JP4223483B2 - 酢酸菌セラミドを含む肌機能改善用組成物 - Google Patents
酢酸菌セラミドを含む肌機能改善用組成物 Download PDFInfo
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
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- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
「フレグランス・ジャーナル(Fragrance Journal)」、23巻、p.81〜89、1995年 「バイオインダストリー(Bioindustry)」、19巻、p.16〜26、2002年
また、請求項2に記載の本発明は、酢酸菌セラミドを含有する酢酸菌の細胞破砕物を有効成分として含有することを特徴とする肌機能改善用組成物に関する。
さらに、請求項3に記載の本発明は、酢酸菌セラミドが酢酸菌から極性溶媒を用いて抽出されたものであることを特徴とする請求項1に記載の肌機能改善用組成物に関する。
また、請求項4に記載の本発明は、飲食品であることを特徴とする請求項1〜請求項3に記載の肌機能改善用組成物に関する。
そして、請求項5に記載の本発明は、飲食品が食酢であることを特徴とする請求項4に記載の肌機能改善用組成物に閲する。
グルコノバクター・フラトウリ(Gluconobacter frateurii) NBRC 3264、同セリナス(G.cerinus) NBRC 3267など、
アサイア・ボゴレンシス(Asaia bogorensis) NBRC 16594、同シアメンシス(A.siamensis) NBRC 16457など、
アシドモナス・メタノリカ(Acidomonas methanolica) DSM 5432など。
<ヒト皮膚器官培養を用いた酢酸菌セラミドの抗シワ活性>
酢酸菌セラミドの抗シワ活性を以下の要領で実施した。
(2)酢酸菌セラミドならびに対照物を添加後、2時間後に、皮膚片に紫外線A波(UV−A)を3J/cm2の強度で、1日当り2回照射した。なお、ランプと検体の間に珪酸ガラスを挟んだ。
(3)皮膚片を器官培養した。なお、培養基はDMEMab培地(+)10%FBS(ウシ胎児血清)を用いた。
(4)毎日同様な処理を行い、5〜10目間、器官培養を行った。
(5)器官培養終了跡、チャンバーから皮膚片を単離し、実体顕微鏡/CCDビデオカメラで皮膚表面を撮影し、皮膚表面写真を得た。
(6)その後、皮膚表面に対して、シリコンゴムでレプリカ作製を行い、そのレプリカの写真を撮影して、レプリカ写真を得た。
(7)上記(6)で作製したレプリカの表面凸凹形状をスキャンして、ラインヒストグラムを作成した。
上記の結果を表1に示した。
――――――――――――――――――――――――――――――――――――――――
名称 評価 評価の根拠
――――――――――――――――――――――――――――――――――――――――
ヒト型糖セラミド EXCELLENT 肌理があって幅広や長いシワがない。
酢酸菌セラミド GOOD 広幅陥没がほぼ無い。細く短いシワが散見、総
じて平滑である。
ヒト型セラミド MEDIUM 皮膚表面は皮丘が僅かに存在する程度でシワ
が殆どないが、表面レプリカでは広幅で陰影
の濃い皮溝が目立つ。
植物型糖セラミド MEDIUM 幅広で長いシワが見られる。
無投与区 POOR 随所に広幅の陥没部が認められる。
――――――――――――――――――――――――――――――――――――――――
<ヒト皮膚器官培養を用いた酢酸菌セラミド体内吸収分解物の抗シワ活性>
経口摂取したセラミドの一部は分解され吸収され作用すると考えられる。
以上の結果を表2に示す。
――――――――――――――――――――――――――――――――――――――――
名称 評価 評価の根拠
――――――――――――――――――――――――――――――――――――――――
スフィンガニン EXCELLENT 皮膚表面も表面レプリカもシワが殆ど存在しない。
スフインゴシン GOOD 皮膚表面は皮丘が幾つか見られるが、表面レプリカでは広幅の皮溝はない。
無投与区 POOR 随所に広幅の陥没部が認められる。
――――――――――――――――――――――――――――――――――――――――
<アトピー性皮膚炎モデルマウスを用いた酢酸菌セラミドの肌機能改善効果>
アトピー性皮膚炎のモデルマウスとして4週齢のNC/Nga Tnd Crj系オスマウスを使用した。NC/Nga Tnd Crj系オスマウスは、SPF飼育環境下では肉眼的所見として異常を呈さないが、空気中の微生物制御を行っていない通常飼育環境下では、肌荒れ、保湿能力の低下等の強い皮膚炎症状を自然発症するマウスである。
<錠剤の調製>
酢酸菌としてAcetobacter aceti NBRC 14818を用い、その酢酸発酵液10キロリッターを高速遠心機器(8000rpm、20分)で集菌し、湿菌体10Kgを得た。得られた湿菌体10Kgを蒸留水にて洗浄後に大型凍結乾燥機で凍結減圧乾固し、乾燥菌体1.8Kgを得た。
<ゼリーの製造>
酢酸菌としてAcetobacter aceti NBRC 14818を用い、その酢酸発酵液10キロリッターを高速遠心機器(8000rpm、20分)で集菌し、湿菌体10Kgを得た。得られた湿菌体10Kgを等量の蒸留水に分散させた。分散させた20kgの酢酸菌分散液を高圧ホモジナイザー(20000psi)に3回通過させ細胞破壊処理を施した後に、大型凍結乾燥機で凍結減圧乾固し、乾燥菌体粉末1.5Kgを得た。
<飲料の製造>
酢酸菌としてAcetobacter aceti NBRC 14818を用い、その酢酸発酵液10キロリッターを高速遠心機器(8000rpm、20分)で集菌し、湿菌体10Kgを得た。得られた湿菌体10Kgを食酢100リッターに分散させた。分散させた酢酸菌分散液を高圧ホモジナイザー(20000psi)に3回通過させ細胞破壊処理を施した。その溶液を500ml容の瓶に分注し、75℃まで加温により殺菌し酢酸菌体含有食酢を得た。
Claims (4)
- 2−Hydroxy−C16−Dihydroceramideを有効成分とすることを特徴とする経口摂取用の肌機能改善用医薬組成物。
- 2−Hydroxy−C16−Dihydroceramideを含有する酢酸菌の細胞破砕物を有効成分として含有することを特徴とする経口摂取用の肌機能改善用医薬組成物。
- 2−Hydroxy−C16−Dihydroceramideが酢酸菌から極性溶媒を用いて抽出されたものであることを特徴とする請求項1に記載の経口摂取用の肌機能改善用医薬組成物。
- 錠剤、カプセル剤、粉剤、顆粒剤、散剤、液剤の少なくともひとつの経口摂取用剤形に製剤化したものであること、を特徴とする請求項1〜3のいずれか1項に記載の経口摂取用の肌機能改善用医薬組成物。
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