JP4255514B2 - 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア - Google Patents

疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア Download PDF

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JP4255514B2
JP4255514B2 JP52779397A JP52779397A JP4255514B2 JP 4255514 B2 JP4255514 B2 JP 4255514B2 JP 52779397 A JP52779397 A JP 52779397A JP 52779397 A JP52779397 A JP 52779397A JP 4255514 B2 JP4255514 B2 JP 4255514B2
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polymer
dye
cyclodextrin
group
signal generating
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JP2000509412A5 (OSRAM
JP2000509412A (ja
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バイエニアーツ，クリストフアー
ハフ，ジエフリイ・ビイ
コーンウエル，マイケル・ジエイ
タタ，ベンカタ・セシヤギリ・アール
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アボツト・ラボラトリーズ
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111—Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP52779397A 1996-02-01 1997-01-30 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア Expired - Fee Related JP4255514B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/595,092 US5994143A (en) 1996-02-01 1996-02-01 Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US08/595,092 1996-02-01
PCT/US1997/001429 WO1997028447A1 (en) 1996-02-01 1997-01-30 Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment

Publications (3)

Publication Number Publication Date
JP2000509412A JP2000509412A (ja) 2000-07-25
JP2000509412A5 JP2000509412A5 (OSRAM) 2004-11-11
JP4255514B2 true JP4255514B2 (ja) 2009-04-15

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JP52779397A Expired - Fee Related JP4255514B2 (ja) 1996-02-01 1997-01-30 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア

Country Status (7)

Country Link
US (1) US5994143A (OSRAM)
EP (1) EP1019722B1 (OSRAM)
JP (1) JP4255514B2 (OSRAM)
AT (1) ATE237138T1 (OSRAM)
DE (1) DE69720809T2 (OSRAM)
ES (1) ES2197332T3 (OSRAM)
WO (1) WO1997028447A1 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6437099B1 (en) * 1998-01-07 2002-08-20 Hamamatsu Photonics K.K. Fluorescene—activating antisera and IgG fraction therefrom
JP3437094B2 (ja) * 1998-07-03 2003-08-18 松下電器産業株式会社 多波長蛍光偏光法
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
DE10331093A1 (de) * 2003-07-09 2005-02-10 Schering Ag Vorrichtung und Verfahren zur direkten quantitativen in vitro-Bestimmung einer in einer Probe enthaltenen Substanz
US20050233465A1 (en) * 2004-04-14 2005-10-20 Bioprocessors Corp. Compositions of matter useful as pH indicators and related methods
DE102004033050A1 (de) * 2004-07-08 2006-01-26 International University Bremen Gmbh Photostabilisierung von Fluoreszenzfarbstoffen
WO2007053594A2 (en) * 2005-10-31 2007-05-10 Clontech Laboratories, Inc. Large dynamic range proteomic analysis methods and compositions for practicing the same
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
GB2437545B (en) * 2006-04-28 2011-07-06 Novexin Ltd Dextrin-containing reagents for detecting and quantifying proteins
JP2013040136A (ja) * 2011-08-17 2013-02-28 Tosoh Corp ４−アルコキシ−２−（４−アミノスチリル）ベンゾチアゾリウム塩、その製造方法およびそれを用いる核酸の検出方法
US9765220B2 (en) 2013-08-22 2017-09-19 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
CN103525117A (zh) * 2013-10-30 2014-01-22 苏州大学 一种半花菁荧光染料、制备方法及应用
JP6464534B2 (ja) * 2014-08-02 2019-02-06 エルジー・ケム・リミテッド 染料複合体、光変換フィルムおよびそれを含む電子素子
CN107454903B (zh) 2015-02-26 2021-01-01 索尼公司 包含共轭基团的水溶性荧光或着色染料
CN104788991B (zh) * 2015-03-04 2017-01-25 苏州大学 一种二氯三嗪反应基半花菁荧光活性染料及其制备方法
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
EP3455238A1 (en) 2016-05-10 2019-03-20 Sony Corporation Ultra bright polymeric dyes with peptide backbones
WO2017197014A2 (en) * 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
BR112018073199A2 (pt) 2016-05-11 2019-04-16 Sony Corporation corantes diméricos ou poliméricos ultrabrilhantes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
KR20200064059A (ko) 2017-10-05 2020-06-05 소니 주식회사 프로그램가능한 수지상 약물
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
EP4616912A3 (en) 2018-01-12 2025-11-19 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
EP3769085B1 (en) 2018-03-19 2022-08-24 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
CN113383043A (zh) 2019-09-26 2021-09-10 索尼集团公司 具有连接体基团的聚合物串联染料
CN111500110B (zh) * 2020-04-28 2022-09-06 陕西大风印务科技有限公司 烟用包装纸用透明油墨及其涂层、烟用包装纸
US20240132725A1 (en) 2020-12-07 2024-04-25 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619990A (en) * 1985-03-11 1986-10-28 Minnesota Mining And Manufacturing Company Polymeric dyes with pendent chromophore groups capable of undergoing thermoplastic deformation
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
CA1323293C (en) * 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
DE3921498A1 (de) * 1988-09-28 1990-03-29 Bayer Ag Polymer-gebundene-farbstoffe, verfahren zu deren herstellung und verwendung
US5401469A (en) * 1989-04-19 1995-03-28 Ibiden Co., Ltd. Plastic optical biomaterials assay device
EP0439182B1 (en) * 1990-01-26 1996-04-24 Abbott Laboratories Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
DE4114482A1 (de) * 1991-05-03 1992-11-05 Bayer Ag Polymere farbstoffe, verfahren zu deren herstellung und deren verwendung
WO1992020746A1 (en) * 1991-05-14 1992-11-26 Hybritech, Incorporated Polymeric compositions having bound antibodies
JPH09500411A (ja) * 1993-07-13 1997-01-14 アボツト・ラボラトリーズ 蛍光性ポリマー標識された接合体および中間体

Also Published As

Publication number Publication date
ATE237138T1 (de) 2003-04-15
EP1019722B1 (en) 2003-04-09
DE69720809T2 (de) 2004-04-01
EP1019722A1 (en) 2000-07-19
DE69720809D1 (de) 2003-05-15
WO1997028447A1 (en) 1997-08-07
US5994143A (en) 1999-11-30
JP2000509412A (ja) 2000-07-25
ES2197332T3 (es) 2004-01-01

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