CN113398236B

CN113398236B - Microcapsule composition with alopecia preventing and nourishing effects and application thereof

Info

Publication number: CN113398236B
Application number: CN202110756957.9A
Authority: CN
Inventors: 桑伟
Original assignee: Beijing Jianxun Pharmaceutical Technology Co ltd
Current assignee: Beijing Jianxun Pharmaceutical Technology Co ltd
Priority date: 2021-07-05
Filing date: 2021-07-05
Publication date: 2022-07-29
Anticipated expiration: 2041-07-05
Also published as: CN113398236A

Abstract

The invention relates to a microcapsule composition with alopecia preventing and nourishing effects, which comprises the following components in percentage by mass: 0.5 to 20.0 percent of vitamin E, 0.5 to 20.0 percent of ginger root oil, 0.5 to 20.0 percent of rice fermentation liquor and a pharmaceutically acceptable carrier. The microcapsule composition disclosed by the invention has the advantages of good oxidation resistance, good anti-hair loss and nourishing effects, high stability, safety, no toxicity, environmental friendliness and the like, is used for preparing products such as shampoo, hair conditioner, hair mask and the like, and meets the anti-hair loss and nourishing requirements of various people.

Description

Microcapsule composition with alopecia preventing and nourishing effects and application thereof

Technical Field

The invention relates to the field of medicines, in particular to a microcapsule composition with alopecia prevention and nourishing effects, a preparation method and application thereof.

Background

The hair is one of the important indexes of human health and plays an important role in instrument appearance. Modern people are affected by factors such as busy life, working pressure, environmental pollution and the like, and the conditions of easy hair breakage, early aging and the like occur, so that the personal image is seriously affected. Male and female baldness people are more and show a trend of youthfulness.

beta-Nicotinamide Mononucleotide (NMN) is a precursor substance with high safety and used for increasing the concentration of NAD + in vivo, participates in the synthesis of important intracellular energy conversion coenzyme NAD (Nicotinamide adenine dinucleotide), and has the obvious effects of resisting aging and oxidation, reducing apoptosis, prolonging the service life, inhibiting the aging of nerves and blood vessels, improving diabetes and complications thereof and the like. Research shows that NMN supplementation can prolong the life of mammals by over 30%.

NAD + is an important coenzyme for the tricarboxylic acid cycle and cell energy conversion of the body, promotes the metabolism of sugar, fat and amino acid, participates in energy synthesis, and is a unique substrate of coenzyme I consuming enzymes (such as DNA repair enzyme PARP, longevity protein Sirtuins, cyclic ADP ribose synthetase CD38/157 and the like). With the aging, the body NAD + concentration shows a gradual decline trend, thereby causing problems of neural degeneration, vision decline, obesity, heart function decline, aging and the like, and exogenous NAD + supplementation is needed.

Aging is mainly manifested by loss of body tissue cells and constituent substances, slowing of metabolic rate and hypofunction, and presentation of time-dependent endogenous changes. The low cellular immune function is one of the important causes of aging and various senile diseases. Research shows that the anti-aging effect can be realized by enhancing cell activity and immunity, oxygen radical scavenging capacity and the like. The immunoactive substance has antiaging effect. The oxygen radicals cause lipid peroxidation of polyunsaturated fatty acids in biological membranes to produce Lipid Peroxides (LPO). The decomposition of LPO produces harmful Malondialdehyde (MDA) to cause various biochemical toxic reactions, including the formation of abnormal metabolites such as senile plaque, lipofuscin, etc., which cause aging of the body and various diseases. The antioxidant system in human body, including superoxide dismutase (SOD), Catalase (CAT) and glutathione peroxidase (GSH-Px), can eliminate free radicals in vivo, reduce oxidative damage of organism and resist aging.

The ginger root oil is volatile oil extracted from ginger root, is rich in mineral substances, has the effects of promoting hair growth, removing scalp dryness and itching, enhancing skin activity, activating skin, resisting oxidation and aging, inhibiting dermatophyte, preventing corrosion and inflammation, keeping scalp clean and healthy and the like, and has the effects of preventing alopecia, nourishing and the like. But the concentration is selected to reduce the skin irritation.

