JP2925105B2 - 標的成分アッセイ法 - Google Patents
標的成分アッセイ法Info
- Publication number
- JP2925105B2 JP2925105B2 JP5035368A JP3536893A JP2925105B2 JP 2925105 B2 JP2925105 B2 JP 2925105B2 JP 5035368 A JP5035368 A JP 5035368A JP 3536893 A JP3536893 A JP 3536893A JP 2925105 B2 JP2925105 B2 JP 2925105B2
- Authority
- JP
- Japan
- Prior art keywords
- vesicles
- sample
- mixture
- target component
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003556 assay Methods 0.000 title claims abstract description 14
- 239000002502 liposome Substances 0.000 claims abstract description 52
- 239000000203 mixture Substances 0.000 claims description 23
- 230000005484 gravity Effects 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 19
- 102000036639 antigens Human genes 0.000 claims description 19
- 108091007433 antigens Proteins 0.000 claims description 19
- 210000004369 blood Anatomy 0.000 claims description 19
- 239000008280 blood Substances 0.000 claims description 19
- 239000003550 marker Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 12
- 210000004698 lymphocyte Anatomy 0.000 claims description 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 239000013060 biological fluid Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 210000000601 blood cell Anatomy 0.000 claims description 2
- 238000011002 quantification Methods 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 abstract description 4
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 description 17
- 239000012528 membrane Substances 0.000 description 8
- 210000001995 reticulocyte Anatomy 0.000 description 8
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 6
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 6
- 208000002476 Falciparum Malaria Diseases 0.000 description 6
- 206010035500 Plasmodium falciparum infection Diseases 0.000 description 6
- 201000011336 Plasmodium falciparum malaria Diseases 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 238000004159 blood analysis Methods 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 239000012581 transferrin Substances 0.000 description 3
- 201000010374 Down Syndrome Diseases 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 206010044688 Trisomy 21 Diseases 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 102000006354 HLA-DR Antigens Human genes 0.000 description 1
- 108010058597 HLA-DR Antigens Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 101100342977 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) leu-1 gene Proteins 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 102000007238 Transferrin Receptors Human genes 0.000 description 1
- 108010033576 Transferrin Receptors Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940033495 antimalarials Drugs 0.000 description 1
- 239000012911 assay medium Substances 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000003040 circulating cell Anatomy 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 150000002270 gangliosides Chemical class 0.000 description 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/5375—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84197692A | 1992-02-25 | 1992-02-25 | |
| US841976 | 2001-04-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0821833A JPH0821833A (ja) | 1996-01-23 |
| JP2925105B2 true JP2925105B2 (ja) | 1999-07-28 |
Family
ID=25286232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5035368A Expired - Lifetime JP2925105B2 (ja) | 1992-02-25 | 1993-02-24 | 標的成分アッセイ法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5593848A (enExample) |
| EP (1) | EP0557595B1 (enExample) |
| JP (1) | JP2925105B2 (enExample) |
| CN (1) | CN1091521A (enExample) |
| AT (1) | ATE155889T1 (enExample) |
| AU (1) | AU662571B2 (enExample) |
| BR (1) | BR9300639A (enExample) |
| CA (1) | CA2090282A1 (enExample) |
| DE (1) | DE69221118T2 (enExample) |
| DK (1) | DK0557595T3 (enExample) |
| ES (1) | ES2106121T3 (enExample) |
| FI (1) | FI930821L (enExample) |
| GR (1) | GR3024970T3 (enExample) |
| MX (1) | MX9300965A (enExample) |
| NO (1) | NO930649L (enExample) |
| RU (1) | RU2116068C1 (enExample) |
| TW (1) | TW246716B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342790A (en) * | 1992-10-30 | 1994-08-30 | Becton Dickinson And Company | Apparatus for indirect fluorescent assay of blood samples |
| AU4101697A (en) * | 1996-11-22 | 1998-05-28 | Robert A. Levine | Process for enhancing the aggregation and/or agglutination of erythrocytes prior to centrifugation |
| CA2253965C (en) * | 1997-11-22 | 2003-01-21 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer cells and/or hematologic progenitor cells in whole blood |
| US6197523B1 (en) | 1997-11-24 | 2001-03-06 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood |
| US6911315B2 (en) * | 1997-11-24 | 2005-06-28 | David L. Rimm | Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood |
| IL139585A0 (en) * | 1998-06-26 | 2002-02-10 | Pfizer Prod Inc | Improved process for preparing schiff base adducts of amines with 0-hydroxy aldehydes and compositions of matter based thereon |
| GB0021303D0 (en) * | 2000-08-30 | 2000-10-18 | Medinnova Sf | Use |
| CA2504481A1 (en) * | 2002-10-30 | 2004-05-21 | Pointilliste, Inc. | Systems for capture and analysis of biological particles and methods using the systems |
| EP1648299A4 (en) * | 2003-07-09 | 2008-10-22 | California Pacific Med Center | REMOTE DETERMINATION OF THE DELIVERY OF SUBSTANCES IN CELLS |
| US7996825B2 (en) * | 2003-10-31 | 2011-08-09 | Hewlett-Packard Development Company, L.P. | Cross-file inlining by using summaries and global worklist |
| US20060018911A1 (en) * | 2004-01-12 | 2006-01-26 | Dana Ault-Riche | Design of therapeutics and therapeutics |
| CA2720068C (en) | 2008-04-02 | 2013-11-19 | Abbott Point Of Care, Inc. | Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood |
| WO2009126505A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Point Of Care, Inc. | Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber |
| FR2965273B1 (fr) * | 2010-09-29 | 2015-07-17 | Centre Nat Rech Scient | Procede de preparation d'une structure chimique presentant une partition de phases, apte a generer un spectre de fluorescence specifique et ses applications |
| US9624474B2 (en) | 2010-12-01 | 2017-04-18 | Samsung Electronics Co, Ltd. | Method of separating target cell in biological sample |
| CN102788879B (zh) * | 2011-05-20 | 2015-04-01 | 常州康卫生物技术有限公司 | 一种生物检测试剂 |
| EP3292221B1 (en) * | 2015-05-06 | 2021-06-23 | Seracare Life Sciences Inc. | Liposomal preparations for non-invasive-prenatal or cancer screening |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4332785A (en) | 1980-04-09 | 1982-06-01 | University Patents, Inc. | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein |
| GB2239197A (en) | 1989-12-22 | 1991-06-26 | Syntex Inc | Separating a material of interest from a mixture |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862303A (en) * | 1972-02-02 | 1975-01-21 | Atomic Energy Commission | Method for rapid detection and identification of serological factors |
| US4027660A (en) * | 1976-04-02 | 1977-06-07 | Wardlaw Stephen C | Material layer volume determination |
| US4181609A (en) * | 1977-12-20 | 1980-01-01 | Levine Robert A | Blood constituents testing method |
| DE3000483A1 (de) * | 1979-01-09 | 1980-07-17 | Fuji Photo Film Co Ltd | Mikrokapseln fuer immunologische bestimmungen |
