JP3819032B2 - 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 - Google Patents
組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 Download PDFInfo
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- JP3819032B2 JP3819032B2 JP51047197A JP51047197A JP3819032B2 JP 3819032 B2 JP3819032 B2 JP 3819032B2 JP 51047197 A JP51047197 A JP 51047197A JP 51047197 A JP51047197 A JP 51047197A JP 3819032 B2 JP3819032 B2 JP 3819032B2
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Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US274695P | 1995-08-24 | 1995-08-24 | |
US60/002,746 | 1995-08-24 | ||
PCT/US1996/013658 WO1997008538A1 (fr) | 1995-08-24 | 1996-08-23 | Imagerie et spectroscopie des tissus, basees sur la duree de vie de la fluorescence et autres supports programmables |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000500228A JP2000500228A (ja) | 2000-01-11 |
JP2000500228A5 JP2000500228A5 (fr) | 2004-09-09 |
JP3819032B2 true JP3819032B2 (ja) | 2006-09-06 |
Family
ID=21702295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51047197A Expired - Lifetime JP3819032B2 (ja) | 1995-08-24 | 1996-08-23 | 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5865754A (fr) |
EP (1) | EP0846262A4 (fr) |
JP (1) | JP3819032B2 (fr) |
CN (1) | CN1200174A (fr) |
AU (1) | AU1130797A (fr) |
CA (1) | CA2230228C (fr) |
MX (1) | MX9801351A (fr) |
NO (1) | NO980750L (fr) |
WO (1) | WO1997008538A1 (fr) |
Families Citing this family (265)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5353799A (en) * | 1991-01-22 | 1994-10-11 | Non Invasive Technology, Inc. | Examination of subjects using photon migration with high directionality techniques |
US6304771B1 (en) * | 1993-10-29 | 2001-10-16 | The Trustees Of The University Of Pennsylvania | Systems and methods for imaging fluorophores |
US5919140A (en) * | 1995-02-21 | 1999-07-06 | Massachusetts Institute Of Technology | Optical imaging using time gated scattered light |
US7328059B2 (en) * | 1996-08-23 | 2008-02-05 | The Texas A & M University System | Imaging of light scattering tissues with fluorescent contrast agents |
US6766183B2 (en) | 1995-11-22 | 2004-07-20 | Medtronic Minimed, Inc. | Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
JP3796635B2 (ja) * | 1996-03-06 | 2006-07-12 | 富士写真フイルム株式会社 | 蛍光検出装置 |
US6571119B2 (en) | 1996-03-06 | 2003-05-27 | Fuji Photo Film Co., Ltd. | Fluorescence detecting apparatus |
US6525862B2 (en) * | 1996-10-30 | 2003-02-25 | Photogen, Inc. | Methods and apparatus for optical imaging |
EP0983501A1 (fr) | 1996-11-08 | 2000-03-08 | Purdue Research Foundation | Systeme et procede d'analyse de particules |
US5952664A (en) * | 1997-01-17 | 1999-09-14 | Imaging Diagnostic Systems, Inc. | Laser imaging apparatus using biomedical markers that bind to cancer cells |
US5963658A (en) * | 1997-01-27 | 1999-10-05 | University Of North Carolina | Method and apparatus for detecting an abnormality within a host medium |
US7865230B1 (en) | 1997-02-07 | 2011-01-04 | Texas A&M University System | Method and system for detecting sentinel lymph nodes |
US6208886B1 (en) * | 1997-04-04 | 2001-03-27 | The Research Foundation Of City College Of New York | Non-linear optical tomography of turbid media |
US6124597A (en) | 1997-07-07 | 2000-09-26 | Cedars-Sinai Medical Center | Method and devices for laser induced fluorescence attenuation spectroscopy |
US6422994B1 (en) * | 1997-09-24 | 2002-07-23 | Olympus Optical Co., Ltd. | Fluorescent diagnostic system and method providing color discrimination enhancement |
CA2318180A1 (fr) * | 1998-01-26 | 1999-07-29 | Massachusetts Institute Of Technology | Imagerie endoscopique par fluorescence |
US6592847B1 (en) * | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
US6059820A (en) | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
US7107116B2 (en) | 1999-03-29 | 2006-09-12 | Genex Technologies, Inc. | Diffuse optical tomography system and method of use |
CN1325022C (zh) * | 1999-04-01 | 2007-07-11 | 成象诊断系统公司 | 使用约束肿瘤细胞的生化标记的激光成像装置 |
US6167297A (en) * | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
US6795195B1 (en) * | 1999-09-14 | 2004-09-21 | Research Foundation Of State University Of New York | System and method for tomographic imaging of dynamic properties of a scattering medium |
WO2001020305A1 (fr) * | 1999-09-14 | 2001-03-22 | The Research Foundation Of State University Of New York, Technology Transfer Office | Procede et systeme d'imagerie de la dynamique d'un milieu de dispersion |
US20050182434A1 (en) | 2000-08-11 | 2005-08-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US6915154B1 (en) | 1999-09-24 | 2005-07-05 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US7054002B1 (en) | 1999-10-08 | 2006-05-30 | The Texas A&M University System | Characterization of luminescence in a scattering medium |
US7006676B1 (en) | 2000-01-21 | 2006-02-28 | Medical Optical Imaging, Inc. | Method and apparatus for detecting an abnormality within a host medium utilizing frequency-swept modulation diffusion tomography |
US20010032053A1 (en) * | 2000-01-24 | 2001-10-18 | Hielscher Andreas H. | Imaging of a scattering medium using the equation of radiative transfer |