The rice fermentation liquor is a natural rice bran fermentation product, is rich in effective components such as gamma-oryzanol, biological polysaccharide, amino acid and the like, has the effects of activating glutathione reductase, whitening skin, inhibiting melanin from growing, inhibiting tyrosinase from activating and the like, promotes the generation of cholesterol, cerebral amide and sebum, improves the skin softness, has the effects of resisting oxidation, conditioning, activating skin, resisting aging and the like, effectively improves the broken hair and alopecia caused by rough and branched hair, and increases the hair luster.

The seaweed extract contains alginic acid, crude protein, multiple vitamins, enzymes, trace elements and the like, has a remarkable moisturizing effect, increases the color and softness of hair, reduces static charge of the hair, improves split ends of the hair, and increases the conditioning property of the hair.

The existing anti-hair loss nourishing composition containing NMN has the following defects: firstly, the problems of alopecia, hair loss, scalp itching and the like easily caused by silicon containing; secondly, most of the plant extracts are compounded, and the compatibility among the components is insufficient to influence the stability of the product and the like. Therefore, it is required to develop a nutritious and economically stable composition for preventing alopecia and nourishing hair.

Disclosure of Invention

The invention aims to provide a microcapsule composition with alopecia prevention and nourishing effects, which comprises the following components in percentage by mass: 0.5 to 20.0 percent of vitamin E, 0.5 to 20.0 percent of ginger root oil, 0.5 to 20.0 percent of rice fermentation liquor and a pharmaceutically acceptable carrier.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 1.0-8.0% of vitamin E, 1.0-8.0% of ginger root oil and 1.0-15.0% of rice fermentation liquor.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 2.0 to 6.0 percent of vitamin E, 2.0 to 6.0 percent of ginger root oil and 2.0 to 12.0 percent of rice fermentation liquor.

In the preferred technical scheme of the invention, the ginger root oil extraction process uses supercritical CO ₂ And (4) extracting.

In the preferred technical scheme of the invention, the preparation of the rice fermentation liquor comprises the following steps of inoculating yeast into rice according to the inoculation amount of 1-5%, and fermenting at the fermentation temperature of 20-30 ℃ for 30-120h to obtain the rice fermentation liquor.

In the preferable technical scheme of the invention, the pharmaceutically acceptable carrier comprises 5.0-30.0% of sucrose palmitate, 5.0-40.0% of water, 2.0-20.0% of glycerol linoleate, 0.5-4.0% of phenoxyethanol, 0-0.5% of potassium sorbate and 0.05-0.20% of citric acid.

In the preferable technical scheme of the invention, the pharmaceutically acceptable carrier contains 10.0-25.0% of sucrose palmitate, 10.0-35.0% of water, 5.0-15.0% of glycerol linoleate, 1-3.5% of phenoxyethanol, 0.1-0.4% of potassium sorbate and 0.1-0.15% of citric acid.

In the preferable technical scheme of the invention, the pharmaceutically acceptable carrier comprises 15.0-20.0% of sucrose palmitate, 15.0-30.0% of water, 8.0-12.0% of glycerol linoleate, 1.5-3% of phenoxyethanol, 0.15-0.35% of potassium sorbate and 0.11-0.13% of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 0.5 to 10.0 percent of vitamin E, 0.5 to 10.0 percent of ginger root oil, 0.5 to 20.0 percent of rice fermentation liquor, 5.0 to 30.0 percent of sucrose palmitate, 5.0 to 40.0 percent of water, 2.0 to 20.0 percent of glycerol linoleate, 0.5 to 4.0 percent of phenoxyethanol, 0.05 to 0.5 percent of potassium sorbate and 0.05 to 0.20 percent of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 1.0-8.0% of vitamin E, 1.0-8.0% of ginger root oil, 1.0-15.0% of rice fermentation liquor, 5.0-30.0% of sucrose palmitate, 5.0-40.0% of water, 2.0-20.0% of glycerol linoleate, 0.5-4.0% of phenoxyethanol, 0.05-0.5% of potassium sorbate and 0.05-0.20% of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 2.0-6.0% of vitamin E, 2.0-6.0% of ginger root oil, 2.0-12.0% of rice fermentation liquor, 5.0-30.0% of sucrose palmitate, 5.0-40.0% of water, 2.0-20.0% of glycerol linoleate, 0.5-4.0% of phenoxyethanol, 0.05-0.5% of potassium sorbate and 0.05-0.20% of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 0.5 to 10.0 percent of vitamin E, 0.5 to 10.0 percent of ginger root oil, 0.5 to 20.0 percent of rice fermentation liquor, 10.0 to 25.0 percent of sucrose palmitate, 10.0 to 35.0 percent of water, 5.0 to 15.0 percent of glycerol linoleate, 1 to 3.5 percent of phenoxyethanol, 0.1 to 0.4 percent of potassium sorbate and 0.1 to 0.15 percent of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 1.0-8.0% of vitamin E, 1.0-8.0% of ginger root oil, 1.0-15.0% of rice fermentation liquor, 10.0-25.0% of sucrose palmitate, 10.0-35.0% of water, 5.0-15.0% of glycerol linoleate, 1-3.5% of phenoxyethanol, 0.1-0.4% of potassium sorbate and 0.1-0.15% of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 2.0-6.0% of vitamin E, 2.0-6.0% of ginger root oil, 2.0-12.0% of rice fermentation liquor, 10.0-25.0% of sucrose palmitate, 10.0-35.0% of water, 5.0-15.0% of glycerol linoleate, 1-3.5% of phenoxyethanol, 0.1-0.4% of potassium sorbate and 0.1-0.15% of citric acid.

