CA2404864A1 - Synergistic compositions containing choline base and succinic acid for insulin resistance and diabetes - Google Patents
Synergistic compositions containing choline base and succinic acid for insulin resistance and diabetes Download PDFInfo
- Publication number
- CA2404864A1 CA2404864A1 CA002404864A CA2404864A CA2404864A1 CA 2404864 A1 CA2404864 A1 CA 2404864A1 CA 002404864 A CA002404864 A CA 002404864A CA 2404864 A CA2404864 A CA 2404864A CA 2404864 A1 CA2404864 A1 CA 2404864A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- succinic acid
- mammal
- choline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title claims abstract description 113
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229960001231 choline Drugs 0.000 title claims abstract description 57
- 239000001384 succinic acid Substances 0.000 title claims abstract description 56
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 45
- 206010022489 Insulin Resistance Diseases 0.000 title claims abstract description 39
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 89
- 238000000034 method Methods 0.000 claims abstract description 46
- 241000124008 Mammalia Species 0.000 claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 18
- ZKMDOYRDBAGOAD-UHFFFAOYSA-L butanedioate;2-hydroxyethyl(trimethyl)azanium Chemical compound C[N+](C)(C)CCO.C[N+](C)(C)CCO.[O-]C(=O)CCC([O-])=O ZKMDOYRDBAGOAD-UHFFFAOYSA-L 0.000 claims abstract description 13
- 208000032928 Dyslipidaemia Diseases 0.000 claims abstract description 11
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- 230000008569 process Effects 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 58
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 24
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- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims description 12
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims description 11
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- LXMXJLNOLAGNQG-UHFFFAOYSA-M 2-hydroxyethyl(trimethyl)azanium;4-hydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)CCC([O-])=O LXMXJLNOLAGNQG-UHFFFAOYSA-M 0.000 description 3
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
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- 230000014616 translation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/RU2000/000122 WO2001076583A1 (en) | 2000-04-10 | 2000-04-10 | Synergistic compositions containing choline base and succinic acid for insulin resistance and diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2404864A1 true CA2404864A1 (en) | 2001-10-18 |
Family
ID=20129496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002404864A Abandoned CA2404864A1 (en) | 2000-04-10 | 2000-04-10 | Synergistic compositions containing choline base and succinic acid for insulin resistance and diabetes |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1272171A1 (enExample) |
| JP (1) | JP3944393B2 (enExample) |
| KR (1) | KR20020089444A (enExample) |
| CN (1) | CN1452482A (enExample) |
| AU (1) | AU2000263274A1 (enExample) |
| BR (1) | BR0017206A (enExample) |
| CA (1) | CA2404864A1 (enExample) |
| WO (1) | WO2001076583A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004112773A1 (en) * | 2003-04-24 | 2004-12-29 | Shin-Jen Shiao | Pharmaceutical compositions used for immune disease treatment and improvement |
| EA017094B1 (ru) * | 2007-08-02 | 2012-09-28 | Игорь Анатольевич Помыткин | Фармацевтические композиции, содержащие холиновые соли янтарной кислоты, для интраназального введения |
| KR101360569B1 (ko) | 2008-11-26 | 2014-02-10 | 이고르 아나토리에비치 포밋트킨 | 우울증, 불안증, 정신분열증, 수면장애 및 간질의 치료를 위한 숙신산의 콜린염 |
| US8314080B2 (en) | 2010-04-06 | 2012-11-20 | Kuwait University | Method of treating type I diabetes |
| CN106727476A (zh) * | 2016-12-09 | 2017-05-31 | 杨远志 | 一种组合物及其在改善动物肌纤维类型中的应用 |
| GB202112170D0 (en) * | 2021-08-25 | 2021-10-06 | Mitocholine Ltd | Nutritional compositions |
| WO2024231663A1 (en) | 2023-05-05 | 2024-11-14 | Mitocholine Ltd | Method of synthesis |
| WO2025163212A2 (en) | 2024-08-09 | 2025-08-07 | Jantar Gmbh | Succinic acid or a pharmaceutically acceptable salt thereof for use in the treatment of chronic rhinosinusitis |
| WO2025120626A2 (en) | 2025-04-14 | 2025-06-12 | Mitocholine Ltd | Synthetic method |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6346669D0 (pt) * | 1962-02-12 | 1973-06-14 | Squibb & Sons Inc | Processo de preparacao de uma composicao farmaceutica estavel de sais de esteres de colina |
| JPS61171417A (ja) * | 1985-01-23 | 1986-08-02 | Wakunaga Seiyaku Kk | 抗糖尿病剤 |
| US6294520B1 (en) * | 1989-03-27 | 2001-09-25 | Albert T. Naito | Material for passage through the blood-brain barrier |
| JPH03169498A (ja) * | 1989-11-28 | 1991-07-23 | Yotsukaichi Gosei Kk | 水溶性はんだフラックス |
| JPH0586319A (ja) * | 1991-09-27 | 1993-04-06 | Pentel Kk | 水性インキ組成物 |
| US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
| ES2222717T3 (es) * | 1999-03-01 | 2005-02-01 | Verteletsky, Pavel Vasilievich | Uso de acido succinico o sus sales y metodo de tratamiento de la resistencia a la insulina. |
| WO2000059499A1 (en) * | 1999-04-05 | 2000-10-12 | Verteletsky, Pavel Vasilievich | Use of succinic acid or salts thereof for the treatment of diabetes mellitus and wound healing |
-
2000
- 2000-04-10 CA CA002404864A patent/CA2404864A1/en not_active Abandoned
- 2000-04-10 BR BR0017206-5A patent/BR0017206A/pt not_active IP Right Cessation
- 2000-04-10 WO PCT/RU2000/000122 patent/WO2001076583A1/en not_active Ceased
- 2000-04-10 CN CN00819413A patent/CN1452482A/zh active Pending
- 2000-04-10 AU AU2000263274A patent/AU2000263274A1/en not_active Abandoned
- 2000-04-10 EP EP00950127A patent/EP1272171A1/en not_active Withdrawn
- 2000-04-10 JP JP2001574101A patent/JP3944393B2/ja not_active Expired - Fee Related
- 2000-04-10 KR KR1020027013553A patent/KR20020089444A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1452482A (zh) | 2003-10-29 |
| KR20020089444A (ko) | 2002-11-29 |
| JP3944393B2 (ja) | 2007-07-11 |
| AU2000263274A1 (en) | 2001-10-23 |
| JP2004506605A (ja) | 2004-03-04 |
| EP1272171A1 (en) | 2003-01-08 |
| WO2001076583A1 (en) | 2001-10-18 |
| BR0017206A (pt) | 2003-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |