FR2823752B1 - Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2823752B1
FR2823752B1 FR0105216A FR0105216A FR2823752B1 FR 2823752 B1 FR2823752 B1 FR 2823752B1 FR 0105216 A FR0105216 A FR 0105216A FR 0105216 A FR0105216 A FR 0105216A FR 2823752 B1 FR2823752 B1 FR 2823752B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
ones derivatives
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0105216A
Other languages
English (en)
French (fr)
Other versions
FR2823752A1 (fr
Inventor
Vielle Gilbert La
Thierry Dubuffet
Olivier Muller
Mark Millan
Anne Dekeyne
Mauricette Brocco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to FR0105216A priority Critical patent/FR2823752B1/fr
Priority to ES02290945T priority patent/ES2246380T3/es
Priority to EP02290945A priority patent/EP1256583B1/fr
Priority to SI200230180T priority patent/SI1256583T1/sl
Priority to AT02290945T priority patent/ATE301662T1/de
Priority to DK02290945T priority patent/DK1256583T3/da
Priority to PT02290945T priority patent/PT1256583E/pt
Priority to DE60205424T priority patent/DE60205424T2/de
Priority to JP2002114443A priority patent/JP3781698B2/ja
Priority to ARP020101385A priority patent/AR034308A1/es
Priority to HU0201255A priority patent/HUP0201255A3/hu
Priority to NZ518425A priority patent/NZ518425A/en
Priority to EA200200379A priority patent/EA005402B1/ru
Priority to MXPA02003849A priority patent/MXPA02003849A/es
Priority to NO20021806A priority patent/NO328014B1/no
Priority to ZA200203086A priority patent/ZA200203086B/xx
Priority to AU34406/02A priority patent/AU781663B2/en
Priority to CA002383315A priority patent/CA2383315C/fr
Priority to US10/125,188 priority patent/US6747032B2/en
Priority to PL353511A priority patent/PL207047B1/pl
Priority to CNB021161038A priority patent/CN1181075C/zh
Priority to BR0201312-6A priority patent/BR0201312A/pt
Publication of FR2823752A1 publication Critical patent/FR2823752A1/fr
Priority to HK03101849.8A priority patent/HK1049669B/xx
Application granted granted Critical
Publication of FR2823752B1 publication Critical patent/FR2823752B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0105216A 2001-04-18 2001-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Lifetime FR2823752B1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR0105216A FR2823752B1 (fr) 2001-04-18 2001-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP02290945A EP1256583B1 (fr) 2001-04-18 2002-04-16 Dérivés de pyrimidin-4-ones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
SI200230180T SI1256583T1 (sl) 2001-04-18 2002-04-16 Derivati pirimidin-4-onov, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
AT02290945T ATE301662T1 (de) 2001-04-18 2002-04-16 Pyrimidin-4-one derivate, verfahren zu ihrer herstellung and sie enthaltende zusammensetzungen
DK02290945T DK1256583T3 (da) 2001-04-18 2002-04-16 Pyrimidin-4-on-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
PT02290945T PT1256583E (pt) 2001-04-18 2002-04-16 Derivados de pirimidin-4-onas processo para a sua preparacao e as composicoes farmaceuticas que os contem
DE60205424T DE60205424T2 (de) 2001-04-18 2002-04-16 Pyrimidin-4-on-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Zusammensetzungen
ES02290945T ES2246380T3 (es) 2001-04-18 2002-04-16 Derivados pirimidin-4-ona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
MXPA02003849A MXPA02003849A (es) 2001-04-18 2002-04-17 Nuevos compuestos de pirimidin-4-ona, un proceso para su preparacion y las composiciones farmaceuticas que los contienen.
HU0201255A HUP0201255A3 (en) 2001-04-18 2002-04-17 Novel pyrimidin-4-one derivatives a process for their preparation and pharmaceutical compositions containing them
NZ518425A NZ518425A (en) 2001-04-18 2002-04-17 Fused pyrimidin-4-one compounds useful as 5-HT2c and alpha2-AR inhibitors
EA200200379A EA005402B1 (ru) 2001-04-18 2002-04-17 Соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции
JP2002114443A JP3781698B2 (ja) 2001-04-18 2002-04-17 新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物
NO20021806A NO328014B1 (no) 2001-04-18 2002-04-17 Nye pyrimidin-4-on-forbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem
ARP020101385A AR034308A1 (es) 2001-04-18 2002-04-17 Compuestos de pirimidin-4-ona, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AU34406/02A AU781663B2 (en) 2001-04-18 2002-04-18 New pyrimidin-4-one compounds, a process for their preparation and pharmaceutical compositions containing them
CA002383315A CA2383315C (fr) 2001-04-18 2002-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10/125,188 US6747032B2 (en) 2001-04-18 2002-04-18 Pyrimidin-4-one compounds
PL353511A PL207047B1 (pl) 2001-04-18 2002-04-18 Nowe związki pirymidyn-4-onu i zawierające je kompozycje farmaceutyczne
CNB021161038A CN1181075C (zh) 2001-04-18 2002-04-18 新型嘧啶-4-酮化合物、其制备方法和含有它们的药物组合物
ZA200203086A ZA200203086B (en) 2001-04-18 2002-04-18 Pyrimidin-4-one compounds, a process for their preparation and pharmaceutical compositions containing them.
BR0201312-6A BR0201312A (pt) 2001-04-18 2002-04-18 Compostos de pirimidin-4-ona, processo para sua preparação e composições farmacêuticas contendo os referidos
HK03101849.8A HK1049669B (en) 2001-04-18 2003-03-14 New pyrimidin-4-one compounds a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0105216A FR2823752B1 (fr) 2001-04-18 2001-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2823752A1 FR2823752A1 (fr) 2002-10-25
FR2823752B1 true FR2823752B1 (fr) 2004-10-22