In the preferable technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 0.5 to 10.0 percent of vitamin E, 0.5 to 10.0 percent of ginger root oil, 0.5 to 20.0 percent of rice fermentation liquor, 15.0 to 20.0 percent of sucrose palmitate, 15.0 to 30.0 percent of water, 8.0 to 12.0 percent of glycerol linoleate, 1.5 to 3 percent of phenoxyethanol, 0.15 to 0.35 percent of potassium sorbate and 0.11 to 0.13 percent of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 1.0-8.0% of vitamin E, 1.0-8.0% of ginger root oil, 1.0-15.0% of rice fermentation liquor, 15.0-20.0% of sucrose palmitate, 15.0-30.0% of water, 8.0-12.0% of glycerol linoleate, 1.5-3% of phenoxyethanol, 0.15-0.35% of potassium sorbate and 0.11-0.13% of citric acid.

In the preferred technical scheme of the invention, the microcapsule composition contains the following components in percentage by mass: 2.0-6.0% of vitamin E, 2.0-6.0% of ginger root oil, 2.0-12.0% of rice fermentation liquor, 15.0-20.0% of sucrose palmitate, 15.0-30.0% of water, 8.0-12.0% of glycerol linoleate, 1.5-3% of phenoxyethanol, 0.15-0.35% of potassium sorbate and 0.11-0.13% of citric acid.

In the preferred technical scheme of the invention, the rice fermentation liquor contains 93-95% of rice fermentation product filtrate, 3-5% of propylene glycol, 0.4-0.6% of phenoxyethanol and 0.08-0.12% of ethylhexyl glycerol.

In the preferred technical scheme of the invention, the rice fermentation product filtrate is prepared by fermenting rice with saccharomycetes.

In the preferable technical scheme of the invention, the rice fermentation liquor is colorless to yellowish liquid.

In the preferable technical scheme of the invention, the pH of the rice fermentation liquor is 3.5-6.5, and the preferable pH is 4-6.

In the preferred technical scheme of the invention, the refractive index of the rice fermentation liquor is 1.3-1.4.

In the preferred technical scheme of the invention, the vitamin E is natural VE, and the preferred VE purity is more than 99.0%.

In the preferred technical scheme of the invention, the ginger root oil is prepared by adopting a supercritical carbon dioxide extraction technology, and the purity of the ginger root oil is preferably more than 99.0%.

In the preferred technical scheme of the invention, the ginger root oil is a red brown oily liquid.

In the preferable technical scheme of the invention, the refractive index of the ginger root oil at 20 ℃ is 1.467-1.487.

In the preferred technical scheme of the invention, the density of the ginger root oil is 1.048-1.068.

In the preferred technical scheme of the invention, the ginger root oil has the pH of 4-8, preferably 5.5-7.

In the preferred embodiment of the present invention, the microcapsule composition has a pH of 4-8, preferably 5.5-7.

In the preferred embodiment of the present invention, the microcapsule composition is prepared by a conventional preparation method in the art.

In a preferred embodiment of the present invention, the microcapsule composition is prepared by a single coacervation method or a double coacervation method.

In a preferred embodiment of the present invention, the microcapsule composition has a multi-layer structure including an aqueous active layer and an oil active layer.

The invention aims to provide a composition with the effects of preventing alopecia and nourishing, which comprises 10.0-80.0% of microcapsule composition, 5.0-50.0% of NMN, 5.0-50.0% of seaweed extract and a pharmaceutically acceptable carrier.

