JP3884087B2 - 質量標識結合ハイブリダイゼーションプローブ - Google Patents

質量標識結合ハイブリダイゼーションプローブ Download PDF

Info

Publication number
JP3884087B2
JP3884087B2 JP53394298A JP53394298A JP3884087B2 JP 3884087 B2 JP3884087 B2 JP 3884087B2 JP 53394298 A JP53394298 A JP 53394298A JP 53394298 A JP53394298 A JP 53394298A JP 3884087 B2 JP3884087 B2 JP 3884087B2
Authority
JP
Japan
Prior art keywords
mass
probe
mass label
label
base sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP53394298A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001508307A5 (https=
JP2001508307A (ja
Inventor
シュミット、グンテル
ヒュージン トムソン、アンドリュー
アレクサンダー ウォーカー ジョンストン、ロバート
Original Assignee
イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9700746.2A external-priority patent/GB9700746D0/en
Priority claimed from GBGB9718255.4A external-priority patent/GB9718255D0/en
Priority claimed from GBGB9726953.4A external-priority patent/GB9726953D0/en
Application filed by イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト filed Critical イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
Publication of JP2001508307A publication Critical patent/JP2001508307A/ja
Publication of JP2001508307A5 publication Critical patent/JP2001508307A5/ja
Application granted granted Critical
Publication of JP3884087B2 publication Critical patent/JP3884087B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Discharge Heating (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Surgical Instruments (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP53394298A 1997-01-15 1998-01-15 質量標識結合ハイブリダイゼーションプローブ Expired - Fee Related JP3884087B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9700746.2 1997-01-15
GBGB9700746.2A GB9700746D0 (en) 1996-10-04 1997-01-15 Hybridisation probes
GB9718255.4 1997-08-28
GBGB9718255.4A GB9718255D0 (en) 1996-10-04 1997-08-28 Hybridisation probes
GB9726953.4 1997-12-19
GBGB9726953.4A GB9726953D0 (en) 1997-12-19 1997-12-19 Hybridisation probes
PCT/GB1998/000127 WO1998031830A1 (en) 1997-01-15 1998-01-15 Mass label linked hybridisation probes

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2004036206A Division JP2004357697A (ja) 1997-01-15 2004-02-13 質量標識結合ハイブリダイゼーションプローブ
JP2006115777A Division JP2006208400A (ja) 1997-01-15 2006-04-19 質量標識結合ハイブリダイゼーションプローブ

Publications (3)

Publication Number Publication Date
JP2001508307A JP2001508307A (ja) 2001-06-26
JP2001508307A5 JP2001508307A5 (https=) 2004-12-09
JP3884087B2 true JP3884087B2 (ja) 2007-02-21

Family

ID=27268674

Family Applications (3)

Application Number Title Priority Date Filing Date
JP53394298A Expired - Fee Related JP3884087B2 (ja) 1997-01-15 1998-01-15 質量標識結合ハイブリダイゼーションプローブ
JP2004036206A Withdrawn JP2004357697A (ja) 1997-01-15 2004-02-13 質量標識結合ハイブリダイゼーションプローブ
JP2006115777A Pending JP2006208400A (ja) 1997-01-15 2006-04-19 質量標識結合ハイブリダイゼーションプローブ

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2004036206A Withdrawn JP2004357697A (ja) 1997-01-15 2004-02-13 質量標識結合ハイブリダイゼーションプローブ
JP2006115777A Pending JP2006208400A (ja) 1997-01-15 2006-04-19 質量標識結合ハイブリダイゼーションプローブ

Country Status (10)