CA2400305A1 (fr) * | 2000-02-18 | 2001-08-23 | Argose,Inc. | Generation de cartes d'excitation-emission spatialement moyennees dans des tissus heterogenes |
AU2001263776A1 (en) * | 2000-06-02 | 2001-12-11 | Medicometrics Aps | Method and system for classifying a biological sample |
US6748259B1 (en) * | 2000-06-15 | 2004-06-08 | Spectros Corporation | Optical imaging of induced signals in vivo under ambient light conditions |
US6587703B2 (en) | 2000-09-18 | 2003-07-01 | Photonify Technologies, Inc. | System and method for measuring absolute oxygen saturation |
US6801648B2 (en) * | 2000-08-04 | 2004-10-05 | Xuefeng Cheng | Optical imaging system with symmetric optical probe |
US6516209B2 (en) | 2000-08-04 | 2003-02-04 | Photonify Technologies, Inc. | Self-calibrating optical imaging system |
US6597931B1 (en) | 2000-09-18 | 2003-07-22 | Photonify Technologies, Inc. | System and method for absolute oxygen saturation |
WO2002028273A2 (fr) | 2000-10-06 | 2002-04-11 | Yang Victor X D | Dispositif d'imagerie et de spectroscopie a fluorescence multispectrale |
JP4241038B2 (ja) | 2000-10-30 | 2009-03-18 | ザ ジェネラル ホスピタル コーポレーション | 組織分析のための光学的な方法及びシステム |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
US7383076B2 (en) | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
US6615063B1 (en) * | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
US6826424B1 (en) * | 2000-12-19 | 2004-11-30 | Haishan Zeng | Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices |
US20030044353A1 (en) * | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
US6609015B2 (en) * | 2001-01-18 | 2003-08-19 | Koninklijke Philips Electronics N.V. | Analysis of a composition |
AU2002251944A1 (en) * | 2001-02-15 | 2002-09-04 | Medtronic Minimed, Inc. | Polymers functionalized with fluorescent boronate motifs |
NO325061B1 (no) * | 2001-03-06 | 2008-01-28 | Photosense As | Fremgangsmate og arrangement for bestemmelse av den optiske egenskap av et multisjiktvev |
US6930777B1 (en) * | 2001-04-03 | 2005-08-16 | The Texas A&M University System | Method for characterizing particles in suspension from frequency domain photon migration measurements |
US7268873B2 (en) * | 2001-04-03 | 2007-09-11 | The Texas A&M University System | Method for characterising particles in suspension from frequency domain photon migration measurements |
EP2333523B1 (fr) * | 2001-04-30 | 2020-04-08 | The General Hospital Corporation | Procédé et appareil permettant d'améliorer la clarté et la sensibilité de l'image en tomographie à cohérence optique au moyen d'une interaction permettant de contrôler les propriétés focales et la synchronisation de cohérence |
CA2473587C (fr) * | 2001-05-01 | 2014-07-15 | The General Hospital Corporation | Procede et appareil pour determiner un type de plaque d'atherosclerose par mesure de proprietes optiques de tissu |
US7403812B2 (en) * | 2001-05-17 | 2008-07-22 | Xenogen Corporation | Method and apparatus for determining target depth, brightness and size within a body region |
US7116354B2 (en) | 2001-06-20 | 2006-10-03 | Xenogen Corporation | Absolute intensity determination for a light source in low level light imaging systems |
US7298415B2 (en) * | 2001-07-13 | 2007-11-20 | Xenogen Corporation | Structured light imaging apparatus |
US7045361B2 (en) | 2001-09-12 | 2006-05-16 | Medtronic Minimed, Inc. | Analyte sensing via acridine-based boronate biosensors |
US6980299B1 (en) | 2001-10-16 | 2005-12-27 | General Hospital Corporation | Systems and methods for imaging a sample |
US20040082940A1 (en) * | 2002-10-22 | 2004-04-29 | Michael Black | Dermatological apparatus and method |
US20030109787A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser diagnostics |
US20030216719A1 (en) * | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
US20030109860A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser treatment |
CN1639539A (zh) * | 2002-01-11 | 2005-07-13 | 通用医疗公司 | 用于具有可提高分辨率和景深的轴线焦点的oct成像的装置 |
US7355716B2 (en) * | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US7629573B2 (en) * | 2002-02-06 | 2009-12-08 | Xenogen Corporation | Tissue phantom calibration device for low level light imaging systems |
US7649185B2 (en) * | 2002-02-06 | 2010-01-19 | Xenogen Corporation | Fluorescent phantom device |
US20110201924A1 (en) * | 2002-04-30 | 2011-08-18 | The General Hospital Corporation | Method and Apparatus for Improving Image Clarity and Sensitivity in Optical Tomography Using Dynamic Feedback to Control Focal Properties and Coherence Gating |
WO2003102558A1 (fr) | 2002-06-04 | 2003-12-11 | Visen Medical, Inc. | Tomographie avec et sans contact : volumes d'imagerie avec geometries arbitraires |
US7599731B2 (en) * | 2002-07-16 | 2009-10-06 | Xenogen Corporation | Fluorescent light tomography |
US7616985B2 (en) * | 2002-07-16 | 2009-11-10 | Xenogen Corporation | Method and apparatus for 3-D imaging of internal light sources |
CN1774623B (zh) * | 2002-07-31 | 2012-02-01 | 阿尔利克斯公司 | 利用全息激光控制分类物质的系统和方法 |
DE10255013B4 (de) * | 2002-11-25 | 2004-12-09 | Siemens Ag | Verfahren und Vorrichtung zur Lokalisierung von Licht emittierenden Bereichen |