In the preferable technical scheme of the invention, the microcapsule composition in the composition comprises 40.0-70.0 percent of NMN 10.0-30.0 percent and 10.0-30.0 percent of seaweed extract.

In the preferable technical scheme of the invention, the microcapsule composition comprises 55-65.0% of microcapsule composition, 15.0-20.0% of NMN and 15-20.0% of seaweed extract.

In the preferred technical scheme of the invention, the NMN is obtained by enzymatic synthesis.

In the preferred technical scheme of the invention, the NMN purity is more than or equal to 99.0 percent, and preferably more than or equal to 99.5 percent.

In the preferable technical scheme of the invention, the seaweed extract is prepared by a compound extraction method.

In the preferable technical scheme of the invention, the content of the effective substances in the seaweed extract is more than or equal to 90.0%.

In the preferable technical scheme of the invention, the seaweed extract is colorless semitransparent viscous liquid.

In the preferred technical scheme of the invention, the seaweed extract has the pH of 3-8, preferably the pH of 4-5.

In the preferred technical scheme of the invention, the refractive index of the seaweed extract is 1.33-1.4, and preferably 1.36-1.37.

In the preferred embodiment of the present invention, the gel viscosity of the seaweed extract at 25 ℃ is 1500-3500 mPas, preferably 2000-3100 mPas.

In the preferred technical scheme of the invention, the total solid content in the seaweed extract is more than or equal to 25 percent, and preferably more than or equal to 25.5 percent.

In the preferred technical scheme of the invention, the polysaccharide content in the seaweed extract is more than or equal to 1000mg/kg, preferably 1160-1200 mg/kg.

In the preferred technical scheme of the invention, the specific gravity of the seaweed extract is 0.9-1.35, preferably 1.0-1.1.

In the preferred technical scheme of the invention, the total number of colonies of the seaweed extract is not higher than 100 cfu/g.

Another object of the present invention is to provide the use of the microcapsule composition or the composition of the present invention for preparing any one of shampoo, conditioner and hair mask.

Another object of the present invention is to provide a hair composition having alopecia prevention and nourishing effects, which contains the microcapsule composition of the present invention in an amount of 0.5 to 50.0% and a hair composition carrier.

In a preferred embodiment of the present invention, the hair composition contains 1 to 40.0%, preferably 5.0 to 35.0%, more preferably 10 to 30%, and still more preferably 15 to 25% of the microcapsule composition or the composition of the present invention.

In a preferred embodiment of the present invention, the hair composition is selected from any one of shampoo, conditioner and hair mask.

Unless otherwise indicated, when the present invention relates to percentages between liquids, said percentages are volume/volume percentages; when the invention relates to percentages between liquid and solid, said percentages are volume/weight percentages; the invention relates to the percentages between solid and liquid, said percentages being weight/volume percentages; the balance being weight/weight percent.

Compared with the prior art, the invention has the following beneficial technical effects:

1. the invention scientifically selects and matches microcapsule compositions (vitamin E, ginger root oil, rice fermentation liquor and the like) with the effects of preventing alopecia and nourishing, and the components and the proportion of the compositions (the microcapsule compositions, NMN, seaweed extracts and the like), and encapsulates various effective components in micro-sealed microcapsules by adopting a microencapsulation technology, thereby improving the stability of the preparation, realizing the controlled release of the effective components, improving the resource utilization rate and the effects of preventing alopecia and nourishing of the microcapsule compositions, having the advantages of good stability, excellent and lasting effects of preventing alopecia and nourishing, safety, no toxicity, environmental protection and the like, and being widely suitable for various crowds.

2. The microcapsule composition (vitamin E, ginger root oil, rice fermentation liquor and the like) with the anti-hair loss and nourishing effects and the composition (the microcapsule composition, NMN, seaweed extract and the like) thereof are used for preparing hair compositions such as shampoo, hair conditioner, hair mask and the like, so that the anti-hair loss and nourishing effects of the hair composition are remarkably enhanced, and the anti-hair loss and nourishing requirements of various people are met.

3. The preparation method has the advantages of simple and convenient operation, high yield, environmental protection, suitability for industrial production and the like.

Detailed Description

The following specific embodiments are provided to further illustrate the present invention, but the present invention is not limited to only the following embodiments.

The test methods used in the embodiments are all conventional methods unless otherwise specified; the materials, reagents and the like used are commercially available unless otherwise specified.

