JP3433295B2 - キシリトールの製造のための組換え方法および宿主 - Google Patents
キシリトールの製造のための組換え方法および宿主Info
- Publication number
- JP3433295B2 JP3433295B2 JP51074894A JP51074894A JP3433295B2 JP 3433295 B2 JP3433295 B2 JP 3433295B2 JP 51074894 A JP51074894 A JP 51074894A JP 51074894 A JP51074894 A JP 51074894A JP 3433295 B2 JP3433295 B2 JP 3433295B2
- Authority
- JP
- Japan
- Prior art keywords
- host
- dehydrogenase
- gene
- phosphate
- xylitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
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- FKCRAVPPBFWEJD-UHFFFAOYSA-N orotidine Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1C(O)=O FKCRAVPPBFWEJD-UHFFFAOYSA-N 0.000 description 1
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
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- BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 239000011541 reaction mixture Substances 0.000 description 1
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- 108020005610 ribose 5-phosphate isomerase Proteins 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 244000000000 soil microbiome Species 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- 238000000856 sucrose gradient centrifugation Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
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- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229960002363 thiamine pyrophosphate Drugs 0.000 description 1
- 235000008170 thiamine pyrophosphate Nutrition 0.000 description 1
- 239000011678 thiamine pyrophosphate Substances 0.000 description 1
- YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- 230000014621 translational initiation Effects 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97332592A | 1992-11-05 | 1992-11-05 | |
| US07/973,325 | 1992-11-05 | ||
| PCT/FI1993/000450 WO1994010325A1 (en) | 1992-11-05 | 1993-11-05 | Recombinant method and host for manufacture of xylitol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08505522A JPH08505522A (ja) | 1996-06-18 |
| JP3433295B2 true JP3433295B2 (ja) | 2003-08-04 |
Family
ID=25520759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51074894A Expired - Fee Related JP3433295B2 (ja) | 1992-11-05 | 1993-11-05 | キシリトールの製造のための組換え方法および宿主 |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JP3433295B2 (fi) |
| KR (1) | KR950704503A (fi) |
| AT (1) | ATE184917T1 (fi) |
| AU (1) | AU5421594A (fi) |
| BR (1) | BR9307391A (fi) |
| CA (1) | CA2148622A1 (fi) |
| DE (1) | DE69326559T2 (fi) |
| ES (1) | ES2139024T3 (fi) |
| FI (1) | FI108300B (fi) |
| HU (1) | HU219016B (fi) |
| NO (1) | NO951747L (fi) |
| NZ (1) | NZ257561A (fi) |
| PL (1) | PL178040B1 (fi) |
| RU (1) | RU2142999C1 (fi) |
| WO (1) | WO1994010325A1 (fi) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7226761B2 (en) | 1992-11-05 | 2007-06-05 | Danisco Sweeteners Oy | Manufacture of five-carbon sugars and sugar alcohols |
| US6723540B1 (en) | 1992-11-05 | 2004-04-20 | Xyrofin Oy | Manufacture of xylitol using recombinant microbial hosts |
| GB9514538D0 (en) | 1995-07-15 | 1995-09-13 | Cerestar Holding Bv | Process for the production of xylitol |
| FR2762011B1 (fr) * | 1997-04-11 | 1999-06-25 | Roquette Freres | Procede de preparation de ribitol par voie fermentaire et souche de microorganismes mise en oeuvre dans ce procede |
| FR2765589B1 (fr) * | 1997-07-03 | 1999-09-17 | Roquette Freres | Fragment d'adn comprenant le promoteur de la ribulose reductase nadph specifique de yamadazyma ohmeri, vecteur le contenant et procede de preparation de proteines utilisant ce vecteur |
| JP3855486B2 (ja) * | 1997-10-17 | 2006-12-13 | 味の素株式会社 | キシリトールの製造法 |
| JPH11266888A (ja) * | 1997-10-17 | 1999-10-05 | Ajinomoto Co Inc | キシリトールの製造法 |
| US6335177B1 (en) | 1998-07-08 | 2002-01-01 | Ajinomoto Co., Inc. | Microorganisms and method for producing xylitol or d-xylulose |
| PE20001023A1 (es) | 1998-07-30 | 2000-10-10 | Ajinomoto Kk | Deshidrogenasa de xilitol de bacterias de acido acetico y su gen |
| JP2002531130A (ja) | 1998-12-08 | 2002-09-24 | チルドレンズ ホスピタル アンド レジオナル メディカル センター | ＥｓｃｈｅｒｉｃｈｉａｃｏｌｉＯ１５７：Ｈ７と他の株とを識別する多形遺伝子座 |
