JP2594251B2 - リン酸二カルシウム二水塩の製法 - Google Patents
リン酸二カルシウム二水塩の製法Info
- Publication number
- JP2594251B2 JP2594251B2 JP57227890A JP22789082A JP2594251B2 JP 2594251 B2 JP2594251 B2 JP 2594251B2 JP 57227890 A JP57227890 A JP 57227890A JP 22789082 A JP22789082 A JP 22789082A JP 2594251 B2 JP2594251 B2 JP 2594251B2
- Authority
- JP
- Japan
- Prior art keywords
- dicalcium phosphate
- phosphate dihydrate
- slurry
- monofluorophosphate
- dihydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 title claims description 41
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 51
- 239000002002 slurry Substances 0.000 claims description 36
- 239000001506 calcium phosphate Substances 0.000 claims description 34
- 229940074371 monofluorophosphate Drugs 0.000 claims description 28
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 21
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 21
- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 21
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 20
- 239000000920 calcium hydroxide Substances 0.000 claims description 20
- 235000011116 calcium hydroxide Nutrition 0.000 claims description 20
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 20
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 18
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 12
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 12
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 12
- 229940005657 pyrophosphoric acid Drugs 0.000 claims description 12
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 9
- QODIJDCJNHJZDA-UHFFFAOYSA-N dicalcium dihydrate Chemical compound O.O.[Ca+2].[Ca+2] QODIJDCJNHJZDA-UHFFFAOYSA-N 0.000 claims description 2
- 150000004683 dihydrates Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 24
- 238000009472 formulation Methods 0.000 description 14
- 239000000606 toothpaste Substances 0.000 description 14
- 239000000292 calcium oxide Substances 0.000 description 11
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 11
- 239000012452 mother liquor Substances 0.000 description 11
- 229940034610 toothpaste Drugs 0.000 description 11
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 10
- 235000011941 Tilia x europaea Nutrition 0.000 description 10
- 239000004571 lime Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000003381 stabilizer Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 235000011180 diphosphates Nutrition 0.000 description 4
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 4
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229940048084 pyrophosphate Drugs 0.000 description 4
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 3
- -1 alkali metal pyrophosphate Chemical class 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 235000019791 dimagnesium phosphate Nutrition 0.000 description 2
- MHJAJDCZWVHCPF-UHFFFAOYSA-L dimagnesium phosphate Chemical compound [Mg+2].OP([O-])([O-])=O MHJAJDCZWVHCPF-UHFFFAOYSA-L 0.000 description 2
- 229910000395 dimagnesium phosphate Inorganic materials 0.000 description 2
- 239000004137 magnesium phosphate Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- PJQJKHNLFUSIGI-UHFFFAOYSA-K dimagnesium phosphate trihydrate Chemical compound O.O.O.[Mg+2].[Mg+2].[O-]P([O-])([O-])=O PJQJKHNLFUSIGI-UHFFFAOYSA-K 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- DWYMPOCYEZONEA-UHFFFAOYSA-L fluoridophosphate Chemical compound [O-]P([O-])(F)=O DWYMPOCYEZONEA-UHFFFAOYSA-L 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- MOMDCAYSCWFERX-UHFFFAOYSA-H trimagnesium;diphosphate;octahydrate Chemical compound O.O.O.O.O.O.O.O.[Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O MOMDCAYSCWFERX-UHFFFAOYSA-H 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/322—Preparation by neutralisation of orthophosphoric acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Paper (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33621481A | 1981-12-31 | 1981-12-31 | |
| US336214 | 1999-06-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59121106A JPS59121106A (ja) | 1984-07-13 |
| JP2594251B2 true JP2594251B2 (ja) | 1997-03-26 |
Family
ID=23315067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57227890A Expired - Lifetime JP2594251B2 (ja) | 1981-12-31 | 1982-12-28 | リン酸二カルシウム二水塩の製法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2594251B2 (enrdf_load_stackoverflow) |
| CA (1) | CA1190378A (enrdf_load_stackoverflow) |
| DE (1) | DE3246884A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2112762B (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59223205A (ja) * | 1983-05-30 | 1984-12-15 | Toyo Sutoufuaa Chem:Kk | 球状無水第二リン酸カルシウムの製造方法 |
| JPS59223206A (ja) * | 1983-05-30 | 1984-12-15 | Toyo Sutoufuaa Chem:Kk | 球状無水第二リン酸カルシウムの製造方法 |
| JPS59223204A (ja) * | 1983-05-30 | 1984-12-15 | Lion Corp | 球状無水第二リン酸カルシウム |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2287699A (en) * | 1940-02-15 | 1942-06-23 | Monsanto Chemicals | Stabilized dicalcium phosphate |
| US3012852A (en) * | 1956-06-06 | 1961-12-12 | Monsanto Chemicals | Stabilized calcium phosphates and process therefor |
| DE1189527B (de) * | 1959-06-30 | 1965-03-25 | Stauffer Chemical Co | Verfahren zur Herstellung von stabilisiertem Dicalciumphosphat |
| DE1259861B (de) * | 1965-06-16 | 1968-02-01 | Knapsack Ag | Verfahren zur Herstellung von stabilisiertem Dicalciumphosphat-Dihydrat |
| DE1277222B (de) * | 1965-12-22 | 1968-09-12 | Knapsack Ag | Verfahren zur Stabilisierung von Dicalciumphosphatdihydrat |
| US4193973A (en) * | 1978-12-22 | 1980-03-18 | Monsanto Company | Process for stabilization of dicalcium phosphate |
| US4247526A (en) * | 1979-05-29 | 1981-01-27 | Monsanto Company | Method for preparing dicalcium phosphate dihydrate with improved stability |
-
1982
- 1982-12-02 GB GB08234362A patent/GB2112762B/en not_active Expired
- 1982-12-08 CA CA000417237A patent/CA1190378A/en not_active Expired
- 1982-12-17 DE DE19823246884 patent/DE3246884A1/de active Granted
- 1982-12-28 JP JP57227890A patent/JP2594251B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB2112762A (en) | 1983-07-27 |
| GB2112762B (en) | 1985-05-01 |
| DE3246884A1 (de) | 1983-08-04 |
| JPS59121106A (ja) | 1984-07-13 |
| CA1190378A (en) | 1985-07-16 |
| DE3246884C2 (enrdf_load_stackoverflow) | 1992-01-09 |
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