ES2106121T3 - Ensayo de componentes diana. - Google Patents

Ensayo de componentes diana.

Info

Publication number
ES2106121T3
ES2106121T3 ES92120505T ES92120505T ES2106121T3 ES 2106121 T3 ES2106121 T3 ES 2106121T3 ES 92120505 T ES92120505 T ES 92120505T ES 92120505 T ES92120505 T ES 92120505T ES 2106121 T3 ES2106121 T3 ES 2106121T3
Authority
ES
Spain
Prior art keywords
attached
sample
targets
specific gravity
diana
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92120505T
Other languages
English (en)
Inventor
Robert A Levine
Stephen C Wardlaw
Rodolfo Rodriguez
Judith Britz
Thomas J Mercolino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Application granted granted Critical
Publication of ES2106121T3 publication Critical patent/ES2106121T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/5375—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PRESENTA UN ENSAYO MEJORADO PARA LA OBJETIVACION DE COMPONENTES EN UNA MUESTRA QUE UTILIZA PARTICULAS ALTERADORAS DE LA GRAVEDAD ESPECIFICA QUE SE UNEN A LOS COMPONENTES BUSCADOS MEDIANTE ANTICUERPOS ESPECIFICOS. LAS PARTICULAS ALTERADORAS DE LA GRAVEDAD ESPECIFICA QUE SE UNEN A LOS COMPONENTES SON PREFERIBLEMENTE LIPOSOMAS QUE HUNDIRAN LOS COMPONENTES BUSCADOS HASTA UN NIVEL COMUN EN LA MUESTRA DEL ESPECIMEN CUANDO ESTA ULTIMA HAYA SIDO CENTRIFUGADA EN UN TUBO TRANSPARENTE. LOS LIPOSOMAS PUEDEN SUMINISTRAR UNA INDICACION ACENTUADA O MAS PRONUNCIADA DE LA PRESENCIA DE LOS COMPONENTES BUSCADOS EN LA MUESTRA DEBIDO A SU CAPACIDAD PARA CONTENER UNA GRAN MULTIPLICIDAD DE MOLECULAS COLORANTES FLUORESCENTES O NO FLUORESCENTES CON UNA MINIMA INTERFERENCIA ESTERICA CON LA CAPACIDAD DE UNION DE LOS ANTICUERPOS UNIDOS.
ES92120505T 1992-02-25 1992-12-01 Ensayo de componentes diana. Expired - Lifetime ES2106121T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84197692A 1992-02-25 1992-02-25

Publications (1)

Publication Number Publication Date
ES2106121T3 true ES2106121T3 (es) 1997-11-01

Family

ID=25286232

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92120505T Expired - Lifetime ES2106121T3 (es) 1992-02-25 1992-12-01 Ensayo de componentes diana.

Country Status (17)

