JP3504999B2 - New cosmetic composition - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition that suppresses sebum lipid peroxide and restores the skin normalizing function.

[0002]

2. Description of the Related Art The skin, especially the skin of women, shows so-called skin troubles such as the appearance of spots and the increase of wrinkles in accordance with the aging. It has a lot to do with the degree of sebum peroxidation.
In other words, the decrease in skin collagen that is the background of the increase in wrinkles is due to the accumulation of sebum lipid peroxide, and the fact that brown spots such as melasma and dark brown spots on female facial melanosis are both due to an increase in sebum lipid peroxide. It will appear in proportion. (Ritsuko Hayakawa, Lipid peroxide in sebum and skin diseases, Clinical dermatology, 2
9, 1975. )

This increase in sebum lipid peroxide depends not only on the intrinsic factors of the individual, but on the facial skin which is always in contact with the outside air, it depends on the mass of oxide in the atmosphere. The oxide mass in the atmosphere, which is large and is represented by nitrogen oxide, tends to increase more and more in recent years. While cosmetic quality in Japan has reached one of the highest levels in the world in terms of formulation, the dermatologists point out that, for example, female spots are 100 times more pre-war. However, the current countermeasures by cosmetics are completely ineffective, and antioxidants commonly used in cosmetics are exclusively formulated to prevent deterioration of oils and waxes which are cosmetic ingredients, such as ascorbic acid, tocopherol, and vitamins. A
In terms of stability and safety, etc., the cosmetics on the market do not actively prevent the peroxidation of skin lipids.

Further, it goes without saying that the increase in sebum lipid peroxide promotes the aging of the skin, but since this aging is synonymous with the decrease of the skin moisturizing property, the incorporation of a moisturizing agent into cosmetics causes an increase in the amount of softness It is one of the means to prevent the aging of the skin that is embodied by. Here, honey has been used as a natural moisturizer in cosmetics, but its moisturizing power is not particularly dry compared to other moisturizers such as glycerin, sorbitol, propylene glycol and butylene glycol. The natural use of the moisturizer is that it can give a sense of security to users of cosmetics.

In any case, it is clear that the aging of the skin is deteriorating in terms of both the tendency to lose skin moisturizing properties and the tendency to promote sebum peroxidation, and the cosmetic composition that can contribute to the improvement is extremely scarce. .

[0006]

It is needless to say that the skin has a resistance to dryness and oxidization against aging, but it must be remembered that the basic immunity of the skin, that is, the normalizing power, must be remembered. It is maintenance. The present invention is such a need in view, to help immune function maintenance of skin suppresses peroxidation of sebum, safe moisturizer of natural capable allowed decelerate the acceleration of skin aging functionally, over the new skin lipids Oxidation
It is intended to be provided as an inhibitor .

[0007]

A novel skin according to the present invention
Skin lipid antioxidants are used in order to achieve such a purpose, β-carboxyethyl germanium sesquioxy
De-water solution is mixed with honey, and this is fed to bees and honey is collected.
Honey or β-carboxyethyl obtained by
Mixed aqueous solution of rugermanium sesquioxide and sucrose
Fluid and invertase, diastase and glucose
To react with oxidase and mix it with honey
The honey obtained from these (hereinafter, these honeys are referred to as “natural compound
It is characterized in that it is composed of "organic germanium-containing honey") .

Organic germanium is used for internal
-Activator, interferon inducer
It is obvious that it shows the function as
When directly converting to cosmetics, use it as a synthetic chemical raw material.
To prevent the skin from feeling uncomfortable,
From the general usage of cosmetics that is continuously applied to one place,
Gives a more natural skin familiarity and further safety
There is a need. According to the present inventionSkin lipid peroxide
In order to achieve such an objective, synthetic organic germanium
A group of bees fed by Ni and fed
The honey produced by the natural organic germanium
And honey compatibilization, as well as the moisturizing properties of honey,
It was able to give sustained release of rumanium on the skin.
It In the above structure, a natural synthetic organic germanium-containing material is included.
Honey can be obtained as follows, for example.

