JP4235544B2 - 欠陥折畳み蛋白質センサー方法 - Google Patents

欠陥折畳み蛋白質センサー方法 Download PDF

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Publication number
JP4235544B2
JP4235544B2 JP2003500572A JP2003500572A JP4235544B2 JP 4235544 B2 JP4235544 B2 JP 4235544B2 JP 2003500572 A JP2003500572 A JP 2003500572A JP 2003500572 A JP2003500572 A JP 2003500572A JP 4235544 B2 JP4235544 B2 JP 4235544B2
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protein
peptide
peptide probe
sample
probe
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Japanese (ja)
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JP2004536296A (ja
Inventor
シンディー オーサー，
アンヌ グロセ，
ユージン デヴィッドソン，
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アドライフ インコーポレーティッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2003500572A 2001-05-31 2002-05-30 欠陥折畳み蛋白質センサー方法 Expired - Fee Related JP4235544B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29545601P 2001-05-31 2001-05-31
PCT/US2002/017212 WO2002097444A2 (fr) 2001-05-31 2002-05-30 Procede de detection de proteines mal pliees

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JP2004536296A JP2004536296A (ja) 2004-12-02
JP4235544B2 true JP4235544B2 (ja) 2009-03-11

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JP2003500572A Expired - Fee Related JP4235544B2 (ja) 2001-05-31 2002-05-30 欠陥折畳み蛋白質センサー方法

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US (4) US7691639B2 (fr)
EP (1) EP1395833B1 (fr)
JP (1) JP4235544B2 (fr)
AU (2) AU2002320045B2 (fr)
CA (1) CA2448981C (fr)
MX (1) MXPA03011000A (fr)
WO (1) WO2002097444A2 (fr)

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US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
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US8114832B2 (en) * 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
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CN104777307B (zh) * 2008-10-31 2019-10-18 耶鲁大学 先兆子痫检测和治疗的方法和组合物
CN102365295A (zh) * 2009-01-30 2012-02-29 阿德利夫股份有限公司 构象动力肽
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US9588129B2 (en) * 2013-03-15 2017-03-07 Amira Medical Technologies Inc. Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
JP7136790B2 (ja) 2017-02-17 2022-09-13 ブリストル－マイヤーズ スクイブ カンパニー アルファ－シヌクレインに対する抗体およびその使用
TWI698641B (zh) * 2017-12-28 2020-07-11 大陸商浙江數問生物技術有限公司 一種檢測錯誤折疊蛋白質的裝置、試劑盒和方法

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Also Published As

Publication number Publication date
EP1395833B1 (fr) 2013-02-27
US20060275910A1 (en) 2006-12-07
US20100267151A1 (en) 2010-10-21
US7166471B2 (en) 2007-01-23
WO2002097444A3 (fr) 2003-10-30
CA2448981C (fr) 2014-03-18
US20060286672A1 (en) 2006-12-21
WO2002097444A2 (fr) 2002-12-05
JP2004536296A (ja) 2004-12-02
AU2008203542A1 (en) 2008-08-28
EP1395833A2 (fr) 2004-03-10
AU2008203542B2 (en) 2011-01-20
US7691639B2 (en) 2010-04-06
MXPA03011000A (es) 2004-02-27
AU2002320045B2 (en) 2008-05-08
CA2448981A1 (fr) 2002-12-05
US20030104633A1 (en) 2003-06-05
US8062895B2 (en) 2011-11-22

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