JP4014590B2 - ナチュラルキラー刺激因子 - Google Patents
ナチュラルキラー刺激因子 Download PDFInfo
- Publication number
- JP4014590B2 JP4014590B2 JP2004287126A JP2004287126A JP4014590B2 JP 4014590 B2 JP4014590 B2 JP 4014590B2 JP 2004287126 A JP2004287126 A JP 2004287126A JP 2004287126 A JP2004287126 A JP 2004287126A JP 4014590 B2 JP4014590 B2 JP 4014590B2
- Authority
- JP
- Japan
- Prior art keywords
- nksf
- protein
- amino acid
- glycosylation site
- glycosylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/584,941 US5457038A (en) | 1988-11-10 | 1990-09-18 | Natural killer stimulatory factor |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1991516686A Division JP3652365B6 (ja) | 1990-09-18 | 1991-09-04 | ナチュラルキラー刺激因子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007173878A Division JP4423313B2 (ja) | 1990-09-18 | 2007-07-02 | ナチュラルキラー刺激因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005046158A JP2005046158A (ja) | 2005-02-24 |
| JP2005046158A5 JP2005046158A5 (enExample) | 2005-09-29 |
| JP4014590B2 true JP4014590B2 (ja) | 2007-11-28 |
Family
ID=24339390
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004287126A Expired - Lifetime JP4014590B2 (ja) | 1990-09-18 | 2004-09-30 | ナチュラルキラー刺激因子 |
| JP2007173878A Expired - Lifetime JP4423313B2 (ja) | 1990-09-18 | 2007-07-02 | ナチュラルキラー刺激因子 |
| JP2009104301A Pending JP2009178164A (ja) | 1990-09-18 | 2009-04-22 | ナチュラルキラー刺激因子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007173878A Expired - Lifetime JP4423313B2 (ja) | 1990-09-18 | 2007-07-02 | ナチュラルキラー刺激因子 |
| JP2009104301A Pending JP2009178164A (ja) | 1990-09-18 | 2009-04-22 | ナチュラルキラー刺激因子 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US5457038A (enExample) |
| EP (1) | EP0549711A1 (enExample) |
| JP (3) | JP4014590B2 (enExample) |
| AU (1) | AU8723691A (enExample) |
| WO (1) | WO1992005256A1 (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5811523A (en) | 1988-11-10 | 1998-09-22 | Trinchieri; Giorgio | Antibodies to natural killer stimulatory factor |
| US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| US5780597A (en) * | 1989-12-22 | 1998-07-14 | Hoffmann-La Roche Inc. | Monoclonal antibodies to cytotoxic lymphocyte maturation factor |
| DK0433827T3 (da) * | 1989-12-22 | 1998-09-28 | Hoffmann La Roche | Cytotoksisk lumfocytmodningsfaktor |
| US20080070842A1 (en) * | 1991-11-04 | 2008-03-20 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| US6399379B1 (en) | 1992-09-29 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Antisense modulation of interleukin 12 p35 subunit expression |
| CA2125763C (en) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| EP0733109B9 (en) * | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
| US6706264B1 (en) | 1994-03-14 | 2004-03-16 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y |
| ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
| US5635182A (en) * | 1994-06-16 | 1997-06-03 | Genetics Institute, Inc. | Method of detecting ligand interactions |
| DE69519454T2 (de) | 1994-07-14 | 2001-05-03 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen |
| TW581771B (en) * | 1994-11-15 | 2004-04-01 | Hayashibara Biochem Lab | Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide |
| JP2724987B2 (ja) | 1994-11-15 | 1998-03-09 | 株式会社林原生物化学研究所 | インターフェロン−γの産生を誘導するポリペプチド |
| JP4004088B2 (ja) | 1995-09-26 | 2007-11-07 | 株式会社林原生物化学研究所 | 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 |
| US7135458B1 (en) | 1995-11-15 | 2006-11-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use |
| US5674483A (en) * | 1995-01-31 | 1997-10-07 | National Jewish Medical And Research Center | Treatment for diseases involving inflammation |
| JP2000510813A (ja) * | 1995-02-06 | 2000-08-22 | ジェネテイックス・インスティテュート・インコーポレイテッド | Il−12用処方 |