Country Link
EP (2) EP1400599B1 (https=)
JP (3) JP3884087B2 (https=)
CN (1) CN100434531C (https=)
AT (2) ATE374836T1 (https=)
AU (1) AU725966B2 (https=)
CA (2) CA2441655A1 (https=)
DE (2) DE69836013T2 (https=)
IL (1) IL130885A (https=)
NZ (1) NZ336769A (https=)
WO (1) WO1998031830A1 (https=)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9707980D0 (en) 1997-04-21 1997-06-11 Brax Genomics Ltd Characterising DNA
AU8234898A (en) * 1997-07-11 1999-02-08 Brax Group Limited Characterising nucleic acid
AU738237B2 (en) * 1997-07-22 2001-09-13 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
CA2303790A1 (en) * 1997-09-15 1999-03-25 Brax Group Limited Characterising nucleic acid by mass spectrometry
DE59804008D1 (de) * 1997-12-05 2002-06-06 Max Planck Gesellschaft Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
GB9823646D0 (en) * 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
GB9815166D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
GB9815164D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
EP1428810A3 (en) 1998-05-15 2004-07-14 Oxford Gene Technology IP Limited Libraries of oligomers labelled with different tags
US7399844B2 (en) * 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6270976B1 (en) 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
JP3668075B2 (ja) * 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたＳＮＰｓ高速スコアリング方法
US6509157B1 (en) * 1999-11-05 2003-01-21 Roche Molecular Systems, Inc 3 blocked nucleic acid amplification primers
DE19963536C2 (de) * 1999-12-20 2003-04-10 Epigenomics Ag Verfahren zur Analyse von Nukleinsäuresequenzen
JP2001204463A (ja) * 2000-01-27 2001-07-31 Toyo Kohan Co Ltd ヌクレオチド固定用担体
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
CA2408291C (en) 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
WO2002066952A2 (en) 2000-10-19 2002-08-29 Target Discovery, Inc Mass defect labeling for the determination of oligomer sequences
WO2002050307A1 (en) * 2000-12-12 2002-06-27 Chugai Seiyaku Kabushiki Kaisha Method of detecting polymorphism in dna by using mass spectroscopy
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
CA2460131C (en) 2001-09-14 2006-11-21 Xzillion Gmbh & Co. Kg Mass labels
AU2003224253A1 (en) * 2002-04-04 2003-10-27 Electrophoretics Limited Method for characterising analytes
JP2004037128A (ja) * 2002-06-28 2004-02-05 Canon Inc マトリクス援助レーザー脱着／イオン化飛行時間型質量分析法による基板上の物質の解析方法
EP1579187B1 (en) 2002-10-29 2012-12-19 Target Discovery, Inc. Method for increasing ionization efficiency in mass spectroscopy
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
JP4613299B2 (ja) 2003-01-30 2011-01-12 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 分析物分析に関する方法、混合物、キット、および組成物
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US7956175B2 (en) 2003-09-11 2011-06-07 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
JP4613320B2 (ja) 2004-03-01 2011-01-19 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 結合特性に基づく分析物の特徴の決定
EP2458619B1 (en) 2004-05-24 2017-08-02 Ibis Biosciences, Inc. Mass spectrometry with selective ion filtration by digital thresholding
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
DK2299275T3 (en) 2004-07-30 2018-05-07 Adeza Biomedical Corp Classification of oncofetal fetronectin level for pregnancy-related indications
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
WO2006094238A2 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
CA2616281C (en) 2005-07-21 2014-04-22 Isis Pharmaceuticals, Inc. Methods for rapid identification and quantitation of mitochondrial dna variants
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0518585D0 (en) * 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
WO2007140380A2 (en) 2006-05-26 2007-12-06 Applera Corporation Tagging reagents and methods for hydroxylated compounds
US11098345B2 (en) 2006-06-05 2021-08-24 California Institute Of Technology Methods for detecting target analytes
US7906341B2 (en) 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US8362242B2 (en) 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
JP5420412B2 (ja) 2006-09-14 2014-02-19 アイビス バイオサイエンシズ インコーポレイティッド 病原体の同定のための標的全ゲノム増幅方法
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
CN101519698B (zh) * 2008-03-10 2013-05-22 周国华 一种利用序列标签定量测定核酸的方法
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033599A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
EP2406634A4 (en) 2009-03-10 2013-06-19 Univ Maryland ISOBARE DEUTERIUM MARKING REAGENTS FOR QUANTITATIVE ANALYSIS
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
US9194877B2 (en) 2009-07-17 2015-11-24 Ibis Biosciences, Inc. Systems for bioagent indentification
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP2462244B1 (en) 2009-08-06 2016-07-20 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
WO2011115840A2 (en) 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
EP2588144B1 (en) 2010-07-02 2018-05-09 Ventana Medical Systems, Inc. Detecting targets using mass tags and mass spectrometry
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US9708647B2 (en) * 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
EP3400444A4 (en) * 2016-01-04 2019-10-16 QuantuMDx Group Limited DESIGN, SYNTHESIS AND USE OF SYNTHETIC NUCLEOTIDES WITH LOADING MASS MARKINGS
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
CN116490620A (zh) * 2020-11-06 2023-07-25 沃特世科技公司 可用于核酸分析的方法和组合物
WO2023282061A1 (ja) * 2021-07-08 2023-01-12 株式会社島津製作所 微生物の質量分析方法
CN116496335B (zh) * 2023-03-21 2024-03-08 中国药科大学 一种修饰核苷酸及其应用
CN118980740B (zh) * 2024-09-19 2025-01-24 常州越泰检测科技有限公司 一种磁粉检测用喷照一体装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2153387A1 (en) * 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DE69621507T2 (de) * 1995-03-28 2003-01-09 Japan Science And Technology Corp., Kawaguchi Verfahren zur molekularen Indexierung von Genen unter Verwendung von Restriktionsenzymen
AU5544696A (en) * 1995-04-11 1996-10-30 Trustees Of Boston University Solid phase sequencing of biopolymers
CN1202260C (zh) * 1996-01-23 2005-05-18 佳根基因组学公司 利用大小分离技术分析核酸分子的方法和组合物
GB9618544D0 (en) * 1996-09-05 1996-10-16 Brax Genomics Ltd Characterising DNA