Examples 1 to 5Preparation of the microcapsule composition with alopecia preventing and nourishing effects

The compositions and proportions of the microcapsule compositions with the effects of preventing alopecia and nourishing hair in examples 1-5 are shown in Table 1.

TABLE 1

Wherein, the ginger root oil and the rice fermentation liquor are all sold in the market. Examples 1-5 preparation of microcapsule compositions comprising the following steps: weighing vitamin E, ginger root oil, rice fermentation liquor and pharmaceutically acceptable carriers, uniformly mixing, and preparing the microcapsule composition. Wherein the microcapsule composition is prepared by a method conventional in the art.

Examples 6 to 10Preparation of hair composition with alopecia preventing and nourishing effects

The compositions and proportions of the compositions with anti-alopecia and nourishing effects of examples 6-10 are shown in Table 2.

TABLE 2

Wherein, the ginger root oil, the rice fermentation liquor and the seaweed extract are all sold in the market.

Examples 6-10 preparation of hair compositions comprising the following steps: the microcapsule composition prepared in examples 1 to 5 was uniformly mixed with the required amount of NMN and the seaweed extract, and stirred.

Example 11Preparation of shampoo with anti-hair loss and nourishing effects

Heating 56.94% of deionized water, 20% of sodium laureth sulfate, 0.3% of guar gum hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 2.5% of cocamide MEA, 0.5% of ethylene glycol distearate, 5% of sodium lauroyl sarcosinate MEA, 0.2% of polyquaternary ammonium salt and 0.06% of citric acid to 80-90 ℃, uniformly stirring, and cooling to 40-55 ℃; adding 8% of cocamidopropyl betaine, 0.2% of sodium chloride and 0.2% of methylisothiazolinone, heating to 85-95 ℃, uniformly mixing, and homogenizing for 30 minutes; cooling to below 40 ℃, adding 6.0% of the hair composition prepared in example 6, and mixing uniformly to obtain the hair care composition.

Example 12Preparation of hair conditioner with alopecia prevention and nourishing effects

75.3 percent of deionized water, 8.0 percent of cetearyl alcohol, 5.0 percent of behenyl trimethyl ammonium chloride, 4.0 percent of synthetic spermaceti, 0.2 percent of essence, 1.0 percent of glycerol, 0.2 percent of dilauryl thiodipropionate, 0.1 percent of potassium sorbate, 0.1 percent of citric acid and 0.1 percent of salicylic acid are added into the hair composition prepared in the example 7 to obtain the hair composition.

Example 13The preparation method of the hair mask with the effects of preventing alopecia and nourishing

78.0% of deionized water, 6.0% of behenyl trimethyl ammonium methyl sulfate, 5.0% of bis-aminopropyl polydimethylsiloxane, 2.0% of cetyl alcohol, 0.2% of essence, 1.0% of stearyl alcohol, 1.0% of disodium EDTA, 0.2% of sodium hydroxide, 0.1% of potassium sorbate and 0.5% of phenoxyethanol are added into 6.0% of the hair composition prepared in example 8, so that the hair care composition is obtained.

Comparative examples 1 to 2The preparation method of the hair mask with the effects of preventing alopecia and nourishing

A hair mask having alopecia preventing and nourishing effects was prepared according to table 2 and the effect thereof was verified.

TABLE 2

Test example 1Study of skin sensitization by the composition of the present invention

A skin sensitization test is carried out by adopting a local closed skin coating method in a skin allergy test method published in technical Specification for cosmetic safety, and adopting healthy guinea pigs.

A total of 35 healthy guinea pigs were used for the test and divided into 7 groups. The shampoo prepared in example 11 was used in test 1, the conditioner prepared in example 12 was used in test 2, the hair mask prepared in example 13 was used in test 3, the hair mask prepared in comparative example 1 was used in test 4, the hair mask prepared in comparative example 2 was used in test 5, and a butanediol solution (volume fraction of 2/98) of 2, 4-dinitrochlorobenzene was used as a positive sensitizer in the positive control.

1. Induced contact test: on day 1, 0.2g of the prepared hair composition of example 11 above was applied to the depilatory area of 2cm × 2cm on the back of the left side of the subject guinea pig, covered with 2 layers of gauze and 1 layer of cellophane, and sealed with a non-irritating adhesive tape for 6 hours. The same procedure was repeated on day 7 and day 14. The blank control group was not subjected to the contact induction test, and the positive control group was subjected to the positive control for the left-side depilated area of the back, and the contact induction method was the same as above.