WO2004065997A2 (fr) * | 2003-01-23 | 2004-08-05 | Jobin Yvon Inc. | Microscope pour effectuer des mesures fluorometriques multifrequences |
US7582882B2 (en) * | 2003-01-23 | 2009-09-01 | Horiba Jobin Yvon, Inc. | Solid state multi frequency fluorometric measurements system and method |
US7297962B2 (en) * | 2003-01-23 | 2007-11-20 | Horiba Jobin Yvon, Inc. | Method for performing spacially coordinated high speed fluorometric measurements |
JP2006516739A (ja) * | 2003-01-24 | 2006-07-06 | ザ・ジェネラル・ホスピタル・コーポレイション | 低コヒーレンス干渉計を用いて組織を識別するためのシステムおよび方法 |
US7643153B2 (en) * | 2003-01-24 | 2010-01-05 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
EP1593095B1 (fr) * | 2003-02-05 | 2019-04-17 | The General Hospital Corporation | Methode et procede de tomographie optique en espace libre de milieux diffus |
ATE361699T1 (de) * | 2003-03-18 | 2007-06-15 | Koninkl Philips Electronics Nv | Analyse einer zusammenstellung mit beobachtung |
ES2441407T3 (es) | 2003-03-27 | 2014-02-04 | The General Hospital Corporation | Aparato para tratamiento dermatológico y rejuvenecimiento cutáneo fraccional |
EP2436307B1 (fr) | 2003-03-31 | 2015-10-21 | The General Hospital Corporation | Réduction des taches dans la tomographie de cohérence optique par combinaison angulaire codée pour la longueur de chemin |
EP1611541B1 (fr) * | 2003-04-04 | 2010-12-15 | Lumidigm, Inc. | Capteur biometrique multispectral |
US7181219B2 (en) | 2003-05-22 | 2007-02-20 | Lucent Technologies Inc. | Wireless handover using anchor termination |
EP1639330B1 (fr) * | 2003-06-06 | 2008-10-08 | The General Hospital Corporation | Source lumière accordable en longueur d'onde |
US7599732B2 (en) | 2003-06-20 | 2009-10-06 | The Texas A&M University System | Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection |
WO2005002425A2 (fr) * | 2003-07-02 | 2005-01-13 | U.S. Government As Represented By The Secretary Of The Army | Unite de diagnostic de viabilite tissulaire portable |
JP2007531544A (ja) * | 2003-07-11 | 2007-11-08 | リライアント・テクノロジーズ・インコーポレイテッド | 皮膚の分画光治療のための方法と装置 |
US7920908B2 (en) | 2003-10-16 | 2011-04-05 | David Hattery | Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue |
CN1875242A (zh) * | 2003-10-27 | 2006-12-06 | 通用医疗公司 | 用于使用频域干涉测量法进行光学成像的方法和设备 |
WO2005054780A1 (fr) * | 2003-11-28 | 2005-06-16 | The General Hospital Corporation | Procede et appareil d'imagerie codee de maniere spectrale tridimensionnelle |
US7330032B2 (en) * | 2003-12-30 | 2008-02-12 | The Mitre Corporation | Techniques for building-scale electrostatic tomography |
US20050165427A1 (en) * | 2004-01-22 | 2005-07-28 | Jahns Scott E. | Vessel sealing devices |
US8353896B2 (en) | 2004-04-19 | 2013-01-15 | The Invention Science Fund I, Llc | Controllable release nasal system |
US9011329B2 (en) | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
US20070244520A1 (en) * | 2004-04-19 | 2007-10-18 | Searete Llc | Lumen-traveling biological interface device and method of use |
US9801527B2 (en) * | 2004-04-19 | 2017-10-31 | Gearbox, Llc | Lumen-traveling biological interface device |
US8092549B2 (en) * | 2004-09-24 | 2012-01-10 | The Invention Science Fund I, Llc | Ciliated stent-like-system |
US20050234440A1 (en) * | 2004-04-19 | 2005-10-20 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System with a sensor for perfusion management |
US8337482B2 (en) * | 2004-04-19 | 2012-12-25 | The Invention Science Fund I, Llc | System for perfusion management |
US8019413B2 (en) * | 2007-03-19 | 2011-09-13 | The Invention Science Fund I, Llc | Lumen-traveling biological interface device and method of use |
US20070010868A1 (en) * | 2004-04-19 | 2007-01-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Lumenally-active device |
US8361013B2 (en) * | 2004-04-19 | 2013-01-29 | The Invention Science Fund I, Llc | Telescoping perfusion management system |
JP4750786B2 (ja) | 2004-05-29 | 2011-08-17 | ザ ジェネラル ホスピタル コーポレイション | 光コヒーレンストモグラフィ(oct)イメージングにおける屈折層を用いた色分散補償プロセス、システム及びソフトウェア構成 |
US7413572B2 (en) * | 2004-06-14 | 2008-08-19 | Reliant Technologies, Inc. | Adaptive control of optical pulses for laser medicine |
JP4995720B2 (ja) | 2004-07-02 | 2012-08-08 | ザ ジェネラル ホスピタル コーポレイション | ダブルクラッドファイバを有する内視鏡撮像プローブ |
US20060217788A1 (en) * | 2004-07-09 | 2006-09-28 | Herron G S | Method of using laser induced injury to activate topical prodrugs |
US8081316B2 (en) | 2004-08-06 | 2011-12-20 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
JP5334415B2 (ja) * | 2004-08-24 | 2013-11-06 | ザ ジェネラル ホスピタル コーポレイション | 試料の機械的歪み及び弾性的性質を測定するプロセス、システム及びソフトウェア |
KR20070058523A (ko) * | 2004-08-24 | 2007-06-08 | 더 제너럴 하스피탈 코포레이션 | 혈관절편 영상화 방법 및 장치 |
WO2006039091A2 (fr) | 2004-09-10 | 2006-04-13 | The General Hospital Corporation | Systeme et procede pour l'imagerie de coherence optique |
JP4997112B2 (ja) | 2004-09-29 | 2012-08-08 | ザ ジェネラル ホスピタル コーポレイション | 少なくとも1つの電磁放射を伝送させるための装置およびその製造方法 |
US20060122584A1 (en) * | 2004-10-27 | 2006-06-08 | Bommannan D B | Apparatus and method to treat heart disease using lasers to form microchannels |
