JP3565442B2 - 哺乳類の関節炎の診断剤および／または治療剤 - Google Patents

哺乳類の関節炎の診断剤および／または治療剤 Download PDF

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Publication number
JP3565442B2
JP3565442B2 JP12097793A JP12097793A JP3565442B2 JP 3565442 B2 JP3565442 B2 JP 3565442B2 JP 12097793 A JP12097793 A JP 12097793A JP 12097793 A JP12097793 A JP 12097793A JP 3565442 B2 JP3565442 B2 JP 3565442B2
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JP
Japan
Prior art keywords
mesochlorin
tri
alanyl
mono
bacteriochlorin
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Expired - Lifetime
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JP12097793A
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English (en)
Japanese (ja)
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JPH06305961A (ja
Inventor
勝夫 会沢
ゆかり 黒岩
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新日本石油化学株式会社
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Application filed by 新日本石油化学株式会社 filed Critical 新日本石油化学株式会社
Priority to JP12097793A priority Critical patent/JP3565442B2/ja
Priority to US08/229,940 priority patent/US5430051A/en
Priority to EP94106083A priority patent/EP0629409A1/en
Priority to CA002121716A priority patent/CA2121716C/en
Priority to KR1019940008364A priority patent/KR100254135B1/ko
Priority to CN94104956A priority patent/CN1074665C/zh
Priority to TW083106082A priority patent/TW259706B/zh
Publication of JPH06305961A publication Critical patent/JPH06305961A/ja
Priority to US08/353,882 priority patent/US5567409A/en
Application granted granted Critical
Publication of JP3565442B2 publication Critical patent/JP3565442B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP12097793A 1993-04-22 1993-04-22 哺乳類の関節炎の診断剤および／または治療剤 Expired - Lifetime JP3565442B2 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP12097793A JP3565442B2 (ja) 1993-04-22 1993-04-22 哺乳類の関節炎の診断剤および／または治療剤
EP94106083A EP0629409A1 (en) 1993-04-22 1994-04-19 Tetrapyrrole carboxylic acid derivatives for diagnosis and/or therapy of arthritis
US08/229,940 US5430051A (en) 1993-04-22 1994-04-19 Treatment of arthritis using derivatives of porphorins
KR1019940008364A KR100254135B1 (ko) 1993-04-22 1994-04-20 관절염의 진단 및/ 또는 치료를 위한 방법 및 약제
CA002121716A CA2121716C (en) 1993-04-22 1994-04-20 Method and medical agent for diagnosis of arthritis
CN94104956A CN1074665C (zh) 1993-04-22 1994-04-21 诊断和/或治疗关节炎的药剂
TW083106082A TW259706B (enExample) 1993-04-22 1994-07-04
US08/353,882 US5567409A (en) 1993-04-22 1994-12-12 Method and medical agent for diagnosis of arthritis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12097793A JP3565442B2 (ja) 1993-04-22 1993-04-22 哺乳類の関節炎の診断剤および／または治療剤

Publications (2)

Publication Number Publication Date
JPH06305961A JPH06305961A (ja) 1994-11-01
JP3565442B2 true JP3565442B2 (ja) 2004-09-15

Family

ID=14799730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12097793A Expired - Lifetime JP3565442B2 (ja) 1993-04-22 1993-04-22 哺乳類の関節炎の診断剤および／または治療剤

Country Status (7)

Country Link
US (2) US5430051A (enExample)
EP (1) EP0629409A1 (enExample)
JP (1) JP3565442B2 (enExample)
KR (1) KR100254135B1 (enExample)
CN (1) CN1074665C (enExample)
CA (1) CA2121716C (enExample)
TW (1) TW259706B (enExample)