Also Published As

Publication number Publication date
CN1250483A (zh) 2000-04-12
WO1998031830A1 (en) 1998-07-23
JP2001508307A (ja) 2001-06-26
EP0979305A1 (en) 2000-02-16
CA2277786A1 (en) 1998-07-23
DE69838519D1 (de) 2007-11-15
CA2441655A1 (en) 1998-07-23
EP0979305B1 (en) 2006-09-27
DE69836013T2 (de) 2007-05-24
DE69838519T2 (de) 2008-07-03
AU725966B2 (en) 2000-10-26
JP2004357697A (ja) 2004-12-24
IL130885A (en) 2005-05-17
IL130885A0 (en) 2001-01-28
AU5570098A (en) 1998-08-07
NZ336769A (en) 2001-01-26
CN100434531C (zh) 2008-11-19
EP1400599B1 (en) 2007-10-03
EP1400599A1 (en) 2004-03-24
DE69836013D1 (de) 2006-11-09
JP2006208400A (ja) 2006-08-10
ATE340869T1 (de) 2006-10-15
ATE374836T1 (de) 2007-10-15

Similar Documents

Publication Publication Date Title
JP3884087B2 (ja) 質量標識結合ハイブリダイゼーションプローブ
US20050042625A1 (en) Mass label linked hybridisation probes
US6194144B1 (en) DNA sequencing by mass spectrometry
US20110172115A1 (en) Characterising planar samples by mass spectrometry
JP4467589B2 (ja) オリゴマー配列の決定のための質量欠損標識
EP1251136B1 (en) Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6436640B1 (en) Use of LNA in mass spectrometry
US20040115694A1 (en) Methods and compositions for determining the sequence of nucleic acid molecules
AU734636B2 (en) Characterising nucleic acids
KR19990081925A (ko) 핵산 분자의 서열을 결정하는 방법 및 이를 위한 조성물
US6270976B1 (en) Characterizing nucleic acid by mass spectrometry
US6699668B1 (en) Mass label linked hybridisation probes
US6649354B1 (en) Catalytically generated mass labels
AU746443B2 (en) Characterising nucleic acid by mass spectrometry
EP1161681A2 (en) Use of lna in mass spectrometry

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20040213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20051115

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060214

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20060403

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20060411

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060501

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20061024

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20061116

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20101124

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111124

Year of fee payment: 5

LAPS Cancellation because of no payment of annual fees