WO2001014412A1 - Composes servant a imiter les brins beta - Google Patents

Composes servant a imiter les brins beta Download PDF

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Publication number
WO2001014412A1
WO2001014412A1 PCT/US2000/023049 US0023049W WO0114412A1 WO 2001014412 A1 WO2001014412 A1 WO 2001014412A1 US 0023049 W US0023049 W US 0023049W WO 0114412 A1 WO0114412 A1 WO 0114412A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
compound
peptide
aryl
amino acid
Prior art date
Application number
PCT/US2000/023049
Other languages
English (en)
Inventor
James S. Nowick
Santanu Maitra
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to EP00959312A priority Critical patent/EP1210360A4/fr
Priority to AU70655/00A priority patent/AU7065500A/en
Publication of WO2001014412A1 publication Critical patent/WO2001014412A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne, de manière générale, de nouvelles compositions de substances, ainsi que des méthodes d'utilisation desdites compositions à des fins de recherche ou à des fins thérapeutiques. L'invention concerne, en particulier, des compositions qui a) imitent les brins β, b) bloquent la dimérisation en feuillets β des protéines, c) bloquent les interactions du type feuillets β entre protéines et/ou interagissent avec les protéines par formation de feuillets β, ainsi que d) des méthodes de recherche ou de conception de composés qui imitent les brins et/ou les feuillets β, e) des méthodes de traitement de maladies ou de troubles consistant à administrer à des patients humains ou vétérinaires des doses thérapeutiquement efficaces de ces composés et f) des méthodes d'utilisation d'un nouveau groupe protecteur (2,7-di-tert-butylfluorénylméthoxycarbonyl(Fmoc*)) dans la synthèse de peptides.
PCT/US2000/023049 1999-08-23 2000-08-23 Composes servant a imiter les brins beta WO2001014412A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00959312A EP1210360A4 (fr) 1999-08-23 2000-08-23 Composes servant a imiter les brins beta
AU70655/00A AU7065500A (en) 1999-08-23 2000-08-23 Compounds useful to mimic peptide beta-strands

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15026099P 1999-08-23 1999-08-23
US60/150,260 1999-08-23
US15116999P 1999-08-27 1999-08-27
US60/151,169 1999-08-27
US15269699P 1999-09-07 1999-09-07
US60/152,696 1999-09-07

Publications (1)

Publication Number Publication Date
WO2001014412A1 true WO2001014412A1 (fr) 2001-03-01

Family

ID=27386942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023049 WO2001014412A1 (fr) 1999-08-23 2000-08-23 Composes servant a imiter les brins beta

Country Status (3)

Country Link
EP (1) EP1210360A4 (fr)
AU (1) AU7065500A (fr)
WO (1) WO2001014412A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097444A3 (fr) * 2001-05-31 2003-10-30 Arete Associates Procede de detection de proteines mal pliees
WO2006105850A1 (fr) * 2005-04-04 2006-10-12 Merck Patent Gmbh Acylhydrazides utilises comme inhibiteur de kinase, notamment de la sgk
EP1826199A1 (fr) 2006-02-27 2007-08-29 Technische Universität Wien Acides aminés modifiés
US8372593B2 (en) 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
CN103588661A (zh) * 2012-08-17 2014-02-19 北京维德维康生物技术有限公司 尼卡巴嗪半抗原和人工抗原的制备
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
US9638702B2 (en) 2001-05-31 2017-05-02 System Of Systems Analytics, Inc. Detection of conformationally altered proteins
WO2022266494A1 (fr) * 2021-06-17 2022-12-22 The Regents Of The University Of California Dimères ondulés ss-croisés antiparallèles et matériaux, compositions et procédés associés

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618914A (en) * 1991-02-07 1997-04-08 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274676B (it) * 1994-04-14 1997-07-24 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3-diossani

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618914A (en) * 1991-02-07 1997-04-08 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1210360A4 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8062895B2 (en) 2001-05-31 2011-11-22 Adlyfe, Inc. Misfolded protein sensor method
US7691639B2 (en) 2001-05-31 2010-04-06 Adlyfe, Inc. Misfolded protein sensor method
US7166471B2 (en) 2001-05-31 2007-01-23 Arete Associates Misfolded protein sensor method in body fluids
US9638702B2 (en) 2001-05-31 2017-05-02 System Of Systems Analytics, Inc. Detection of conformationally altered proteins
WO2002097444A3 (fr) * 2001-05-31 2003-10-30 Arete Associates Procede de detection de proteines mal pliees
US8372593B2 (en) 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
JP2008535833A (ja) * 2005-04-04 2008-09-04 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 特にｓｇｋについてのキナーゼ阻害剤としてのアシルヒドラジド類
AU2006231008B2 (en) * 2005-04-04 2011-04-14 Merck Patent Gmbh Acyl hydrazides as kinase inhibitors, in particular for SGK
WO2006105850A1 (fr) * 2005-04-04 2006-10-12 Merck Patent Gmbh Acylhydrazides utilises comme inhibiteur de kinase, notamment de la sgk
US7767716B2 (en) 2005-04-04 2010-08-03 Merck Patent Gmbh Acyl hydrazines as kinase inhibitors, in particular for SGK
JP2009528282A (ja) * 2006-02-27 2009-08-06 テヒニシェ ウニベルジテート ウィーン 修飾アミノ酸
EP1826199A1 (fr) 2006-02-27 2007-08-29 Technische Universität Wien Acides aminés modifiés
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
CN103588661A (zh) * 2012-08-17 2014-02-19 北京维德维康生物技术有限公司 尼卡巴嗪半抗原和人工抗原的制备
WO2022266494A1 (fr) * 2021-06-17 2022-12-22 The Regents Of The University Of California Dimères ondulés ss-croisés antiparallèles et matériaux, compositions et procédés associés

Also Published As

Publication number Publication date
AU7065500A (en) 2001-03-19
EP1210360A4 (fr) 2005-03-02
EP1210360A1 (fr) 2002-06-05

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