JP3845059B2 - シロスタゾールの製造方法 - Google Patents

シロスタゾールの製造方法 Download PDF

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Publication number
JP3845059B2
JP3845059B2 JP2002519426A JP2002519426A JP3845059B2 JP 3845059 B2 JP3845059 B2 JP 3845059B2 JP 2002519426 A JP2002519426 A JP 2002519426A JP 2002519426 A JP2002519426 A JP 2002519426A JP 3845059 B2 JP3845059 B2 JP 3845059B2
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JP
Japan
Prior art keywords
chloride
water
tetrazole
cilostazol
bromide
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Expired - Fee Related
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JP2002519426A
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English (en)
Japanese (ja)
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JP2004506043A (ja
Inventor
メンデロビチ，マリオアラ
フィンケルスタイン，ニナ
ピラルクシ，ギデオン
Original Assignee
テバ ファーマシューティカル インダストリーズ リミティド
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Application filed by テバ ファーマシューティカル インダストリーズ リミティド filed Critical テバ ファーマシューティカル インダストリーズ リミティド
Publication of JP2004506043A publication Critical patent/JP2004506043A/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
JP2002519426A 2000-08-14 2001-08-14 シロスタゾールの製造方法 Expired - Fee Related JP3845059B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22536200P 2000-08-14 2000-08-14
PCT/US2001/025398 WO2002014283A1 (en) 2000-08-14 2001-08-14 Processes for preparing cilostazol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005181031A Division JP2005350474A (ja) 2000-08-14 2005-06-21 シロスタゾールの製造方法

Publications (2)

Publication Number Publication Date
JP2004506043A JP2004506043A (ja) 2004-02-26
JP3845059B2 true JP3845059B2 (ja) 2006-11-15

Family

ID=22844569

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002519426A Expired - Fee Related JP3845059B2 (ja) 2000-08-14 2001-08-14 シロスタゾールの製造方法
JP2005181031A Pending JP2005350474A (ja) 2000-08-14 2005-06-21 シロスタゾールの製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005181031A Pending JP2005350474A (ja) 2000-08-14 2005-06-21 シロスタゾールの製造方法

Country Status (17)

Country Link
EP (1) EP1311485A4 (cs)
JP (2) JP3845059B2 (cs)
KR (1) KR20030024865A (cs)
CN (1) CN1469864A (cs)
AU (1) AU2001284887A1 (cs)
CA (1) CA2419181A1 (cs)
CZ (1) CZ2003667A3 (cs)
HK (1) HK1053116A1 (cs)
HU (1) HUP0302688A2 (cs)
IL (1) IL154458A0 (cs)
IS (1) IS6716A (cs)
MX (1) MXPA03001470A (cs)
NO (1) NO20030699L (cs)
NZ (1) NZ524363A (cs)
PL (1) PL365672A1 (cs)
SK (1) SK2992003A3 (cs)
WO (1) WO2002014283A1 (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045547A1 (en) 2001-05-02 2003-03-06 Shinji Aki Process for producing carbostyril derivatives
US20050101631A1 (en) 2002-08-01 2005-05-12 Otsuka Pharmaceuticals Company Process for producing carbostyril derivatives
US7399864B2 (en) 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
DE60335865D1 (de) 2002-09-10 2011-03-10 Otsuka Pharma Co Ltd Verfahren zur herstellung von cilostazol
CN1914176A (zh) 2004-02-05 2007-02-14 特瓦制药工业有限公司 制备阿立哌唑的方法
KR100633232B1 (ko) * 2004-08-25 2006-10-11 주식회사유한양행 신규한 6-[4-(1-시클로헥실-1ｈ-테트라졸-5-일)부톡시]-3,4-디히드로-2(1ｈ)-퀴놀리논 정제방법
US20070270590A1 (en) * 2006-04-20 2007-11-22 Marioara Mendelovici Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
TW200848041A (en) 2007-03-30 2008-12-16 Otsuka Pharma Co Ltd A medicament for treating schizophrenia comprising cilostazol
ES2401914T3 (es) 2007-04-25 2013-04-25 Concert Pharmaceuticals Inc. Análogos de Cilostazol
CN101434598B (zh) * 2008-12-19 2012-11-07 重庆康乐制药有限公司 西洛他唑的制备方法
CN102086190B (zh) * 2011-01-28 2013-07-10 海南美兰史克制药有限公司 西洛他唑化合物及其制法
CN107382970A (zh) * 2017-07-26 2017-11-24 浙江金立源药业有限公司 一种西洛他唑的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPH01265051A (ja) * 1988-04-14 1989-10-23 Fuji Photo Film Co Ltd ジアリールオキシアルカン製造方法

Also Published As

Publication number Publication date
WO2002014283A1 (en) 2002-02-21
MXPA03001470A (es) 2005-06-30
IS6716A (is) 2003-02-13
EP1311485A1 (en) 2003-05-21
JP2004506043A (ja) 2004-02-26
NO20030699L (no) 2003-04-10
HUP0302688A2 (hu) 2003-12-29
JP2005350474A (ja) 2005-12-22
EP1311485A4 (en) 2004-05-12
KR20030024865A (ko) 2003-03-26
CN1469864A (zh) 2004-01-21
CZ2003667A3 (cs) 2003-08-13
SK2992003A3 (en) 2003-10-07
PL365672A1 (en) 2005-01-10
HK1053116A1 (zh) 2003-10-10
NZ524363A (en) 2004-03-26
AU2001284887A1 (en) 2002-02-25
CA2419181A1 (en) 2002-02-21
IL154458A0 (en) 2003-09-17
NO20030699D0 (no) 2003-02-13

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