JP2680192B2 - 血液凝固タンパク質のアンタゴニストおよびその利用方法 - Google Patents

血液凝固タンパク質のアンタゴニストおよびその利用方法

Info

Publication number
JP2680192B2
JP2680192B2 JP3518610A JP51861091A JP2680192B2 JP 2680192 B2 JP2680192 B2 JP 2680192B2 JP 3518610 A JP3518610 A JP 3518610A JP 51861091 A JP51861091 A JP 51861091A JP 2680192 B2 JP2680192 B2 JP 2680192B2
Authority
JP
Japan
Prior art keywords
factor
viia
monoclonal antibody
fragment
vii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP3518610A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06502307A (ja
Inventor
ソウル、ハワード・アール
ブランク、テレンス・ケー
Original Assignee
コルバス・インターナショナル、インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by コルバス・インターナショナル、インコーポレイテッド filed Critical コルバス・インターナショナル、インコーポレイテッド
Publication of JPH06502307A publication Critical patent/JPH06502307A/ja
Application granted granted Critical
Publication of JP2680192B2 publication Critical patent/JP2680192B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP3518610A 1990-10-22 1991-10-17 血液凝固タンパク質のアンタゴニストおよびその利用方法 Expired - Fee Related JP2680192B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60145490A 1990-10-22 1990-10-22
US601,454 1990-10-22
US759,443 1991-09-13
US07/759,443 US5506134A (en) 1990-10-22 1991-09-13 Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex

Publications (2)

Publication Number Publication Date
JPH06502307A JPH06502307A (ja) 1994-03-17
JP2680192B2 true JP2680192B2 (ja) 1997-11-19

Family

ID=27083860

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3518610A Expired - Fee Related JP2680192B2 (ja) 1990-10-22 1991-10-17 血液凝固タンパク質のアンタゴニストおよびその利用方法

Country Status (9)

Country Link
US (1) US5506134A (https=)
EP (1) EP0554383B1 (https=)
JP (1) JP2680192B2 (https=)
AT (1) ATE195149T1 (https=)
AU (1) AU654311B2 (https=)
CA (1) CA2094372A1 (https=)
DE (1) DE69132352T2 (https=)
ES (1) ES2151880T3 (https=)
WO (1) WO1992006711A1 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843442A (en) * 1990-10-22 1998-12-01 Corvas International, Inc. Blood coagulation protein antagonists and uses therefor
CA2180140A1 (en) * 1993-12-27 1995-07-06 Jeffrey I. Weitz Methods and compositions for inhibiting thrombogenesis
US5683899A (en) * 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
DE19802139C1 (de) * 1998-01-22 1999-09-23 Centeon Pharma Gmbh Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung
EP0987274A1 (en) 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
CA2351470A1 (en) * 1998-11-20 2000-06-02 Charles Jack Fisher Method of treating viral hemorrhagic fever
EP1059302A1 (en) 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
EP1095933A1 (en) 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
US6677473B1 (en) 1999-11-19 2004-01-13 Corvas International Inc Plasminogen activator inhibitor antagonists
EP1162194A1 (en) 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
PL362320A1 (en) 2000-12-06 2004-10-18 Aventis Pharma Deutschland Gmbh Guanidine and amidine derivatives as factor xa inhibitors
EP1348443A4 (en) * 2000-12-08 2005-07-06 Takeda Pharmaceutical COMBINED MEDICINES
WO2002059268A2 (en) * 2001-01-23 2002-08-01 Saint Louis University Factor ixa: factor viiia interaction and methods therefor
EP1260817A3 (en) 2001-05-08 2002-12-18 Warner-Lambert Company Method for direct measurement of coagulation factor VIIa activity in plasma
EP1270551A1 (en) 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
JP4584574B2 (ja) * 2001-07-03 2010-11-24 オゥクラホゥマ、メディカル、リサーチ、ファウンデイシャン 第ＶＩＩａ因子−アンチトロンビン複合体を測定するためのアッセイ
EA200400548A1 (ru) 2001-10-15 2005-06-30 Чирон Корпорейшн Лечение тяжёлой пневмонии путём введения ингибитора пути тканевого фактора (tfpi)
WO2003039585A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors
EP1314733A1 (en) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
US20040126856A1 (en) * 2002-01-23 2004-07-01 Bajaj Paul S. Factor ixa: factor Vllla interaction and methods therefor
AP2004003113A0 (en) * 2002-02-22 2004-09-30 Prophy Med Ab Use of an inhibitor or antagonist against tissue factor
US6706068B2 (en) 2002-04-23 2004-03-16 Bret A. Ferree Artificial disc replacements with natural kinematics
US7579000B2 (en) * 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
HK1080372A1 (zh) * 2002-05-01 2006-04-28 Schering Aktiengesellschaft 作为抗凝剂的新型组织因子目标抗体
US20040110929A1 (en) * 2002-07-12 2004-06-10 Bjorn Soren E. TF binding compound
US7358268B2 (en) 2002-12-04 2008-04-15 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives as factor Xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US7223780B2 (en) 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
EP1479675A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
EP1479677A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
US7741341B2 (en) 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
US7317027B2 (en) 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
WO2005001080A2 (en) 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
WO2006071794A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
DE10333508A1 (de) * 2003-07-18 2005-02-17 Technische Universität Dresden Gegen Prothrombin gerichtete Erkennungsmoleküle und die Verwendung dieser
EP1568698A1 (en) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrole-derivatives as factor Xa inhibitors
US20070207154A1 (en) * 2004-04-16 2007-09-06 Martin Friedlander Method of modulating vascularization
TR201820051T4 (tr) * 2008-06-19 2019-01-21 Prothix Bv Anti-faktör XI Antikorlarının Trombüs Oluşumunun Engellenmesi Veya Tedavisi İçin Kullanılması
BR112012031727B1 (pt) 2010-06-15 2022-03-29 Genmab A/S Conjugado de droga-anticorpo, composição farmacêutica, e, uso do conjugado de droga- anticorpo
IL230564B2 (en) 2011-07-22 2023-09-01 Csl Ltd Anticoagulant monoclonal antibodies anti–factor xii/fxiia, a method for their preparation, a pharmaceutical compound containing them and medical uses.
ES2984405T3 (es) 2012-09-13 2024-10-29 Bristol Myers Squibb Co Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
TW202506732A (zh) 2018-05-07 2025-02-16 丹麥商珍美寶股份有限公司 使用抗ｐｄ－１抗體與抗組織因子抗體－藥物共軛體之組合以治療癌症之方法
TWI844571B (zh) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
PH12021552586A1 (en) 2019-04-17 2023-07-31 Novo Nordisk As Bispecific antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382083A (en) * 1981-06-25 1983-05-03 Baxter Travenol Laboratories, Inc. Therapeutic method for treating blood-clotting defects with factor VIIa
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
SE461315B (sv) * 1988-06-16 1990-02-05 Jan Niels Faergemann Anvaendning av en komposition innehaallande aluminiumacetotartrat och en diol foer att minska hudirritationer orsakade av urin eller avfoering, samt bloeja impregnerad med kompositionen
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Ｊ．Ｂｉｏｃｈｅｍ．，１０８（１９９０）ｐ．６５４−６６２
J.BIOCHEM=1990 *
Ｊ．Ｃｌｉｎ．Ｐａｔｈｏｌ，．４１（１９８８）ｐ．３３７−３４１
J.CLIN.PATHOL=1988 *

