JP2968367B2 - １，４，７，１０−テトラアザシクロドデカン−ブチルトリオール、そのガドリニウム錯体、これを含有する医薬品及び診断剤、その化合物の製法及び医薬品の製法 - Google Patents

１，４，７，１０−テトラアザシクロドデカン−ブチルトリオール、そのガドリニウム錯体、これを含有する医薬品及び診断剤、その化合物の製法及び医薬品の製法

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Publication number
JP2968367B2
JP2968367B2 JP3077058A JP7705891A JP2968367B2 JP 2968367 B2 JP2968367 B2 JP 2968367B2 JP 3077058 A JP3077058 A JP 3077058A JP 7705891 A JP7705891 A JP 7705891A JP 2968367 B2 JP2968367 B2 JP 2968367B2
Authority
JP
Japan
Prior art keywords
tetraazacyclododecane
compound
group
general formula
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3077058A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05320146A (ja
Inventor
プラッツェク ヨハネス
グリース ハインツ
ヴァインマン ハンス−ヨアヒム
シューマン−ギアムピエリ ガブリエレ
プレス ヴォルフ−リューディガー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHEERINGU AG
Original Assignee
SHEERINGU AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHEERINGU AG filed Critical SHEERINGU AG
Publication of JPH05320146A publication Critical patent/JPH05320146A/ja
Application granted granted Critical
Publication of JP2968367B2 publication Critical patent/JP2968367B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
JP3077058A 1990-03-19 1991-03-18 １，４，７，１０−テトラアザシクロドデカン−ブチルトリオール、そのガドリニウム錯体、これを含有する医薬品及び診断剤、その化合物の製法及び医薬品の製法 Expired - Lifetime JP2968367B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4009119.8 1990-03-19

Publications (2)

Publication Number Publication Date
JPH05320146A JPH05320146A (ja) 1993-12-03
JP2968367B2 true JP2968367B2 (ja) 1999-10-25

Family

ID=6402765

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3077058A Expired - Lifetime JP2968367B2 (ja) 1990-03-19 1991-03-18 １，４，７，１０−テトラアザシクロドデカン−ブチルトリオール、そのガドリニウム錯体、これを含有する医薬品及び診断剤、その化合物の製法及び医薬品の製法

Country Status (17)

Country Link
US (4) US5980864A (US06399043-20020604-C00002.png)
EP (1) EP0448191B1 (US06399043-20020604-C00002.png)
JP (1) JP2968367B2 (US06399043-20020604-C00002.png)
AT (1) ATE124405T1 (US06399043-20020604-C00002.png)
AU (1) AU647091B2 (US06399043-20020604-C00002.png)
CA (1) CA2038493C (US06399043-20020604-C00002.png)
DE (3) DE4009119A1 (US06399043-20020604-C00002.png)
DK (1) DK0448191T3 (US06399043-20020604-C00002.png)
ES (1) ES2074219T3 (US06399043-20020604-C00002.png)
FI (1) FI109695B (US06399043-20020604-C00002.png)
HK (1) HK1002811A1 (US06399043-20020604-C00002.png)
HU (1) HU215964B (US06399043-20020604-C00002.png)
IE (1) IE67643B1 (US06399043-20020604-C00002.png)
IL (1) IL97592A (US06399043-20020604-C00002.png)
NO (2) NO179610C (US06399043-20020604-C00002.png)
NZ (1) NZ237461A (US06399043-20020604-C00002.png)
PT (1) PT97065B (US06399043-20020604-C00002.png)

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CN108779082B (zh) 2016-04-13 2022-08-02 伯拉考成像股份公司 造影剂
HUE050553T2 (hu) 2016-09-27 2020-12-28 Bayer Pharma AG Eljárás A módosulatú kalkobutrol kristályos alakjának elõállítására
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WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
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KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP3820853A4 (en) 2018-07-10 2022-08-17 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF 2,2',2''-( 10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECAN-1,4 ,7-TRIYL)-TRIACETIC ACID AND THEIR COMPLEXES
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
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Also Published As

Publication number Publication date
IE910902A1 (en) 1991-09-25
HUT60478A (en) 1992-09-28
IL97592A0 (en) 1992-06-21
DE10075007I2 (de) 2003-06-12
EP0448191B1 (de) 1995-06-28
DE59105815D1 (de) 1995-08-03
AU647091B2 (en) 1994-03-17
US5980864A (en) 1999-11-09
FI911330A0 (fi) 1991-03-19
NZ237461A (en) 1993-12-23
NO2001003I1 (no) 2001-03-05
IL97592A (en) 1995-10-31
NO179610B (no) 1996-08-05
NO911063D0 (no) 1991-03-18
US20020176823A1 (en) 2002-11-28
HU215964B (hu) 1999-03-29
PT97065A (pt) 1991-10-31
NO179610C (no) 1996-11-13
EP0448191A1 (de) 1991-09-25
US20060078503A1 (en) 2006-04-13
DK0448191T3 (da) 1995-11-20
ATE124405T1 (de) 1995-07-15
FI911330A (fi) 1991-09-20
AU7361091A (en) 1991-09-19
US6399043B1 (en) 2002-06-04
PT97065B (pt) 1998-07-31
IE67643B1 (en) 1996-04-17
CA2038493A1 (en) 1991-09-20
DE4009119A1 (de) 1991-09-26
FI109695B (fi) 2002-09-30
HK1002811A1 (en) 1998-09-18
ES2074219T3 (es) 1995-09-01
NO911063L (no) 1991-09-20
JPH05320146A (ja) 1993-12-03
HU910874D0 (en) 1991-09-30
CA2038493C (en) 2002-07-02
US6951639B2 (en) 2005-10-04

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