Family

ID=8862407

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0105216A Expired - Lifetime FR2823752B1 (fr) 2001-04-18 2001-04-18 Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (22)

Country Link
US (1) US6747032B2 (cg-RX-API-DMAC7.html)
EP (1) EP1256583B1 (cg-RX-API-DMAC7.html)
JP (1) JP3781698B2 (cg-RX-API-DMAC7.html)
CN (1) CN1181075C (cg-RX-API-DMAC7.html)
AR (1) AR034308A1 (cg-RX-API-DMAC7.html)
AT (1) ATE301662T1 (cg-RX-API-DMAC7.html)
AU (1) AU781663B2 (cg-RX-API-DMAC7.html)
BR (1) BR0201312A (cg-RX-API-DMAC7.html)
CA (1) CA2383315C (cg-RX-API-DMAC7.html)
DE (1) DE60205424T2 (cg-RX-API-DMAC7.html)
DK (1) DK1256583T3 (cg-RX-API-DMAC7.html)
EA (1) EA005402B1 (cg-RX-API-DMAC7.html)
ES (1) ES2246380T3 (cg-RX-API-DMAC7.html)
FR (1) FR2823752B1 (cg-RX-API-DMAC7.html)
HU (1) HUP0201255A3 (cg-RX-API-DMAC7.html)
MX (1) MXPA02003849A (cg-RX-API-DMAC7.html)
NO (1) NO328014B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ518425A (cg-RX-API-DMAC7.html)
PL (1) PL207047B1 (cg-RX-API-DMAC7.html)
PT (1) PT1256583E (cg-RX-API-DMAC7.html)
SI (1) SI1256583T1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200203086B (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349850B2 (en) * 2006-03-28 2013-01-08 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP3581567A1 (en) 2011-04-10 2019-12-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
JP2016509066A (ja) * 2013-02-22 2016-03-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アダプター関連キナーゼ１（ａａｋ１）の阻害剤としての５ｈ−クロメノ［３，４−ｃ］ピリジン
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
FR2764890B1 (fr) * 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU1481701A (en) 1999-11-12 2001-06-06 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds

Also Published As

Publication number Publication date
BR0201312A (pt) 2003-06-10
AU3440602A (en) 2002-10-24
AU781663B2 (en) 2005-06-02
CN1381456A (zh) 2002-11-27
NO328014B1 (no) 2009-11-09
CA2383315A1 (fr) 2002-10-18
ES2246380T3 (es) 2006-02-16
EA200200379A3 (ru) 2002-12-26
NO20021806D0 (no) 2002-04-17
NZ518425A (en) 2003-08-29
DE60205424T2 (de) 2006-07-13
JP2002356486A (ja) 2002-12-13
CN1181075C (zh) 2004-12-22
HK1049669A1 (en) 2003-05-23
AR034308A1 (es) 2004-02-18
SI1256583T1 (sl) 2005-12-31
US6747032B2 (en) 2004-06-08
MXPA02003849A (es) 2003-07-14
ZA200203086B (en) 2002-10-28
HUP0201255A2 (hu) 2002-12-28
HU0201255D0 (cg-RX-API-DMAC7.html) 2002-06-29
HUP0201255A3 (en) 2003-02-28
PL207047B1 (pl) 2010-10-29
PT1256583E (pt) 2005-10-31
DE60205424D1 (de) 2005-09-15
NO20021806L (no) 2002-10-21
EA200200379A2 (ru) 2002-10-31
ATE301662T1 (de) 2005-08-15
EP1256583B1 (fr) 2005-08-10
US20030087916A1 (en) 2003-05-08
CA2383315C (fr) 2008-02-05
DK1256583T3 (da) 2005-10-31
PL353511A1 (en) 2002-10-21
EP1256583A1 (fr) 2002-11-13
EA005402B1 (ru) 2005-02-24
FR2823752A1 (fr) 2002-10-25
JP3781698B2 (ja) 2006-05-31

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