JP4189043B2 - Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤 - Google Patents

Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤 Download PDF

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Publication number
JP4189043B2
JP4189043B2 JP08593797A JP8593797A JP4189043B2 JP 4189043 B2 JP4189043 B2 JP 4189043B2 JP 08593797 A JP08593797 A JP 08593797A JP 8593797 A JP8593797 A JP 8593797A JP 4189043 B2 JP4189043 B2 JP 4189043B2
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group
salt
compound
formula
reaction
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Expired - Lifetime
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JP08593797A
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English (en)
Japanese (ja)
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JPH10152487A5 (enExample
JPH10152487A (ja
Inventor
親生 西野
文孝 佐藤
宏忠 福西
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Shiseido Co Ltd
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Shiseido Co Ltd
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Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Priority to JP08593797A priority Critical patent/JP4189043B2/ja
Priority to US08/939,912 priority patent/US5962456A/en
Priority to CA002216763A priority patent/CA2216763A1/en
Priority to AU39322/97A priority patent/AU717312B2/en
Priority to DE69706012T priority patent/DE69706012T2/de
Priority to KR1019970051173A priority patent/KR19980025185A/ko
Priority to EP97307709A priority patent/EP0832887B1/en
Priority to AT97307709T priority patent/ATE203989T1/de
Publication of JPH10152487A publication Critical patent/JPH10152487A/ja
Publication of JPH10152487A5 publication Critical patent/JPH10152487A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
JP08593797A 1996-09-30 1997-03-18 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤 Expired - Lifetime JP4189043B2 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP08593797A JP4189043B2 (ja) 1996-09-30 1997-03-18 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
CA002216763A CA2216763A1 (en) 1996-09-30 1997-09-29 N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug
US08/939,912 US5962456A (en) 1996-09-30 1997-09-29 N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug
DE69706012T DE69706012T2 (de) 1996-09-30 1997-09-30 N-Acylpiperazinderivat, antibakterielle und gegen Geschwüre wirksame Medikamente
AU39322/97A AU717312B2 (en) 1996-09-30 1997-09-30 N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug
KR1019970051173A KR19980025185A (ko) 1996-09-30 1997-09-30 Ｎ-아실피페라진 유도체 및 항균제, 항궤양제
EP97307709A EP0832887B1 (en) 1996-09-30 1997-09-30 N-acylpiperazine derivative, anti-ulcer drug, and antibacterial drug
AT97307709T ATE203989T1 (de) 1996-09-30 1997-09-30 N-acylpiperazinderivat, antibakterielle und gegen geschwüre wirksame medikamente

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27887296 1996-09-30
JP8-278872 1996-09-30
JP08593797A JP4189043B2 (ja) 1996-09-30 1997-03-18 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤

Publications (3)

Publication Number Publication Date
JPH10152487A JPH10152487A (ja) 1998-06-09
JPH10152487A5 JPH10152487A5 (enExample) 2005-02-17
JP4189043B2 true JP4189043B2 (ja) 2008-12-03

Family

ID=26426951

Family Applications (1)

Application Number Title Priority Date Filing Date
JP08593797A Expired - Lifetime JP4189043B2 (ja) 1996-09-30 1997-03-18 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤

Country Status (8)

Country Link
US (1) US5962456A (enExample)
EP (1) EP0832887B1 (enExample)
JP (1) JP4189043B2 (enExample)
KR (1) KR19980025185A (enExample)
AT (1) ATE203989T1 (enExample)
AU (1) AU717312B2 (enExample)
CA (1) CA2216763A1 (enExample)
DE (1) DE69706012T2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
ATE396187T1 (de) * 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
UA75425C2 (en) 2001-07-09 2006-04-17 Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB964232A (en) * 1962-04-16 1964-07-22 Analyses Et De Rech S Biolog M Substituted benzamides and pharmaceutical compositions containing them
US4208205A (en) * 1977-10-03 1980-06-17 E. I. Du Pont De Nemours And Company Herbicidal benzamides
JPS6058954A (ja) * 1983-09-13 1985-04-05 Kureha Chem Ind Co Ltd ジヒドロキシベンズアミド誘導体
US5143910A (en) * 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
HUT60458A (en) * 1991-02-01 1992-09-28 Sandoz Ag Process for producing benzyloxyphenyl derivatives and pharmaceutical compositions comprising same
FR2701259B1 (fr) * 1993-02-08 1995-03-24 Rhone Poulenc Agrochimie Procédé pour la préparation de dérivés phénylbenzamides fongicides agricoles.
JP3081773B2 (ja) * 1995-03-31 2000-08-28 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤

Also Published As

Publication number Publication date
JPH10152487A (ja) 1998-06-09
KR19980025185A (ko) 1998-07-06
CA2216763A1 (en) 1998-03-30
EP0832887A1 (en) 1998-04-01
DE69706012D1 (de) 2001-09-13
AU717312B2 (en) 2000-03-23
US5962456A (en) 1999-10-05
DE69706012T2 (de) 2002-05-29
ATE203989T1 (de) 2001-08-15
AU3932297A (en) 1998-04-02
EP0832887B1 (en) 2001-08-08

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