JP3781698B2 - 新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物 - Google Patents

新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物 Download PDF

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Publication number
JP3781698B2
JP3781698B2 JP2002114443A JP2002114443A JP3781698B2 JP 3781698 B2 JP3781698 B2 JP 3781698B2 JP 2002114443 A JP2002114443 A JP 2002114443A JP 2002114443 A JP2002114443 A JP 2002114443A JP 3781698 B2 JP3781698 B2 JP 3781698B2
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compound
formula
branched
methyl
linear
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JP2002356486A (ja
Inventor
ジルベール・ラヴィエル
ティエリ・デュビュフェ
オリヴィエ・ミュレ
マルク・ミラン
アンヌ・ドゥケイン
モリセット・ブロッコ
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Laboratoires Servier SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2002114443A 2001-04-18 2002-04-17 新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物 Expired - Fee Related JP3781698B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0105216A FR2823752B1 (fr) 2001-04-18 2001-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0105216 2001-04-18

Publications (2)

Publication Number Publication Date
JP2002356486A JP2002356486A (ja) 2002-12-13
JP3781698B2 true JP3781698B2 (ja) 2006-05-31

Family

ID=8862407

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002114443A Expired - Fee Related JP3781698B2 (ja) 2001-04-18 2002-04-17 新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物

Country Status (22)

Country Link
US (1) US6747032B2 (cg-RX-API-DMAC7.html)
EP (1) EP1256583B1 (cg-RX-API-DMAC7.html)
JP (1) JP3781698B2 (cg-RX-API-DMAC7.html)
CN (1) CN1181075C (cg-RX-API-DMAC7.html)
AR (1) AR034308A1 (cg-RX-API-DMAC7.html)
AT (1) ATE301662T1 (cg-RX-API-DMAC7.html)
AU (1) AU781663B2 (cg-RX-API-DMAC7.html)
BR (1) BR0201312A (cg-RX-API-DMAC7.html)
CA (1) CA2383315C (cg-RX-API-DMAC7.html)
DE (1) DE60205424T2 (cg-RX-API-DMAC7.html)
DK (1) DK1256583T3 (cg-RX-API-DMAC7.html)
EA (1) EA005402B1 (cg-RX-API-DMAC7.html)
ES (1) ES2246380T3 (cg-RX-API-DMAC7.html)
FR (1) FR2823752B1 (cg-RX-API-DMAC7.html)
HU (1) HUP0201255A3 (cg-RX-API-DMAC7.html)
MX (1) MXPA02003849A (cg-RX-API-DMAC7.html)
NO (1) NO328014B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ518425A (cg-RX-API-DMAC7.html)
PL (1) PL207047B1 (cg-RX-API-DMAC7.html)
PT (1) PT1256583E (cg-RX-API-DMAC7.html)
SI (1) SI1256583T1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200203086B (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349850B2 (en) * 2006-03-28 2013-01-08 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP3581567A1 (en) 2011-04-10 2019-12-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
JP2016509066A (ja) * 2013-02-22 2016-03-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アダプター関連キナーゼ１（ａａｋ１）の阻害剤としての５ｈ−クロメノ［３，４−ｃ］ピリジン
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
FR2764890B1 (fr) * 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU1481701A (en) 1999-11-12 2001-06-06 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds

Also Published As

Publication number Publication date
BR0201312A (pt) 2003-06-10
AU3440602A (en) 2002-10-24
AU781663B2 (en) 2005-06-02
CN1381456A (zh) 2002-11-27
NO328014B1 (no) 2009-11-09
CA2383315A1 (fr) 2002-10-18
ES2246380T3 (es) 2006-02-16
EA200200379A3 (ru) 2002-12-26
NO20021806D0 (no) 2002-04-17
FR2823752B1 (fr) 2004-10-22
NZ518425A (en) 2003-08-29
DE60205424T2 (de) 2006-07-13
JP2002356486A (ja) 2002-12-13
CN1181075C (zh) 2004-12-22
HK1049669A1 (en) 2003-05-23
AR034308A1 (es) 2004-02-18
SI1256583T1 (sl) 2005-12-31
US6747032B2 (en) 2004-06-08
MXPA02003849A (es) 2003-07-14
ZA200203086B (en) 2002-10-28
HUP0201255A2 (hu) 2002-12-28
HU0201255D0 (cg-RX-API-DMAC7.html) 2002-06-29
HUP0201255A3 (en) 2003-02-28
PL207047B1 (pl) 2010-10-29
PT1256583E (pt) 2005-10-31
DE60205424D1 (de) 2005-09-15
NO20021806L (no) 2002-10-21
EA200200379A2 (ru) 2002-10-31
ATE301662T1 (de) 2005-08-15
EP1256583B1 (fr) 2005-08-10
US20030087916A1 (en) 2003-05-08
CA2383315C (fr) 2008-02-05
DK1256583T3 (da) 2005-10-31
PL353511A1 (en) 2002-10-21
EP1256583A1 (fr) 2002-11-13
EA005402B1 (ru) 2005-02-24
FR2823752A1 (fr) 2002-10-25

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