US20080007734A1 (en) * | 2004-10-29 | 2008-01-10 | The General Hospital Corporation | System and method for providing Jones matrix-based analysis to determine non-depolarizing polarization parameters using polarization-sensitive optical coherence tomography |
US7382949B2 (en) * | 2004-11-02 | 2008-06-03 | The General Hospital Corporation | Fiber-optic rotational device, optical system and method for imaging a sample |
WO2006058049A1 (fr) * | 2004-11-24 | 2006-06-01 | The General Hospital Corporation | Interferometre a trajet commun pour oct endoscopique |
US8922781B2 (en) * | 2004-11-29 | 2014-12-30 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
US7966051B2 (en) * | 2005-01-11 | 2011-06-21 | Olympus Corporation | Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method |
US7729750B2 (en) * | 2005-01-20 | 2010-06-01 | The Regents Of The University Of California | Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography |
KR20080013919A (ko) * | 2005-04-22 | 2008-02-13 | 더 제너럴 하스피탈 코포레이션 | 스펙트럼 도메인 편광 민감형 광간섭 단층촬영을 제공할 수있는 장치, 시스템 및 방법 |
US20060239921A1 (en) | 2005-04-26 | 2006-10-26 | Novadaq Technologies Inc. | Real time vascular imaging during solid organ transplant |
JP5684452B2 (ja) | 2005-04-28 | 2015-03-11 | ザ ジェネラル ホスピタル コーポレイション | 光干渉測定法により解剖学的構造に関連する情報を評価するためのシステム、方法及びソフトウエア装置 |
US8044996B2 (en) * | 2005-05-11 | 2011-10-25 | Xenogen Corporation | Surface construction using combined photographic and structured light information |
EP1886121A1 (fr) * | 2005-05-13 | 2008-02-13 | The General Hospital Corporation | Arrangements, systemes et procedes permettant d'obtenir une reflectrometrie de coherence optique du domaine spectral pour une detection sensible d'un echantillon chimique et biologique |
EP1887926B1 (fr) * | 2005-05-31 | 2014-07-30 | The General Hospital Corporation | Systeme et procede qui utilisent des techniques d'interferometrie d'heterodyne a codage spectral pour l'imagerie |
US9060689B2 (en) * | 2005-06-01 | 2015-06-23 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
ES2354287T3 (es) * | 2005-08-09 | 2011-03-11 | The General Hospital Corporation | Aparato y método para realizar una desmodulación en cuadratura por polarización en tomografía de coherencia óptica. |
WO2007022220A2 (fr) * | 2005-08-16 | 2007-02-22 | The General Hospital Corporation | Ensembles et procedes pour la mise en image dans des vaisseaux sanguins |
WO2007027962A2 (fr) * | 2005-08-29 | 2007-03-08 | Reliant Technologies, Inc. | Procede et appareil pour la surveillance et la regulation de traitement tissulaire induit thermiquement |
US20070049996A1 (en) * | 2005-08-29 | 2007-03-01 | Reliant Technologies, Inc. | Monitoring Method and Apparatus for Fractional Photo-Therapy Treatment |
US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location |
KR20080066705A (ko) | 2005-09-29 | 2008-07-16 | 더 제너럴 하스피탈 코포레이션 | 점진적으로 증가하는 분해능을 이용하여 하나 이상의 생물학적 샘플을 관찰 및 분석하기 위한 방법 및 장치 |
US7889348B2 (en) * | 2005-10-14 | 2011-02-15 | The General Hospital Corporation | Arrangements and methods for facilitating photoluminescence imaging |
US20070178067A1 (en) * | 2005-11-09 | 2007-08-02 | John Maier | System and method for cytological analysis by raman spectroscopic imaging |
JP2009515583A (ja) * | 2005-11-10 | 2009-04-16 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 光学蛍光断層撮影のための吸収及び散乱マップ再構成 |
CN101312685A (zh) * | 2005-11-23 | 2008-11-26 | 皇家飞利浦电子股份有限公司 | 用于对混浊介质的内部成像的设备 |
US20080308746A1 (en) * | 2005-11-25 | 2008-12-18 | Koninklijke Philips Electronics, N.V. | Optical Fluorescence Tomography |
JP5680826B2 (ja) * | 2006-01-10 | 2015-03-04 | ザ ジェネラル ホスピタル コーポレイション | 1以上のスペクトルを符号化する内視鏡技術によるデータ生成システム |
EP2289397A3 (fr) | 2006-01-19 | 2011-04-06 | The General Hospital Corporation | Procédés et systèmes pour visualiser de manière optique des organes intracavitaires épithéliaux lors d'un balayage au faisceau |
US20070223006A1 (en) * | 2006-01-19 | 2007-09-27 | The General Hospital Corporation | Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements |
US8145018B2 (en) * | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
CN101370426A (zh) * | 2006-01-20 | 2009-02-18 | 通用医疗公司 | 利用对光学相干断层扫描的波阵面调制来提供散斑减少的系统、装置和过程 |
WO2007084959A1 (fr) * | 2006-01-20 | 2007-07-26 | The General Hospital Corporation | Systemes et procedes utilises dans la microscopie a effet tunnel a miroirs |
WO2007084933A2 (fr) * | 2006-01-20 | 2007-07-26 | The General Hospital Corporation | Systemes et procedes pour produire une imagerie moleculaire endogene avec un eclairage mid-infrarouge |
US10426548B2 (en) * | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
EP2659851A3 (fr) * | 2006-02-01 | 2014-01-15 | The General Hospital Corporation | Appareil pour appliquer une pluralité de rayonnements électromagnétiques à un échantillon |
EP1986562B1 (fr) * | 2006-02-01 | 2015-04-08 | The General Hospital Corporation | Appareil destiné à commander au moins l'une d'au moins deux sections d'au moins une fibre |
EP3143926B1 (fr) | 2006-02-08 | 2020-07-01 | The General Hospital Corporation | Procédés, agencements et systèmes pour obtenir des informations associées à un prélèvement anatomique utilisant la microscopie optique |
