ATE195149T1 - Protein-antagonisten der blut-koagulation und ihre verwendung - Google Patents

Protein-antagonisten der blut-koagulation und ihre verwendung

Info

Publication number
ATE195149T1
ATE195149T1 AT91920567T AT91920567T ATE195149T1 AT E195149 T1 ATE195149 T1 AT E195149T1 AT 91920567 T AT91920567 T AT 91920567T AT 91920567 T AT91920567 T AT 91920567T AT E195149 T1 ATE195149 T1 AT E195149T1
Authority
AT
Austria
Prior art keywords
viia
factors vii
factor
complex
protein antagonists
Prior art date
Application number
AT91920567T
Other languages
English (en)
Inventor
Howard R Soule
Terence K Brunck
Original Assignee
Corvas Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvas Int Inc filed Critical Corvas Int Inc
Application granted granted Critical
Publication of ATE195149T1 publication Critical patent/ATE195149T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91920567T 1990-10-22 1991-10-17 Protein-antagonisten der blut-koagulation und ihre verwendung ATE195149T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60145490A 1990-10-22 1990-10-22
US07/759,443 US5506134A (en) 1990-10-22 1991-09-13 Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
PCT/US1991/007811 WO1992006711A1 (en) 1990-10-22 1991-10-17 Blood coagulation protein antagonists and uses therefor

Publications (1)

Publication Number Publication Date
ATE195149T1 true ATE195149T1 (de) 2000-08-15

Family

ID=27083860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91920567T ATE195149T1 (de) 1990-10-22 1991-10-17 Protein-antagonisten der blut-koagulation und ihre verwendung

Country Status (9)

Country Link
US (1) US5506134A (de)
EP (1) EP0554383B1 (de)
JP (1) JP2680192B2 (de)
AT (1) ATE195149T1 (de)
AU (1) AU654311B2 (de)
CA (1) CA2094372A1 (de)
DE (1) DE69132352T2 (de)
ES (1) ES2151880T3 (de)
WO (1) WO1992006711A1 (de)

Families Citing this family (43)

