JP3944393B2 - インスリン抵抗性および糖尿病のための、コリン塩基とコハク酸とを含む相乗効果のある組成物 - Google Patents

インスリン抵抗性および糖尿病のための、コリン塩基とコハク酸とを含む相乗効果のある組成物 Download PDF

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Publication number
JP3944393B2
JP3944393B2 JP2001574101A JP2001574101A JP3944393B2 JP 3944393 B2 JP3944393 B2 JP 3944393B2 JP 2001574101 A JP2001574101 A JP 2001574101A JP 2001574101 A JP2001574101 A JP 2001574101A JP 3944393 B2 JP3944393 B2 JP 3944393B2
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Japan
Prior art keywords
succinic acid
pharmaceutically acceptable
insulin resistance
acceptable salt
insulin
Prior art date
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Expired - Fee Related
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JP2001574101A
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English (en)
Japanese (ja)
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JP2004506605A5 (enExample
JP2004506605A (ja
Inventor
イゴール・アナトリエヴィッチ・ポミトキン
オルガ・エフゲニエフナ・コレソヴァ
タチアナ・ユリエフナ・ウクハノヴァ
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Individual
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Publication of JP2004506605A publication Critical patent/JP2004506605A/ja
Publication of JP2004506605A5 publication Critical patent/JP2004506605A5/ja
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Publication of JP3944393B2 publication Critical patent/JP3944393B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001574101A 2000-04-10 2000-04-10 インスリン抵抗性および糖尿病のための、コリン塩基とコハク酸とを含む相乗効果のある組成物 Expired - Fee Related JP3944393B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2000/000122 WO2001076583A1 (en) 2000-04-10 2000-04-10 Synergistic compositions containing choline base and succinic acid for insulin resistance and diabetes

Publications (3)

Publication Number Publication Date
JP2004506605A JP2004506605A (ja) 2004-03-04
JP2004506605A5 JP2004506605A5 (enExample) 2005-02-03
JP3944393B2 true JP3944393B2 (ja) 2007-07-11

Family

ID=20129496

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001574101A Expired - Fee Related JP3944393B2 (ja) 2000-04-10 2000-04-10 インスリン抵抗性および糖尿病のための、コリン塩基とコハク酸とを含む相乗効果のある組成物

Country Status (8)

Country Link
EP (1) EP1272171A1 (enExample)
JP (1) JP3944393B2 (enExample)
KR (1) KR20020089444A (enExample)
CN (1) CN1452482A (enExample)
AU (1) AU2000263274A1 (enExample)
BR (1) BR0017206A (enExample)
CA (1) CA2404864A1 (enExample)
WO (1) WO2001076583A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025163212A2 (en) 2024-08-09 2025-08-07 Jantar Gmbh Succinic acid or a pharmaceutically acceptable salt thereof for use in the treatment of chronic rhinosinusitis

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004112773A1 (en) * 2003-04-24 2004-12-29 Shin-Jen Shiao Pharmaceutical compositions used for immune disease treatment and improvement
CN101801368B (zh) * 2007-08-02 2012-06-13 布达生物制药有限公司 包含琥珀酸的胆碱盐的用于鼻内给药的药物组合物
EP2349246A1 (en) * 2008-11-26 2011-08-03 Igor Anatolievich Pomytkin Choline salts of succinic acid for the treatment of depression, anxiety, schizophrenia, sleep disorder, and epilepsy
US8314080B2 (en) 2010-04-06 2012-11-20 Kuwait University Method of treating type I diabetes
CN106727476A (zh) * 2016-12-09 2017-05-31 杨远志 一种组合物及其在改善动物肌纤维类型中的应用
WO2024231663A1 (en) 2023-05-05 2024-11-14 Mitocholine Ltd Method of synthesis
WO2025120626A2 (en) 2025-04-14 2025-06-12 Mitocholine Ltd Synthetic method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6346669D0 (pt) * 1962-02-12 1973-06-14 Squibb & Sons Inc Processo de preparacao de uma composicao farmaceutica estavel de sais de esteres de colina
JPS61171417A (ja) * 1985-01-23 1986-08-02 Wakunaga Seiyaku Kk 抗糖尿病剤
US6294520B1 (en) * 1989-03-27 2001-09-25 Albert T. Naito Material for passage through the blood-brain barrier
JPH03169498A (ja) * 1989-11-28 1991-07-23 Yotsukaichi Gosei Kk 水溶性はんだフラックス
JPH0586319A (ja) * 1991-09-27 1993-04-06 Pentel Kk 水性インキ組成物
US5895652A (en) * 1996-07-29 1999-04-20 Longevity Institute International Method of metabolic adjuvanation and cellular repair
DE69917809T2 (de) * 1999-03-01 2004-11-04 Verteletsky, Pavel Vasilievich Verwendung von Bernsteinsäure oder deren Salze zur Behandlung von Insulinresistenz
CA2362116A1 (en) * 1999-04-05 2000-10-12 Igor Anatolievich Pomytkin Use of succinic acid or salts thereof for the treatment of diabetes mellitus and wound healing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025163212A2 (en) 2024-08-09 2025-08-07 Jantar Gmbh Succinic acid or a pharmaceutically acceptable salt thereof for use in the treatment of chronic rhinosinusitis

Also Published As

Publication number Publication date
BR0017206A (pt) 2003-01-14
KR20020089444A (ko) 2002-11-29
CA2404864A1 (en) 2001-10-18
AU2000263274A1 (en) 2001-10-23
WO2001076583A1 (en) 2001-10-18
EP1272171A1 (en) 2003-01-08
JP2004506605A (ja) 2004-03-04
CN1452482A (zh) 2003-10-29

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