EP1987318B1 (fr) | 2006-02-24 | 2015-08-12 | The General Hospital Corporation | Procédés et systèmes destinés à réaliser une tomographie par cohérence optique dans le domaine de fourier avec résolution angulaire |
JP2009533076A (ja) * | 2006-03-01 | 2009-09-17 | ザ ジェネラル ホスピタル コーポレイション | 光吸収体をマクロファージに標的化することによるアテローム班の細胞特異的レーザー治療を提供するシステム及び方法 |
WO2007109540A2 (fr) * | 2006-03-17 | 2007-09-27 | The General Hospital Corporation | Appareil, procédé et support accessible par ordinateur pour l'identification de caractéristiques d'au moins une partie d'un vaisseau sanguin compris à l'intérieur d'un tissu au moyen d'une interférométrie faible cohérence à domaine spectral |
US7742173B2 (en) * | 2006-04-05 | 2010-06-22 | The General Hospital Corporation | Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample |
US8160680B2 (en) * | 2006-04-12 | 2012-04-17 | The Invention Science Fund I, Llc | Autofluorescent imaging and target ablation |
US20120035437A1 (en) | 2006-04-12 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Navigation of a lumen traveling device toward a target |
US20080058786A1 (en) * | 2006-04-12 | 2008-03-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Autofluorescent imaging and target ablation |
US8755866B2 (en) * | 2006-05-03 | 2014-06-17 | Covidien Lp | Method and apparatus for lymph node mapping |
JP2009536740A (ja) | 2006-05-10 | 2009-10-15 | ザ ジェネラル ホスピタル コーポレイション | サンプルの周波数領域画像形成を提供するためのプロセス、構成およびシステム |
WO2007133964A2 (fr) * | 2006-05-12 | 2007-11-22 | The General Hospital Corporation | Processus, agencements et systèmes pour produire une carte d'épaisseur de couche de fibres sur la base d'images de tomographie à cohérence optique |
CN101484067B (zh) * | 2006-07-07 | 2011-07-06 | 皇家飞利浦电子股份有限公司 | 光学成像系统和方法 |
US20100165335A1 (en) * | 2006-08-01 | 2010-07-01 | The General Hospital Corporation | Systems and methods for receiving and/or analyzing information associated with electro-magnetic radiation |
JP2008043396A (ja) * | 2006-08-11 | 2008-02-28 | Olympus Corp | 内視鏡システム |
WO2008025005A2 (fr) * | 2006-08-24 | 2008-02-28 | Baylor College Of Medicine | procédé pour mesurer la propulsion dans des structures lymphatiques |
US10335038B2 (en) | 2006-08-24 | 2019-07-02 | Xenogen Corporation | Spectral unmixing for in-vivo imaging |
US10775308B2 (en) | 2006-08-24 | 2020-09-15 | Xenogen Corporation | Apparatus and methods for determining optical tissue properties |
US20080050316A1 (en) * | 2006-08-24 | 2008-02-28 | Baylor College Of Medicine | Molecular imaging of epithelial cells in lymph |
CN101589301B (zh) * | 2006-08-25 | 2012-11-07 | 通用医疗公司 | 利用体积测定过滤技术来增强光学相干断层成像的装置和方法 |
US20080058782A1 (en) * | 2006-08-29 | 2008-03-06 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling density of fractional tissue treatments |
CA2662893A1 (fr) * | 2006-09-06 | 2008-03-13 | University Health Network | Quantification de fluorescence et acquisition d'image dans un support extremement trouble |
US20080161744A1 (en) | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes |
US20080287808A1 (en) * | 2006-09-12 | 2008-11-20 | The General Hospital Corporation | Apparatus, probe and method for providing depth assessment in an anatomical structure |
WO2008049118A2 (fr) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Dispositif et procédé d'obtention et de fourniture d'informations d'image associées à au moins une portion d' échantillon et permettant de réaliser une telle portion |
WO2008060833A2 (fr) * | 2006-10-24 | 2008-05-22 | The Research Foundation Of State University Of New York | Composition, procédé, système et trousse pour l'électrophysiologie du nerf optique |
WO2008052189A2 (fr) * | 2006-10-26 | 2008-05-02 | Reliant Technologies, Inc. | Administration de substances actives dans des micropores |
JP2008148791A (ja) * | 2006-12-14 | 2008-07-03 | Olympus Corp | 内視鏡システム |
US20080206804A1 (en) * | 2007-01-19 | 2008-08-28 | The General Hospital Corporation | Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis |
EP2102583A2 (fr) | 2007-01-19 | 2009-09-23 | The General Hospital Corporation | Appareil et procédé pour contrôler la profondeur de télémétrie dans une imagerie de domaine de fréquence optique |
US7949019B2 (en) * | 2007-01-19 | 2011-05-24 | The General Hospital | Wavelength tuning source based on a rotatable reflector |
US20080234567A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | Apparatus and method for providing a noninvasive diagnosis of internal bleeding |
US20080234586A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | System and method for providing noninvasive diagnosis of compartment syndrome using exemplary laser speckle imaging procedure |
US9176319B2 (en) * | 2007-03-23 | 2015-11-03 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
US10534129B2 (en) * | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
WO2008131082A1 (fr) * | 2007-04-17 | 2008-10-30 | The General Hospital Corporation | Appareil et procédés de mesure des vibrations à l'aide de techniques d'endoscopie spectralement codées |