Country Link
US (1) US5593848A (es)
EP (1) EP0557595B1 (es)
JP (1) JP2925105B2 (es)
CN (1) CN1091521A (es)
AT (1) ATE155889T1 (es)
AU (1) AU662571B2 (es)
BR (1) BR9300639A (es)
CA (1) CA2090282A1 (es)
DE (1) DE69221118T2 (es)
DK (1) DK0557595T3 (es)
ES (1) ES2106121T3 (es)
FI (1) FI930821A (es)
GR (1) GR3024970T3 (es)
MX (1) MX9300965A (es)
NO (1) NO930649L (es)
RU (1) RU2116068C1 (es)
TW (1) TW246716B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342790A (en) * 1992-10-30 1994-08-30 Becton Dickinson And Company Apparatus for indirect fluorescent assay of blood samples
AU4101697A (en) * 1996-11-22 1998-05-28 Robert A. Levine Process for enhancing the aggregation and/or agglutination of erythrocytes prior to centrifugation
US6197523B1 (en) 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
AU9233698A (en) * 1997-11-22 1999-06-17 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer cells and/or hematologic progenitor cells in whole blood
US6911315B2 (en) * 1997-11-24 2005-06-28 David L. Rimm Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
GB0021303D0 (en) * 2000-08-30 2000-10-18 Medinnova Sf Use
CA2504481A1 (en) * 2002-10-30 2004-05-21 Pointilliste, Inc. Systems for capture and analysis of biological particles and methods using the systems
US20050112065A1 (en) * 2003-07-09 2005-05-26 Drummond Daryl C. Remote detection of substance delivery to cells
US7996825B2 (en) * 2003-10-31 2011-08-09 Hewlett-Packard Development Company, L.P. Cross-file inlining by using summaries and global worklist
US20060018911A1 (en) * 2004-01-12 2006-01-26 Dana Ault-Riche Design of therapeutics and therapeutics
JP5189201B2 (ja) * 2008-04-02 2013-04-24 アボット ポイント オブ ケア インコーポレイテッド 全血を含む生体体液のイムノアッセイを実施するためのリガンドアッセイにおける結合標識と遊離標識との仮想分離
CN102047116A (zh) * 2008-04-09 2011-05-04 艾博特健康公司 检测包含在薄厚度腔室中的薄膜流体样本内的非常少量的分析物的方法
FR2965273B1 (fr) * 2010-09-29 2015-07-17 Centre Nat Rech Scient Procede de preparation d'une structure chimique presentant une partition de phases, apte a generer un spectre de fluorescence specifique et ses applications
US9624474B2 (en) 2010-12-01 2017-04-18 Samsung Electronics Co, Ltd. Method of separating target cell in biological sample
CN102788879B (zh) * 2011-05-20 2015-04-01 常州康卫生物技术有限公司 一种生物检测试剂
AU2016258171B2 (en) * 2015-05-06 2021-12-09 LGC Clinical Diagnostics, Inc. Liposomal preparations for non-invasive-prenatal or cancer screening

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862303A (en) * 1972-02-02 1975-01-21 Atomic Energy Commission Method for rapid detection and identification of serological factors
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination
US4342739A (en) * 1979-01-09 1982-08-03 Fuji Photo Film Co., Ltd. Novel material for immunological assay of biochemical components and a process for the determination of said components
US4332785A (en) * 1980-04-09 1982-06-01 University Patents, Inc. Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein
IL64878A (en) * 1982-01-27 1986-01-31 Yissum Res Dev Co Method for detection of and determination of malaria antibodies and malaria antigens in human blood
JPS5984162A (ja) * 1982-11-05 1984-05-15 Toshiba Corp 免疫分析法
JPS6035267A (ja) * 1983-08-05 1985-02-23 Fuji Photo Film Co Ltd 多項目免疫検査法
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
FR2571498B1 (fr) * 1984-10-04 1988-04-08 Immunotech Sa Procede de separation de cellules utilisant des anticorps et des billes de faible densite
EP0241042A3 (en) * 1986-04-11 1988-05-04 Hitachi, Ltd. A method for cell analysis
US5001225A (en) * 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
GB2200448B (en) * 1987-01-23 1991-01-16 Univ London Targetted liposomes and their use in immunoassay
US5017472A (en) * 1987-09-09 1991-05-21 Bankert Richard B Microflotation devices used for immunoassays and cell/molecular fractionation
US4978625A (en) * 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
DE4041300A1 (de) * 1989-12-22 1991-06-27 Syntex Inc Verfahren zur trennung von komponenten in einer mischung
JPH03249561A (ja) * 1990-02-28 1991-11-07 Toshiba Corp 免疫分析試薬

Also Published As

Publication number Publication date
FI930821A0 (fi) 1993-02-24
CA2090282A1 (en) 1993-08-26
EP0557595A3 (es) 1993-11-10
JPH0821833A (ja) 1996-01-23
DE69221118D1 (de) 1997-09-04
EP0557595A2 (en) 1993-09-01
DK0557595T3 (da) 1997-12-29
EP0557595B1 (en) 1997-07-23
NO930649D0 (no) 1993-02-24
JP2925105B2 (ja) 1999-07-28
TW246716B (es) 1995-05-01
AU662571B2 (en) 1995-09-07
ATE155889T1 (de) 1997-08-15
DE69221118T2 (de) 1998-02-26
AU2983692A (en) 1993-08-26
US5593848A (en) 1997-01-14
RU2116068C1 (ru) 1998-07-27
GR3024970T3 (en) 1998-01-30
NO930649L (no) 1993-08-26
FI930821A (fi) 1993-08-26
MX9300965A (es) 1994-08-31
CN1091521A (zh) 1994-08-31
BR9300639A (pt) 1993-08-31

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