| JP2000210095A (ja) * | 1999-01-20 | 2000-08-02 | Ajinomoto Co Inc | キシリト―ル又はｄ―キシルロ―スの製造法 |
| JP2000295994A (ja) * | 1999-02-09 | 2000-10-24 | Ajinomoto Co Inc | キシリトールの製造法 |
| BR0012712B1 (pt) | 1999-07-23 | 2011-12-13 | métodos de produção de l-aminoácidos aumentando-se o nadph celular. | |
| US6830903B1 (en) | 1999-07-23 | 2004-12-14 | Archer-Daniels-Midland Company | Methods for producing L-amino acids using a corynebacterium glutamicum with a disrupted pgi gene |
| ATE464387T1 (de) * | 2000-01-21 | 2010-04-15 | Danisco | Herstellung von durch 5 kohlenstoffatome charakterisierte zucker und zuckeralkohole |
| US6894199B2 (en) | 2001-04-27 | 2005-05-17 | Danisco Sweeteners Oy | Process for the production of xylitol |
| GB2406855A (en) * | 2003-02-07 | 2005-04-13 | Danisco Sweeteners Oy | Production of xylitol from a carbon source other than xylose and xylulose |
| US20060110805A1 (en) * | 2004-05-19 | 2006-05-25 | Biotechnology Research And Development Corporation | Microbial production of xylitol via hexose phosphate and pentose phosphate intermediate |
| CA2566949C (en) * | 2004-05-20 | 2015-03-24 | Warnex Research Inc. | Polynucleotides for the detection of escherichia coli o157:h7 and escherichia coli o157:nm verotoxin producers |
| KR101246780B1 (ko) * | 2010-10-06 | 2013-03-26 | 한국과학기술원 | 아라비노스 대사경로가 도입된 자일리톨 생산균주 및 이를 이용한 자일리톨 생산방법 |
| ES2673865T3 (es) | 2014-06-18 | 2018-06-26 | Roquette Frères | Producción de xilitol a partir de glucosa mediante una cepa recombinante |
| WO2023220547A1 (en) * | 2022-05-09 | 2023-11-16 | Cargill, Incorporated | Genetically modified yeast and fermentation processes for the production of polyols |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4009676A1 (de) * | 1990-03-26 | 1991-10-02 | Rhein Biotech Proz & Prod Gmbh | Dna-sequenz, umfassend ein fuer xylosereduktase und/oder xylitoldehydrogenase codierendes strukturgen |
| FI901771A (fi) * | 1990-04-06 | 1991-10-07 | Valtion Teknillinen | Anvaendning av xylos hos hybridjaest. |
-
1993
- 1993-11-05 NZ NZ257561A patent/NZ257561A/en unknown
- 1993-11-05 RU RU95113172A patent/RU2142999C1/ru active
- 1993-11-05 CA CA002148622A patent/CA2148622A1/en not_active Abandoned
- 1993-11-05 ES ES93924615T patent/ES2139024T3/es not_active Expired - Lifetime
- 1993-11-05 AU AU54215/94A patent/AU5421594A/en not_active Abandoned
- 1993-11-05 JP JP51074894A patent/JP3433295B2/ja not_active Expired - Fee Related
- 1993-11-05 KR KR1019950701792A patent/KR950704503A/ko not_active Application Discontinuation
- 1993-11-05 BR BR9307391-7A patent/BR9307391A/pt not_active Application Discontinuation
- 1993-11-05 WO PCT/FI1993/000450 patent/WO1994010325A1/en active IP Right Grant
- 1993-11-05 HU HU9501288A patent/HU219016B/hu not_active IP Right Cessation
- 1993-11-05 DE DE69326559T patent/DE69326559T2/de not_active Expired - Lifetime
- 1993-11-05 AT AT93924615T patent/ATE184917T1/de not_active IP Right Cessation
- 1993-11-05 PL PL93308742A patent/PL178040B1/pl unknown
-
1995
- 1995-05-04 FI FI952148A patent/FI108300B/fi not_active IP Right Cessation
- 1995-05-04 NO NO951747A patent/NO951747L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE184917T1 (de) | 1999-10-15 |
| WO1994010325A1 (en) | 1994-05-11 |
| DE69326559D1 (de) | 1999-10-28 |
| FI952148A (fi) | 1995-07-04 |
| CA2148622A1 (en) | 1994-05-11 |
| HU9501288D0 (en) | 1995-06-28 |
| AU5421594A (en) | 1994-05-24 |
| NO951747D0 (no) | 1995-05-04 |
| DE69326559T2 (de) | 2000-02-10 |
| PL178040B1 (pl) | 2000-02-29 |
| BR9307391A (pt) | 1999-08-31 |
| HUT72187A (en) | 1996-03-28 |
| FI952148A0 (fi) | 1995-05-04 |
| JPH08505522A (ja) | 1996-06-18 |
| NO951747L (no) | 1995-07-05 |
| NZ257561A (en) | 1996-09-25 |
| RU95113172A (ru) | 1997-03-27 |
| RU2142999C1 (ru) | 1999-12-20 |
| PL308742A1 (en) | 1995-08-21 |
| KR950704503A (ko) | 1995-11-20 |
| ES2139024T3 (es) | 2000-02-01 |
| FI108300B (fi) | 2001-12-31 |
| HU219016B (hu) | 2001-01-29 |
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| Publication | Publication Date | Title |
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