JP3245465B2 - 凍結乾燥器棚 - Google Patents
凍結乾燥器棚Info
- Publication number
- JP3245465B2 JP3245465B2 JP32515392A JP32515392A JP3245465B2 JP 3245465 B2 JP3245465 B2 JP 3245465B2 JP 32515392 A JP32515392 A JP 32515392A JP 32515392 A JP32515392 A JP 32515392A JP 3245465 B2 JP3245465 B2 JP 3245465B2
- Authority
- JP
- Japan
- Prior art keywords
- plates
- shelf
- permeable fluid
- lyophilizer
- section
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 claims description 73
- 239000003507 refrigerant Substances 0.000 claims description 42
- 238000004108 freeze drying Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000005219 brazing Methods 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims 3
- 230000002093 peripheral effect Effects 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 3
- 238000003491 array Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 238000012546 transfer Methods 0.000 description 8
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 238000000859 sublimation Methods 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 229910052759 nickel Inorganic materials 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 230000008022 sublimation Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 238000012792 lyophilization process Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/849,846 US5519946A (en) | 1992-03-12 | 1992-03-12 | Freeze dryer shelf |
| US849846 | 1992-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05288465A JPH05288465A (ja) | 1993-11-02 |
| JP3245465B2 true JP3245465B2 (ja) | 2002-01-15 |
Family
ID=25306662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32515392A Expired - Lifetime JP3245465B2 (ja) | 1992-03-12 | 1992-12-04 | 凍結乾燥器棚 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5519946A (Sortimente) |
| EP (1) | EP0560632B1 (Sortimente) |
| JP (1) | JP3245465B2 (Sortimente) |
| DE (1) | DE69315726T2 (Sortimente) |
| ES (1) | ES2110569T3 (Sortimente) |
| FI (1) | FI108881B (Sortimente) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103140731A (zh) * | 2010-09-28 | 2013-06-05 | 巴克斯特国际公司 | 使用间隙冷冻来优化冻干的成核和结晶 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5398426A (en) * | 1993-12-29 | 1995-03-21 | Societe' De Gestion Et De Diffusion North America, Inc. | Process and apparatus for desiccation |
| US5743023A (en) * | 1996-09-06 | 1998-04-28 | Fay; John M. | Method and apparatus for controlling freeze drying process |
| US5701745A (en) * | 1996-12-16 | 1997-12-30 | Praxair Technology, Inc. | Cryogenic cold shelf |
| US6047484A (en) * | 1998-07-10 | 2000-04-11 | Bolland; Karin Marie | Method and apparatus for evaporating liquid from a product |
| US6220048B1 (en) | 1998-09-21 | 2001-04-24 | Praxair Technology, Inc. | Freeze drying with reduced cryogen consumption |
| US6610250B1 (en) | 1999-08-23 | 2003-08-26 | 3M Innovative Properties Company | Apparatus using halogenated organic fluids for heat transfer in low temperature processes requiring sterilization and methods therefor |
| RU2179810C2 (ru) * | 1999-12-22 | 2002-02-27 | Белгородская государственная сельскохозяйственная академия | Технологическое устройство сушки кормов и сушилка |