EP2155048B1 (fr) | 2007-04-25 | 2014-10-15 | Ruder Boskovic Institute | Procédé de visualisation et de démarcation de tumeur en temps réel au moyen d'un diagnostic photodynamique |
WO2008137637A2 (fr) * | 2007-05-04 | 2008-11-13 | The General Hospital Corporation | Procédés, agencements et systèmes pour obtenir des informations associées à un échantillon à l'aide d'une microscopie optique |
US7692160B2 (en) * | 2007-05-31 | 2010-04-06 | General Electric Company | Method and system of optical imaging for target detection in a scattering medium |
US7812945B2 (en) * | 2007-06-15 | 2010-10-12 | Art Advanced Research Technologies Inc. | Fluorescence tomography using line-by-line forward model |
EP2173254A2 (fr) * | 2007-07-31 | 2010-04-14 | The General Hospital Corporation | Systèmes et procédés pour fournir des motifs de balayage de faisceau pour une imagerie dans le domaine de la fréquence optique doppler de vitesse élevée |
EP2191254B1 (fr) * | 2007-08-31 | 2017-07-19 | The General Hospital Corporation | Systeme et procede pour une microscopie par fluorescence a auto-interference, et support lisible par ordinateur associe à ceux-ci |
WO2009036396A1 (fr) * | 2007-09-14 | 2009-03-19 | Light Sciences Oncology, Inc. | Systèmes, dispositifs et procédés pour résection assistée par système photoactif |
US20090073439A1 (en) * | 2007-09-15 | 2009-03-19 | The General Hospital Corporation | Apparatus, computer-accessible medium and method for measuring chemical and/or molecular compositions of coronary atherosclerotic plaques in anatomical structures |
WO2009049296A2 (fr) * | 2007-10-12 | 2009-04-16 | The General Hospital Corporation | Systèmes et procédés d'imagerie optique de structures anatomiques luminales |
US7933021B2 (en) * | 2007-10-30 | 2011-04-26 | The General Hospital Corporation | System and method for cladding mode detection |
US20090225324A1 (en) * | 2008-01-17 | 2009-09-10 | The General Hospital Corporation | Apparatus for providing endoscopic high-speed optical coherence tomography |
DK2244741T3 (en) * | 2008-01-18 | 2015-05-26 | Visen Medical Inc | Fluorescent imaging agents |
US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
US11123047B2 (en) | 2008-01-28 | 2021-09-21 | The General Hospital Corporation | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood |
US9332942B2 (en) * | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
US20090240138A1 (en) * | 2008-03-18 | 2009-09-24 | Steven Yi | Diffuse Optical Tomography System and Method of Use |
US20090240139A1 (en) * | 2008-03-18 | 2009-09-24 | Steven Yi | Diffuse Optical Tomography System and Method of Use |
US20090236541A1 (en) * | 2008-03-24 | 2009-09-24 | General Electric Company | System and Methods for Optical Imaging |
WO2009120228A1 (fr) * | 2008-03-24 | 2009-10-01 | General Electric Company | Systèmes de traitement d’image et procédés pour applications chirurgicales |
US8520921B2 (en) * | 2008-03-27 | 2013-08-27 | Koninklijke Philips Electronics N.V. | Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium |
US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
EP2285421B1 (fr) | 2008-05-02 | 2018-04-11 | Novadaq Technologies ULC | Procédés de production et d'utilisation d'érythrocytes chargés d'une substance pour l'observation et le traitement de l'hémodynamique vasculaire |
JP5607610B2 (ja) | 2008-05-07 | 2014-10-15 | ザ ジェネラル ホスピタル コーポレイション | 構造の特徴を決定する装置、装置の作動方法およびコンピュータアクセス可能な媒体 |
WO2009140757A1 (fr) | 2008-05-20 | 2009-11-26 | University Health Network | Dispositif et procédé pour imagerie et surveillance par fluorescence |
JP4575474B2 (ja) * | 2008-06-11 | 2010-11-04 | 国立大学法人東京工業大学 | 生体組織識別装置および方法 |
JP5795531B2 (ja) * | 2008-06-20 | 2015-10-14 | ザ ジェネラル ホスピタル コーポレイション | フューズドファイバオプティックカプラ構造、及びその使用方法 |
WO2010009136A2 (fr) | 2008-07-14 | 2010-01-21 | The General Hospital Corporation | Appareil et procédés d'endoscopie couleur |
WO2010042815A2 (fr) * | 2008-10-09 | 2010-04-15 | Duke University | Fragments d'anticorps vhh utilisables dans le cadre de la détection et du traitement du cancer |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
WO2010085775A2 (fr) * | 2009-01-26 | 2010-07-29 | The General Hospital Corporation | Système, procédé et support accessible par ordinateur permettant de fournir une microscopie de super-résolution à large champ |
EP2394336B1 (fr) | 2009-02-04 | 2023-05-24 | The General Hospital Corporation | Appareil et procédé d'utilisation d'une source d'ajustement de longueur d'onde optique à grande vitesse |
US9351642B2 (en) | 2009-03-12 | 2016-05-31 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s) |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
US9595028B2 (en) | 2009-06-08 | 2017-03-14 | Boku, Inc. | Systems and methods to add funds to an account via a mobile communication device |
BR112012001042A2 (pt) | 2009-07-14 | 2016-11-22 | Gen Hospital Corp | equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica. |
US20110071403A1 (en) * | 2009-09-21 | 2011-03-24 | Board Of Regents Of The University Of Texas System | Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders |
JP5856061B2 (ja) * | 2009-10-06 | 2016-02-09 | ザ ジェネラル ホスピタル コーポレイション | スペクトル符号化共焦点顕微鏡法を用いた特定の細胞を撮像するための装置及び方法 |
