JP2525958B2 - 化学的試験方法において使用する装置 - Google Patents

化学的試験方法において使用する装置

Info

Publication number
JP2525958B2
JP2525958B2 JP2507983A JP50798390A JP2525958B2 JP 2525958 B2 JP2525958 B2 JP 2525958B2 JP 2507983 A JP2507983 A JP 2507983A JP 50798390 A JP50798390 A JP 50798390A JP 2525958 B2 JP2525958 B2 JP 2525958B2
Authority
JP
Japan
Prior art keywords
waveguide
sample
reagent
light
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2507983A
Other languages
English (en)
Japanese (ja)
Other versions
JPH03506078A (ja
Inventor
ワーシントン アトリッジ，ジョン
マルティン スミス，アラン
Original Assignee
アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ filed Critical アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ
Publication of JPH03506078A publication Critical patent/JPH03506078A/ja
Application granted granted Critical
Publication of JP2525958B2 publication Critical patent/JP2525958B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7733—Reservoir, liquid reagent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2507983A 1989-05-18 1990-05-17 化学的試験方法において使用する装置 Expired - Fee Related JP2525958B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8911462.3 1989-05-18
GB898911462A GB8911462D0 (en) 1989-05-18 1989-05-18 Devices for use in chemical test procedures

Publications (2)

Publication Number Publication Date
JPH03506078A JPH03506078A (ja) 1991-12-26
JP2525958B2 true JP2525958B2 (ja) 1996-08-21

Family

ID=10656979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2507983A Expired - Fee Related JP2525958B2 (ja) 1989-05-18 1990-05-17 化学的試験方法において使用する装置

Country Status (11)

Country Link
US (1) US5192502A (fr)
EP (1) EP0426817B1 (fr)
JP (1) JP2525958B2 (fr)
AT (1) ATE96228T1 (fr)
AU (1) AU617254B2 (fr)
CA (1) CA2031515C (fr)
DE (1) DE69004049T2 (fr)
DK (1) DK0426817T3 (fr)
ES (1) ES2045921T3 (fr)
GB (1) GB8911462D0 (fr)
WO (1) WO1990014590A1 (fr)

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GB9008261D0 (en) * 1990-04-11 1990-06-13 Ares Serono Res & Dev Ltd Method of improving assay sensitivity
GB9212302D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Method for improving measurement precision in evanescent wave optical biosensor assays
GB9212305D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Sensor for optical assay
AU749504B2 (en) * 1993-05-18 2002-06-27 University Of Utah Research Foundation Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
CA2162996C (fr) * 1993-05-18 2008-02-05 James N. Herron Appareil et methodes pour fluoro-immuno-essais homogenes multi-analysats
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
JP3326708B2 (ja) * 1993-08-31 2002-09-24 日水製薬株式会社 光学的測定装置およびその方法
GB9325718D0 (en) * 1993-12-16 1994-02-16 Ars Holding 89 Nv Sensor device for sandwich assay
GB9404749D0 (en) * 1994-03-10 1994-04-27 Ars Holding 89 Nv Device for use in spectrophotometry
US5490972A (en) * 1994-04-29 1996-02-13 Johnson & Johnson Clinical Diagnostics, Inc. Raising mechanism for incubator cover
US5515170A (en) * 1994-09-08 1996-05-07 Lifescan, Inc. Analyte detection device having a serpentine passageway for indicator strips
US6335203B1 (en) 1994-09-08 2002-01-01 Lifescan, Inc. Optically readable strip for analyte detection having on-strip orientation index
US5563031A (en) * 1994-09-08 1996-10-08 Lifescan, Inc. Highly stable oxidative coupling dye for spectrophotometric determination of analytes
US5526120A (en) * 1994-09-08 1996-06-11 Lifescan, Inc. Test strip with an asymmetrical end insuring correct insertion for measuring
CA2199494C (fr) * 1994-09-08 2007-11-06 David P. Matzinger Bandelette a lecture optique et etalon incorpore pour la detection d'un analyte
GB9419001D0 (en) 1994-09-21 1994-11-09 Applied Research Systems Assay method
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5909227A (en) * 1995-04-12 1999-06-01 Eastman Kodak Company Photograph processing and copying system using coincident force drop-on-demand ink jet printing
WO1997010056A2 (fr) * 1995-09-12 1997-03-20 Becton Dickinson And Company Dispositif et procede d'amplification et de dosage d'adn
US6794127B1 (en) 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
GB9609653D0 (en) * 1996-05-09 1996-07-10 Applied Research Ars Holding N Method of assay
WO1998028623A1 (fr) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation Systeme a base de liaisons par affinite permettant de detecter des particules dans un fluide
US6511854B1 (en) * 1997-07-31 2003-01-28 The Uab Research Foundation Regenerable biosensor using total internal reflection fluorescence with electrochemical control
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
DE19753851A1 (de) * 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Vorrichtung zum kapillaren Flüssigkeitstransport
DE19753847A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit Kapillarkanal
DE19753850A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Probennahmevorrichtung
US6438279B1 (en) 1999-01-07 2002-08-20 Cornell Research Foundation, Inc. Unitary microcapiliary and waveguide structure and method of fabrication
ATE340996T1 (de) 1999-07-05 2006-10-15 Novartis Pharma Gmbh Verfahren zur anwendung einer sensoreinheit
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6395483B1 (en) 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6492133B1 (en) 2000-05-01 2002-12-10 3M Innovative Properties Company Reflective disc assay devices, systems and methods
JP2002202305A (ja) * 2000-12-28 2002-07-19 Ebara Corp アフィニテイー検出分析チップ、その作製方法、それを用いる検出方法及び検出システム
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JP3878144B2 (ja) * 2003-03-19 2007-02-07 富士フイルムホールディングス株式会社 生化学解析用ユニット
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EP0171148B1 (fr) * 1984-06-13 1991-04-17 ARES-SERONO RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP Dispositifs utilisés pour des méthodes d'analyse chimique
US4824789B1 (en) * 1986-10-10 1996-08-13 Minnesota Mining & Mfg Gas sensor

Also Published As

Publication number Publication date
AU617254B2 (en) 1991-11-21
CA2031515C (fr) 1996-06-04
EP0426817A1 (fr) 1991-05-15
CA2031515A1 (fr) 1990-11-19
AU5740390A (en) 1990-12-18
ATE96228T1 (de) 1993-11-15
GB8911462D0 (en) 1989-07-05
EP0426817B1 (fr) 1993-10-20
ES2045921T3 (es) 1994-01-16
DE69004049T2 (de) 1994-04-07
DE69004049D1 (de) 1993-11-25
US5192502A (en) 1993-03-09
DK0426817T3 (da) 1994-02-21
WO1990014590A1 (fr) 1990-11-29
JPH03506078A (ja) 1991-12-26

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