| JP4312339B2 (ja) * | 2000-02-24 | 2009-08-12 | ナブテスコ株式会社 | 蛇行通路付熱伝達装置 |
| US6434913B1 (en) | 2000-09-15 | 2002-08-20 | Thomas Hatch | Single-use syringe |
| US6557366B1 (en) | 2001-08-14 | 2003-05-06 | Donatos Pizzeria Corporation | Apparatus for cold-holding food products |
| US7347004B1 (en) | 2005-01-13 | 2008-03-25 | Lyophilization Services Of New England, Inc. | Freeze drying apparatus and method |
| US20070137061A1 (en) * | 2005-12-19 | 2007-06-21 | Gerald Bogdan | Freeze dryer shelf assembly |
| GB2434633A (en) * | 2006-01-27 | 2007-08-01 | Boc Group Plc | Freeze dryer shelf comprising a corrugated sheet defining a flow channel |
| GB0609113D0 (en) * | 2006-05-09 | 2006-06-21 | Boc Group Plc | Freeze Dryer Shelf |
| US8015841B2 (en) * | 2006-09-08 | 2011-09-13 | Praxair Technology, Inc. | Cryogenic refrigeration system for lyophilization |
| US7914904B2 (en) * | 2008-03-25 | 2011-03-29 | General Electric Company | Component in a combustion system, and process for preventing slag, ash, and char buildup |
| WO2011008245A1 (en) * | 2009-07-14 | 2011-01-20 | Ima Life North America Inc. | Enhanced freeze dryer shelf manufacturability through the use of open shape or line contact spacers |
| CN101782310A (zh) * | 2010-03-16 | 2010-07-21 | 上海东富龙制药设备制造有限公司 | 一种冻干机钎焊板层 |
| CN101780574A (zh) * | 2010-03-16 | 2010-07-21 | 上海东富龙制药设备制造有限公司 | 一种冻干机板层筋条的焊接方法 |
| CN101839621A (zh) * | 2010-03-16 | 2010-09-22 | 上海东富龙制药设备制造有限公司 | 一种冻干机钎焊板层结构 |
| US9604428B2 (en) | 2010-08-24 | 2017-03-28 | James Walker | Ventilated structural panels and method of construction with ventilated structural panels |
| US9091049B2 (en) * | 2010-08-24 | 2015-07-28 | James Walker | Ventilated structural panels and method of construction with ventilated structural panels |
| CN102029477A (zh) * | 2010-12-01 | 2011-04-27 | 上海共和真空技术有限公司 | 一种用于冻干机的板层的焊接结构及其焊接方法 |
| DE102017204751A1 (de) * | 2017-03-22 | 2018-09-27 | Robert Bosch Gmbh | Gefriertrocknungsanlage |
| KR20220041150A (ko) * | 2019-07-26 | 2022-03-31 | 머크 샤프 앤드 돔 코포레이션 | 제약 조성물의 리오스피어를 제조 및 분배하기 위한 방법 및 어셈블리 |
| US11054185B1 (en) | 2020-02-24 | 2021-07-06 | Lyophilization Technology, Inc. | Apparatus for lyophilization of products contained in product delivery units |
| US11686539B2 (en) * | 2020-03-09 | 2023-06-27 | Raytheon Company | Coldplate with heat transfer module |
| CN115989390B (zh) * | 2020-08-20 | 2024-10-25 | 豪夫迈·罗氏有限公司 | 冻干物保持器、其制造方法以及干燥底物的过程 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB552821A (en) * | 1941-12-18 | 1943-04-27 | Arthur Sproul Mcfarlane | Improvements in and relating to the desiccation of solutions at low temperatures |
| US2433951A (en) * | 1946-05-18 | 1948-01-06 | Charles E Hickman | Refrigerator evaporator |
| US3030703A (en) * | 1957-09-03 | 1962-04-24 | Martin Marietta Corp | Method of making brazed honeycomb structures |
| US2960197A (en) * | 1958-10-07 | 1960-11-15 | Engelhard Ind Inc | Sandwich structure |
| US3145562A (en) * | 1961-07-18 | 1964-08-25 | Pennsalt Chemicals Corp | Apparatus and method for ascertaining optimum drying conditions |
| US3146077A (en) * | 1961-07-20 | 1964-08-25 | Pennsalt Chemicals Corp | Freeze drying apparatus |