| US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| US5872154A (en) * | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
| US6372208B1 (en) | 1999-09-28 | 2002-04-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
| US6251957B1 (en) | 1995-02-24 | 2001-06-26 | Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
| US5853714A (en) * | 1995-03-27 | 1998-12-29 | Genetics Institute, Inc. | Method for purification of IL-12 |
| US6509313B1 (en) * | 1996-02-28 | 2003-01-21 | Cornell Research Foundation, Inc. | Stimulation of immune response with low doses of cytokines |
| GB9609932D0 (en) * | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
| EP0931156A2 (en) * | 1996-10-18 | 1999-07-28 | Valentis Inc. | Gene expression and delivery systems and uses |
| WO1998017689A2 (en) * | 1996-10-18 | 1998-04-30 | Valentis Inc. | Il-12 gene expression and delivery systems and uses |
| CA2745736C (en) * | 1996-10-23 | 2016-11-22 | The Trustees Of The University Of Pennsylvania | Immunotherapy and improved vaccines |
| US5994104A (en) * | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
| WO1998041229A1 (en) * | 1997-03-19 | 1998-09-24 | F. Hoffmann-La Roche Ag | USE OF IL-12p40 AS IMMUNOSTIMULANT |
| EP1030681A4 (en) * | 1997-11-03 | 2001-07-04 | Wistar Inst | METHOD AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS AND TREATING CANCER |
| ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
| DE69916022T2 (de) * | 1998-01-23 | 2004-09-02 | Genetics Institute, LLC, Cambridge | Methode zur Verwendung von IL-11 zur Verstärkung der zellvermittelten Immunität zur Behandlung verschiedener viraler und parasitärer Infektionen und Krebs |
| US7026456B1 (en) | 1998-01-23 | 2006-04-11 | Hoffman-La Roche, Inc. | Antibodies against human IL-12 |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| US7247442B1 (en) | 1998-05-12 | 2007-07-24 | Human Genome Sciences, Inc. | Antibodies to HHPEN62 polypeptide |
| US6375944B1 (en) | 1998-09-25 | 2002-04-23 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for enhancing the immunostimulatory effect of interleukin-12 |
| US6448081B1 (en) * | 2001-05-07 | 2002-09-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of interleukin 12 p40 subunit expression |
| US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| US6570002B1 (en) * | 1999-02-26 | 2003-05-27 | The Johns Hopkins University | Inhibitor of programmed cell death |
| US6800460B1 (en) | 1999-03-11 | 2004-10-05 | Schering Corporation | Mammalian cytokine complexes |
| JP2003508013A (ja) * | 1999-03-12 | 2003-03-04 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 50個のヒト分泌タンパク質 |
| AU3517000A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | 50 human secreted proteins |
| WO2000061628A1 (en) * | 1999-04-09 | 2000-10-19 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| WO2000055201A1 (en) * | 1999-03-12 | 2000-09-21 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| AU3767000A (en) * | 1999-03-26 | 2000-10-16 | Human Genome Sciences, Inc. | 50 human secreted proteins |
| EP1171462A2 (en) * | 1999-03-26 | 2002-01-16 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| AU4066800A (en) * | 1999-04-01 | 2000-10-23 | Genetics Institute Inc. | Angiopoietin-like proteins, crisp proteins and polynucleotides encoding same |
| EP1203018A1 (en) * | 1999-07-21 | 2002-05-08 | Human Genome Sciences, Inc. | 26 human prostate and prostate cancer associated proteins |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| WO2001010912A1 (en) | 1999-08-09 | 2001-02-15 | Lexigen Pharmaceuticals Corp. | Multiple cytokine-antibody complexes |
| JP2003507036A (ja) * | 1999-08-16 | 2003-02-25 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | レチノイドレセプター相互作用ポリヌクレオチド、ポリペプチド、および抗体 |