Also Published As

Publication number Publication date
DE69132352D1 (de) 2000-09-07
JPH06502307A (ja) 1994-03-17
AU9029891A (en) 1992-05-20
DE69132352T2 (de) 2001-03-15
WO1992006711A1 (en) 1992-04-30
ATE195149T1 (de) 2000-08-15
ES2151880T3 (es) 2001-01-16
CA2094372A1 (en) 1992-04-23
EP0554383A1 (en) 1993-08-11
US5506134A (en) 1996-04-09
EP0554383A4 (https=) 1994-04-27
EP0554383B1 (en) 2000-08-02
AU654311B2 (en) 1994-11-03

Similar Documents

Publication Publication Date Title
JP2680192B2 (ja) 血液凝固タンパク質のアンタゴニストおよびその利用方法
US6221659B1 (en) Blood coagulation protein antagonists and uses therefor
US6555319B2 (en) Antibodies for inhibiting blood coagulation and methods of use thereof
US5990079A (en) Agents affecting thrombosis and hemostasis
US20260062499A1 (en) Compositions and Methods of Inhibiting MASP-2 for the Treatment of Various Thrombotic Diseases and Disorders
KR100553629B1 (ko) 혈전증치료에유용한항응고제
US7749498B2 (en) Antibodies for inhibiting blood coagulation and methods of use thereof
JPWO2004009641A1 (ja) ａＰＣ非中和抗体
JP2004516236A (ja) 抗血栓剤
US20040229282A1 (en) Antibodies for inhibiting blood coagulation and methods of use thereof
JPH0542920B2 (https=)
JP7635223B2 (ja) 好中球細胞外トラップに関連する線維素溶解不全の診断方法
JP2009503009A (ja) 抗血小板剤としての直接的および間接的エフェクター細胞プロテアーゼ受容体−１（ｅｐｒ−１）阻害剤
JPH04228088A (ja) 血小板因子４の生物学的作用を阻害するモノクローナル抗体
US5837540A (en) Method of producing fibrin-specific antibodies using soluble fibrin polymers as an immunogen
US20040072757A1 (en) Agents affecting thrombosis and hemostasis
JPH03200066A (ja) 活性化ヒトプロテインｃの測定方法
HK1029123B (en) Antibodies for inhibiting blood coagulation and methods of use thereof

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees