JP3763414B2 - N−{2−クロロ−4−[(6,7−ジメトキシ−4−キノリル)オキシ]フェニル}−n’−(5−メチル−3−イソキサゾリル)ウレアの塩の結晶形 - Google Patents
N−{2−クロロ−4−[(6,7−ジメトキシ−4−キノリル)オキシ]フェニル}−n’−(5−メチル−3−イソキサゾリル)ウレアの塩の結晶形 Download PDFInfo
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- JP3763414B2 JP3763414B2 JP2004544999A JP2004544999A JP3763414B2 JP 3763414 B2 JP3763414 B2 JP 3763414B2 JP 2004544999 A JP2004544999 A JP 2004544999A JP 2004544999 A JP2004544999 A JP 2004544999A JP 3763414 B2 JP3763414 B2 JP 3763414B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2002306101 | 2002-10-21 | ||
JP2002306101 | 2002-10-21 | ||
PCT/JP2003/013439 WO2004035572A1 (ja) | 2002-10-21 | 2003-10-21 | N−{2−クロロ−4−[(6,7−ジメトキシ−4−キノリル)オキシ]フェニル}−n’−(5−メチル−3−イソキサゾリル)ウレアの塩の結晶形 |
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JPWO2004035572A1 JPWO2004035572A1 (ja) | 2006-02-16 |
JP3763414B2 true JP3763414B2 (ja) | 2006-04-05 |
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Country | Link |
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US (1) | US7166722B2 (de) |
EP (1) | EP1559715B1 (de) |
JP (1) | JP3763414B2 (de) |
AT (1) | ATE374199T1 (de) |
AU (1) | AU2003301430A1 (de) |
DE (1) | DE60316590T2 (de) |
DK (1) | DK1559715T3 (de) |
ES (1) | ES2294317T3 (de) |
PT (1) | PT1559715E (de) |
WO (1) | WO2004035572A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE253051T1 (de) * | 1999-01-22 | 2003-11-15 | Kirin Brewery | Chinolinderivate und chinazolinderivate |
EP2280003B1 (de) | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Verfahren zur Herstellung von Rezeptorkinase-Modulatoren |
SI2213661T1 (sl) | 2003-09-26 | 2011-11-30 | Exelixis Inc | c-Met modulatorji in postopki uporabe |
CA2581835C (en) * | 2004-09-29 | 2012-12-18 | Bayer Healthcare Ag | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
US9037466B2 (en) * | 2006-03-09 | 2015-05-19 | Nuance Communications, Inc. | Email administration for rendering email on a digital audio player |
EP2387563B2 (de) | 2009-01-16 | 2022-04-27 | Exelixis, Inc. | Malatsalz von n-(4-{[6,7-bis(methyloxy)chinolin-4-yl]-oxy}phenyl-n'-(4-fluorphenyl)cyclo-propan-1,1-dicarbonsäureamid und kristalline formen davon zur behandlung von krebs |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
US7998973B2 (en) * | 2009-11-13 | 2011-08-16 | Aveo Pharmaceuticals, Inc. | Tivozanib and temsirolimus in combination |
SI2621481T2 (sl) | 2010-09-27 | 2023-02-28 | Exelixis, Inc., | Dvojni inhibitorji MET in VEGF za zdravljenje proti kastraciji odpornega raka prostate in osteoblastnih kostnih metastaz |
KR20210010671A (ko) * | 2011-02-10 | 2021-01-27 | 엑셀리시스, 인코포레이티드 | 퀴놀린 화합물들의 제조 방법들 및 상기 화합물들을 함유하는 약학 조성물들 |
CN102532116B (zh) * | 2011-08-09 | 2015-01-21 | 武汉迈德森医药科技有限公司 | 抗肿瘤靶向治疗药物tivozanib的合成方法 |
CN104072492A (zh) * | 2013-11-27 | 2014-10-01 | 苏州摩尔医药有限公司 | 一种抗肿瘤靶向治疗药物Tivozanib的合成方法 |
KR102340311B1 (ko) * | 2016-09-13 | 2021-12-20 | 쿄와 기린 가부시키가이샤 | 의약 조성물 |
CA3118690A1 (en) | 2018-11-05 | 2020-05-14 | Aveo Pharmaceuticals, Inc. | Use of tivozanib to treat subjects with refractory cancer |
WO2023096651A1 (en) | 2021-11-26 | 2023-06-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for treating bile duct cancers with tivozanib |
CN114213404A (zh) * | 2021-12-27 | 2022-03-22 | 武汉九州钰民医药科技有限公司 | Vegfr抑制剂替沃扎尼的合成工艺 |
WO2024095127A1 (en) | 2022-10-31 | 2024-05-10 | Pliva Hrvatska D.O.O. | Solid state forms of tivozanib and process for preparation thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ505844A (en) | 1997-12-22 | 2003-10-31 | Bayer Ag | Inhibition of raf kinase using substituted heterocyclic ureas |
AU2223201A (en) * | 1999-12-24 | 2001-07-09 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives and drugs containing the same |
DE60134679D1 (de) * | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
RU2283841C2 (ru) * | 2001-04-27 | 2006-09-20 | Кирин Бир Кабусики Кайся | Азолильные производные хинолина и хиназолина, содержащая их фармацевтическая композиция, их применение и способ лечения заболеваний |
AU2003292838A1 (en) * | 2002-12-27 | 2004-07-29 | Kirin Beer Kabushiki Kaisha | Therapeutic agent for wet age-related macular degeneration |
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2003
- 2003-10-21 PT PT03756734T patent/PT1559715E/pt unknown
- 2003-10-21 DE DE60316590T patent/DE60316590T2/de not_active Expired - Lifetime
- 2003-10-21 AT AT03756734T patent/ATE374199T1/de not_active IP Right Cessation
- 2003-10-21 AU AU2003301430A patent/AU2003301430A1/en not_active Abandoned
- 2003-10-21 DK DK03756734T patent/DK1559715T3/da active
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- 2003-10-21 ES ES03756734T patent/ES2294317T3/es not_active Expired - Lifetime
- 2003-10-21 JP JP2004544999A patent/JP3763414B2/ja not_active Expired - Lifetime
- 2003-10-21 US US10/532,104 patent/US7166722B2/en not_active Expired - Lifetime
- 2003-10-21 EP EP03756734A patent/EP1559715B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPWO2004035572A1 (ja) | 2006-02-16 |
PT1559715E (pt) | 2007-10-24 |
US20060052415A1 (en) | 2006-03-09 |
US7166722B2 (en) | 2007-01-23 |
DK1559715T3 (da) | 2007-12-27 |
EP1559715B1 (de) | 2007-09-26 |
WO2004035572A1 (ja) | 2004-04-29 |
ATE374199T1 (de) | 2007-10-15 |
EP1559715A1 (de) | 2005-08-03 |
DE60316590T2 (de) | 2008-06-19 |
ES2294317T3 (es) | 2008-04-01 |
AU2003301430A1 (en) | 2004-05-04 |
DE60316590D1 (en) | 2007-11-08 |
EP1559715A4 (de) | 2006-03-29 |
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