| US3264756A (en) * | 1964-06-01 | 1966-08-09 | Pennsalt Chemicals Corp | Drying tray |
| US3259991A (en) * | 1965-01-07 | 1966-07-12 | Abbott Lab | Freeze drying method and apparatus |
| US3448556A (en) * | 1965-12-06 | 1969-06-10 | Everett Ray Taggart | Apparatus for preserving biological and like preparations |
| US3514842A (en) * | 1968-01-16 | 1970-06-02 | North American Rockwell | Brazing process |
| US3545097A (en) * | 1968-12-09 | 1970-12-08 | Pennwalt Corp | High thermal conductivity plastic tray for freeze drying of products |
| FR2303622A1 (fr) * | 1975-03-10 | 1976-10-08 | Microturbo Sa | Procede de fabrication d'une unite du type echangeur de chaleur |
| US4109396A (en) * | 1976-12-06 | 1978-08-29 | Fts Systems, Inc. | Method and apparatus for an improved shelf and tray assembly for a freeze dryer |
| US4521975A (en) * | 1981-05-04 | 1985-06-11 | Marquest Medical Products, Inc. | Lyophilizing and forming biologicals having a predetermined unit dosage |
| US4474226A (en) * | 1981-09-25 | 1984-10-02 | Iowa State University Research Foundation, Inc. | Method and means of exchanging heat between fluid bodies |
| US4606495A (en) * | 1983-12-22 | 1986-08-19 | United Technologies Corporation | Uniform braze application process |
| JPS61262593A (ja) * | 1985-05-15 | 1986-11-20 | Showa Alum Corp | 熱交換器 |
| JPS6363567A (ja) * | 1986-09-04 | 1988-03-19 | Showa Alum Corp | 耐食性の優れた熱交換器の製造方法 |
| JPH0539323Y2 (Sortimente) * | 1987-05-29 | 1993-10-05 | ||
| FR2623277B1 (fr) * | 1987-11-17 | 1990-04-27 | Bioetica Sa | Procede et appareil de lyophilisation comportant des moyens formant ecran thermique entre les etageres de lyophilisation |
| US5452758A (en) * | 1993-03-31 | 1995-09-26 | Contaminant Separations, Inc. | Heat exchanger |
| JPH0874103A (ja) * | 1994-06-30 | 1996-03-19 | Hironari Kida | 滑止め機能を有するストッキングとその製造方法 |
-
1992
- 1992-03-12 US US07/849,846 patent/US5519946A/en not_active Expired - Lifetime
- 1992-12-04 JP JP32515392A patent/JP3245465B2/ja not_active Expired - Lifetime
-
1993
- 1993-03-12 FI FI931120A patent/FI108881B/fi not_active IP Right Cessation
- 1993-03-12 DE DE69315726T patent/DE69315726T2/de not_active Expired - Lifetime
- 1993-03-12 ES ES93301911T patent/ES2110569T3/es not_active Expired - Lifetime
- 1993-03-12 EP EP93301911A patent/EP0560632B1/en not_active Expired - Lifetime
-
1996
- 1996-03-07 US US08/610,817 patent/US5689898A/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103140731A (zh) * | 2010-09-28 | 2013-06-05 | 巴克斯特国际公司 | 使用间隙冷冻来优化冻干的成核和结晶 |
| CN103140731B (zh) * | 2010-09-28 | 2015-12-16 | 巴克斯特国际公司 | 使用间隙冷冻来优化冻干的成核和结晶 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2110569T3 (es) | 1998-02-16 |
| DE69315726T2 (de) | 1998-07-16 |
| JPH05288465A (ja) | 1993-11-02 |
| FI931120A0 (fi) | 1993-03-12 |
| FI108881B (fi) | 2002-04-15 |
| EP0560632A3 (Sortimente) | 1994-08-31 |
| EP0560632B1 (en) | 1997-12-17 |
| EP0560632A2 (en) | 1993-09-15 |
| US5689898A (en) | 1997-11-25 |
| FI931120A7 (fi) | 1993-09-13 |
| US5519946A (en) | 1996-05-28 |
| DE69315726D1 (de) | 1998-01-29 |
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