-27 |
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