JP3961064B2 - 腎疾患予防及び/又は治療剤 - Google Patents
腎疾患予防及び/又は治療剤 Download PDFInfo
- Publication number
- JP3961064B2 JP3961064B2 JP09498997A JP9498997A JP3961064B2 JP 3961064 B2 JP3961064 B2 JP 3961064B2 JP 09498997 A JP09498997 A JP 09498997A JP 9498997 A JP9498997 A JP 9498997A JP 3961064 B2 JP3961064 B2 JP 3961064B2
- Authority
- JP
- Japan
- Prior art keywords
- tcf
- ala
- lys
- mutant
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000017169 kidney disease Diseases 0.000 title description 24
- 239000003814 drug Substances 0.000 title description 13
- 229940124597 therapeutic agent Drugs 0.000 title description 8
- 230000002554 disease preventive effect Effects 0.000 title description 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 11
- 201000006370 kidney failure Diseases 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 6
- 108010084094 alanyl-alanyl-alanyl-alanine Proteins 0.000 claims description 6
- 230000003449 preventive effect Effects 0.000 claims description 4
- 230000034994 death Effects 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 8
- 238000004659 sterilization and disinfection Methods 0.000 description 8
- 229960002523 mercuric chloride Drugs 0.000 description 7
- LWJROJCJINYWOX-UHFFFAOYSA-L mercury dichloride Chemical compound Cl[Hg]Cl LWJROJCJINYWOX-UHFFFAOYSA-L 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 208000023275 Autoimmune disease Diseases 0.000 description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 4
- 206010018372 Glomerulonephritis membranous Diseases 0.000 description 4
- 206010051920 Glomerulonephropathy Diseases 0.000 description 4
- 206010029164 Nephrotic syndrome Diseases 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 239000007979 citrate buffer Substances 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 208000033679 diabetic kidney disease Diseases 0.000 description 4
- 239000013613 expression plasmid Substances 0.000 description 4
- 206010061989 glomerulosclerosis Diseases 0.000 description 4
- 201000008350 membranous glomerulonephritis Diseases 0.000 description 4
- 231100000855 membranous nephropathy Toxicity 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000009928 nephrosis Diseases 0.000 description 4
- 231100001027 nephrosis Toxicity 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 206010069384 Ischaemic nephropathy Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 239000012228 culture supernatant Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 229930189065 blasticidin Natural products 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 238000004520 electroporation Methods 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000012264 purified product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241001262617 Japonica Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000000432 density-gradient centrifugation Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000013094 purity test Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP09498997A JP3961064B2 (ja) | 1997-03-28 | 1997-03-28 | 腎疾患予防及び/又は治療剤 |
| PCT/JP1998/001221 WO1998043665A1 (fr) | 1997-03-28 | 1998-03-20 | Agent preventif et/ou therapeutique pour les maladies des reins |
| AU64208/98A AU734794B2 (en) | 1997-03-28 | 1998-03-20 | Agent for preventing and/or treating renal disease |
| US09/194,326 US6306827B1 (en) | 1997-03-28 | 1998-03-20 | Method for preventing and/or treating renal disease |
| CA002253929A CA2253929A1 (en) | 1997-03-28 | 1998-03-20 | Preventive and/or therapeutic agent for kidney diseases |
| EP98909799A EP0925791A4 (en) | 1997-03-28 | 1998-03-20 | PREVENTIVE AND / OR THERAPEUTICALLY ACTIVE SUBSTANCE FOR KIDNEY DISEASES |
| ZA982606A ZA982606B (en) | 1997-03-28 | 1998-03-27 | Agent for preventing and/or treating renal disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP09498997A JP3961064B2 (ja) | 1997-03-28 | 1997-03-28 | 腎疾患予防及び/又は治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH10273446A JPH10273446A (ja) | 1998-10-13 |
| JPH10273446A5 JPH10273446A5 (enExample) | 2005-01-20 |
| JP3961064B2 true JP3961064B2 (ja) | 2007-08-15 |
Family
ID=14125298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09498997A Expired - Fee Related JP3961064B2 (ja) | 1997-03-28 | 1997-03-28 | 腎疾患予防及び/又は治療剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6306827B1 (enExample) |
| EP (1) | EP0925791A4 (enExample) |
| JP (1) | JP3961064B2 (enExample) |
| AU (1) | AU734794B2 (enExample) |
| CA (1) | CA2253929A1 (enExample) |
| WO (1) | WO1998043665A1 (enExample) |
