JP3978258B2 - プロトロンビンおよびトロンビンに結合するペプチド - Google Patents

プロトロンビンおよびトロンビンに結合するペプチド Download PDF

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Publication number
JP3978258B2
JP3978258B2 JP18189597A JP18189597A JP3978258B2 JP 3978258 B2 JP3978258 B2 JP 3978258B2 JP 18189597 A JP18189597 A JP 18189597A JP 18189597 A JP18189597 A JP 18189597A JP 3978258 B2 JP3978258 B2 JP 3978258B2
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JP
Japan
Prior art keywords
thrombin
peptide
prothrombin
seq
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP18189597A
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English (en)
Japanese (ja)
Other versions
JPH1075778A5 (enExample
JPH1075778A (ja
Inventor
ジヨージ・エイ・ボームバツク
ジヨゼフ・エイ・ビユツトナー
クリストフアー・エイ・ダツド
デイビツド・ジエイ・ハモンド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Publication of JPH1075778A publication Critical patent/JPH1075778A/ja
Publication of JPH1075778A5 publication Critical patent/JPH1075778A5/ja
Application granted granted Critical
Publication of JP3978258B2 publication Critical patent/JP3978258B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
JP18189597A 1996-06-28 1997-06-24 プロトロンビンおよびトロンビンに結合するペプチド Expired - Fee Related JP3978258B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/672,805 US5831003A (en) 1996-06-28 1996-06-28 Peptides which bind to prothrombin and thrombin
US08/672805 1996-06-28

Publications (3)

Publication Number Publication Date
JPH1075778A JPH1075778A (ja) 1998-03-24
JPH1075778A5 JPH1075778A5 (enExample) 2005-04-21
JP3978258B2 true JP3978258B2 (ja) 2007-09-19

Family

ID=24700072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18189597A Expired - Fee Related JP3978258B2 (ja) 1996-06-28 1997-06-24 プロトロンビンおよびトロンビンに結合するペプチド

Country Status (10)

Country Link
US (1) US5831003A (enExample)
EP (1) EP0816377B1 (enExample)
JP (1) JP3978258B2 (enExample)
AT (1) ATE215964T1 (enExample)
AU (1) AU712575B2 (enExample)
CA (1) CA2206663A1 (enExample)
DE (1) DE69711765T2 (enExample)
DK (1) DK0816377T3 (enExample)
ES (1) ES2175218T3 (enExample)
PT (1) PT816377E (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6462180B1 (en) * 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
EP1343809B2 (en) 2000-12-14 2023-03-15 Grifols Therapeutics Inc. Method of preparing alpha-1 proteinase inhibitor
GB0211849D0 (en) * 2002-05-23 2002-07-03 Mok Kenneth H Improvments to retro-inverso isomers
FR2884418B1 (fr) * 2005-04-15 2008-11-21 Soc Extraction Principes Actif Utilisation d'un peptide comme principe actif amincissant
EP2502628B1 (en) 2006-06-23 2016-12-14 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
WO2010060186A1 (en) 2008-11-03 2010-06-03 Alethia Biotherapeutics Inc. Antibodies that specifically block the biological activity of a tumor antigen
US8945895B2 (en) 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
DK3173427T3 (da) 2011-03-31 2019-08-05 Adc Therapeutics Sa Antistoffer mod nyre-associeret antigen 1 og antigen-bindende fragmenter deraf
HRP20190946T1 (hr) 2012-01-09 2019-07-26 Adc Therapeutics Sa Sredstva za liječenje trostruko negativnog raka dojke
EP3262409B1 (en) 2015-02-25 2020-03-25 Omrix Biopharmaceuticals Ltd. Method for purifying and quantifying thrombin and its degradation polypeptides
ES2791982T3 (es) * 2015-02-25 2020-11-06 Omrix Biopharmaceuticals Ltd Método para purificar y cuantificar la trombina y sus polipéptidos de degradación

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin

Also Published As

Publication number Publication date
CA2206663A1 (en) 1997-12-28
DE69711765T2 (de) 2002-10-02
PT816377E (pt) 2002-08-30
DK0816377T3 (da) 2002-07-22
AU712575B2 (en) 1999-11-11
DE69711765D1 (de) 2002-05-16
EP0816377B1 (en) 2002-04-10
EP0816377A2 (en) 1998-01-07
EP0816377A3 (en) 1998-07-15
AU2622097A (en) 1998-01-15
ATE215964T1 (de) 2002-04-15
US5831003A (en) 1998-11-03
JPH1075778A (ja) 1998-03-24
ES2175218T3 (es) 2002-11-16

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