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US5807881A (en) 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
AU6031096A (en) * 1995-06-05 1996-12-24 Duke University Nitrosylated and nitrated superoxide oxidants and reductants
WO1998015273A1 (en) * 1996-10-10 1998-04-16 The General Hospital Corporation Photodynamic therapy for the treatment of osteoarthritis
CA2270558C (en) * 1996-11-06 2006-08-15 Meiji Seika Kaisha, Ltd. Treatment of autoimmune diseases by photochemotherapy
US5952664A (en) * 1997-01-17 1999-09-14 Imaging Diagnostic Systems, Inc. Laser imaging apparatus using biomedical markers that bind to cancer cells
AU747753B2 (en) * 1997-08-05 2002-05-23 Meiji Seika Kaisha Ltd. Immunosuppression by photochemotherapy
EP1131100B1 (en) * 1999-01-15 2003-03-12 Light Sciences Corporation Therapeutic compositions for metabolic bone disorders or bone metastases comprising a photosensitizer and a bisphosphonate
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
WO2000041726A2 (en) * 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
CA2395567A1 (en) * 2000-01-12 2001-07-19 Light Sciences Corporation Novel treatment for eye disease
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
US7582670B2 (en) * 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
WO2004002476A2 (en) 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US7053210B2 (en) 2002-07-02 2006-05-30 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
EP1594875A4 (en) 2003-01-16 2007-07-11 Technomart Co Ltd porphyrin derivatives
US10376711B2 (en) * 2003-03-14 2019-08-13 Light Sciences Oncology Inc. Light generating guide wire for intravascular use
CN2885311Y (zh) 2006-01-18 2007-04-04 郑成福 经尿道光动力疗法前列腺治疗仪
US20080269846A1 (en) * 2003-03-14 2008-10-30 Light Sciences Oncology, Inc. Device for treatment of blood vessels using light
WO2007103427A2 (en) * 2006-03-06 2007-09-13 Wang Xiang H Medical use of bilirubin and its structural analogues
US8057464B2 (en) * 2006-05-03 2011-11-15 Light Sciences Oncology, Inc. Light transmission system for photoreactive therapy
KR101456839B1 (ko) * 2006-06-30 2014-11-03 유로-셀티큐 에스.에이. 광활성제 조성물 및 광활성제의 제조 방법
EP2182835B1 (en) * 2007-08-14 2019-06-19 mivenion GmbH Device and procedure for the diagnosis or diagnostic preparation and/or therapy monitoring of inflammatory diseases such as rheumatoid arthritis
CN101426268B (zh) * 2007-11-02 2010-08-25 大唐移动通信设备有限公司 导频资源分配方法、系统和设备
WO2009065065A1 (en) * 2007-11-15 2009-05-22 Ceramoptec Industries, Inc. Pegylated liposomal formulations for photodynamic treatment of inflammatory diseases
CN107987081B (zh) * 2016-10-26 2019-12-06 刘辉 一种二氢卟吩e6衍生物及其药学上可接受的盐、其制备方法和应用
US20230330138A1 (en) * 2022-04-14 2023-10-19 Creative Medical Technologies, Inc. Treatment of cartilage degeneration using myeloid suppressor cells and exosomes derived thereof

Family Cites Families (13)

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US3102891A (en) * 1959-11-16 1963-09-03 Elmer A Allen New porphyrinic and chlorophyllic compositions and process therefor
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4693885A (en) * 1984-07-18 1987-09-15 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4656186A (en) * 1985-04-30 1987-04-07 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US5066274A (en) * 1985-04-30 1991-11-19 Nippon Petrochemicals Company, Ltd. Tetrapyrrole therapeutic agents
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
US5004811A (en) * 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US4997639A (en) * 1989-11-27 1991-03-05 Nippon Petrochemicals Company, Limited Method for detecting cholesterol deposited in bodies of mammals
JP3154742B2 (ja) * 1991-04-30 2001-04-09 日本石油化学株式会社 哺乳類の動脈硬化症治療剤
PT680365E (pt) * 1992-11-20 2000-07-31 Univ British Columbia Activacao de agentes fotossensibilizadores
US5368841A (en) * 1993-02-11 1994-11-29 The General Hospital Corporation Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides

Also Published As

Publication number Publication date
CN1074665C (zh) 2001-11-14
CN1099613A (zh) 1995-03-08
US5430051A (en) 1995-07-04
TW259706B (enExample) 1995-10-11
JPH06305961A (ja) 1994-11-01
EP0629409A1 (en) 1994-12-21
KR100254135B1 (ko) 2000-05-01
US5567409A (en) 1996-10-22
CA2121716A1 (en) 1994-10-23
CA2121716C (en) 2008-01-08

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