2. Excitation contact test: the challenge contact test was performed on day 28, and the right depilated area of the guinea pig was treated in the same manner as the challenge contact, and the test substance was removed after 6 hours, immediately observed, and then the skin allergy was observed again at 24 and 48/72 hours. The hair composition prepared in example 11 was applied to the right depilatory area of the blank control group, and the positive control was applied to the right depilatory area of the positive control group, and the contact stimulation method was the same as above.

The compositions of the present invention did not cause weight loss in guinea pigs, but rather increased slightly, during both the induction contact and challenge contact tests compared to the placebo controls. The positive control group of guinea pigs had a significant weight loss.

Positive sensitizer 2, 4-dinitrochlorobenzene is a strong sensitizer, and all guinea pigs of the positive control group developed erythema and edema during induction contact; within three days after the contact excitation test, the phenomena of erythema and edema are more obvious, the skin reaction is moderate, and the sensitization rate reaches extremely strong intensity. In contrast, in the test group of guinea pigs and the placebo group using the composition of the present invention, no erythema and edema were found in all of the guinea pigs during and three days after the induction and challenge contact, and the guinea pigs produced no skin allergy and no sensitization.

The results show that the hair composition prepared from the composition of the invention is safe and effective.

Test example 2Research on alopecia prevention and nourishing effects of composition

The test selects 60 seborrheic alopecia and physiological alopecia volunteers with the age of 18-59 years, and the male and female are not limited. The participators can complete observation according to the requirement in a voluntary matching way, have no other diseases which can influence the research and observation results, and have not used similar anti-alopecia and nourishing products for three months before the experiment.

The test was performed by dividing 60 volunteers into 3 groups of 20 persons. Of these, the hair composition obtained in example 11 of the present invention was used in test 1, the hair pack obtained in comparative example 1 was used in test 2, and the hair pack obtained in comparative example 2 was used in test 3. The trial was tested for 8 weeks. The test subjects shampooed 4g each time every 2 days. After shampooing in the early morning, the subjects were observed for the improvement in the number of hair loss and the growth of new hairs before and after use.

The criteria for judging the effect are as follows:

the effect is shown: the number of hair loss is reduced by more than 50 percent compared with that before treatment in a combing test, and new hairs grow more;

the method has the following advantages: the hair loss number is reduced by less than or equal to 50 percent in a combing test of more than 20 percent than before treatment, and new hairs grow less;

and (4) invalidation: the hair loss number of the hair in the combing test is reduced by less than or equal to 20 percent compared with that before treatment, and no new hair grows.

The results are shown in Table 3.

TABLE 3

The results show that the hair composition prepared in example 11 of the present invention has significantly better anti-alopecia nourishing effects than comparative examples 1 and 2.

Although the present invention has been described with reference to the above embodiments, it should be understood that the present invention is not limited thereto, and various changes and modifications may be made by those skilled in the art without departing from the spirit and scope of the present invention.

Claims

1. The shampoo with the effects of preventing hair loss and nourishing is characterized in that the preparation method of the shampoo comprises the following steps: heating 56.94% of deionized water, 20% of sodium laureth sulfate, 0.3% of guar gum hydroxypropyl trimethyl ammonium chloride, 0.1% of EDTA disodium, 2.5% of cocamide MEA, 0.5% of ethylene glycol distearate, 5% of sodium lauroyl sarcosinate MEA, 0.2% of polyquaternary ammonium salt and 0.06% of citric acid to 80-90 ℃, uniformly stirring, and cooling to 40-55 ℃; adding 8% of cocamidopropyl betaine, 0.2% of sodium chloride and 0.2% of methylisothiazolinone, heating to 85-95 ℃, uniformly mixing, and homogenizing for 30 minutes; cooling to below 40 deg.C, adding 6.0% of the hair composition, and mixing;

the preparation method of the hair composition comprises the following steps: weighing 28.3% of deionized water, 20% of sucrose palmitate, 4.5% of glycerol linoleate, 0.8% of phenoxyethanol, 0.3% of potassium sorbate, 0.1% of citric acid, 2% of vitamin E, 3% of ginger root oil and 6% of rice fermentation liquor, uniformly mixing, and preparing the microcapsule composition; and uniformly mixing the prepared microcapsule composition with 15% of NMN and 20% of seaweed extract, and stirring to obtain the hair composition.