| JP2003533968A (ja) * | 1999-09-03 | 2003-11-18 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 免疫グロブリンスーパーファミリーポリヌクレオチド、ポリペプチド、および抗体 |
| CA2384672A1 (en) * | 1999-09-09 | 2001-03-15 | Human Genome Sciences, Inc. | Steroid hormone receptor polynucleotides, polypeptides, and antibodies |
| AU7603800A (en) * | 1999-09-24 | 2001-04-24 | Human Genome Sciences, Inc. | 32 human secreted proteins |
| EP1223990B1 (en) | 1999-10-15 | 2004-07-28 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| US7115712B1 (en) * | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
| EP1248801A4 (en) * | 2000-01-18 | 2003-08-27 | Human Genome Sciences Inc | HUMANE POLYNUCLEOTIDES, POLYPEPTIDES AND ANTIBODIES |
| WO2001055448A1 (en) * | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| JP5179689B2 (ja) | 2000-02-11 | 2013-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗体ベース融合タンパク質の循環系内半減期の増強 |
| AU2001238585A1 (en) * | 2000-02-24 | 2001-09-03 | Human Genome Sciences, Inc. | Human polynucleotides, polypeptides, and antibodies |
| WO2001070804A1 (en) * | 2000-03-17 | 2001-09-27 | Human Genome Sciences, Inc. | 7 human ovarian and ovarian cancer associated proteins |
| US20030166044A1 (en) * | 2000-03-31 | 2003-09-04 | Kenneth Jacobs | Novel proteins |
| CA2404074A1 (en) * | 2000-04-03 | 2001-10-11 | Human Genome Sciences, Inc. | Human polynucleotides, polypeptides, and antibodies |
| AU2001253362A1 (en) * | 2000-04-13 | 2001-10-30 | Smith Kline Beecham Corporation | Novel compounds |
| NZ523122A (en) * | 2000-06-22 | 2004-06-25 | Smithkline Beecham Corp | Polypeptides and polynucleotides and methods of identifying agonists and antagonists in relation to treatment of diseases |
| CZ2003214A3 (cs) * | 2000-06-29 | 2003-08-13 | Merck Patent Gmbh | Zesílení odpovědi mediovaných fúzním proteinem protilátka-cytokin kombinovanou léčbou pomocí činidel zvyšujících uptake imunocytokinu |
| US6902734B2 (en) * | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| EP1313761A4 (en) * | 2000-08-28 | 2005-01-26 | Human Genome Sciences Inc | 18 HUMAN, SPECIFIC PROTEINS |
| US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
| DK1366067T3 (da) | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| BR0209177A (pt) | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Anticorpo especìfico a tumor recombinante e uso do mesmo |
| US7226587B2 (en) * | 2001-06-01 | 2007-06-05 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| ATE471946T1 (de) | 2002-12-17 | 2010-07-15 | Merck Patent Gmbh | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
| US7939058B2 (en) | 2003-07-03 | 2011-05-10 | University Of Southern California | Uses of IL-12 in hematopoiesis |
| TW200518767A (en) * | 2003-09-12 | 2005-06-16 | Wyeth Corp | Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins |
| CA2552590A1 (en) * | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
| US20040260068A1 (en) * | 2004-02-26 | 2004-12-23 | Naoya Tsurushita | Humanized chicken antibodies |
| TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| CA2591813A1 (en) | 2004-12-21 | 2006-06-29 | Centocor, Inc. | Anti-il-12 antibodies, epitopes, compositions, methods and uses |
| US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
| JP2008534607A (ja) * | 2005-03-30 | 2008-08-28 | ワイス | Bmpを投与することによって毛髪の成長を刺激するための方法 |
| SI1966238T1 (sl) * | 2005-12-30 | 2012-08-31 | Merck Patent Gmbh | Variante interlevkina-12P40 z izboljšano stabilnostjo |
| WO2008070647A1 (en) * | 2006-12-07 | 2008-06-12 | Wyeth | Methods and compositions for assessing il-12 or the neutralization of il-12 in a sample |