US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
EP2501288B1 (fr) | 2009-11-19 | 2016-12-21 | Modulated Imaging Inc. | Procédé et appareil pour analyse de milieux troubles par détection mono-élément en utilisant une illumination structurée |
EP2509488A4 (fr) * | 2009-12-08 | 2014-04-09 | Gen Hospital Corp | Procédés et agencements pour l'analyse, le diagnostic et la surveillance d'un traitement des cordes vocales par tomographie par cohérence optique |
LU91641B1 (en) * | 2010-01-21 | 2011-07-22 | Ct De Rech Public Gabriel Lippmann | Cancerous or pre-cancerous tissue visualization method and device |
EP2542145B1 (fr) | 2010-03-05 | 2020-08-12 | The General Hospital Corporation | Systèmes qui procurent des images microscopiques d'au moins une structure anatomique à une résolution particulière |
JP5566751B2 (ja) * | 2010-03-31 | 2014-08-06 | 富士フイルム株式会社 | 光断層情報生成装置、光強度分布算出方法および光強度分布算出プログラム |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US8681247B1 (en) * | 2010-05-12 | 2014-03-25 | Li-Cor, Inc. | Field flattening correction method for fluorescence imaging system |
EP2575598A2 (fr) | 2010-05-25 | 2013-04-10 | The General Hospital Corporation | Appareil, systèmes, procédés et support accessible par ordinateur pour l'analyse spectrale d'images de tomographie par cohérence optique |
US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
JP6066901B2 (ja) | 2010-06-03 | 2017-01-25 | ザ ジェネラル ホスピタル コーポレイション | 1つまたは複数の管腔器官内または管腔器官にある構造を撮像するための装置およびデバイスのための方法 |
GB201011913D0 (en) * | 2010-07-15 | 2010-09-01 | Lux Innovate Ltd | Detecting device |
US9347894B2 (en) | 2010-09-01 | 2016-05-24 | Spectral Instruments Imaging, LLC | Methods and systems for producing visible light and x-ray image data |
JP2013538350A (ja) | 2010-09-01 | 2013-10-10 | スペクトラル・インストゥルメンツ・イメージング・エルエルシー | 励起光源組立体 |
CN101975769A (zh) * | 2010-09-17 | 2011-02-16 | 福建师范大学 | 一种基于不同波长光源激发的人体组织自体荧光检测系统 |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
WO2012149175A1 (fr) | 2011-04-29 | 2012-11-01 | The General Hospital Corporation | Moyens pour déterminer des propriétés physiques et/ou optiques résolues en profondeur de milieux de diffusion |
JP2014523536A (ja) | 2011-07-19 | 2014-09-11 | ザ ジェネラル ホスピタル コーポレイション | 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体 |
WO2013029047A1 (fr) | 2011-08-25 | 2013-02-28 | The General Hospital Corporation | Procédés, systèmes, configurations et support accessible par ordinateur permettant de mettre en œuvre des procédures de tomographie par cohérence micro-optique |
WO2013066631A1 (fr) | 2011-10-18 | 2013-05-10 | The General Hospital Corporation | Appareil et procédés de production et/ou d'utilisation de retard(s) optique(s) de recirculation |
JP5970785B2 (ja) * | 2011-11-16 | 2016-08-17 | ソニー株式会社 | 生体計測装置、生体計測方法、プログラムおよび記録媒体 |
EP2833776A4 (fr) | 2012-03-30 | 2015-12-09 | Gen Hospital Corp | Système d'imagerie, procédé et fixation distale permettant une endoscopie à champ de vision multidirectionnel |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
CA2914778A1 (fr) | 2012-06-21 | 2013-12-27 | Novadaq Technologies Inc. | Quantification et analyse d'angiographie et de perfusion |
JP6227652B2 (ja) | 2012-08-22 | 2017-11-08 | ザ ジェネラル ホスピタル コーポレイション | ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体 |
AU2013341165B2 (en) | 2012-11-07 | 2019-08-01 | Modulated Imaging, Inc. | Efficient modulated imaging |
WO2014120791A1 (fr) | 2013-01-29 | 2014-08-07 | The General Hospital Corporation | Appareil, systèmes et procédés pour donner des informations sur la valvule aortique |
WO2014121082A1 (fr) | 2013-02-01 | 2014-08-07 | The General Hospital Corporation | Agencement d'objectif pour endomicroscopie confocale |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
DE102013008003B4 (de) * | 2013-05-08 | 2015-03-19 | Freshdetect Gmbh | Messgerät zum Messen eines Oberflächenbelags auf einem Messobjekt, insbesondere auf einem Lebensmittel, und dessen Verwendung |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
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WO2015013651A2 (fr) | 2013-07-26 | 2015-01-29 | The General Hospital Corporation | Système, appareil et procédé utilisant une dispersion optique pour réaliser une tomographie en cohérence optique dans le domaine de fourier |
US11096584B2 (en) * | 2013-11-14 | 2021-08-24 | The George Washington University | Systems and methods for determining lesion depth using fluorescence imaging |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
WO2015116986A2 (fr) | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | Système et procédé pour faciliter une imagerie volumétrique manuelle et/ou automatique avec un retour de tension ou d'effort en temps réel au moyen d'un dispositif d'imagerie amarré |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
EP3783034A1 (fr) | 2014-07-23 | 2021-02-24 | Ohio State Innovation Foundation | Méthodes et compositions associées à des fragments d'anticorps qui se lient à la glycoprotéine 72 associée aux tumeurs (tag 72) |
ES2894912T3 (es) | 2014-07-24 | 2022-02-16 | Univ Health Network | Recopilación y análisis de datos con fines de diagnóstico |
