JP4187441B2 - インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤 - Google Patents

インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤 Download PDF

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JP4187441B2
JP4187441B2 JP2001523374A JP2001523374A JP4187441B2 JP 4187441 B2 JP4187441 B2 JP 4187441B2 JP 2001523374 A JP2001523374 A JP 2001523374A JP 2001523374 A JP2001523374 A JP 2001523374A JP 4187441 B2 JP4187441 B2 JP 4187441B2
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indole
illustrates
combretastatin
tubulin
methoxyphenyl
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JP2003509408A (ja
JP2003509408A5 (enExample
Inventor
ピニー，ケビン・ジー
ワング，フエング
デル・ピラー・メジア，マリア
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ベイラー・ユニバーシテイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/247—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aromatic amines (N-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2001523374A 1999-09-17 2000-09-15 インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤 Expired - Fee Related JP4187441B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15463999P 1999-09-17 1999-09-17
US60/154,639 1999-09-17
PCT/US2000/025408 WO2001019794A2 (en) 1999-09-17 2000-09-15 Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents

Publications (3)

Publication Number Publication Date
JP2003509408A JP2003509408A (ja) 2003-03-11
JP2003509408A5 JP2003509408A5 (enExample) 2005-06-30
JP4187441B2 true JP4187441B2 (ja) 2008-11-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001523374A Expired - Fee Related JP4187441B2 (ja) 1999-09-17 2000-09-15 インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤

Country Status (6)

Country Link
US (1) US20070082872A1 (enExample)
EP (1) EP1214298B1 (enExample)
JP (1) JP4187441B2 (enExample)
AU (1) AU777725B2 (enExample)
CA (1) CA2383988A1 (enExample)
WO (1) WO2001019794A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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CA2408220A1 (en) * 2000-05-09 2001-11-15 George R. Pettit Antitubulin assembly and cell growth inhibitor denominated "dioxostatin"
EP1289952A1 (en) 2000-05-31 2003-03-12 AstraZeneca AB Indole derivatives with vascular damaging activity
AUPR283801A0 (en) * 2001-02-01 2001-03-01 Australian National University, The Chemical compounds and methods
US7632955B2 (en) 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
US7528165B2 (en) 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
EP1515716A2 (en) 2002-04-03 2005-03-23 Astrazeneca AB Indole derivatives having anti-angiogenetic activity
EP1506960B1 (en) 2003-08-07 2011-04-06 National Health Research Institutes Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders
US7456214B2 (en) * 2004-05-03 2008-11-25 Baylor University Chromene-containing compounds with anti-tubulin and vascular targeting activity
EP1778252A4 (en) * 2004-08-11 2010-01-27 Williamsburg Holdings Llc NON-CARDIOTOXIC PHARMACEUTICAL COMPOUNDS
US7456289B2 (en) * 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
EP1896391B1 (en) * 2005-06-14 2015-08-12 Baylor University Combretastatin analogs with tubulin binding activity
CA2640678C (en) 2006-02-03 2015-03-31 Bionomics Limited Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
EP2150112A1 (en) * 2007-04-26 2010-02-10 Merck & Co., Inc. 2-substituted indole derivatives as calcium channel blockers
NZ598489A (en) 2009-08-27 2014-03-28 Bionomics Ltd Combination therapy for treating proliferative diseases
CN102596929A (zh) 2009-08-27 2012-07-18 生物学特性有限公司 黄斑变性的治疗
IT1399130B1 (it) 2010-04-01 2013-04-05 Consiglio Nazionale Ricerche Derivati indolici e loro uso in campo medico.
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
CA2905509A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
CN104098499B (zh) * 2013-04-08 2016-05-04 上海医药工业研究院 5-苄氧基-2-(4-苄氧基苯基)-3-甲基-1h-吲哚的制备方法
US9944597B2 (en) 2013-09-16 2018-04-17 The Board Of Regents Of The University Of Texas System Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof
CN104262229B (zh) * 2014-08-18 2016-10-05 广东颐正达医药科技有限公司 一种2-苯基取代-3-苯甲酰基取代吲哚的制备方法
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN107652194B (zh) * 2017-08-08 2020-02-28 首都医科大学附属北京天坛医院 一类用于治疗神经系统疾病的化合物
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2963288B2 (ja) * 1992-01-14 1999-10-18 株式会社海洋バイオテクノロジー研究所 水中有害付着生物防除剤
US5596106A (en) * 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
US5886025A (en) * 1997-03-06 1999-03-23 Baylor University Anti-mitotic agents which inhibit tubulin polymerization
US5948808A (en) * 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
US6001868A (en) * 1997-05-30 1999-12-14 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
US6150395A (en) * 1997-05-30 2000-11-21 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
JP2002500184A (ja) * 1998-01-09 2002-01-08 アリゾナ ボード オブ リーゼンツ フェンスタチンとそのプロドラッグの合成
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
US6162930A (en) * 1998-03-06 2000-12-19 Baylor University Anti-mitotic agents which inhibit tubulin polymerization
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6358992B1 (en) * 1998-11-25 2002-03-19 Cell Pathways, Inc. Method of inhibiting neoplastic cells with indole derivatives
JP2002537262A (ja) * 1999-02-18 2002-11-05 オキシジェン，インコーポレイティド 血管破壊のターゲッティングに使用するための組成物および方法
US6521658B1 (en) * 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
US6849656B1 (en) * 1999-09-17 2005-02-01 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US6323228B1 (en) * 2000-09-15 2001-11-27 Abbott Laboratories 3-substituted indole angiogenesis inhibitors

Also Published As

Publication number Publication date
EP1214298A2 (en) 2002-06-19
AU7493400A (en) 2001-04-17
WO2001019794A2 (en) 2001-03-22
CA2383988A1 (en) 2001-03-22
JP2003509408A (ja) 2003-03-11
EP1214298B1 (en) 2012-05-30
US20070082872A1 (en) 2007-04-12
AU777725B2 (en) 2004-10-28
WO2001019794A3 (en) 2001-09-27

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