| EP2248903A1 (en) | 2009-04-29 | 2010-11-10 | Universitat Autònoma De Barcelona | Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| EP2571516B1 (en) | 2010-05-18 | 2017-11-15 | Neumedicines, Inc | Il-12 formulations for enhancing hematopoiesis |
| WO2012174056A1 (en) | 2011-06-13 | 2012-12-20 | Neumedicines, Inc. | Mitigation of cutaneous injury with il-12 |
| EP2736530B1 (en) | 2011-07-27 | 2018-06-06 | Neumedicines, Inc | Use of il-12 to generate endogenous erythropoietin |
| US9636381B2 (en) | 2012-01-18 | 2017-05-02 | Neumedicines, Inc. | Methods for radiation protection by administering IL-12 |
| US20140350087A9 (en) | 2012-03-22 | 2014-11-27 | Halozyme, Inc. | Oncovector Nucleic Acid Molecules and Methods of Use |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
| AU2016334401A1 (en) | 2015-10-10 | 2018-04-26 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| EP3436477A2 (en) | 2016-03-29 | 2019-02-06 | Janssen Biotech, Inc. | Method of treating psoriasis with increased interval dosing of anti-il12 and/or -23 antibody |
| TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗il12/il23抗體治療狼瘡之安全且有效之方法 |
| WO2019220412A2 (en) | 2018-05-18 | 2019-11-21 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
| HUE063462T2 (hu) | 2018-09-24 | 2024-01-28 | Janssen Biotech Inc | A colitis ulcerosa kezelésének biztonságos és hatékony eljárása anti-IL12/IL23 antitesttel |
| EP3972690A4 (en) | 2019-05-23 | 2023-07-05 | Janssen Biotech, Inc. | METHOD OF TREATMENT OF INFLAMMATORY BOWEL DISEASE USING COMBINATION THERAPY OF ANTIBODIES TO IL-23 AND TNF-ALPHA |
| CA3183927A1 (en) | 2020-05-21 | 2021-11-25 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| IL312221A (en) | 2021-10-20 | 2024-06-01 | Synthekine Inc | Heterodimeric fc cytokines and uses thereof |
| WO2023070038A2 (en) * | 2021-10-20 | 2023-04-27 | Synthekine, Inc. | Human il-12p40 variants and uses thereof |
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| US4473555A (en) * | 1983-10-17 | 1984-09-25 | Syntex (U.S.A.) Inc. | Nona- and dodecapeptides for augmenting natural killer cell activity |
| US4879111A (en) * | 1986-04-17 | 1989-11-07 | Cetus Corporation | Treatment of infections with lymphokines |
| US5185431A (en) * | 1988-08-31 | 1993-02-09 | Eisai Co., Ltd. | Recombinant natural killer cell activator |
| WO1990005147A1 (en) * | 1988-11-10 | 1990-05-17 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| DK0433827T3 (da) * | 1989-12-22 | 1998-09-28 | Hoffmann La Roche | Cytotoksisk lumfocytmodningsfaktor |
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1991
- 1991-09-04 EP EP91918119A patent/EP0549711A1/en not_active Withdrawn
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- 1991-09-04 AU AU87236/91A patent/AU8723691A/en not_active Abandoned
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1995
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- 1995-03-13 US US08/403,086 patent/US5569454A/en not_active Expired - Lifetime
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2004
- 2004-09-30 JP JP2004287126A patent/JP4014590B2/ja not_active Expired - Lifetime
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2007
- 2007-07-02 JP JP2007173878A patent/JP4423313B2/ja not_active Expired - Lifetime
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| AU8723691A (en) | 1992-04-15 |
| US5457038A (en) | 1995-10-10 |
| WO1992005256A1 (en) | 1992-04-02 |
| US5648072A (en) | 1997-07-15 |
| JP2005046158A (ja) | 2005-02-24 |
| JPH06501009A (ja) | 1994-01-27 |
| JP4423313B2 (ja) | 2010-03-03 |
| US5648467A (en) | 1997-07-15 |
| EP0549711A1 (en) | 1993-07-07 |
| JP2009178164A (ja) | 2009-08-13 |
| JP2007306929A (ja) | 2007-11-29 |
| US5569454A (en) | 1996-10-29 |
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