ES2907287T3 (es) | 2014-07-25 | 2022-04-22 | Massachusetts Gen Hospital | Aparato para imagenología y diagnóstico in vivo |
WO2016049756A1 (fr) | 2014-09-29 | 2016-04-07 | Novadaq Technologies Inc. | Imagerie d'un fluorophore cible dans une matière biologique en présence d'auto-fluorescence |
WO2016055837A1 (fr) | 2014-10-09 | 2016-04-14 | Novadaq Technologies Inc. | Quantification de circulation sanguine absolue dans un tissu à l'aide de photopléthysmographie induite par fluorescence |
AU2015343258B2 (en) * | 2014-11-03 | 2020-07-16 | 460Medical, Inc. | Systems and methods for lesion assessment |
US9626754B2 (en) * | 2015-05-28 | 2017-04-18 | Jabil Circuit, Inc. | System, apparatus and method for dispensed adhesive material inspection |
US10084365B1 (en) | 2016-02-04 | 2018-09-25 | Harivallabh Pandya | Electromagnetic machinery systems, device, assemblies, methods, processes, uses, and apparatus operable as a motor or generator with one or more stator coils, at least one permanent magnet rotor, and associated circuitry |
EP3580609B1 (fr) | 2017-02-10 | 2023-05-24 | Stryker European Operations Limited | Systèmes et procédés d'imagerie à fluorescence portative à champ ouvert |
US10378006B2 (en) | 2017-04-19 | 2019-08-13 | The Florida International University Board Of Trustees | Near-infrared ray exposure system for biological studies |
WO2019109090A1 (fr) * | 2017-12-03 | 2019-06-06 | Munro Design & Technologies, Llc | Systèmes de génération de signal pour systèmes d'imagerie tridimensionnelle et procédés associés |
CN112449683A (zh) * | 2018-04-26 | 2021-03-05 | 达特默斯大学托管会 | 用于确定表面下荧光物体的深度和浓度的装置和方法 |
DE102018126183B4 (de) * | 2018-10-22 | 2020-08-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Bestimmung der Konzentration eines fluoreszierenden und/oder fluoreszenzmarkierten Analyten und Kalibrierverfahren zur Vorbereitung dieser Bestimmung |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4541438A (en) * | 1983-06-02 | 1985-09-17 | The Johns Hopkins University | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light |
US5353799A (en) * | 1991-01-22 | 1994-10-11 | Non Invasive Technology, Inc. | Examination of subjects using photon migration with high directionality techniques |
US5022757A (en) * | 1989-01-23 | 1991-06-11 | Modell Mark D | Heterodyne system and method for sensing a target substance |
JP2525894B2 (ja) * | 1989-04-07 | 1996-08-21 | 浜松ホトニクス株式会社 | 半導体試料の螢光特性検査装置 |
US5421337A (en) * | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5070455A (en) * | 1989-11-22 | 1991-12-03 | Singer Imaging, Inc. | Imaging system and method using scattered and diffused radiation |
US5142372A (en) * | 1990-03-08 | 1992-08-25 | Alfano Robert R | Three-dimensional optical imaging of semi-transparent and opaque objects using ultrashort light pulses, a streak camera and a coherent fiber bundle |
US5213105A (en) * | 1990-12-04 | 1993-05-25 | Research Corporation Technologies, Inc. | Frequency domain optical imaging using diffusion of intensity modulated radiation |
CA2042075C (fr) * | 1991-05-08 | 2001-01-23 | Branko Palcic | Systeme d'imagerie endoscopique |
US5413098A (en) * | 1991-12-24 | 1995-05-09 | Sextant Medical Corporation | Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium |
JP3107914B2 (ja) * | 1992-07-20 | 2000-11-13 | 浜松ホトニクス株式会社 | 散乱吸収体内部の吸収情報計測装置及び方法 |
US5452723A (en) * | 1992-07-24 | 1995-09-26 | Massachusetts Institute Of Technology | Calibrated spectrographic imaging |
US5421339A (en) * | 1993-05-12 | 1995-06-06 | Board Of Regents, The University Of Texas System | Diagnosis of dysplasia using laser induced fluoroescence |
US5340991A (en) * | 1993-05-21 | 1994-08-23 | The Board Of Regents Of The University Of Oklahoma | Fluorokinetic analysis of diffusion from a vessel |
CA2175348A1 (fr) * | 1993-10-29 | 1995-05-04 | Arjun G. Yodh | Imagerie d'objets a l'aide de lumiere diffuse |
US5590660A (en) * | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
US5579773A (en) * | 1994-09-30 | 1996-12-03 | Martin Marietta Energy Systems, Inc. | Laser-induced differential normalized fluorescence method for cancer diagnosis |
US5647368A (en) * | 1996-02-28 | 1997-07-15 | Xillix Technologies Corp. | Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract |
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- 1996-08-23 AU AU11307/97A patent/AU1130797A/en not_active Abandoned
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- 1996-08-23 JP JP51047197A patent/JP3819032B2/ja not_active Expired - Lifetime
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- 1996-08-23 CA CA002230228A patent/CA2230228C/fr not_active Expired - Lifetime
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NO980750D0 (no) | 1998-02-23 |
CA2230228C (fr) | 2006-11-14 |
CN1200174A (zh) | 1998-11-25 |
WO1997008538A1 (fr) | 1997-03-06 |
US5865754A (en) | 1999-02-02 |
EP0846262A1 (fr) | 1998-06-10 |
MX9801351A (es) | 1998-07-31 |
EP0846262A4 (fr) | 1999-11-03 |
NO980750L (no) | 1998-04-23 |
CA2230228A1 (fr) | 1997-03-06 |
JP2000500228A (ja) | 2000-01-11 |
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