| ZA (1) | ZA982606B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69531673T2 (de) * | 1994-12-27 | 2004-07-08 | Daiichi Pharmaceutical Co., Ltd. | Tcf mutante |
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び/又は治療剤 |
| ES2274567T3 (es) | 1997-03-14 | 2007-05-16 | Daiichi Pharmaceutical Co., Ltd. | Utilizacion de tcf-ii para el tratamiento de la perdida de peso corporal, la anemia y la elevacion de tnf causadas por el cancer. |
| JP4252591B2 (ja) * | 2006-08-08 | 2009-04-08 | クロリンエンジニアズ株式会社 | オゾン製造装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6468400A (en) | 1987-09-09 | 1989-03-14 | Sapporo Breweries | Human tumor cytotoxic factor htcf, production thereof and antitumor agent comprising said factor as active ingredient |
| JP3380573B2 (ja) * | 1992-07-16 | 2003-02-24 | 第一製薬株式会社 | Tcf−iiを有効成分とする蛋白合成促進剤 |
| CA2100720C (en) * | 1992-07-16 | 2003-03-11 | Hiroaki Masunaga | Medicinal composition comprising tcf-ii |
| DE69531673T2 (de) | 1994-12-27 | 2004-07-08 | Daiichi Pharmaceutical Co., Ltd. | Tcf mutante |
-
1997
- 1997-03-28 JP JP09498997A patent/JP3961064B2/ja not_active Expired - Fee Related
-
1998
- 1998-03-20 EP EP98909799A patent/EP0925791A4/en not_active Withdrawn
- 1998-03-20 CA CA002253929A patent/CA2253929A1/en not_active Abandoned
- 1998-03-20 WO PCT/JP1998/001221 patent/WO1998043665A1/ja not_active Ceased
- 1998-03-20 US US09/194,326 patent/US6306827B1/en not_active Expired - Fee Related
- 1998-03-20 AU AU64208/98A patent/AU734794B2/en not_active Ceased
- 1998-03-27 ZA ZA982606A patent/ZA982606B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6306827B1 (en) | 2001-10-23 |
| JPH10273446A (ja) | 1998-10-13 |
| AU734794B2 (en) | 2001-06-21 |
| EP0925791A4 (en) | 2004-06-16 |
| ZA982606B (en) | 1998-09-30 |
| WO1998043665A1 (fr) | 1998-10-08 |
| AU6420898A (en) | 1998-10-22 |
| EP0925791A1 (en) | 1999-06-30 |
| CA2253929A1 (en) | 1998-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20190248864A1 (en) | Polynucleotides encoding low density lipoprotein receptor | |
| US20190192653A1 (en) | Compositions and methods for tolerizing cellular systems | |
| US20170348415A1 (en) | Tolerogenic compositions and methods | |
| US7705140B2 (en) | DNAs encoding TNF receptor family members | |
| EP3307305A1 (en) | Targeted adaptive vaccines | |
| AU2012358384A1 (en) | Methods of increasing the viability or longevity of an organ or organ explant | |
| CA2181431A1 (en) | Haemopoietic maturation factor | |
| JP2010509181A (ja) | 融合ポリペプチドを細胞へ輸送する方法 | |
| US6338949B1 (en) | Nucleic acids encoding receptor recognition factor stat4 and methods of use thereof | |
| EP1809660B1 (en) | A thymus-specific protein | |
| JP3961064B2 (ja) | 腎疾患予防及び/又は治療剤 | |
| JPH10500850A (ja) | インターロイキン−6 スプライス変異体 | |
| JP2002501032A (ja) | 急性間欠性ポルフィリン症(aip)及び他のポルフィリン症の治療方法 | |
| JP4422330B2 (ja) | 新規な免疫異常性疾患予防・治療用剤 | |
| KR100552434B1 (ko) | 신질환 예방 및/또는 치료제_ | |
| EA009389B1 (ru) | Использование растворимого cd164 при воспалительных и/или аутоиммунных нарушениях | |
| US6605442B1 (en) | Methods of testing drugs or agents that modulate the activity of receptor recognition factors | |
| CN120285149A (zh) | Pou2f2蛋白或其突变体在预防和治疗感染中的用途 | |
| CN100556455C (zh) | 一种用于预防和治疗i型糖尿病的药物复合物及其应用 | |
| JP2553425B2 (ja) | トロンビン結合性物質及びその製造法 | |
| WO1998056819A1 (en) | Methods of regulating t cell and macrophage cytokine production, function and pathogenicity | |
| CN117899223A (zh) | 以nup35基因和或以nup35蛋白作为作用靶点的物质的应用及组合物 | |
| JPH08198899A (ja) | 新規なポリペプチド、その製造方法、そのポリペプチドをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物 | |
| WO2001038372A1 (en) | A novel polypeptide-human paneth cell enhanced expression-like protein and the polynucleotide encoding said polypeptide | |
| JPH08301898A (ja) | 新規なポリペプチド、その製造方法、そのポリペプチドをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040219 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040219 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070216 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070412 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20070510 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20070516 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| R360 | Written notification for declining of transfer of rights |
Free format text: JAPANESE INTERMEDIATE CODE: R360 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| R360 | Written notification for declining of transfer of rights |
Free format text: JAPANESE INTERMEDIATE CODE: R360 |
|
| R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100525 Year of fee payment: 3 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| LAPS | Cancellation because of no payment of annual fees |