| IL64878A (en) * | 1982-01-27 | 1986-01-31 | Yissum Res Dev Co | Method for detection of and determination of malaria antibodies and malaria antigens in human blood |
| JPS5984162A (ja) * | 1982-11-05 | 1984-05-15 | Toshiba Corp | 免疫分析法 |
| US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
| JPS6035267A (ja) * | 1983-08-05 | 1985-02-23 | Fuji Photo Film Co Ltd | 多項目免疫検査法 |
| US5011771A (en) * | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| FR2571498B1 (fr) * | 1984-10-04 | 1988-04-08 | Immunotech Sa | Procede de separation de cellules utilisant des anticorps et des billes de faible densite |
| JPS6345563A (ja) * | 1986-04-11 | 1988-02-26 | Hitachi Ltd | 細胞分析方法 |
| US5001225A (en) * | 1986-12-08 | 1991-03-19 | Georgetown University | Monoclonal antibodies to a pan-malarial antigen |
| GB2200448B (en) * | 1987-01-23 | 1991-01-16 | Univ London | Targetted liposomes and their use in immunoassay |
| US5017472A (en) * | 1987-09-09 | 1991-05-21 | Bankert Richard B | Microflotation devices used for immunoassays and cell/molecular fractionation |
| US4978625A (en) * | 1987-10-19 | 1990-12-18 | Becton, Dickinson And Company | Fluorescence immunoassay using water insoluble dyes |
| JPH03249561A (ja) * | 1990-02-28 | 1991-11-07 | Toshiba Corp | 免疫分析試薬 |
-
1992
- 1992-12-01 DE DE69221118T patent/DE69221118T2/de not_active Expired - Fee Related
- 1992-12-01 AT AT92120505T patent/ATE155889T1/de active
- 1992-12-01 ES ES92120505T patent/ES2106121T3/es not_active Expired - Lifetime
- 1992-12-01 EP EP92120505A patent/EP0557595B1/en not_active Expired - Lifetime
- 1992-12-01 DK DK92120505.0T patent/DK0557595T3/da active
- 1992-12-02 AU AU29836/92A patent/AU662571B2/en not_active Ceased
-
1993
- 1993-02-19 BR BR9300639A patent/BR9300639A/pt not_active Application Discontinuation
- 1993-02-23 MX MX9300965A patent/MX9300965A/es unknown
- 1993-02-24 NO NO93930649A patent/NO930649L/no unknown
- 1993-02-24 JP JP5035368A patent/JP2925105B2/ja not_active Expired - Lifetime
- 1993-02-24 RU RU93004564A patent/RU2116068C1/ru active
- 1993-02-24 CA CA002090282A patent/CA2090282A1/en not_active Abandoned
- 1993-02-24 TW TW082101315A patent/TW246716B/zh active
- 1993-02-24 FI FI930821A patent/FI930821L/fi unknown
- 1993-02-24 CN CN93101332A patent/CN1091521A/zh active Pending
-
1994
- 1994-11-07 US US08/335,310 patent/US5593848A/en not_active Expired - Fee Related
-
1997
- 1997-10-09 GR GR970402612T patent/GR3024970T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4332785A (en) | 1980-04-09 | 1982-06-01 | University Patents, Inc. | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein |
| GB2239197A (en) | 1989-12-22 | 1991-06-26 | Syntex Inc | Separating a material of interest from a mixture |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2116068C1 (ru) | 1998-07-27 |
| FI930821A0 (fi) | 1993-02-24 |
| BR9300639A (pt) | 1993-08-31 |
| JPH0821833A (ja) | 1996-01-23 |
| ATE155889T1 (de) | 1997-08-15 |
| EP0557595A3 (enExample) | 1993-11-10 |
| US5593848A (en) | 1997-01-14 |
| NO930649D0 (no) | 1993-02-24 |
| EP0557595B1 (en) | 1997-07-23 |
| DK0557595T3 (da) | 1997-12-29 |
| FI930821A7 (fi) | 1993-08-26 |
| FI930821L (fi) | 1993-08-26 |
| CA2090282A1 (en) | 1993-08-26 |
| EP0557595A2 (en) | 1993-09-01 |
| MX9300965A (es) | 1994-08-31 |
| CN1091521A (zh) | 1994-08-31 |
| NO930649L (no) | 1993-08-26 |
| AU662571B2 (en) | 1995-09-07 |
| GR3024970T3 (en) | 1998-01-30 |
| AU2983692A (en) | 1993-08-26 |
| DE69221118D1 (de) | 1997-09-04 |
| DE69221118T2 (de) | 1998-02-26 |
| TW246716B (enExample) | 1995-05-01 |
| ES2106121T3 (es) | 1997-11-01 |
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