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Publication number Priority date Publication date Assignee Title
US5843442A (en) * 1990-10-22 1998-12-01 Corvas International, Inc. Blood coagulation protein antagonists and uses therefor
EP0738156A1 (de) * 1993-12-27 1996-10-23 Hamilton Civic Hospitals Research Development, Inc. Methode und zusammensetzungen zur hemmung der thrombose-entstehung
US5683899A (en) * 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
DE19802139C1 (de) * 1998-01-22 1999-09-23 Centeon Pharma Gmbh Monoklonaler Antikörper spezifisch für aktivierten Gerinnungsfaktor VII und seine Verwendung
EP0987274A1 (de) 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Faktor VIIa Inhibitore
CN1326356A (zh) * 1998-11-20 2001-12-12 伊莱利利公司 治疗病毒性出血热的方法
EP1059302A1 (de) 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Faktor VIIa Inhibitore
EP1095933A1 (de) 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH N-Guanidinoalkylamide, Verfahren zu ihrer Herstellung, ihre Verwendung und pharmazeutische Zusammensetzungen, die sie enthalten
US6677473B1 (en) 1999-11-19 2004-01-13 Corvas International Inc Plasminogen activator inhibitor antagonists
EP1162194A1 (de) 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Auf Faktor VIIa inhibitorisch wirkende (Thio)-Harnstoff Verbindungen, Verfahren zu deren Herstellung und deren Verwendung
CZ20031554A3 (cs) 2000-12-06 2003-08-13 Aventis Pharma Deutschland Gmbh Guanidinové a amidinové deriváty jako inhibitory faktoru XA
CA2431206C (en) * 2000-12-08 2009-09-01 Takeda Chemical Industries, Ltd. Combination drugs containing anti-sepsis cycloalkene compound
WO2002059268A2 (en) * 2001-01-23 2002-08-01 Saint Louis University Factor ixa: factor viiia interaction and methods therefor
EP1260817A3 (de) 2001-05-08 2002-12-18 Warner-Lambert Company Methode zur Direktbestimmung von Koagulationsfaktor VIIa in Plasma
EP1270551A1 (de) 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Harnstoffverbindungen mit antiproteolytischer Wirkung
AU2002327192B2 (en) * 2001-07-03 2007-02-15 Oklahoma Medical Research Foundation Assay for measuring factor VIIa-antithrombin complexes
BR0213293A (pt) 2001-10-15 2004-12-21 Chiron Corp Uso de tfpi ou de um análogo de tfpi no tratamento de septicemia
JP2005510515A (ja) * 2001-11-09 2005-04-21 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチドおよびプロテインｃ阻害剤を含む薬学的組成物
EP1314733A1 (de) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indol-2-carbonsäureamide als Faktor-Xa-Hemmer
US20040126856A1 (en) * 2002-01-23 2004-07-01 Bajaj Paul S. Factor ixa: factor Vllla interaction and methods therefor
AU2003206571A1 (en) * 2002-02-22 2003-09-09 Prophy Med Ab Use of an inhibitor or antagonist against tissue factor
US6706068B2 (en) 2002-04-23 2004-03-16 Bret A. Ferree Artificial disc replacements with natural kinematics
ES2354419T3 (es) * 2002-05-01 2011-03-14 Bayer Schering Pharma Aktiengesellschaft Nuevas proteínas de fusión de trombomodulina dirigidas hacia el factor tisular como agentes anticoagulantes.
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
US20040110929A1 (en) * 2002-07-12 2004-06-10 Bjorn Soren E. TF binding compound
US7358268B2 (en) 2002-12-04 2008-04-15 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives as factor Xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US7741341B2 (en) 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
EP1479677A1 (de) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Neue Indolderivate als Faktor Xa-Inhibitoren
EP1479675A1 (de) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazolderivate als Faktor Xa-Inhibitoren
US7317027B2 (en) 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
US7223780B2 (en) 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
PL1649013T3 (pl) 2003-06-27 2016-07-29 Depuy Synthes Products Inc Regeneracja i naprawa chrząstki i kości z wykorzystaniem komórek poporodowych
DE10333508A1 (de) * 2003-07-18 2005-02-17 Technische Universität Dresden Gegen Prothrombin gerichtete Erkennungsmoleküle und die Verwendung dieser
EP1568698A1 (de) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrolderivate als faktor-xa-inhibitoren
KR20070012715A (ko) * 2004-04-16 2007-01-26 더 스크립스 리서치 인스티튜트 혈관신생 조절방법
CA2589041C (en) 2004-12-23 2019-08-20 Ethicon, Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
WO2009154461A1 (en) * 2008-06-19 2009-12-23 Prothix Bv Use of anti-factors xi antibodies for prevention of thrombus formation
NO2582728T3 (de) 2010-06-15 2018-01-20
KR102042982B1 (ko) 2011-07-22 2019-11-11 체에스엘 베링 게엠베하 억제성 항-ｘｉｉ/ｘｉｉａ 인자 모노클로날 항체 및 이들의 사용
KR20220107082A (ko) 2012-09-13 2022-08-01 브리스톨-마이어스 스큅 컴퍼니 미오스타틴에 결합하는 피브로넥틴 기반 스캐폴드 도메인 단백질
WO2020212415A1 (en) 2019-04-17 2020-10-22 Novo Nordisk A/S Bispecific antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382083A (en) * 1981-06-25 1983-05-03 Baxter Travenol Laboratories, Inc. Therapeutic method for treating blood-clotting defects with factor VIIa
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
SE461315B (sv) * 1988-06-16 1990-02-05 Jan Niels Faergemann Anvaendning av en komposition innehaallande aluminiumacetotartrat och en diol foer att minska hudirritationer orsakade av urin eller avfoering, samt bloeja impregnerad med kompositionen
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides

Also Published As

Publication number Publication date
AU9029891A (en) 1992-05-20
JP2680192B2 (ja) 1997-11-19
JPH06502307A (ja) 1994-03-17
EP0554383A1 (de) 1993-08-11
AU654311B2 (en) 1994-11-03
EP0554383A4 (de) 1994-04-27
WO1992006711A1 (en) 1992-04-30
DE69132352D1 (de) 2000-09-07
DE69132352T2 (de) 2001-03-15
ES2151880T3 (es) 2001-01-16
CA2094372A1 (en) 1992-04-23
US5506134A (en) 1996-04-09
EP0554383B1 (de) 2000-08-02

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