Organic germanium, for example, Japanese Examined Patent Publication No. 59-3
5917, β obtained by JP-A-61-5087, etc.
Mixing an aqueous solution of carboxyethyl germanium sesquioxide with honey and feeding it to a group of bees for nectaring.

Further, for example, the above β-carboxyethyl germanium sesquioxide is dissolved in an aqueous sucrose solution,
Invertase (β-fructofuranosidase, α-glucosidase) which is a bee enzyme, diastase, glucose oxidase and the like are added and mixed for a certain period of time, and then mixed with honey.

[0011] When the honey containing the synthetic organic germanium thus naturalized is compared with the honey containing the non-natural synthetic organic germanium which is obtained by mixing the same amount of the honey having the same concentration of the starting synthetic organic germanium, the total honey The acidity is 107.6 in the case of non-naturalization, whereas in the case of naturalization, the feed honey is 88.9 and the bee enzyme reaction honey is 87.7. Furthermore, its oral LD ₅₀ value is 2000 mg / kg or more, confirming the negative mutagenicity (both by the Japanese Food Analysis Center) and supporting high safety.

The thus-obtained honey containing natural synthetic organogermanium meets the honey specifications as a raw material for cosmetics, and can be used as a composition for all cosmetics and quasi drugs.

Examples of the present invention will be described in detail below with reference to synthetic organic germanium-fed honey (hereinafter referred to as feeding honey) and honey enzyme reaction-synthesized organic germanium-containing honey (hereinafter referred to as enzyme honey). .

(Example 1) Feeding honey-β-carboxyethyl germanium sesquioxide 8 g was dissolved in 670 g of water and mixed well with 4.8 kg of honey (sugar content 71, specific gravity 1.375, PH4). This was fed to a group of about 50,000 bees, and after 3 days, 4.7 kg of germanium-containing honey (germanium concentration 446 ppm ... by optical emission spectroscopy) was obtained. On the other hand, under the same conditions, the honey collected from the feed which did not add β-carboxyethylgermanium sesquioxide was 4.3 kg, and the number of honeybees was 10% higher than that of the latter.

Example 2 Enzyme honey-β-carboxyethylgermanium sesquioxide (5 g) was dissolved in 40% sucrose aqueous solution (95 g) to give β-fructofuracinidase and α.
-Adding glucosidase, diastase, glucose oxidase, PH 5.0-7.0, temperature 30-40
After mixing and reacting at ℃ for 6 hours, it was mixed with 957g of normal honey, and gently stirred at room temperature under normal pressure for 3 weeks, then vacuum-dried and 1.0kg of germanium-containing honey (germanium concentration 2,140ppm ... By spectroscopic analysis).

(Test Example 1) The synthetic organic germanium-fed honey of Example 1 was placed to prepare a cosmetic cream with the following formulation. ~ Cream A. Prescription ~ Stearic acid ... 5.0 (% by weight, the same applies below) Cetanol ... 3.0 Squalane ... 6.0 Isopropyl myristate ... 4.0 Glycerin fatty acid ester ... 3.0 Feeding Honey …… 10.0 Sorbit …… 10.0 Paraben ………… 0.2 Triethanolamine ………… 0.9 Made up to 100.0 with purified water. Separately, a cosmetic cream was prepared in which the honey not fed with the synthetic organic germanium of Example 1 was replaced with the fed honey in the above formulation. ~ Cream B. Volunteer woman with no abnormalities on her facial skin 2
The names (46 years old and 43 years old) were tried using the above-mentioned cosmetic creams, Cream A and Cream B, under the following conditions, and the transition of lipid peroxide after pre-application for each cream was observed on the same face portion.

Two volunteer women were separately applied with cream A and cream B for 5 days before going to bed and washed with warm water when waking up. The lipstick was used as the only makeup during the day, and changes in the amount of sebum lipid peroxide before and after the cream trial were observed.

Regarding sebum lipid peroxide, after washing with soap for 1 hour, 2 cm ² gauze previously dipped in an ether / methanol mixture (2: 1, V / V) was sealed at the center of the forehead and 3 places on both cheeks. 2 minutes after application, soak this gauze in 10 ml of ether / methanol mixture for 2 minutes,
Numerical values measured by the A (thiobarbituric acid) method were compared before and after the test.

The change in the amount of sebum lipid peroxide before and after the test increased 0.88 times in the case of the cream A (containing fed honey) trial and 2.1 in the case of the cream B (containing non-fed honey) trial.
It was a 9-fold increase. Since no makeup other than lipstick was applied during the day of the test period, there was a tendency for the peroxidation of sebum to be accelerated due to the thinning of the shielding of ultraviolet rays and atmospheric oxides.
In the case of (combined with honey containing natural synthetic organic germanium), the suppressing effect is clearly seen.

Test Example 2 Honeybee enzyme reaction-synthesized organic germanium-containing honey of Example 2 was placed, and a bath agent was prepared according to the following formulation. ~ Bath agent A. Prescription ~ Touki extract ………… 0.2 (wt%, same below) Matsukasa extract …… 0.2 Clove extract …… 0.05 Enzyme honey ………… 5.0 Hot water glycerin …… 15.0 Ethanol …… ... 10.0 Paraben ... 0.3 Chlorhexidine gluconate solution (20%) ... 0.1 Sodium hydroxide, anhydrous citric acid ... Each appropriate amount Purified water to 100.0. Separately, a bath agent was prepared in which normal honey (without organic germanium) conforming to cosmetic standards was blended in place of the enzyme honey in the above formulation. ~ Bath agent B. Two volunteers with no history of skin allergies (28 years old, 33 years old-equivalent to skin color tone by visual observation with colorimeter) tried bath agent A and bath agent B under the following conditions. The bath sun resistance after pre-application of each bath agent was observed.

Two volunteer men were made to separately use bath agent A and bath agent 4 for 4 weeks. When bathing once a day, the bathing time in a bath containing a prescribed amount of this bath agent is set to a total of 10 minutes or longer, and the trial period (from summer 1st August
(August 28) Before and after, the degree of redness of the skin on the upper arm 1 hour after noon and after 24 hours of bathing sunlight was visually compared with a colorimeter.

In both the bath agent A and bath agent B trials, in the 1-hour bathing sun test before the trial, the skin redness of the upper arm was remarkable after 24 hours, and a remarkable heat sensation continued for several hours. On the day, there was a lot of pain due to contact with clothing and bedding. At 24 hours after the bath sunlight test after the end of the trial, both had skin erythema on the upper arm, but the extent of the change was the same as before the trial for bath agent B. The person who tried the agent A had a very slight degree of reddening of the skin, and did not feel any skin pain or hot flashes thereafter. It is presumed that organogermanium in the enzyme honey is the result of activating the immune system against UV stress, that is, suppressing lipid peroxide.

In Test Example 1 and Test Example 2, no skin abnormality was observed during the test period and one week after the test period, which may be caused by the use of the trial product.

In addition to the above examples, the honey containing natural synthetic organic germanium can be incorporated into all cosmetics and quasi-drugs for external use.

[0025]

The novel skin lipid peroxidation according to the present invention
As described above, the use of the inhibitor in cosmetics and quasi-drugs can suppress the peroxidation of skin sebum and effectively slow down the acceleration of skin aging. In other words, it has certain significance as a countermeasure against the environmental conditions that are expected to deteriorate more and more for the skin and eventually the human body.

Claims (3)

(57) [Claims] 1. A method for producing a skin lipid peroxidation inhibitor.
I, β - carboxyethyl germanium sesqui oxy
Solution of indose and sucrose, and invertase
React with stase and glucose oxidase
Β - carbohydrate, which has a skin lipid peroxidation inhibitory effect
Obtaining the xyethyl germanium sesquioxide-containing material,
A manufacturing method in which this is mixed with honey. 2. Invertase is β - fructofurano
Contract that is a mixed enzyme of sidase and α - glucosidase
The manufacturing method according to claim 1. 3. The manufacturing method according to claim 1 or 2.
Antioxidant for skin lipids obtained.